Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 3-formylfuran-2-carboxylate is a selective, triethyl, acrylates, carbonyl groups, phosphite, chloride, carbonyl, diisopropyl, phosphonates, fluoride, potassium and phosphites. It reacts with isomeric hydroxyphosphonates.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Oxo-2,3-dihydro-1H-indene-2-carbonitrile is a chemical compound with the molecular formula C8H6N2. It is a white crystalline solid that is insoluble in water but soluble in organic solvents. This compound is a precursor to various drugs including donepezil and benzylpiperidine. Decyanation of 1-oxo-2,3-dihydro-1H-indene-2-carbonitrile gives benzoic acid.

Versatile small molecule scaffold

Versatile small molecule scaffold

The compound 3-(Phenylsulfanyl)pyridine (3PSP) is a white crystalline solid. It is soluble in water, ethanol, and ether. 3PSP is a nucleophilic compound that reacts with anions such as chloride and nitrite to form disulphides and sulfides. When irradiated, 3PSP will form anion radicals that are able to form inactivated anions. This reaction has been used to produce inactivated anions for use in the polymerization of polymers.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-5-iodothiophene is a chlorinated aromatic compound that is used to produce various drugs and pesticides. This chemical is synthesized by the reaction of 2-chloro-5-iodobenzoic acid with phosphorus pentoxide or aluminium hydride in the presence of lithium aluminum hydride. 2-Chloro-5-iodothiophene has long lasting effects on behavior and can be used for the treatment of neuroleptic disorders. It was also shown to have antihistamine properties and may be used as an antipyretic drug. 2-Chloro-5-iodothiophene can inhibit the activity of acetylcholinesterase, which is responsible for breaking down acetylcholine, leading to paralysis and death by respiratory arrest.

1H,4H,5H-Imidazo[4,5-d]pyridazin-4-one is a tautomeric form of guanine. It can be synthesized from 1H,4H,5H-imidazo[4,5-d]pyridazine and purine. This experimental compound is an analog to adenine and has been shown to have anti-parasitic properties in toxoplasma. 1H,4H,5H-Imidazo[4,5-d]pyridazin-4-one is a nucleobase that binds to the purine receptor on the parasite's surface. This binding inhibits the parasite's ability to produce ATP by inhibiting adenosine phosphorylation.

Versatile small molecule scaffold

Versatile small molecule scaffold

(S)-2-Bromo-4-methylpentanoic acid ee is a peptidomimetic that has been synthesized using triphosgene and a chiral amide. This compound is a synthetic molecule that contains a nitrogen atom. The (S) enantiomer of this compound was synthesized by nature and the structure of this compound is structured, with sulfur atoms on the side chains. This chiral molecule has been shown to have antibacterial activity against leucocytes, which may be due to its conformational effects.

4-(1H-Pyrazol-4-yl)pyrimidine is a x-ray crystallography marker that has been shown to have potential as a drug for the treatment of chronic obstructive pulmonary disease. The pharmacokinetics of 4-(1H-pyrazol-4-yl)pyrimidine was studied in rats and its permeability was found to be low. 4-(1H-Pyrazol-4-yl)pyrimidine has been shown to inhibit the activity of cytochrome P450 enzymes, which are responsible for metabolizing drugs. This makes 4-(1H-pyrazol-4-yl)pyrimidine an important lead compound for drug discovery efforts.

Versatile small molecule scaffold

Bromomethylcycloheptane is a chemical compound that has been studied for its ability to inhibit receptor binding, including the c1-c6 alkoxy and acetylcholine receptors. It also has an effect on progesterone receptors, blood platelets and aminophenyl imidazoles. Bromomethylcycloheptane has been shown to modulate the activity of a number of different drugs, including methyl alcohol, fluorine and imidazole derivatives. The effects of this chemical are not yet fully understood.

Versatile small molecule scaffold

Versatile small molecule scaffold

7-Chloro-1,2,3,4-tetrahydroisoquinoline alkaloids are indole alkaloids that have been found in a wide variety of plants. They are synthesized through oxidative coupling and chlorination of tryptamine. The chlorination step is catalyzed by an enzyme called 7-chloroindole synthase (ICS). This enzyme is encoded by a gene that has been cloned from the plant cell line N6. A number of compounds related to 7-chloroindole have been found in soil bacteria. These compounds can be used for the construction of synthetic pathways for the production of different heterocycles. One such compound is 2-(7-chloro-1H-indol-3-yl)ethanamine, which has shown receptor activity against serotonin.

2-Phenylbenzene-1,3-diol is a ligand in the catalytic cycle of the cocl2 reaction. It is used to study the elimination reactions that occur during this process. The ligand was synthesized by reacting phenyliodine with benzoic acid and then hydrolyzing the product with dilute hydrochloric acid. The resulting crystalline compound was found to be thermally unstable and therefore required cocl2 for activation. This catalyst induced an elimination reaction which yielded two products: 2-phenylbenzene-1,3-diol and benzoic acid.

Versatile small molecule scaffold

4-Methoxybenzo[b]thiophene is a molecule that is activated by fluorescence and emits light as it transfers from an excited state to a lower energy state. This process is called fluorescence, and the emitted light can be detected with ultraviolet (UV) spectroscopy. 4-Methoxybenzo[b]thiophene has been shown to have an olefinic nature, which means it reacts readily with electron-donating groups such as alcohols or phenols. The reaction rate for this compound increases with increasing temperatures and the population of acceptor molecules. It has been studied using photophysical techniques and lipid profile analysis, which measures the lipid content of cells in order to determine their health status.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Methylpiperidin-2-one is a hydroxylated piperidine derivative that can be synthesized by the reaction of xylene with triphosgene in the presence of an acid hydrazide. This compound has been shown to have antibacterial activity against Streptococcus faecalis and other bacteria, but it is carcinogenic in rats. 3-Methylpiperidin-2-one has been used as a ligand for metal ions such as copper and nickel. It can be synthesized using methods like alkylation or chiral synthesis with five membered rings.

4-Allyl-3-thiosemicarbazide is a copper complex that inhibits the growth of cancer cells. Copper chloride is an important catalyst for this reaction. The coordination geometry of the copper ion and the structure of the product are key factors in determining its cytotoxicity. This compound has been shown to have significant cytotoxicity against a variety of cancer cell lines, including leukemia, lymphoma, breast, prostate, lung, pancreatic and colon cancer cells. 4-Allyl-3-thiosemicarbazide is also able to inhibit kinesin by binding to its ATPase site and preventing it from transporting cargo along microtubules.

1,2,5-Thiadiazole-3,4-dicarboxylic acid is a dicarboxylic acid that is structurally related to the thiadiazole ring. It has been shown to interact with amines and hydrate in humid conditions. The crystal structure of 1,2,5-thiadiazole-3,4-dicarboxylic acid has been determined by x-ray diffraction. The molecule forms a mononuclear complex with chloride ions in the crystal system called the cycloaliphatic motif. 1,2,5-Thiadiazole-3,4-dicarboxylic acid has also been found to form hydrogen bonds with temperatures in the range of −10°C and 30°C.