Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Bromohexane is an organic compound and a chemical building block. It is produced by the reaction of 1,3-dibromohexane with copper. 2-Bromohexane is used in the production of epoxides and other chemicals. The synthesis of 2-bromohexane starts with the addition of bromine to 1,3-dibromohexane followed by the addition of copper (II) chloride. This reaction produces 3-bromohexane as a byproduct which can be removed from the reaction mixture using a Dean–Stark trap. In this process, two moles of hydrogen are used to convert one mole of bromine into one mole of hydrogen bromide gas, which can be easily condensed into liquid form. The monoalkylation product 2-bromohexane reacts with an alkyl halide to produce a mixture containing two different alkyl halides. These

Versatile small molecule scaffold

Ethyl 3-aminopent-2-enoate is an enantioselective and efficient ligand that is used in asymmetric synthesis. It reacts with a variety of acceptors such as 2-bromo-3-methylpyridine to form the corresponding β-unsaturated ester. The reaction with cuprate leads to the formation of an α,β-unsaturated carbonyl compound. Ethyl 3-aminopent-2-enoate can be used to synthesize crotonates and esters by hydrolysis and alkylation respectively. The crotonate formed can be converted into its corresponding acid or ester using an enolate formed from ethyl malonate.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

PB-22 is a synthetic cannabinoid, which can be classified as a CB1 receptor agonist. It is one of the many cannabinoids that have been created in an attempt to circumvent drug laws by creating compounds that are similar to those found in cannabis but have different chemical structures. PB-22 has shown to increase locomotor activity and stimulate the cb1 receptor in mice. Magnetic resonance spectroscopy (MRS) and assays were used to determine the binding affinity of PB-22 for the CB1 receptor. The MRS data showed that PB-22 bound with high affinity to the CB1 receptor and had a lower affinity for CB2 receptors. This suggests that PB-22 may be more potent than other synthetic cannabinoids, such as JWH-018 and CP 55,940, which bind better with CB2 receptors than CB1 receptors.
PB-22 is an analog of JWH-073 and has been shown to have a stronger effect on locomotor activity than JWH

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5,6-Dimethoxynicotinic acid is a chemical compound that has been shown to inhibit tumor cell growth by inhibiting the synthesis of DNA and RNA. 5,6-Dimethoxynicotinic acid also inhibits the activity of promyelocytic leukemia (PML) protein in human lung cells. This drug has shown anti-tumor efficacy in xenograft mouse models, where it was able to inhibit tumor growth and prolong survival in mice with acute promyelocytic leukemia. 5,6-Dimethoxynicotinic acid is also being investigated as a potential chemotherapeutic agent in clinical trials.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Iodopropanedial is a pyridine compound. It is used as an antineoplastic agent in the treatment of cancer and damages cellular DNA by binding to nucleic acids and inhibiting protein synthesis. 2-Iodopropanedial also has acrylonitrile, a spectrum that includes antitumor activity and herbicides. 2-Iodopropanedial is an aromatic compound with carboxylic and ethynyl groups. The c-c bond provides its anti-tumor properties.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Bromocyclopent-2-en-1-one is an organic compound that belongs to the group of cycloalkenones. It is a methyl ester with a cyclopentane backbone and a ketone group at the end of the molecule. 3-Bromocyclopent-2-en-1-one is synthesized by a cross-coupling reaction between zinc chloride and 3,4,5,6,7,8,9,10,11 bromodecane. The product can be isolated in crystalline form as well as in yields up to 90%. The product has been shown to act as an analog for prostaglandin E2.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methyl-4-oxo-4-phenylbutanenitrile is a chemical compound that is used in the synthesis of pharmaceuticals. It can be obtained by reacting an organic base with an organic acid. This reaction takes place in a reaction vessel and requires an inorganic base and inorganic reagents. The process also requires ethyl cyanoacetate as the starting material and produces 2-methyl-4-oxo-4-phenylbutanenitrile as the product. The use of this chemical has been linked to environmental pollution, so it should never be released into the environment or come into contact with water.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,2-Dimethyltetradecanoic acid is a fatty acid that is biosynthesized by the enzyme synthase from echinocandin A. It has been shown to have antifungal activity against Candida albicans and Saccharomyces cerevisiae. The ring structure of 2,2-dimethyltetradecanoic acid may be important for its chromatographic properties, as it has been shown to separate well on silica gel. This chemical is also used in chemical biology experiments because of its ability to bind to DNA. 2,2-Dimethyltetradecanoic acid binds to the guanine nucleotide binding site and inhibits transcription initiation.

Versatile small molecule scaffold

Metolachlor is a herbicide with antimicrobial properties that is used to control weeds in agricultural and other settings. Metolachlor is a potent inducer of liver enzymes CYP1A2, CYP3A4, and CYP2E1. It also causes drug interactions with drugs metabolized by these enzymes such as the anti-HIV drug efavirenz. Metolachlor has been shown to cause toxic effects in the kidneys, heart, and brain. The chemical structure of metolachlor was first determined by X-ray crystallography in 1969. Metolachlor is not active against many common plant pests, but it does have activity against some fungi and bacteria. Metolachlor can be used for the control of infectious diseases caused by bacteria, such as salmonella or chlamydia.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(2R)-3-[(Carboxymethyl)sulfanyl]-2-acetamidopropanoic acid is a metabolite of the drug sulfapyridine. It is formed by conjugation with glutathione in the liver to form 3-glutathione-2-sulfapyridine, and then excreted into bile. (2R)-3-[(Carboxymethyl)sulfanyl]-2-acetamidopropanoic acid has been found to be genotoxic in mice, which may be due to its ability to form reactive metabolites that bind to DNA. This compound also possesses cytotoxic properties, which may be due to its ability to inhibit protein synthesis.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Bromo-6-fluoropyridine is a versatile building block that can be used to create a range of compounds. It is a useful intermediate and can be applied in the synthesis of high quality reagents, speciality chemicals, and complex compounds. It has been used as a reaction component in the synthesis of 2-(2-bromoethoxy)pyridine and 2-bromopyridine. This compound has CAS No. 144100-07-2, which makes it an important research chemical.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Terbacil is a herbicide that is used to control perennial ryegrass in agricultural fields. It inhibits the growth of perennial ryegrass by binding to the cytochrome P450 in the mitochondria and preventing fatty acid synthesis. Terbacil also inhibits bacterial growth by binding to metal hydroxide ions and prevents bacterial uptake of nutrients. Terbacil may also be toxic to plant cells, as it has been shown to inhibit root development in cell cultures with solanum tuberosum. Terbacil has a hydroxy derivative, which is likely responsible for its herbicidal properties.

2-Pentyl-1H-benzo[d]imidazole is a hydrophobic compound with affinity for the cavity of cytochrome P450. It has been used as a solid catalyst, and is being investigated as an active substance in the treatment of diseases such as asthma and Parkinson's disease. The binding constants have been determined by the microsomal preparations. The nature of this molecule is supramolecular, which means it contains complex molecules that bind to each other through hydrogen bonding or coordination. 2-Pentyl-1H-benzo[d]imidazole binds to substrates by interaction with their functional groups (e.g., OH, NH2).

4-Bromo-1-hydroxynaphthalene-2-carboxylic acid (4BHN) is a spectroscopic compound that has been used as a radioligand to study the binding of dopamine and dopamine D3 receptors. This compound binds to the d3 receptor with high affinity and specificity, but it does not interact with the d1 or d2 receptors. 4BHN has been shown to act as an agonist at the dopamine D3 receptor. It also acts as an antagonist at the piperidine site of the dopamine D2 receptor. The effects of 4BHN are reversible, which means that it can be displaced by unlabeled 4BHN or other compounds that bind to the same site on the receptor. This technique is useful for studying drug interactions and for determining whether drugs have a subtype selectivity profile.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Oxaspiro[4.4]nonane-1,3-dione is a heterocycle that has been developed as a lead molecule for the treatment of cancer. It was discovered by researchers at the University of Illinois who were investigating the use of Friedel-Crafts reaction to synthesize triazoles. 2-Oxaspiro[4.4]nonane-1,3-dione has physicochemical parameters that make it ideal for pharmaceutical research and development. This molecule has been shown to have anti-inflammatory properties and can be used to focus on carbon bond synthesis in order to synthesize pyridazines and ketocarboxylic acid derivatives.

Versatile small molecule scaffold

4-Bromo-3,5-dichlorophenol is a preservative that is used to prevent the growth of microorganisms in water. The compound is added to water at concentrations of 1-10 ppm and can be found in drinking water, swimming pools, and waste water. 4-Bromo-3,5-dichlorophenol is dechlorinated with chlorine to make it more stable. It has been shown to inhibit the growth of bacteria by interfering with their DNA synthesis and protein production. 4-Bromo-3,5-dichlorophenol also inhibits the growth of fungi and algae by interfering with their cell membrane structure. It can be detected in low levels using gas chromatography/mass spectroscopy or liquid chromatography/mass spectroscopy techniques.
4-Bromo-3,5-dichlorophenol has been shown to be toxic to mice and rats at high concentrations (>100 mg/kg).