Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5F-203 is a new chemical entity that has been shown to inhibit the function of cytochrome P450 1A1 (CYP1A1), which is involved in the metabolism of many substances, including drugs. It also inhibits the function of mitochondrial membrane potential and promotes reactive oxygen species production. These effects are thought to be responsible for its anticancer activity. 5F-203 has been studied in cancer cells and breast cancer cells with low potency. The biological properties of 5F-203 have not been determined yet.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Chloro-N-methyl-2-nitroaniline is an antibiotic that belongs to the group of quinolone antibiotics. It has a broad spectrum against Gram-positive and Gram-negative bacteria, including methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. 3-Chloro-N-methyl-2-nitroaniline binds to bacterial DNA gyrase and topoisomerase IV, as well as human DNA gyrase and topoisomerase II, inhibiting their activity. This leads to cell death by interfering with the production of proteins vital for cell division. The optimal parameters for this drug have been found using isothermal titration calorimetry on the enzyme gyrase in the presence of different concentrations of 3CMA. Pharmacological targets for this drug include DNA gyrase and topoisomerase IV.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Quinoline-5-carbonitrile is a cyanide compound that can be used in the synthesis of heterocyclic compounds. The reaction between quinoline and 5-cyanovaleric acid produces 6-nitroquinoline, which is then converted to dimethyl sulfoxide by alcoholysis. This reaction product can then be used to synthesize an amide or nucleophile. Quinoline-5-carbonitrile reacts with potassium in the presence of bifunctional hydrazide to produce a cyanide ion, which can be hydrolyzed by an acid to release hydrogen cyanide gas. This experiment has been shown as a model for reactions involving cyano compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Chloro-2-methyl-5-nitroaniline is an organic compound with the chemical formula C6H4ClNO2. It is a nitro derivative of aniline. 4-Chloro-2-methyl-5-nitroaniline is a white solid that is soluble in water, alcohols, and ethers. It has a melting point around 206 °C and decomposes at temperatures over 350 °C. This compound can be obtained by reacting hydroxylamine with nitrous acid and chlorinating 2,5-dimethylaniline. The sequence of reactions can be summarized as follows: hydroxy group to nitro group, nitro group to methyl group, methyl group to acetyl or acetylamino, acetyl or acetylamino to acetylation or methylation, transformation from hydroxyl group to amino group and esterification from acid hydrazide to acid group.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-6(methylamino)purine is a potent inhibitor of xanthine oxidase. It is structurally similar to allopurinol, an inhibitor of xanthine oxidase that is used to treat gout. 2-Chloro-6(methylamino)purine inhibits the enzyme by forming a noncompetitive complex with it, which prevents the production of uric acid. This compound has been shown to be effective at inhibiting xanthine oxidase in humans and has been used as a lead compound for the development of new inhibitors of this enzyme.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,2',4,4'-tetrahydroxybenzophenone is a hydroxylated benzophenone that has immunomodulatory effects. It binds to the receptor in the immune system and can cause an increase in cytokine production. 2,2',4,4'-tetrahydroxybenzophenone is cytotoxic and has significant toxicity in vitro. The molecule has been shown to disrupt mitochondrial membrane potential. This may be due to its ability to form hydrogen bonds with molecules on the mitochondrial membrane. 2,2',4,4'-tetrahydroxybenzophenone also modulates transcriptional regulation of genes involved in cell proliferation and apoptosis. The drug is detectable at low levels by mass spectrometry and is not known to have any toxicological effects.END&gt;&gt;</p>

<p>3-Methylbenzo[b]thiophene-2-carboxylic acid (MBTCA) is a heterocyclic compound that is an intermediate in the synthesis of 3-methylthiophene-2-carboxylic acid, a precursor to other drugs. MBTCA is an aerobic, nonpolar compound that has shown antimicrobial activity against some bacteria and fungi. It also has been shown to have practicality as a biomolecular probe for methyl groups in organic solvents. MBTCA can be synthesized by nitration of benzene in the presence of sulfur and sulfoxides. This reaction produces nitrobenzene, which can then be oxidized by potassium permanganate or hydrogen peroxide to produce MBTCA. The most common isomer of MBTCA is 2-(3,5-dimethoxybenzylidene)tetrahydrofuran, with three methyl groups on the</p>

<p>2-Acetylbenzoic acid is a functional molecule that contains an acetyl group. It can form hydrogen bonds with other molecules and has been shown to induce apoptosis in cells. The reaction products of 2-acetylbenzoic acid are malonic acid, acetylsalicylic acid, and 2-benzoylbenzoic acid. These three compounds are made by the addition of hydrogen or hydroxide to the molecule 2-acetylbenzoic acid. The molecule has two functional groups: a carbonyl group and an acetyl group. The chemical structure of this molecule can be seen in the figure below.<br>2-Acetylbenzoic Acid</p>