Building Blocks

2,4-Dichloropyrido [2,3-D] pyrimidine is a regioselective chlorination agent that can be used for the synthesis of various organic compounds. It is often used in cross-coupling reactions to form carbon-carbon bonds. 2,4-Dichloropyrido [2,3-D] pyrimidine has been shown to give high yields and is selective for disubstituted or monosubstituted substrates. This compound is also useful for the functionalization of C-H bonds via palladium-catalyzed coupling reactions.

Leu-Leu-Leu-OH is a pentapeptide that is used in cancer treatment to inhibit the growth of cancer cells. It prevents the production of proteins and, as a result, cell division. Leu-Leu-Leu-OH has been shown to be effective against tumor cells with an antibody that binds to the surface of cells. The monoclonal antibody is taken up by the cancer cells through receptor mediated endocytosis, which leads to inhibition of protein synthesis and cell death.

Phentolamine is a synthetic mesylate that is used as an antihypertensive agent, and for the treatment of Raynaud's syndrome and pheochromocytoma. Phentolamine is also used to prevent frostbite and to treat various types of shock. Phentolamine blocks alpha-2-adrenergic receptors, thereby decreasing sympathetic nerve impulses to the heart, blood vessels, kidneys, and other organs. This drug also acts as a histamine antagonist by blocking H1-receptors on vascular smooth muscle cells. Phentolamine has been shown to have no significant effects on 5-hydroxytryptamine (5HT) release in vitro or in vivo.

Methyl trans-4-bromo-2-butenoate is a synthetic compound that contains a hydroxyl group and two bromine atoms. It is synthesized by the reaction of diethyl succinate, hydrogen, and piperazine in an aqueous solution. Methyl trans-4-bromo-2-butenoate has been shown to have antineoplastic activity in combination with epidermal growth factor (EGF) and carbohydrate conjugates. It also binds to cell surface receptors on the epidermal cells, inhibiting their growth. The structural formula of methyl trans-4-bromo-2-butenoate can be seen below: [[File:Methyltrans4bromobutanoate.png|thumb|300px|left|The structural formula of methyl trans-[4] -[bromo]-[2] -butenoate.]]

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3,6-Dichloropicolinonitrile is a peroxide that is used in the synthesis of organic compounds. It is produced by the reaction of sodium carbonate and hydrochloric acid with nitric acid as a catalyst. 3,6-Dichloropicolinonitrile has been shown to be more selective than other oxidizing agents such as hydrogen peroxide and potassium permanganate. The product can then be purified by adding diacetate, which selectively reacts with the chlorine to form acetyl chloride and glycolic acid. The resulting mixture can then be distilled to produce 3,6-dichloropicolinonitrile in high purity. 3,6-Dichloropicolinonitrile can also be used in electrochemical methods for the synthesis of cyanides or biochemically for virulent products such as pesticides and organic solvents.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Acetamidobenzenesulfonyl azide (4ABS) is a low detection reagent that can be used for the determination of 4-acetamidobenzoic acid. It reacts with the amine group in 4-acetamidobenzoic acid to form a sulfonamide intermediate and releases an azide ion. The linear calibration curve was obtained using vibrational spectroscopy and has a detection sensitivity of 0.03 ppm. This method can also be used to determine the functional groups present in dopamine, which have been shown to affect electrochemical impedance spectroscopy measurements.

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Versatile small molecule scaffold

MW 20,000 - 30,000

Used in the preparation of metal-diene reagents (e.g. for carbocyclization)

Versatile small molecule scaffold

(Chloromethyl)cyclohexane is a synthase gene that is responsible for synthesizing the enzyme chloromethyl cyclohexane, which is used as a solid catalyst. The synthesis of (chloromethyl)cyclohexane from phenyl groups and liquid crystal composition has been demonstrated using expression plasmids and active oxygen. The compound inhibits inflammatory diseases by preventing the production of arachidonic acid, which is an inflammatory agent. This compound also inhibits the production of prostaglandins, which are involved in the release of histamine from mast cells. Pharmaceutical preparations that contain this compound are primarily used to treat rheumatoid arthritis and other inflammatory diseases.

Versatile small molecule scaffold

Cabozantinib is a small molecule that is the first to target VEGFR-2, which is a receptor tyrosine kinase involved in the development of fibrosis. Cabozantinib inhibits the activity of VEGFR-2 by binding to its ATP-binding site and blocking the phosphorylation of downstream signaling pathways. Cabozantinib has been shown to have antifibrotic properties in both preclinical and clinical models. The drug candidate has been shown to reduce kidney fibrosis in animal models. The standard dose for cabozantinib was found to be 5 mg/kg, with a maximum tolerated dose of 20 mg/kg. In vitro studies have indicated that cabozantinib binds with high affinity to the ATP-binding pocket of VEGFR-2, exhibiting competitive inhibition against other kinases such as PDGFR-beta and cKit, as well as diaryliodonium (a specific inhibitor). Caboz

Please enquire for more information about SHR 0302 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Versatile small molecule scaffold

Versatile small molecule scaffold

Isocytosine is a prodrug that has been synthesized with the intramolecular hydrogen on the nitrogen atoms, which makes it more chemically stable. Isocytosine is a reactive molecule, and can react with tautomers to form isocytosine derivatives. Isocytosine contains three hydrogen atoms that are transferable through reactions to other molecules. The chemical stability of isocytosine allows for its use in wastewater treatment. It also has metabolic effects, such as the inhibition of colorectal adenocarcinoma and metabolic disorders. Isocytosine can be used as a model system for studying transfer reactions and reaction mechanisms.

Versatile small molecule scaffold

1-Bromo-4-iodobenzene is an aryl halide that can be synthesized by the cross coupling of ethyl formate and hydrochloric acid. This compound is useful in analytical applications, such as chromatographic methods, due to its high solubility in organic solvents. It is also used in synthetic procedures for the preparation of other aryl halides. 1-Bromo-4-iodobenzene has been used to synthesize calcium carbonate via the Suzuki coupling reaction with sodium salts, which are nucleophiles. The carbonyl group on this molecule reacts with the nucleophile, forming an alkyl group and a metal salt. Transfer reactions involving these salts can produce other products with different functional groups.

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 5-hexynoate is a synthetic product that can be synthesized from soybean lipoxygenase and hydrogenation reduction. This product has been shown to be a useful synthon for the synthesis of monoclonal antibodies with high binding affinity. The synthetic pathway, which involves cross-coupling and asymmetric synthesis, is outlined in the diagram below. The following are the steps involved in the production of methyl 5-hexynoate: 1) Addition of ethyl bromide to terminal alkynes 2) Addition of hydrochloric acid 3) Reaction with potassium tert-butoxide 4) Hydrogenation reduction 5) Cross-coupling reaction 6) Asymmetric synthesis

aliphatic diol.  It has been shown to have an inhibitory effect on bacterial growth

2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(4-Methoxy-1H-indol-3-yl)ethan-1-amine is a synthetic compound that belongs to the class of organocatalysts. It is a serotonin receptor agonist, and has been shown to act as an antagonist at the 5HT2AR. This drug has been shown to have stereoselective effects in vitro, with high affinity for the S form of 5HT2AR. 2-(4-Methoxy-1H-indol-3-yl)ethan-1-amine also has some activity against dopamine receptors, but not as much as other compounds in its class. !--[if !supportLists]-->· !--[endif]-->This drug binds to speciogynine and alstovenine receptors, which are part of the opioid system.!--[if !supportLists]-->· !--[endif]-->Modelling studies suggest that 2-(4-M

8-Chloro-3,7-dihydro-1H-purine-2,6-dione is a reactive molecule that binds to the active site of bacterial cyclic nucleotide phosphodiesterases and inhibits their activity. This inhibition prevents the breakdown of cAMP and cGMP, which are important second messengers in eukaryotic cells. 8-Chloro-3,7-dihydro-1H-purine-2,6-dione is also a potent inhibitor of protein synthesis and has been used in research studies on wheat leaves.

Poly(dioxanone) is a biocompatible polymer that has been shown to promote bone growth in animal models. It is a cross-linking agent and can be used as an alternative to copper chromite, which is the most common cross-linking agent used in tissue engineering. Poly(dioxanone) has been shown to promote bone growth by stimulating the production of growth factors and increasing the activity of osteoblasts, cells that produce new bone. The material also promotes matrix deposition and remodeling, leading to increased bone density.

Tripropylphosphine is a fatty acid that can be synthesized by reacting tripropyl alcohol with phosphorus trichloride. Tripropylphosphine is soluble in organic solvents, and has an optical rotation of +58°. It has been shown to have cancer-inhibiting properties, as well as the ability to inhibit tumor growth and induce apoptosis in cancer cells. This compound may also be used as a growth regulator, since it inhibits the synthesis of certain proteins and enzymes.

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4,5-Dihydroxy-2,3-pentanedione is a carbonyl compound that is the product of the oxidation of ascorbic acid. It is used in wastewater treatment and has antimicrobial properties against infectious diseases. This compound has been shown to inhibit protein synthesis by binding to the ribosome and preventing the formation of peptide bonds between amino acids. 4,5-Dihydroxy-2,3-pentanedione has also been shown to bind to plasma proteins, which may be due to its acyl chain structure. 4,5-Dihydroxy-2,3-pentanedione can be synthesized in a catalytic mechanism that involves dehydroascorbic acid and molecular oxygen.

Versatile small molecule scaffold

Chloromethyl cyclohexyl ether is a light-sensitive cross-linking agent that can be activated by light. It has two functional groups, a hydroxyl group and a chlorine atom. The skeleton of chloromethyl cyclohexyl ether is composed of an alicyclic hydrocarbon with six carbons and the molecule contains two divalent hydrocarbons, one of which is a trifluoromethyl group. Chloromethyl cyclohexyl ether has been used as a solid catalyst in the synthesis of amides and is also used in hyperproliferative diseases such as cancer.

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Versatile small molecule scaffold

Piperyline is an alkanoic acid that has shown to be effective against skin cancer. It also has antimicrobial properties, which may be due to its ability to bind metal ions and form polymeric compounds. Piperyline inhibits microbial growth by inhibiting the synthesis of proteins and nucleic acids. The antimicrobial activity is related to its cationic polymerization with hydroxyl groups, which forms a structure that can inhibit microbial enzymes and disrupt microbial cell membranes. This compound also interacts with the skin's natural lipids, making it difficult for microorganisms to attach and grow on the skin. Piperyline is synthesized in organic chemistry laboratories as an amide precursor of other pharmaceuticals such as penicillin.

Versatile small molecule scaffold

Versatile small molecule scaffold

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Versatile small molecule scaffold

Versatile small molecule scaffold

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2,5-Dimethoxytetrahydrofuran is an organic compound that can be synthesized from 2,5-dimethoxybenzaldehyde and tetrahydrofuran. The asymmetric synthesis of this compound was first reported in 1968. The nmr spectrum of 2,5-dimethoxytetrahydrofuran shows two signals at δ 5.89 and δ 7.03 ppm. This compound is soluble in water and organic solvents such as dichloromethane, benzene, toluene, chloroform, and methanol. 2,5-Dimethoxytetrahydrofuran has been shown to have pain-relieving effects using the formalin test in mice and rats. It also has antineoplastic properties when used with other quinoline derivatives.br>br> 2,5-Dimethoxytetrahydrofuran is a white solid

Norreticuline is a virus-induced gene that is primarily found in the opium poppy, Papaver somniferum. Norreticuline has been shown to be biosynthesized from reticuline by a series of enzymatic reactions. It is also involved in the metabolic pathway of papaverine, which is an alkaloid that has been used as a vasodilator and anti-hypertensive drug. The optimum pH for norreticuline production is between 6 and 7. Norreticuline has demonstrated anticancer activity against various tumor cells, such as breast cancer cells and colon cancer cells. Norreticuline may also have antiviral properties due to its ability to inhibit viral DNA replication and synthesis of viral proteins.

Versatile small molecule scaffold