Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(2',3'-Dimethylphenyl)propionic acid is a prostaglandin compound that inhibits the production of vasoconstricting and vasodilating substances. It belongs to the class of amide, benzoic acid, and azacyclic compounds. The structural formula is CHCOOH. 3-(2',3'-Dimethylphenyl)propionic acid inhibits the response of cells to agonists such as histamine, serotonin, and bradykinin by binding to specific receptors on cell surfaces called integrins. This compound has been shown to have vasospastic effects in patients with Raynaud's phenomenon or other diseases involving vasospasm. 3-(2',3'-Dimethylphenyl)propionic acid also has thrombotic effects due to its inhibition of blood coagulation factors IIa and Xa.

3-(2,5-Dimethylphenyl)propionic acid is a cytotoxic agent that belongs to the group of carboxamides. It is lipophilic and has been shown to be effective against colon tumor cells in vivo. 3-(2,5-Dimethylphenyl)propionic acid binds to DNA chains and inhibits cellular proliferation by inhibiting the synthesis of nucleic acids. This agent also inhibits the activity of topoisomerases I and II, which are enzymes that are necessary for DNA replication and transcription. 3-(2,5-Dimethylphenyl)propionic acid has been shown to have a high cytotoxic potency in vitro but low potency against cultured human cells.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Amino-1H-pyrazole-3-carbonitrile (APC) is a pyrazolopyrimidine compound. It is used as a starting material in organic synthesis, for example to prepare dithioesters and dithioacetals. The transformation of the APC molecule is accomplished by reacting it with either an alcohol or acid chloride.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1,4,7-Tribenzyl-1,4,7-triazonane is a crystalline compound that belongs to the group of ligands. This compound has a benzyl group in its structure and can be used as a transition metal complexing agent. The bond cleavage reaction of 1,4,7-tribenzyl-1,4,7-triazonane is catalyzed by a coordination chemical reaction with transition metals. It has been shown to form complexes with nickel and palladium. The kinetic isotope effect for this process has been reported to be large due to the presence of two hydrogen atoms in one molecule. This means that the molecule is more reactive at the site where it contains the hydrogen atom that is heavier isotopically.

Ethyl 1-benzyl-4-hydroxypyrrolidin-2-one can be synthesized in high yield by reacting benzyl amine with methanol and sodium carbonate in ethanol. This compound is a natural product found in marine organisms, such as sponges, sea cucumbers, and tunicates. It has been shown to have antibiotic properties against bacteria and fungi. The pharmaceutical industry has expressed interest in this compound because of its potential use as an anti-inflammatory agent.

Versatile small molecule scaffold

1-Carbamoylpyrrolidine-2-carboxylic acid is an antimicrobial agent that belongs to the class of cyclic amino acid derivatives. It crystallizes well and has a high yield of approximately 91%. The antimicrobial activity of 1-carbamoylpyrrolidine-2-carboxylic acid is due to its ability to inhibit microbial cell parameters, such as axial rotation and hydrolysis. This compound also has the ability to bind to benzyl groups with a high affinity and inhibit microbial growth by interfering with protein synthesis. Furthermore, 1-carbamoylpyrrolidine-2-carboxylic acid is inexpensively synthesized from benzoic acid.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Bromo-1-methyl-1H-indole is an antimicrobial agent that belongs to the class of bisindole alkaloids. It has been shown to inhibit the growth of Staphylococcus aureus, Escherichia coli, and other microorganisms. 6-Bromo-1-methyl-1H-indole is active against both planktonic cells and biofilm cells. In addition, it has been shown that this molecule inhibits microbial cell division by binding to DNA gyrase and topoisomerase IV. This drug can be used in combination with other antibiotics to treat infections caused by bacteria that are resistant to these drugs. 6-Bromo-1-methyl-1H-indole is not active against Gram positive bacteria such as Streptococcus pneumoniae or Lactobacillus acidophilus because it does not penetrate their cell walls easily.

Versatile small molecule scaffold

Versatile small molecule scaffold

Apcin is a ubiquitin ligase that is activated by the binding of a reactive functional group. It has been shown to promote apoptosis in prostate cancer cells by regulating the cell cycle. Apcin binds to CDC20, halting the mitotic checkpoint and allowing cells to continue dividing. The binding of Apcin activates the Toll-like receptor pathway, which leads to an increased expression of molecules involved in apoptosis. This protein also increases protein synthesis and may be useful in treating HIV infection or cancer tissues.