Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Cyano-N-phenylbenzene-1-sulfonamide is a salt that belongs to the group of aromatic sulfonamides. It is a white, crystalline solid with a melting point of 197 °C. 4-Cyano-N-phenylbenzene-1-sulfonamide has been found to be a polymorphic substance, which means that it can exist in more than one form. The systematic name for this compound is 1-(4'-cyano-3'-nitrophenyl)-4-(4'-cyano-3'-nitrophenyl)benzenesulfonamide monohydrochloride (2:1), and it has two polymorphs: the tetragonal crystal system and the orthorhombic crystal system. 4-Cyano-N-phenylbenzene-1 -sulfonamide also has hydrogen bonding interactions between its molecules and diffraction patterns

Methyl cyclohept-1-ene-1-carboxylate is a histone methyltransferase inhibitor that inhibits the synthesis of histones in mammalian cells. Methyl cyclohept-1-ene-1-carboxylate is used for the treatment of cancers, such as leukemia, lymphoma, and multiple myeloma. It binds to the DNA at specific sites and blocks the formation of histones by inhibiting the transfer of methyl groups. This process leads to changes in gene expression and cellular proliferation. Methyl cyclohept-1-ene-1-carboxylate has also been shown to inhibit demethylation, leading to increased methylation of DNA. The effector proteins may be involved in regulating this process, but more research is needed to confirm this hypothesis.

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Cyclohexylamino)acetic acid hydrochloride is a chiral compound that has been shown to inhibit the activity of metalloproteinases, including matrix metalloproteinase (MMP) and peptidyl-arginine deiminases. It also inhibits the production of inflammatory cytokines in response to viral infection. 2-(Cyclohexylamino)acetic acid hydrochloride may be useful for the treatment of liver diseases such as hepatitis or cirrhosis due to its ability to inhibit MMP-2. It is also being investigated as a potential drug for traumatic brain injury because it has been shown to reduce oxidative stress and inflammation in animal models.