Building Blocks

<p>Applications (RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGluR1 and mGluR5. It has been shown that (RS)-3,5-DHPG can modulate Kir4.1 protein and mRNA in cultured rat retinal Müller cells.(RS)-3,5-DHPG acts as a potential target in treatment of parkinson's disease.<br>References (1) Gao, F., et al.: Neurosci Lett. 588, 12 (2015)<br></p>

<p>Applications 2,4-Difluorotoluene-3,5,6-d3 (CAS# 1219798-79-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,4-Dihydroxyanthraquinone is a bioactive compound from a phytochemical extract which may confer antimicrobial, antioxidant or anti-cancer activity.<br>References Balachandran, P. et al.: Molecules, 26, 735 (2021);<br></p>

<p>Applications 1,3-Diiodobenzene is a common chemical reagent used in the synthesis of multinuclear complexes of large porphyrinoids. Also used in the synthesis of small molecular probes as sensors with low viscosity values.<br>References Miguel, D. et al.: Org. Lett., 17, 2844 (2015);<br></p>

<p>Applications 2-[Di(methylthio)methylidene]malononitrile is a useful reagent for synthesis of isoxazolo[5,4-b]pyridine, pyrrolo[3,2-d]isoxazole, isoxazolo[5,4-b]-azepine-4,7-dione and isoxazole derivatives that could possess anti-cancer properties.<br>References El-Mekabaty, A., &amp; Ibrahim, M. E.: Heterocycles, 100, 901 (2020)<br></p>

<p>Applications 6,6-Dimethyl-5,7-dioxaspiro[2.5]octan-4,8-dione is used as a reagent to synthesize Bis-benzimidazoles, compounds that act as inhibitors of Type II Dihydrofolate reductase (an enzyme that is produced by bacteria in response to Trimethoprim [T795615]as a defense mechanism).<br>References Bastien, D., et al.: J. Med. Chem., 55, 3182 (2012)<br></p>

<p>Applications 2,3-Dimethyl-1-butene is used in reactions to convert fatty acids to flavor compounds. It is also used in reactions with asymmetric glyoxylate to form α-hydroxy esters.<br>References Mikami, K. et al.: J. Am. Chem., 112, 3949 (1990);<br></p>

<p>Applications 2,4-Dimethylbenzenesulfonyl Chloride is used as a reagent in the synthesis of dimethyl benzimidazolones as potent and selective inhibitors of BRPF1 bromodomain. 2,4-Dimethylbenzenesulfonyl Chloride is also used as a reagent in the synthesis of quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for the treatment of Gaucher disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Demont, E.H., et al.: ACS Med. Chem. Lett., 5, 1190 (2014); Marugan, J.J., et al.: J. Med. Chem., 54, 1033 (2011)<br></p>

<p>Applications 2,2-Dimethylbutanoyl chloride is a reagent that is used in the synthesis of 4α,5-Dihydro Simvastatin (D450010). 4α,5-Dihydro Simvastatin is an impurity in the synthesis of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),<br></p>

<p>Applications 3,3-Dimethyl-2-butanol is used as a reagent in the synthesis of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists. 3,3-Dimethyl-2-butanol is also used in the preparation of dihydropyrrole derivatives containing N-sulfanyl, sulfinyl, and sulfonyl moieties which have insecticidal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ito, M., et al.: Bioorg. Med. Chem., 11, 489 (2003); Micheli, F., et al.: Bioorg. Med. Chem., 11, 171 (2003)<br></p>

<p>Applications Intermediate used to produce a variety of pharmaceutical agents, such as analgesic compounds and retinoic acid receptor (RAR) antagonists.<br>References Caldwell, J.; et al.: Bioorg. Med. Chem. Lett., 17, 2281 (2007), Tashiro, T., et al.: Biosci., Biotechnol., Biochem., 72, 2398 (2008),<br></p>

<p>Applications 1,8-Dimethylnaphthalene-d12 (CAS# 104489-29-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,4-Dimethoxybenzylamine (cas# 5763-61-1) is a compound useful in organic synthesis.<br></p>