Building Blocks

Versatile small molecule scaffold

2,6-Diaminopurine is a nucleotide analogue that is synthesized from guanosine. It inhibits the enzyme ribonucleotide reductase and blocks the synthesis of DNA precursors, which are necessary for viral replication. 2,6-Diaminopurine has been shown to inhibit hiv infection in tissue culture and animal models by decreasing the levels of nucleotides in cells. This drug can be used as an anti-viral agent against HIV and other retroviruses. 2,6-Diaminopurine has also been shown to be effective against murine sarcoma virus. The compound binds to the enzyme ribonucleotide reductase, which is important for DNA synthesis, and prevents its activity by mimicking adenosine triphosphate (ATP). The binding of 2,6-diaminopurine to ATP results in a coordination geometry that causes a long hydrogen bond with one oxygen

Versatile small molecule scaffold

2,4-Dimethoxybenzaldehyde is a synthetic compound that has been shown to have activity against pancreatic lipase. It has been suggested as a potential drug for the treatment of metabolic disorders such as obesity or diabetes. 2,4-Dimethoxybenzaldehyde can be synthesized by reacting ethyl diazoacetate with an aldehyde in the presence of ammonium acetate. This chemical can also be used to produce ethyl esters and compounds belonging to the group of phlorotannins. 2,4-Dimethoxybenzaldehyde has been shown to have antioxidative activity and inhibitory effects on pancreatic lipase.

Glycine is a non-essential amino acid with a pKa of 9.3. It is a building block of proteins and can be used to synthesize polypeptides. Glycine has been shown to function as an antigen in humans and has been used in pharmaceutical preparations and clinical studies as an immunological agent, such as in the treatment of hepatitis B virus infection. Glycine is also a component of protonated glycoconjugates, which are found in human serum. In addition to its role as an important amino acid, glycine is also an important molecule for kinetic studies because it has a high transfer rate between molecules and macrocyclic structures. This transfer rate can be used to study the conjugation reactions that occur with fluorescent compounds, like fluorescein, which can be used for labeling antibodies.

2,6-Dichloropurine is a nitrogenous base that inhibits the activity of certain enzymes in the body. It has been shown to inhibit protease activity and nitro reductases, which are enzymes that metabolize nitrosamines. 2,6-Dichloropurine also inhibits the synthesis of epidermal growth factor (EGF) and adenosine A3 receptors in vivo. This drug has potent antitumor activity against various cancer cells and is used for the treatment of HIV infections. 2,6-Dichloropurine can be synthesized from 6-fluoro-3-indoxyl-beta-D-galactopyranoside with an intramolecular hydrogen atom.