Building Blocks

<p>2-Chloro-5-nitronicotinamide is a synthetic drug that has been used as an antileprosy, antimycobacterial, and chemotherapeutic agent. It is a dithiocarbamate that inhibits the synthesis of mycolic acids in mycobacteria. The interaction between 2-chloro-5-nitronicotinamide and mycolic acid is synergistic. This drug can be used to investigate the role of mycolic acids in the pathogenesis of leprosy and tuberculosis. 2-Chloro-5-nitronicotinamide is also active against footpad infections caused by erythromycin resistant strains of Mycobacterium smegmatis. It has been shown to be effective in mice when applied topically as an antimicrobial agent or when injected intravenously as an antimicrobial chemotherapy agent.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(Benzyloxy)-5-methoxy-2-nitrobenzoic acid (BMN) is a linker that has been shown to have anticancer activity. It has been found that BMN enhances the effect of a tumor suppressor gene and blocks the growth of tumor cells. In addition, BMN can be used as a linker to introduce drugs into proteins. This compound has also been shown to inhibit platelet-derived growth factor receptor (PDGFR), which is linked to atherosclerosis and cancer cell proliferation.</p>

<p>6,7-Dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine dihydrochloride (DMPQ) is a piperazine derivative that is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5). This drug has been shown to be useful in the treatment of the symptoms of benign prostatic hyperplasia. DMPQ inhibits the hydrolysis of cyclic adenosine monophosphate (cAMP), which leads to an increase in intracellular levels of cAMP. This drug also exhibits antihypertensive effects, as it inhibits the activity of nitric oxide synthase.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(5-Oxooxolan-2-yl)acetic acid is a fluorophore that emits light upon excitation. It binds to the kappa opioid receptor and has been shown to inhibit leukocyte chemotaxis in vivo. 2-(5-Oxooxolan-2-yl)acetic acid has also been shown to function as an acetylcholinesterase inhibitor, which is important for maintaining the stability of the neurotransmitter dopamine. The fluorescence intensity of 2-(5-Oxooxolan-2-yl)acetic acid increases when it is reacted with amines or other functional groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,4-Dihydro-2H-1-benzopyran-3-amine is an organic compound that belongs to the group of heterocyclic amines. It has been used as a pharmaceutical preparation in the treatment of dyslipidemia and cardiovascular disorders. The 5-HT7 receptor is a G protein coupled receptor that binds serotonin, but it is not clear if 3,4-dihydro-2H-1-benzopyran-3-amine binds to this receptor. It is possible that 3,4-dihydro-2H-1-benzopyran-3-amine may have anti depressant effects because it has been shown to inhibit dopamine β hydroxylase and serotonin synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Amino-3-methylbutanenitrile hydrochloride is a chemical that has been shown to have anti-tumor effects. It inhibits the growth of cancer cells and induces programmed cell death (apoptosis). The mechanism of action is not fully understood, but it may involve the immune system by inhibiting certain types of immune cells and suppressing their activity. 2-Amino-3-methylbutanenitrile hydrochloride binds to the mineralocorticoid receptor, which is involved in regulating blood pressure and fluid balance. 2-Amino-3-methylbutanenitrile hydrochloride also has antagonistic activities against C1–6 alkyl groups and C1–4 alkyl groups as well as insoluble properties.</p>

<p>Versatile small molecule scaffold</p>