Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Decahydro-1,5-naphthyridine (DNH) is a colorless crystalline compound with a melting point of 153 °C. It is a chiral compound that can be synthesized by reacting copper with naphthalene in the presence of an oxidant. The reaction product is soluble in organic solvents and can be purified by recrystallization. DNH has been used as a reagent to study the conformational properties of ketones, in which its stereoselectivity is evident. Compounds containing DNH are also trackable via nuclear magnetic resonance spectroscopy.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Phenyl-1-(prop-2-yn-1-yl)-1H-imidazole is a sustainable metallacycle that contains a cyclopropane ring. It has been shown to have high uptake and thermally activated allylamine group p2 (CPA). This molecule has been crystallized in the x-ray crystal structures of both the ground state and the CPA, which are available on the website. The crystallography algorithm was used to obtain these structures and it is also outlined on the website. The functional theory was applied to these structures, which showed that this molecule can be reduced by hydrogenation or reductive elimination. 4-Phenyl-1-(prop-2-yn-1-yl)-1H-imidazole is hydrophilic due to its resonance stabilizing effect.

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Bromo-2-methylbenzofuran is a chiral compound that has been shown to stabilize the DNA of irradiated, homochiral DNA. It is also used as an intermediate in the synthesis of other compounds. 3-Bromo-2-methylbenzofuran has a high melting point, which makes it difficult to purify. The compound crystallizes unsymmetrically and fluoresces. It can undergo photochromism and isomerization under ultraviolet light. 3-Bromo-2-methylbenzofuran has a low solubility in water and can be toxic if inhaled or ingested. This compound exhibits fluorescence properties, which may be due to its ability to absorb light at wavelengths longer than 400 nm and emit light at wavelengths shorter than 400 nm.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(Isocyanomethyl)pyridine is a nucleophilic amine that is used in organic chemistry as a reagent. It can be used either as a primary amine or as an isocyanide, depending on the desired functionality. 3-(Isocyanomethyl)pyridine reacts with electrophiles such as phenols, alcohols, and carboxylic acids to form reactive intermediates. These intermediates are often useful for generating new molecules. 3-(Isocyanomethyl)pyridine is also capable of reacting with primary and secondary amines to yield multigram quantities of products.
3-(Isocyanomethyl)pyridine has been shown to be an innovative chemical that can be used in many different applications.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold