Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methylquinoline-2-carboxaldehyde is a formylating agent that is used in the synthesis of heterocycles. It has been shown to react with methanol and mediated by oxidative conditions to produce formaldehyde. This reagent can be used for the functionalization of biomolecules by reacting with amines, thiols, and hydroxyl groups. 4-Methylquinoline-2-carboxaldehyde can also be used for the oxidative coupling of phenols and naphthols. The functional group on this compound is a carboxylic acid (-COH).</p>

<p>8-Thia-4,6-diazatricyclo[7.5.0.0,2,7]tetradeca-1(9),2(7),5-trien-3-one is a synthetic antifungal molecule with inhibitory properties against the growth of fungi. This compound inhibits the biosynthesis of ergosterol, an essential component of the fungal cell membrane, by inhibiting the enzyme squalene epoxidase. 8-Thia-4,6-diazatricyclo[7.5.0.0,2,7]tetradeca-1(9),2(7),5-trien-3-one has been shown to be effective in killing Candida albicans and other species of pathogenic fungi in cell culture and animal models.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-one (6,7-DHP) is a muscarinic acetylcholine receptor agonist that has been shown to have profiles of both an agonist and antagonist. It was discovered by screening compounds against the acetylcholine receptor in the presence of different concentrations of acetylcholine. 6,7-DHP activates the receptor at low concentrations and inhibits it at higher concentrations. 6,7-DHP is used as an experimental tool to investigate the function of the muscarinic acetylcholine receptor in various diseases such as psychiatric disorders and inflammatory diseases. The molecule also has potential therapeutic applications for these disorders.</p>

<p>1H,2H,3H-pyrrolo[3,4-c]pyridin-3-one is a phosphoinositide synthesis inhibitor. It is an important drug target for the treatment of cancer due to its ability to inhibit the production of phosphoinositides that are necessary for the regulation of cell growth, proliferation and differentiation. The therapeutic potential of 1H,2H,3H-pyrrolo[3,4-c]pyridin-3-one has been demonstrated through chemistry studies and medicinal chemistry approaches. This molecule was synthesized with a 3-kinase inhibitor moiety and a reactive carboxamides group.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(2,3-Dihydro-1H-indol-3-yl)ethan-1-ol is a crystalline compound that can be prepared by the addition of hydrogen chloride to 2-(2,3-dihydroindol-3-yl)ethanol. It is an enantiomer of 1-(2,3-dihydroindol-3-yl)ethanone. The compound has been used as a reagent in analytical chemistry and as a substrate for oxidases and other enzymes.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Diethyl (methylsulfonylmethyl)phosphonate is a synthetic compound that has been shown to inhibit the mineralocorticoid receptor. This receptor is involved in the regulation of electrolyte and fluid balance. The inhibition of this receptor by diethyl (methylsulfonylmethyl)phosphonate may be due to its ability to bind to the receptor's active site and prevent it from binding with other hormones, such as aldosterone. Diethyl (methylsulfonylmethyl)phosphonate also has antiviral and anti-cancer properties. It can inhibit the proteolytic activity of a virus, such as hepatitis, or protease enzymes found in cancer cells. Diethyl (methylsulfonylmethyl)phosphonate can also act as an allergen for some people and cause skin irritation.</p>

<p>2,2-Dimethyl-1,3-dioxan-5-amine is an organic molecule that utilizes electron affinity to synthesize with a variety of orientations. The hydrophobic and intramolecular orientations are the most common. The 2,2-dimethyl-1,3-dioxan-5-amine molecule has been shown to be capable of utilizing the hydrogen atom in water as an electron acceptor and donor. It can also form a monolayer on a gold electrode surface. This molecule is hydrophilic and therefore prefers hydrophilic environments such as the electrode surface or water. Impurities in this compound may include fluoride ion or chloride ion.</p>

<p>3-(3-Methoxyphenyl)propionaldehyde is a ligand that interacts with the mosquito Aedes aegypti. It has been shown to be orally active and has an affinity for the interaction site on the mosquito's olfactory receptor, which is responsible for detecting odors. 3-(3-Methoxyphenyl)propionaldehyde modulates this receptor, thereby interfering with the mosquito's ability to detect certain odors. It is also known to have an affinity for trypsin and collagen and can be used as a potential drug in treating breast cancer.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-2-methylpropan-1-ol is a chiral, neurotoxic alcohol. It has been shown to be a precursor for the synthesis of neurotrophic analogues, which are compounds that help maintain the structure and function of neurons, such as 3-bromo-2-methylpropanal (BMPA) and 3-bromoacetophenone. The enantiomers of BMPA have different effects on fetal rat cerebral neuronal cells. One enantiomer inhibits the growth of neurons, while the other promotes their growth. These differences may be related to their optical activity: one enantiomer is active when present in the form of left circularly polarized light and the other is active in right circularly polarized light.</p>

<p>2-(2-Iodoethyl)-2,3-dihydro-1H-isoindole-1,3-dione is a crystalline compound that is an n-substituted derivative of phthalimide. It has been shown to be effective for the treatment of tuberculosis. This drug binds to DNA and inhibits transcription and replication. 2-(2-Iodoethyl)-2,3-dihydro-1H-isoindole-1,3-dione also inhibits bacterial growth by binding to RNA polymerase.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Phenyl-1H-pyrrole-3-carbonitrile is an acrylonitrile derivative that is a fungicide. It is used to control fungal diseases on plants and to prevent the spread of fungi in commercial buildings. The compound is used as a seed treatment and as a foliar spray. 4-Phenyl-1H-pyrrole-3-carbonitrile has been shown to be effective against many types of fungi, including species of Aspergillus, Alternaria, Cladosporium, Fusarium, Penicillium, Rhizopus, Scopulariopsis and Trichoderma. However it has little or no activity against bacteria or viruses. This fungicide can be absorbed through the skin and may cause kidney damage if ingested in large quantities.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,6-Dichlorophenethyl bromide is a heterocyclic compound that is an agonist of the farnesoid X receptor (FXR). It has been shown to be effective in treating metabolic diseases such as diabetes and obesity. 2,6-Dichlorophenethyl bromide has also been shown to reduce liver damage in experimental models of nonalcoholic steatohepatitis. This drug binds to FXR and activates the receptor, which then induces the production of bile acids. These bile acids are important for the digestion of fats and absorption of fat soluble vitamins. 2,6-Dichlorophenethyl bromide is metabolized by CYP3A4 enzyme and can cause drug interactions with other drugs that are metabolized by this enzyme.</p>

<p>2-Ethynylquinoline is a molecule that has been found to be effective in the treatment of leukemia and other cancers. It inhibits protein synthesis in cells by binding to the molecule eIF4E, which prevents the production of proteins vital for cell division. 2-Ethynylquinoline has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. This drug also has a toxic effect on respiratory system cells, which may be due to its ability to induce apoptosis.<br>2-Ethynylquinoline is a potent cytotoxic agent that inhibits the growth of cancer cells by inhibiting protein synthesis and mitochondrial membrane potential. The drug also suppresses oxidative injury and cardiac dysfunction induced by fatty acid oxidation. In vivo studies have shown that 2-ethynylquinoline can cause regression of bronchial tumors in mice with pulmonary carcinomas, as well as regression of alveolar tumors in mice with metastatic lung</p>

<p>2-Ethynylbenzothiazole is a synthetic chemical that can be used as a fluorescent probe. It has been shown to react with nucleophilic compounds, such as thiols and amines, in the presence of palladium complexes. The reaction is catalyzed by the addition of hydrogen chloride. 2-Ethynylbenzothiazole reacts with thiols and amines to form a new compound called 2-chlorobenzothiazole. This reaction also produces hydrogen gas and heat. When 2-ethynylbenzothiazole is combined with vitamin B1, it undergoes electrophilic attack by an electron-rich heterocycle, leading to the formation of an intermediate product that fluoresces brightly.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Phenylbenzene-1-sulfonamide is a biphenyl compound that inhibits the production of endothelin, a peptide hormone that plays a role in regulating blood pressure and blood flow. It has been shown to be effective in vitro against experimental models of congestive heart disease and bowel disease. 2-Phenylbenzene-1-sulfonamide also inhibits the activity of x-ray crystal structures, which are proteins involved in apoptosis or programmed cell death. 2-Phenylbenzene-1-sulfonamide is not active against bacteria, but it has been shown to inhibit Mcl-1 protein, which regulates the process of apoptosis. This drug also has sodium salt forms that are used to treat metabolic disorders such as diabetes mellitus type II.</p>

<p>Versatile small molecule scaffold</p>

<p>N-(3-Acetyl-4-hydroxyphenyl)butanamide (NAAB) is a flavonoid that has been shown to be activated by the addition of urine samples. This activation leads to protein synthesis and exfoliation. NAAB fluoresces in the presence of an ultraviolet light, making it a useful fluorescent probe for the detection of human serum amide. NAAB is also low molecular weight and linear range, making it suitable for use as a reticulum deformation agent.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Iodo-2,5-dimethylthiophene is an alkenylation agent. It can be synthesized by reacting 3-iodo-2,4,6-trimethylphenol with boronic acid in the presence of ethylene at high temperatures. The reaction is irreversible and can be used to form substituted derivatives that are irreversibly alkenylated. 3-Iodo-2,5-dimethylthiophene has a number of optical properties including photochromism and diffraction. It has been shown to be useful for the synthesis of novel materials with optical properties such as photochromism and diffraction.</p>

<p>Methyl 2-cyclopentylideneacetate is a molecule that is used in cosmetics. It has viscosity-increasing properties, which are beneficial in products that require a creamy consistency. Methyl 2-cyclopentylideneacetate also has an average particle diameter of less than 20 microns and is soluble in water. This compound can be found in fatty acids, ethyl groups, and crystalline cellulose. The deodorizing effects of this product come from the particles it produces when mixed with magnesium oxide. Methyl 2-cyclopentylideneacetate also contains acidic ph levels and is an ester compound.</p>

<p>Methyl 2-cyclohexylideneacetate is a stereospecific, geranyl, and biomimetic chemical compound. It has been shown to be an effective inhibitor of bacterial enzymes that produce ozonides. Methyl 2-cyclohexylideneacetate also inhibits the biosynthesis of phytosteroids in plants and the synthesis of farnesyl diphosphate, which is an intermediate in the production of cholesterol. The compound has been postulated to inhibit bacterial enzyme activity by binding to the active site on the enzyme.</p>

<p>Mono-benzyl malonate is a synthetic molecule that inhibits the growth of cancer cells. It has an intramolecular hydrogen bond that stabilizes the molecule, and it has been shown to be effective at a low dose in preventing tumor growth. Mono-benzyl malonate also binds to receptors and blocks their activity, which may help to reduce insulin resistance in a similar way as metformin. The biological properties of this compound are still being studied.</p>