Building Blocks

1-(Bromomethyl)-2-fluoro-4-iodobenzene is a heterocyclic chemical compound that belongs to the class of linear compounds. It was discovered by diversity-oriented synthesis and is an example of a pharmacophore. The discovery of this compound was based on the interaction between pharmacophores and their biological targets, which are phosphodiesterases. 1-(Bromomethyl)-2-fluoro-4-iodobenzene interacts with dopamine receptors in the nervous system, thereby playing a role in schizophrenia and nervous system diseases such as Parkinson's disease. This compound has been shown to be effective in animal models for these diseases because it inhibits the enzyme phosphodiesterase, which regulates neurotransmitter levels in the brain.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>5-Benzyloxy-2-bromobenzaldehyde is a polyphenolic compound. It has been shown to have antioxidant activity and inhibit the production of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6. This compound also inhibits the production of inflammatory mediators such as COX-2, lipoxygenase, nitric oxide synthase, and inducible nitric oxide synthase. 5-Benzyloxy-2-bromobenzaldehyde has also been shown to be effective in reducing inflammation in animal studies.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(4-Methoxybenzenesulfonamido)propanoic acid is a pyrimidine derivative that has been shown to have pathological effects on the cornea and retina. It has been shown that 2-(4-methoxybenzenesulfonamido)propanoic acid inhibits angiogenesis, which may be due to its effect on vascular endothelial growth factor (VEGF). The crystal form of this compound is orthorhombic with space group P2(1)/c. The x-ray powder diffraction pattern of this compound shows peaks at 8.8, 10.6, 12.0, 13.3, 14.8, 18.1 degrees 2θ and the X-ray powder diffraction spectrum shows peaks at 7.5, 11.2 degrees 2θ in the range of 3 - 50 keV with an intensity ratio of 1:1:1:1:1:1:1 respectively

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

2-[(3-Methoxyphenyl)amino]acetic acid is a potent inhibitor of 3clpro. 2-[(3-Methoxyphenyl)amino]acetic acid has been shown to inhibit the activity of the enzymes with nanomolar potency in the micromolar range. This compound has been shown to have a high affinity for 3clpro and potent inhibitory activity against other proteases such as papain, subtilisin, and trypsin. The inhibition mechanism of 2-[(3-methoxyphenyl)amino]acetic acid is not fully understood but it has been hypothesized that this compound can bind to the active site of 3clpro via its moiety group. Modifications on the molecule have been shown to increase its inhibitory potency and affinity for 3clpro. Optimization studies have also been carried out by titration calorimetry experiments, which show that 2-[(3-

Versatile small molecule scaffold

<p>1,2-Difluoro-4,5-dinitrobenzene is a nitro compound that has been used extensively in supramolecular chemistry. The cavity of the molecule is able to bind with fatty esters and other molecules with lipophilic properties. This property can be exploited for the encapsulation of biomolecules and other organic compounds. 1,2-Difluoro-4,5-dinitrobenzene has also been found to be reactive towards carboxylic acid groups at room temperature and higher temperatures. The nature of this molecule is reactive as it reacts with carbodiimides to form cyclic urea derivatives.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-3-hydroxy-6-iodopyridine is an electrophile that reacts with magnesium to form a reactive intermediate. This intermediate can react with halides to form diaryl compounds and reactive intermediates, which can be used as reagents for organic synthesis. 2-Chloro-3-hydroxy-6-iodopyridine is also a low temperature reactive intermediate and it has been shown to react with sulfonates to form cycloadducts. This compound can be eliminated by reductive amination or hydrolysis, leading to yields of the desired product.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-tert-Butoxybenzonitrile is an organocatalyst that can catalyze the transformation of aryl iodides to aryl radicals, which can then react with organic substrates. It is most often used as a catalyst for the synthesis of α-amino nitriles. 4-tert-Butoxybenzonitrile can be used in the presence of copper salts and N-methylmorpholine to catalyze the reaction of aryl iodides with alcohols. Mechanistic experiments have shown that 4-tert-butoxybenzonitrile operates by radical coupling, generating an alkyl radical intermediate that reacts with the substrate.

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>2-Chloro-N-phenyl-7H-purin-6-amine is a substituted purine that has been shown to have growth promoting properties in cultured callus and excised plants. It also shows cytokinin activity and betacyanin production in wheat leaves, tobacco leaves, and petunia flowers. This compound binds to the betalactamase enzyme, which degrades the antibiotic cephalosporins, causing resistance to this class of antibiotics. The biological activity of 2-Chloro-N-phenyl-7H-purin-6-amine was observed through its ability to activate nitric oxide synthase (iNOS) and inhibit protein synthesis in purified bacterial extracts.</p>

<p>Versatile small molecule scaffold</p>