Building Blocks

Versatile small molecule scaffold

5-Ethynyl-2-methoxypyridine is a drug with analgesic, marginally anti-inflammatory and anti-pyretic properties. It has been proposed to act as an inhibitor of prostaglandin synthesis. This compound is a weak base that is poorly soluble in water and slightly soluble in ethanol. It appears to have low oral bioavailability (less than 10%) but can be taken orally with minimal side effects because it does not cross the blood brain barrier or affect the central nervous system. 5-Ethynyl-2-methoxypyridine also has cyclic pharmacophore features that are similar to those found in aspirin and other drugs used for pain relief.

3,5-Dicyclopropyl-1H-pyrazole is a calcium channel modulator that can be used to treat cancers. 3,5-Dicyclopropyl-1H-pyrazole is activated by the addition of a phenyl group, which helps to increase its stability. As a calcium channel modulator, 3,5-Dicyclopropyl-1H-pyrazole blocks the function of voltage gated calcium channels. This leads to decreased production of cyclic AMP and subsequently decreases levels of protein kinase A activity. It also has an effect on hematological cancers, solid tumors, and esophageal cancer. 3,5-Dicyclopropyl-1H-pyrazole has been shown in animal studies to have cytotoxic effects against solid cancer cells and esophageal cancer cells.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Chloro-7-fluoroquinoxaline is a quinoxaline that has been shown to have antiviral properties, inhibiting the activity of integrase enzymes in human cells. 6-Chloro-7-fluoroquinoxaline is structurally similar to other quinoxalines, with a hydrophobic region and a quinone acceptor. The pharmacophore of this drug is believed to be the same as that of other quinoxalines, which means it binds to the enzyme's active site by inserting into its hydrophobic pocket. 6-Chloro-7-fluoroquinoxaline has been shown to inhibit HIV and other viruses as well as SARS coronavirus (SARS CoV).

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>(3-Chlorophenyl)(phenyl)methanol is a chiral, optically active aldehyde that is used as a reagent in the synthesis of cellulose triacetate. The optical isomers of this compound are separated by densitometric analysis and the yields are determined by measuring the amount of solutes that elute from plates. The functional groups on this compound have been shown to react with dinitrophenyl and form an intermediate that can be identified as an alcohol.</p>

Versatile small molecule scaffold

<p>2-Aminoindolizine-1-carbonitrile is an experimental substance that can form a bispyridinium ion in the presence of halides. It reacts with elemental analysis reagents and formylation agents to produce spectra, which can be used for screening purposes. This compound has been shown to react with electrophilic reagents and dimerize in the presence of a base. 2-Aminoindolizine-1-carbonitrile has antimicrobial activity against Gram negative bacteria, but not Gram positive bacteria. This antibiotic is active against Mycobacterium tuberculosis, but not against Mycobacterium avium complex.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>4-Bromo-3-iodonitrobenzene is a pyrrole derivative that yields 4-bromo-3-iodobenzene upon treatment with palladium. It is a precursor to other products, such as 3-iodo-4-(pyrrolidinomethyl)benzoic acid and 4-(pyrrolidinomethyl)benzoic acid. This compound can be used in the synthesis of biomolecules, such as nucleosides, nucleotides, amino acids, peptides, and proteins. The synthesis of this compound involves deuterium exchange between the bromine and the hydrogen on the nitrogen atom. For example, if 4-bromo-3-iodonitrobenzene reacts with sodium methoxide in methanol it will produce 4-(methylamino)-3-(iodomethyl)aniline hydrochloride. The reaction yield of this</p>

<p>4-Bromo-3-iodoaniline is a compound that can be used in cancer diagnosis. This substance has been shown to have high fluorescence properties and to emit light when exposed to radiation. The trifluoroacetic acid group makes this compound soluble in water, which is useful for medical purposes. 4-Bromo-3-iodoaniline has been shown to bind selectively to DNA and RNA, making it a potential diagnostic tool for cancer. It also shows great promise for use as a nanomaterial in biomedical imaging applications, such as optical imaging and magnetic resonance imaging (MRI).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

5-Propyl-thiophene-2-carboxylic acid is a cyclic hydrocarbon that has been synthesized in an asymmetric synthesis. It has a monosubstituted hydrocarbon group and a heterocyclic group. The 5-propyl-thiophene-2-carboxylic acid is a liquid crystal, which means it can form three different phases, including the isotropic phase, the nematic phase, and the smectic phase. 5-Propyl-thiophene-2-carboxylic acid is also a cyclic compound and can be classified as being a heterocyclic.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>4-Pentynoic acid ethyl ester (4PE) is a hematological agent that can be used to treat cancer. 4PE inhibits the growth of cancer cells by binding to the histone deacetylase enzyme, which is required for the transcription of genes that are involved in cell division and differentiation. The binding of 4PE to the enzyme causes it to become inactive, leading to inhibition of gene transcription and alteration of cellular metabolism. This results in decreased cell proliferation and an increase in apoptosis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

4-Hydroxy-8-(propan-2-yl)quinoline-3-carboxylic acid (4HPCA) is a small molecule that binds to the epidermal growth factor receptor (EGFR). EGFR is a transmembrane protein that is found on the surface of cells. 4HPCA enhances EGFR signaling and induces cellular responses, such as cell proliferation, differentiation, and migration. Binding of 4HPCA to EGFR causes a conformational change in the receptor that activates downstream signaling pathways. This leads to the activation of genes involved in cell proliferation, differentiation, and migration. 4HPCA has been shown to inhibit tumor growth and reduce cancer markers in preclinical models of cancer.

4-Chloro-3-methylquinoline is an intramolecular reaction that is catalyzed by a strong base. It is a reagent that reacts with azide to form the cyclized product. The mechanism of this reaction proceeds in two steps. In the first step, the methyleniminium cation intermediate is formed by intramolecular cyclization. This intermediate then reacts with the azide ion to form the desired product. 4-Chloro-3-methylquinoline can also be used as a sterically demanding methylene group when it undergoes electrophilic substitution reactions with alkyl halides and other nucleophiles.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>