Building Blocks

<p>Versatile small molecule scaffold</p>

6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-one (6,7-DHP) is a muscarinic acetylcholine receptor agonist that has been shown to have profiles of both an agonist and antagonist. It was discovered by screening compounds against the acetylcholine receptor in the presence of different concentrations of acetylcholine. 6,7-DHP activates the receptor at low concentrations and inhibits it at higher concentrations. 6,7-DHP is used as an experimental tool to investigate the function of the muscarinic acetylcholine receptor in various diseases such as psychiatric disorders and inflammatory diseases. The molecule also has potential therapeutic applications for these disorders.

<p>1H,2H,3H-pyrrolo[3,4-c]pyridin-3-one is a phosphoinositide synthesis inhibitor. It is an important drug target for the treatment of cancer due to its ability to inhibit the production of phosphoinositides that are necessary for the regulation of cell growth, proliferation and differentiation. The therapeutic potential of 1H,2H,3H-pyrrolo[3,4-c]pyridin-3-one has been demonstrated through chemistry studies and medicinal chemistry approaches. This molecule was synthesized with a 3-kinase inhibitor moiety and a reactive carboxamides group.</p>

Versatile small molecule scaffold

2-(2,3-Dihydro-1H-indol-3-yl)ethan-1-ol is a crystalline compound that can be prepared by the addition of hydrogen chloride to 2-(2,3-dihydroindol-3-yl)ethanol. It is an enantiomer of 1-(2,3-dihydroindol-3-yl)ethanone. The compound has been used as a reagent in analytical chemistry and as a substrate for oxidases and other enzymes.

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Diethyl (methylsulfonylmethyl)phosphonate is a synthetic compound that has been shown to inhibit the mineralocorticoid receptor. This receptor is involved in the regulation of electrolyte and fluid balance. The inhibition of this receptor by diethyl (methylsulfonylmethyl)phosphonate may be due to its ability to bind to the receptor's active site and prevent it from binding with other hormones, such as aldosterone. Diethyl (methylsulfonylmethyl)phosphonate also has antiviral and anti-cancer properties. It can inhibit the proteolytic activity of a virus, such as hepatitis, or protease enzymes found in cancer cells. Diethyl (methylsulfonylmethyl)phosphonate can also act as an allergen for some people and cause skin irritation.

<p>2,2-Dimethyl-1,3-dioxan-5-amine is an organic molecule that utilizes electron affinity to synthesize with a variety of orientations. The hydrophobic and intramolecular orientations are the most common. The 2,2-dimethyl-1,3-dioxan-5-amine molecule has been shown to be capable of utilizing the hydrogen atom in water as an electron acceptor and donor. It can also form a monolayer on a gold electrode surface. This molecule is hydrophilic and therefore prefers hydrophilic environments such as the electrode surface or water. Impurities in this compound may include fluoride ion or chloride ion.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

2-Oxatricyclo[5.4.0.0,3,5]undeca-1(11),7,9-trien-6-one (2OCTU) is a ketone that can be synthesized from 2-oxatricyclo[5.4.0.0,3,5]undeca-1(11),7,9-trien-6-one (2OCU) by solvolysis with a base such as potassium hydroxide or sodium methoxide in methanol or ethanol. It can also be prepared by reacting cyclopropanes with aldehydes in the presence of catalytic amounts of pyridine and triethylamine at room temperature to form acetal rings that are then hydrolyzed to produce 2OCTU after acidification. The chemical reaction yields 2OCTU in high yield and it is a stable molecule that can be stored for

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Commonly abbreviated as AcBut, it is an aromatic acyl linker that can be cleaved under chemical conditions. It is used for the controlled release of payloads.</p>

<p>2,3-Dimethylbenzene-1-sulfonamide is a crystalline compound that has been shown to have fungicidal and insecticidal activities. It can be used as a combination with other fungicides and insecticides. 2,3-Dimethylbenzene-1-sulfonamide is an active compound in sulfilimines, which are compounds containing the sulfonyl group (-SO2R) attached to a carbon atom in the heterocyclic ring system. This compound has been shown to inhibit carbenes and may be useful for the treatment of fungi that produce mycotoxins. 2,3-Dimethylbenzene-1-sulfonamide also has anti-inflammatory properties and can be used as a nitrogen source for plants.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

3-Amino-1-(thiophen-2-yl)propan-1-ol is a form of 3 amino propanol that has the chemical formula CH3CH2CH2N(CH3)S. It is an optical isomer of 1-(thiophen-2-yl)propan-1-ol and can be used as a pharmaceutical preparation in formulae with other drugs. 3 amino propanol can be prepared by reacting propionamide with ammonia, aralkyl amides, or amido groups. This reaction yields a mixture of the two optical isomers in a ratio of 1:5 to 5:1. The substance is also known as 6-alkyl, optically active, pharmaceutical preparations and formulae (6AOPPF).

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Phenylpropanethioamide is an antibiotic that inhibits bacterial growth by binding to the 50S ribosomal subunit. It has been shown to be a potent inhibitor of bacterial biosynthesis, which may be due to its ability to form reactive oxygen species and dimethyl disulfide. 3-Phenylpropanethioamide also binds to penicillin-binding proteins in the bacterial cell wall by competitive inhibition, preventing the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. 3-Phenylpropanethioamide is capable of forming radical intermediates from peroxide, which can lead to DNA damage and mutations.