Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Chloro-3-iodoanisole is a tetracyclic organic compound. It is an intermediate in the synthesis of arynes and dienes by dehalogenation of substituted benzenes with organolithium reagents. 4CI has been shown to react with dienophiles, such as 1,2-dichlorobenzene, to give the corresponding ethylenic products. The yield of this reaction is dependent on steric factors, such as the electronic nature of substituents on the benzene ring and their orientation relative to one another.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-(Benzyloxy)-1-methyl-1H-indole is a potent inhibitor of human prostate enzyme. It also has inhibitory activity against other nonsteroidal human enzymes, including the potent inhibitory activity against human benzoyl peroxide reductase. 5-(Benzyloxy)-1-methyl-1H-indole inhibits steroid biosynthesis in the human prostate gland, inhibiting the conversion of cholesterol to testosterone. This compound may be used as an alternative to finasteride for treating benign prostatic hyperplasia, due to its low toxicity and lack of side effects.

Versatile small molecule scaffold

Versatile small molecule scaffold

6H,7H,8H,9H,11H-Pyrido[2,1-b]quinazolin-11-one is a biomolecular compound that belongs to the class of aminophenols. It is synthesized by the oxidative coupling of deoxyvasicinone with sodium hypochlorite and irradiation. The reaction time for this reaction is 10 minutes at room temperature. 6H,7H,8H,9H,11H-Pyrido[2,1-b]quinazolin-11-one has been shown to have antimicrobial activity against bacteria and fungi in vitro. Its structure is similar to mackinazolinone and synthetic analogues such as 2-(4'-aminophenyl)thiazole. 6H,7H,8H,9H,11H-Pyrido[2,1-b]quinazolin-11-one also reacts with dien

Versatile small molecule scaffold

1,2,3-Tris(2-cyanoethoxy)propane is a contaminant that has low detection limits and can be detected on-line. It has been shown to interact with oxygenated solutes in the chromatographic method used to analyze silicone. 1,2,3-Tris(2-cyanoethoxy)propane has also been shown to be an injectable solute that can desorb from silicone during the chromatographic analysis. This contaminant is not expressed by S. pneumoniae or S. pyogenes, but is expressed by E. coli and Streptococcus sp.

Versatile small molecule scaffold

4-Amino-2-ethylbenzoic acid is a naturally occurring amino acid. It is a vasopressin analog that has been shown to lower blood pressure in vivo. 4-Amino-2-ethylbenzoic acid binds to the receptor for arginine vasotocin, which is the natural ligand for this receptor and activates the receptor. It also has a high lipophilicity and extracellular Ca2+ binding capacity. 4-Amino-2-ethylbenzoic acid may act as an estrogen antagonist by competing with estradiol for binding to estrogen receptors on cells.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Propylbenzenamine is an attractant for tsetse flies. 3-Propylbenzenamine has been shown to be a potent carbonate catalyst and can also be used as a carbamate pesticide.

Versatile small molecule scaffold

1-Hydroxy-3-methylanthraquinone is a quinone compound that has been shown to have binding constants for the fungal filamentous fungus, Vulgare L. (strain pachybasin), and bacterial strains. This chemical has also been shown to have biological properties such as antimicrobial activity against Acetobacter aceti, inhibition of growth of the human pathogen Streptococcus pyogenes, and induction of locomotor activity in mice. 1-Hydroxy-3-methylanthraquinone binds to fatty acids in the cell membrane and alters the permeability of this membrane. 1HMR spectroscopy data suggests that this compound is regiospecific with respect to its two hydroxyl groups.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(Thien-2-yl)aniline is a compound that can be used as an electron transport material in electrochemical studies. It has been shown to be capable of occluding and transferring electrons, which may be due to its ability to form thin films with a thickness of about 10 nm. 3-(Thien-2-yl)aniline is also magnetic and can undergo optical transitions when exposed to light, giving it the potential for use in photopolymerization and photoelectrochemistry. The nature of this compound is unknown, but it has been shown to inhibit fluorine on a thin film surface.
3-(Thien-2-yl)aniline may also be used as an electrode material in optical devices such as photocurrent generators or light emitting diodes (LEDs).

Versatile small molecule scaffold