Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Amino-1,2-oxazole-4-carboxamide is a heterocyclic compound that is used in the synthesis of aminoisoxazoles. It is prepared by reacting 5-nitrobenzoic acid with hydroxylamine. 5-Amino-1,2-oxazole-4-carboxamide has been shown to be a useful reagent for the synthesis of polyfunctionalized heterocycles. This compound can also be used in the preparation of compounds that are not commercially available.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Benzo[b]furan-7-carboxaldehyde (BBA) is a mitochondrial uncoupler that can be used as an alternative to the toxic and expensive compound dinitrophenol. BBA induces mitochondrial dysfunction and cytosolic Ca2+ levels by inhibiting ATP synthesis and mitochondrial membrane potential. This leads to oxidative injury, which can be reversed with pharmacological treatments. BBA has been shown to have in vitro antifungal activity against Candida albicans and Saccharomyces cerevisiae, but it has not been tested on other fungi. It also has cardioprotective effects in vivo. In rats, intravenous administration of BBA raised the concentration of creatine kinase, indicating myocardial damage. Magnetic resonance spectroscopy revealed the induction of electrophysiological changes in rat cardiomyocytes after treatment with BBA. These changes were accompanied by actin filament depolymerization and disruption of sarcomere structure. Molecular

Versatile small molecule scaffold

3-(3,5-Dichlorophenyl)propionic acid (3,5-DCP) is a tuberculostatic agent that inhibits the growth of bacteria by inhibiting protein synthesis. 3,5-DCP has been shown to have dermal and dermal toxicity in humans. It has been shown to be effective against human melanoma cells and mouse melanoma cells. 3,5-DCP is structurally related to other compounds with known antineoplastic activity including imidazole derivatives and methyl groups.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Sodium fluoride is a salt of sodium and fluoride ions, with the chemical formula NaF. It is an ionic compound, which is a crystalline solid that dissolves in water to give off the strong odor of hydrofluoric acid. This compound has been used for many years as an expectorant in cough medicines. Sodium fluoride is also used as a preservative in mouthwashes and toothpastes. It may be found in combination with other substances such as potassium iodide, sodium laureth sulfate, or sodium lauryl sulfate.

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 4-fluoro-3-oxobutanoate is a reagent in organic chemistry that undergoes scission reactions. It is a colorless liquid with a pungent, irritating odor and a boiling point of 225°C. Methyl 4-fluoro-3-oxobutanoate can be used for the synthesis of various aromatic compounds. The mechanism of this reaction involves nucleophilic attack by pyridine or other basic solvents on the electrophilic carbon atom. This leads to the formation of an intermediate carbocation which then undergoes intramolecular fragmentation to yield the desired product.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-tert-Butoxystyrene is a monomer that is used in the polymerization of cationic polymers. It is soluble in water and hydrochloric acid. 4-tert-Butoxystyrene has a redox potential of -0.15 V, which allows it to be used as a catalyst for the synthesis of polymers with high molecular weight. 4-tert-Butoxystyrene can also be used as a solid catalyst for the formation of polymers with low molecular weight. This monomer has been shown to catalyze reactions that are not possible with other monomers, such as the production of poly(dimethylsiloxane) from chlorosilanes, or the polymerization of epichlorohydrin from chlorohydrins. The ability to form hydrogen bonds and chloride bridges gives 4-tert-Butoxystyrene chemical diversity, which increases its versatility and makes it an excellent choice for polymerization reactions.br>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(2,3-Dihydro-1,4-benzodioxine-6-sulfonyl)piperazine hydrochloride is an experimental drug that belongs to the group of pharmacological agents. It is a piperazine derivative with potent antagonistic effects against opioid receptors. It has been shown to have synergic effects when used with other drugs. Structural analysis revealed the presence of nitrogen atoms in the molecule and crystallinity was confirmed by x-ray diffraction data. The solubility of this compound in human serum is low. 1-(2,3-Dihydro-1,4-benzodioxine-6-sulfonyl)piperazine hydrochloride has been observed to inhibit the production of cytokines such as interleukin and tumor necrosis factor alpha (TNFα).

2-Aminomethyl-3-phenylpropionic acid is a chemical compound that is used as a catalyst in the hydrocyanation of alkyne to produce unsaturated compounds. It is also an amino acid that contains an α-amino group and a carboxylic acid. 2-Aminomethyl-3-phenylpropionic acid has been shown to be effective for producing yields of up to 99% in nickel-based catalysts for the hydrocyanation of alkyne. This compound is also inexpensive, nonhazardous, and stable at high temperatures.

1-Bromo-1-ethoxycyclopropane is a structural modification of the cyclopropanone ring. It has been shown to be resistant to many bacteria, such as Pseudomonas aeruginosa and Escherichia coli, and also inhibits the growth of fungi. 1-Bromo-1-ethoxycyclopropane has been shown to act as an antibacterial agent by inhibiting the synthesis of proteins in bacteria and can work synergistically with aminoglycosides. 1-Bromo-1-ethoxycyclopropane may have a role in nature as it has been found to inhibit the growth of malonate oxidase from organisms such as Acinetobacter calcoaceticus.

Versatile small molecule scaffold