Building Blocks

3-Chloro-5,6-dihydropyridin-2(1H)-one is a chemical compound that has been shown to have antiparasitic properties against Leishmania. The molecule is able to inhibit the growth of promastigotes and surface-exposed amastigotes of Leishmania infantum by inhibiting the synthesis of fatty acids. 3-Chloro-5,6-dihydropyridin-2(1H)-one also blocks the synthesis of glutathione, a major antioxidant in cells that protects against oxidative damage. This compound has been shown to be efficacious in vitro against cancer cells, including A549 cells.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Chlorophthalazin-1-ol is a synthetic organic compound that is used as a medicinal chemical. It has antifungal, anti-inflammatory, and antibacterial properties. 6-Chlorophthalazin-1-ol can be synthesized by the reaction of magnesium with chloroform in the presence of copper, followed by hydrolysis. The synthetic process involves a number of steps and requires a lot of time and effort. The chemical structure contains an ionic bond between the magnesium atom and the chlorine atom. This bond is very strong, which explains its high stability against reactions with other compounds.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-N-Ethylpyridine-2,3-diamine is a small molecule inhibitor that binds to the ATP binding site of HIV reverse transcriptase and inhibits its activity. It has been shown to inhibit the proliferation of human tumor cells in culture. This compound also prevents the formation of new virus particles and leads to a decrease in viral load. 2-N-Ethylpyridine-2,3-diamine does not bind to the same site as nevirapine, but instead binds to a different amino acid residue on the reverse transcriptase enzyme called Y181C. Residues at this location are found in all HIV strains resistant to nevirapine.

4-Chloro-1-methylquinolin-2(1H)-one is a molecule with analgesic activity. It has been shown to produce analgesia in the rat tail flick and hot plate tests, as well as anti-nociceptive effects in the mouse formalin test. The analgesic effect of 4-chloro-1-methylquinolin-2(1H)-one is thought to be due to its ability to inhibit the release of excitatory neurotransmitters from peripheral sensory neurons. This molecule has also been shown to have anti-inflammatory properties and is an intermediate for the synthesis of other drugs, such as diclofenac sodium.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 3-methanesulfonamidobenzoate is an organic compound that is used as a reagent in organic synthesis. It has the chemical formula CH3O2C(CH2)2SO2CH=NOH. Methyl 3-methanesulfonamidobenzoate is a methyl ester of benzoic acid, which is also known as methyl benzoate. This compound has been shown to react with DNA, forming adducts with guanine and cytosine bases.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Isopropoxyphenol is a reactive molecule that can undergo nucleophilic attack. It is an intermediate in the reaction mechanism of phenolic antioxidants, such as salicylaldoxime and mequinol. 4-Isopropoxyphenol is synthesized by the condensation of anilines with phenols, followed by acid hydrolysis. The nature of 4-isopropoxyphenol is primarily nucleophilic, making it a potential candidate for optimization or predictive modelling.

Versatile small molecule scaffold

Diaminophosphoryloxybenzene (DAPOB) is a chemical that can be used to measure the uptake of creatine kinase in human serum. It has been shown to form a complex with the enzyme, which is then transported into cells. The uptake of creatine kinase in the cells can be measured by measuring the amount of DAPOB that is released from the inside of the cells and into the surrounding medium. In order to use this technique, a collagen gel needs to be prepared and placed around the sample containing DAPOB. The kinetic properties of DAPOB are determined by observing how quickly it reacts with other chemicals in solution. DAPOB also forms intramolecular hydrogen bonds with itself, which may affect its ability to react with other compounds. X-ray crystal structures have revealed that DAPOB binds to protein synthesis enzymes such as polymerase chain reaction (PCR). These interactions are thought to be important for understanding how DAPOB affects protein

N,N-Bis(2-hydroxyethyl)acetamide is a nonionic surfactant which is used as an emulsifier and dispersing agent. It is often used in detergents, textile processing, papermaking, and for the production of cosmetics. N,N-Bis(2-hydroxyethyl)acetamide has been shown to suppress the growth of Candida parapsilosis and other microbial strains. It also inhibits the production of fluconazole by wild-type Candida albicans. N,N-Bis(2-hydroxyethyl)acetamide may be used in conjunction with benzyl alcohol as an antifungal agent for topical application.br>br>NMR spectra have shown that this molecule has acetal groups that can copolymerize with other molecules. These acetal groups are resistant to degradation by enzymes such as beta-glucosidase and alpha-amylase.

2-(Diethylamino)acetamide is an aliphatic hydrocarbon that inhibits the replication of viruses. It also has anti-inflammatory activity and can be used to treat respiratory allergies, such as asthma and hay fever. 2-(Diethylamino)acetamide may be used as a scrubbing agent in the removal of pollutants from industrial emissions. The compound is stable at high temperatures and has been shown to inhibit the growth of bacteria by interfering with their respiration process. 2-(Diethylamino)acetamide also inhibits the production of monocarboxylic acids such as formic acid, acetic acid, and lactic acid in bacteria, which are important for their survival.

Versatile small molecule scaffold

3H-Imidazo[4,5-c]pyridin-2-ol is a reactive compound that is used in the synthesis of other compounds. It can be generated by the nitration of aniline and subsequent reduction of the nitro group to an amine. This product can also be synthesized from 2-aminoethane and ethyl acetate. 3H-Imidazo[4,5-c]pyridin-2-ol reacts with nucleophiles such as chloride ions to form carboxylates, which leads to its use in assays for amines. It has been shown that this product dimerizes in the presence of water or alcohols and reacts with primary amines to form tetrones.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold