Building Blocks

3-Amino-2,3-dihydro-1H-inden-5-ol is an optical, chiral compound that is used in the industrial production of 2,3-dihydroindanedione. It can be synthesized from 3-(2-methylpropyl)indole and sodium hydroxide using a lipase. The transesterification reaction occurs at a high efficiency with the use of a diastereomer. This process is followed by introducing the product into an autoclave for pollution control. The 3D structure of this molecule is similar to that of indane but it has different properties because it contains a hydroxyl group on the third carbon atom.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Benzyloxy)-3-fluoroaniline is a substance that is used as an intermediate in organic synthesis. It can be synthesized by reacting 2-chloro-4-nitrobenzaldehyde with 3-fluoroaniline in the presence of hydrazine and a catalyst. The reaction time is typically between 1 hour and 24 hours. The product has been shown to have antimicrobial activity against a wide range of bacteria, including methicillin resistant Staphylococcus aureus (MRSA). Cadazolid is an antibiotic that belongs to the oxazolidinone class and exhibits potent antibacterial activity against Gram-positive bacteria, such as methicillin resistant Staphylococcus aureus (MRSA), by inhibiting cell wall biosynthesis. Cadazolid is a hexahydrate salt, which means it dissolves in water to form a crystalline solid with 6 molecules of water for each molecule of cadazolid

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Research has shown that (4-Ethoxy-3-methoxybenzyl)amine (EMBA) is a potent inhibitor of bacterial growth. The alkylation of EMBA with methylamine and benzene leads to the formation of aureus, which is an antibiotic that can be used to treat staphylococcus infections. In addition, EMBA can also be methylated with hydroxylamine to form benzylamine, a compound that inhibits the synthesis of the cell wall in bacteria. These properties make EMBA an effective antimicrobial agent.

4-Amino-N-(tert-butyl)benzamide is a chemical intermediate that can be used in the preparation of certain pharmaceuticals. This compound is synthesized through the reaction of 4-aminobenzoyl chloride and tert-butanol, which forms an amide bond. The condensation reaction can be catalyzed by either heat or acid. The product of this reaction is hydrogenated to form 4-amino-N-(tert-butyl)-N'-(chloromethyl)benzamide. This compound can also be prepared by refluxing a mixture of 4-aminobenzaldehyde and hydrazine with chloroform and hydrochloric acid.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

MK 1903 is a fatty acid that has been shown to reduce insulin resistance and metabolic disorders by increasing ATP levels in the body. It has also been shown to have anti-angiogenic effects, which may be due to its ability to decrease neutrophil recruitment and improve the clinical use of MK 1903. This drug has been found to synergistically work with ursodeoxycholic acid for the treatment of inflammatory diseases.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Methoxy-9H-carbazole is a fluorescent molecule that belongs to the group of carbazoles. It is activated by thermally generated hypochlorous acid, which provides linear response over a wide range of concentrations. This compound has high values for quantum yield, fluorescence intensity and photostability. 3-Methoxy-9H-carbazole has been shown to be an efficient acceptor in exciton quenching and is responsible for the fluorescence of nature.

Versatile small molecule scaffold

(2R)-2-{[(tert-Butoxy)carbonyl]amino}hex-5-ynoic acid is a synthetic macrocycle that has been shown to have biological and chemical activities. It targets bacterial biofilms, and the cyclodepsipeptide has been shown to inhibit the growth of Gram-positive bacteria in vitro. This compound also inhibits the development of biofilm by inhibiting the production of extracellular polymeric substances (EPS) on the surface of bacteria, which are important for bacterial attachment to surfaces. The cyclodepsipeptide binds to EPS through hydrophobic interactions, promoting its detachment from surfaces. This macrocyclization prevents EPS formation by binding to proteins involved in its synthesis. The cyclodepsipeptide also has an effect on bacterial cell membrane integrity, which may be due to its ability to inhibit protein synthesis and DNA replication.