Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

The bis-Grignard reagent, also known as a bifunctional organometallic compound, is an organic chemistry reactive intermediate used in the synthesis of diverse organic molecules. This type of reagent is prepared by the reaction of a magnesium halide with an alkyl or aryl halide. The Grignard reagent reacts with electrophiles to form carbon-carbon bonds. The catellani reaction is an example of this type of reaction. A new method for the efficient synthesis of 4-(bromomethyl)cyclohexan-1-one has been developed using a cross-coupling strategy and a phosphine ligand. This process begins with the formation of a palladium catalyst via oxidative addition, followed by nucleophilic displacement with methyl iodide to give 4-(bromomethyl)cyclohexan-1-one in high yield and excellent purity.

(1R,3S,5R)-2-(tert-Butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic Acid is a stereoselective and scalable synthesis of (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid that can be synthesized in a two step sequence with high yield and high stereoselectivity. The cyclopropanation of the carboxylate group with allyl bromide provides the desired product in good yield and high selectivity (>90% ee).

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

8-Chloro-[1,3]dioxolo[4,5-g]quinazoline is a fluorophore that is used to measure the emission of light from a sample. It can be detected by techniques such as filtration and gel electrophoresis. 8-Chloro-[1,3]dioxolo[4,5-g]quinazoline is found in the nucleus of cells and has been shown to interact with colloids. It is also used as a pharmacophore in dichroism assays and preparation methods for fluorescence measurements.

4-Cyano-2,6-dimethoxyphenol is a molecule with a hydrogen bond. It has the molecular formula C8H10N2O3 and its molecular weight is 180.16 g/mol. The compound has a coplanar chain of four carbon atoms and two oxygen atoms. The formulae of the compound are shown below:

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-5-(dichloromethyl)pyridine is a chlorinated acetylcholine analog. It is an agonist of the acetylcholine receptor, which is a type of ion channel that is activated by the neurotransmitter acetylcholine. 2-Chloro-5-(dichloromethyl)pyridine has been shown to have insecticidal properties, and has been patented as an insecticide. It was found to be more effective than nicotine in killing insects, with a faster kill time. This chemical also binds to amines and pyridines, which are amino acids and compounds that play an important role in the human body.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Benzylcyclohexan-1-amine is an oxime, which is a class of organic compounds that are derived from an amine and are characterized by the presence of at least one nitrogen atom in their structures. It can be synthesized by deuteration of cyclohexanone with deuterium gas. The reaction mechanism for this process includes catalytic reduction, acetylation, pyrolytic elimination, and reductive amination. 2-Benzylcyclohexan-1-amine has been shown to have a spectrum similar to the postulated spectrum for the compound N-methylphenethylamine, which has been proposed as a possible neurotransmitter in humans.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Trichloromethyl)pyridine is an organic compound that can be used as a pesticide. It is the main active ingredient in chloropicrin, which is used primarily for agricultural purposes to help protect crops from insect damage. 4-(Trichloromethyl)pyridine has been shown to have toxic effects on animals, including humans, and may cause adverse health effects such as headaches, nausea, vomiting and dizziness. The chemical reacts with hydrogen chloride in the presence of an organic solvent to form the chlorinated derivative of 4-chloropyridinol. The reactivity of 4-(trichloromethyl)pyridine towards nucleophilic inorganic bases has also been studied and it was found that it reacts with potassium hydroxide at room temperature to form a 1:1 mixture of 4-chloropyridinol and potassium chloride.

1H-Isoindol-3-amine is a coordination complex with a palladium atom coordinated to three active methylene ligands. It is used as an intermediate in the synthesis of organic compounds. 1H-Isoindol-3-amine can be synthesized by the reaction of sodium hydrogen with hydroxybenzoic acid, followed by the Suzuki coupling reaction with copper chloride and an aryl chloride. The coordination chemistry between 1H-Isoindol-3-amine and palladium has been studied using viscosity measurements and X-ray diffraction data. The coordination complexes are usually based on aryl chlorides, which are electron rich, electron deficient, or electrophilic. The reaction mechanism for 1H-Isoindol-3-amine has been recorded.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 5-amino-2-furoate is a nitrofuran that is used as a reagent in the synthesis of other compounds. It has been shown to be metabolized by acetylation, hydrazine, and reduction. Methyl 5-amino-2-furoate can also act as an inhibitor of xanthine oxidase and xanthine dehydrogenase. The compound has been shown to inhibit the production of xanthine and aminofuran in an incubated system containing these enzymes. Spectrometry analysis showed that methyl 5-amino-2-furoate was reduced to form methyl 2,5-dihydroxybenzoate during incubation with xanthine oxidase and xanthine dehydrogenase.

Versatile small molecule scaffold

1,1-Dimethylguanidine hydrochloride is an oxadiazole derivative that is used in the treatment of bacterial infections. It is a competitive inhibitor of bacterial leukocyte-mediated killing of bacteria and inhibits the growth of staphylococcal and staphylococcus aureus isolates. In vitro, 1,1-dimethylguanidine hydrochloride has been shown to inhibit the growth of gram-positive bacteria by binding to their cell wall. This drug also has a kinetic effect on leukocytes, which may be due to its ability to inhibit the release of reactive oxygen species from these cells.

Versatile small molecule scaffold

Versatile small molecule scaffold