Building Blocks

Versatile small molecule scaffold

Amisometradine-d3 is a beta-blocker medication that belongs to the class of non-selective beta blockers. It is used to treat high blood pressure, congestive heart failure, and angina pectoris. Amisometradine-d3 blocks the action of the enzyme phosphodiesterase, which then prevents the breakdown of cyclic AMP (cAMP). This results in an increase in cAMP levels in cardiac muscle cells. The increased cAMP levels result in relaxation of the myocardial muscles, which can reduce the workload on the heart and lower blood pressure. Amisometradine-d3 also has a lipophilic profile that allows it to cross cell membranes and act on cardiac tissue by binding to collagen molecules or other proteins involved in contraction.

N-Ethylglycine hydrochloride is a pharmaceutical preparation that inhibits the enzyme cholesterol esterase. It is used to treat congestive heart failure and as a diuretic. N-Ethylglycine hydrochloride prevents the production of unsaturated fatty acids by inhibiting the enzyme cholesterol esterase, which converts cholesterol into fatty acid. This leads to lower levels of cholesterol in the blood, which can be beneficial in treating high cholesterol levels. N-Ethylglycine hydrochloride has been shown to have antiviral effects against influenza virus, with an IC50 of 0.5 μM, as well as anti-inflammatory properties.

(S)-(+)-1-Bromo-2-methylbutane is a chiral molecule with two stereoisomers, the cis and trans forms. The cis form has been observed to be the more stable of the two. It is a functional theory that these two forms are not mirror images of each other because they have different conformations. (S)-(+)-1-Bromo-2-methylbutane has been used in the synthesis of a number of important molecules. The stereoisomers can be distinguished by conformational analysis and optical microscopy. (S)-(+)-1-Bromo-2-methylbutane also has an application in biotechnology for use as a precursor for hydrazones, which are important in organic chemistry and molecular biology, such as DNA sequencing.

1-Hydroxyphenazine is an anti-fungal agent that inhibits the growth of opportunistic fungal pathogens. It has been shown to be effective in vitro against some bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa, but not against others such as Escherichia coli. 1-Hydroxyphenazine reacts with intracellular Ca2+ to activate the reactive oxygen species (ROS), which are cytotoxic to fungi and other microorganisms. The compound is a structural analog of phenazone, but has higher antimicrobial activity and lower toxicity. 1-Hydroxyphenazine also chelates metal ions and forms stable complexes with them. This property may contribute to its biological properties.

N,N-Diphenylacetamide is an amide that is used in the pharmaceutical industry as a test compound. It has been shown to be effective at doses of 10 mg/kg in the treatment of inflammatory diseases. The chemical stability of N,N-diphenylacetamide is dependent on the pH and the presence of inorganic acids such as hydrochloric acid and sulfuric acid. In acidic conditions, N,N-diphenylacetamide hydrolyzes to form a sulfamic acid and an amide. The enantiomer of N,N-diphenylacetamide that can be formed under alkaline conditions is also an active ingredient in some medications for inflammatory diseases.

Versatile small molecule scaffold

N-(5-Nitro-1,3-thiazol-2-yl)formamide is a hydrogen bond donor that has been shown to be an occlusive molecule. It is soluble in organic solvents. N-(5-Nitro-1,3-thiazol-2-yl)formamide has a molecular weight of 138.18 and is a white crystalline powder. This molecule is active as an antisolvent and can be used for the preparation of microspheres with fibers.

1-Phenyl-2-buten-1-one is a ketone that is produced by the Friedel-Crafts reaction, which entails the use of an aluminum chloride catalyst in the presence of hydroxy groups. This chemical can also be produced by a reductive carbonylation reaction using acetaldehyde and an organic solvent.
This chemical has been shown to have reductase activities and coordination geometry. It has also been shown to inhibit enzyme activities such as β-unsaturated ketones reductase, indole alkaloid reductase, and acetaldehyde dehydrogenase. The optimal reaction for this compound is borohydride reduction. 1-Phenyl-2-buten-1-one has not been isolated in yields greater than 90%.

2-Hydroxy-3-methylpentanoic acid is a natural compound that has been isolated from the bacteria Corynebacterium glutamicum. It is a cyclic pentapeptide with two ester linkages and one hydroxyl group. This molecule is an antimicrobial agent that inhibits bacterial growth by binding to the active site of enzymes, such as bacterial glutamyl endopeptidase and glutamate decarboxylase, which are involved in peptide and amino acid metabolism. 2-Hydroxy-3-methylpentanoic acid has been shown to have anti-inflammatory properties in bowel disease models, which may be due to its ability to inhibit prostaglandin synthesis. 2-Hydroxy-3-methylpentanoic acid also has cytotoxic effects on carcinoma cell lines in vitro.

Versatile small molecule scaffold

Versatile small molecule scaffold

6,7-dihydro-1h-indazol-4(5h)-one is a chemical compound that has various applications. It is commonly used in research as a cyanobacterial inhibitor, particularly against hydrogen fluoride and elastomeric nodularin. This compound has been found to induce lysis of cyanobacterial cells and can be used in the development of antibodies against microcystins. Additionally, 6,7-dihydro-1h-indazol-4(5h)-one has shown potential antimicrobial activity against Pseudomonas aeruginosa, inhibiting its growth by disrupting chloride transport. It is also utilized in surface treatment processes and as a research chemical for the synthesis of lactones and oligosaccharides. Its versatility makes it a valuable compound for various scientific applications.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

7-Chloro-1H-indole-3-carbonitrile is a compound known for its anti-fibrotic properties. It has been studied in relation to nintedanib, a medication used to treat idiopathic pulmonary fibrosis. 7-Chloro-1H-indole-3-carbonitrile has shown potential as an antifibrotic agent by inhibiting the activation of transforming growth factor-beta 1 (TGF-β1), a key player in the development of fibrosis. This compound has also been investigated for its use in detergent compositions and collagen gel crystallization. Additionally, it is commonly used as a research chemical in various scientific studies involving adipose tissue and phosphoric compounds.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold