Building Blocks

5-Methylpyridin-2-yl)methanol is a heterocyclic compound that can be synthesized by the reaction of sodium ethoxide with hydrogen. This reaction produces the intermediate product 2-(5-methylpyridin-2-yl)ethanol, which can be reacted with potassium to produce (5-methylpyridin-2-yl)methanol. The synthesis of 5-methylpyridin-2-yl)methanol can also be achieved by reacting sodium hydride with 5-(chloromethyl)-2-(4,4,5,5,-tetramethyl-[1,3,2]dioxaborolan-2yl)pyridine. 5-(chloromethyl)-2-(4,4,5,5,-tetramethyl-[1,3,2]dioxaborolan-2yl)pyridine is reacted with methyl iodide

Versatile small molecule scaffold

(1S,4S)-4-(Propan-2-yl)cyclohexan-1-ol is a synthetic compound that has been used in skin care products. It is more potent than cyclohexanol and it has been shown to be stereoselective. In addition, it is hydrolyzed by alcohol dehydrogenases to form hydrochloric acid, which can activate chloride ions. (1S,4S)-4-(Propan-2-yl)cyclohexan-1-ol has also been shown to react with the skin protein ankyrin, leading to a change in the kinetic parameters of the reaction.

2-[(p-chlorobenzyl)amino]-pyridine is a chemical compound that belongs to the group of aliphatic alcohols. It can be prepared by reacting 2-aminopyridine with sodium borohydride and an inorganic acid. This reaction yields a mixture of 2-[(p-chlorobenzyl)amino]-pyridine, hydroxylamine hydrochloride, and sodium chloride. Hydroxylamine hydrochloride can be removed from the mixture by azeotropic distillation. The product is used as a reducing agent for reductive amination reactions or as a catalyst for aliphatic hydrocarbon reductions.

4-Methanesulfinylaniline is a chemical compound that has been used as an inhibitor of cyclooxygenase-2 (COX-2) and COX-1. This drug has been shown to be effective in animal models of inflammation and hyperalgesia. 4-Methanesulfinylaniline is a regioisomeric inhibitor of COX, which means that it binds to the enzyme at a different location from other drugs. The pharmacological effects of this drug are due to its ability to inhibit the production of prostaglandins, leading to anti-inflammatory effects.

3-(3-Bromophenyl)pyrrolidine-2,5-dione is a targetable iontophoretic drug that binds to the skin. It is used for the treatment of inflammatory and neuropathic pain. 3-(3-Bromophenyl)pyrrolidine-2,5-dione has been shown to be effective in both hydrophobic and hydrophilic environments, meaning it can be used in both diluents and in water. The drug is insoluble in water and has an activity index of 0.9. 3-(3-Bromophenyl)pyrrolidine-2,5-dione has a molecular electrostatic potential of -1.7eV, which makes it a good candidate for use with iontophoresis devices (devices that deliver drugs through the skin by passing a current across the skin). The drug is also targeted to specific cells or tissues because of its high concentration.

4'-(Methylsulfonyl)acetanilide is an organic compound that has been shown to have antibacterial and antiviral activity. It targets the benzene nucleus, and inhibits the synthesis of nucleic acids by inhibiting the enzyme ribonucleotide reductase. 4'-(Methylsulfonyl)acetanilide also inhibits viral replication, by binding to the active site of a viral protein (a DNA polymerase), which blocks the incorporation of nucleotides into the virus's DNA. In addition, 4'-(methylsulfonyl)acetanilide is an anti-helminthic agent, as it can inhibit worm motility and kill larvae in vitro. The structure-activity relationships between this molecule and other benzimidazole derivatives were analysed in order to identify new potential drugs for treating diseases caused by viruses or parasites.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold