Building Blocks

Versatile small molecule scaffold

1-Bromocyclohexane-1-carbonitrile (1BCC) is an orthogonal alkylation agent that can react with a wide variety of functionalized organic halides. It reacts with the carbon atom in the organic halide, forming a new carbon-carbon bond. This reaction is highly selective and does not require any protecting groups or activation by copper. 1BCC also has high activity with nitroalkanes, which makes it a useful reagent for synthesizing diamines. 1BCC can be used as an efficient synthetic method for aromatic and nonaromatic diamines.

Versatile small molecule scaffold

Versatile small molecule scaffold

N-(1,3,4-Thiadiazolyl)nicotinamide is an intracellular drug that inhibits the release of a growth factor, which may be involved in the development of migraine. It has been shown to inhibit the activity of the enzyme VEGF and reduces infarction volume in rats. N-(1,3,4-Thiadiazolyl)nicotinamide also has a neuroprotective effect by reducing reactive astrocytes and inhibiting fibrillary acidic protein expression in the cerebral cortex of rats. This drug is osmotically active and can induce neuronal damage due to brain swelling. N-(1,3,4-Thiadiazolyl)nicotinamide is also used as a stain for neurons in histological studies.

Versatile small molecule scaffold

Versatile small molecule scaffold

2,4,6-Trichlorobenzenesulfonyl chloride is a sulfonylating agent that is used to treat metabolic disorders and iron metabolism. It is also used as an x-ray contrast agent for the detection of certain types of cancers. In addition, 2,4,6-trichlorobenzenesulfonyl chloride has been shown to have anti-inflammatory properties in chronic inflammatory diseases. This drug can be used to inhibit the synthesis of hepcidin by blocking the catalytic activity of ferrochelatase. 2,4,6-trichlorobenzenesulfonyl chloride may also be able to reduce inflammation by its ability to form reactive chlorides that react with alcohols and aldehydes. This can lead to deficiency symptoms such as chronic inflammatory disease or alcohol intolerance.

5-(4-Hydroxyphenyl) tetrazole is a hydrophobic ligand that has been shown to bind to cisplatin and therefore may have potential use in cancer therapy. It has also been used as an anti-inflammatory agent with the potential to inhibit prostaglandin synthesis. 5-(4-Hydroxyphenyl) tetrazole binds to hydrogen peroxide, which is a strong oxidizing agent and produces reactive oxygen species (ROS). ROS can cause DNA damage and lead to cell death by apoptosis or necrosis. 5-(4-Hydroxyphenyl) tetrazole reacts with cisplatin, which is a chemotherapeutic agent that is used in the treatment of various types of cancer. Cisplatin binds to DNA and prevents replication, leading to cell death. Hydrophobic ligands such as 5-(4-Hydroxyphenyl) tetrazole are able to bind more tightly than other ligands because

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chlorophenylacetyl Chloride is a chlorinating agent that reacts with alkaline conditions to form a chloride. As an active ingredient in pesticides, it has been shown to have high selectivity and to be selective against fungi. The 2-chlorophenylacetyl chloride can be used as the starting material for epoxiconazole synthesis by Wittig reaction.
2-Chlorophenylacetyl Chloride is also a useful intermediate for the preparation of many other compounds. It can be used to synthesize dimethylchloride, which is used in the production of plastics and polymers; or it can be used to prepare formamide, which is used in the production of pharmaceuticals and agrochemicals. This compound has been shown to have catalysis properties and can be used in Wittig reactions that are selective towards different carbonyl groups.

Versatile small molecule scaffold

Octahydro-1H-cyclopenta[b]pyridine is a pyridine with a hydrogen atom in the 1-position. It has been shown to be an analgesic and may have antihistaminic effects. Octahydro-1H-cyclopenta[b]pyridine is not active against γ-aminobutyric acid (GABA), but can act as a competitive inhibitor of α-mannosidase. The compound is an enantiomer of octahydro-2H,6H-[1,3]dioxolo[4,5-g][1,2]benzopyran and can be synthesized by catalytic reduction using hydrogen chloride gas and dioxane as the solvent.

4,5,6-Trichloropyrimidin-2-amine is a pyrimidine compound that can be synthesized from guanidine nitrate and chloroform. The reaction takes place in the presence of an organic base such as methanol or acetone. This compound has been shown to react with primary amines to form a guanidine derivative, which is then hydrolyzed to form the desired product. 4,5,6-Trichloropyrimidin-2-amine is an efficient synthesis for pyrimidine compounds because it does not require any purification steps before use.

Tetrachloropyridin-2-amine is a chemical compound. It is the product of the reaction between triphenylphosphine oxide and phosphorus pentachloride in the presence of alcohols. Tetrachloropyridine-2-amine has been shown to be effective against fungi, bacteria, and algae. It has also been used as an herbicide for agricultural purposes.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold