Building Blocks

2-(Benzoylamino)-2-phenylacetic acid is a hydrazone that has been used as a precursor for the synthesis of azoalkenes. It is also biologically active and may be useful for the treatment of cancer.

2-(4-Chlorophenyl)butanoic acid is a metabolite of the drug baclofen. It is produced by Streptomyces, and has been found in cultures, experiments, and soil samples. This compound has been shown to metabolize through microbial metabolism with a chiral center (2R), which can be used as an indicator of microbial activity. 2-(4-Chlorophenyl)butanoic acid also has anti-inflammatory properties that may be due to its ability to inhibit prostaglandin synthesis.

4-Aminopyrimidine-5-carboxamide is an amide that is synthesized from the reaction of eosinophil and amine. This compound inhibits transcription in a dose-dependent manner, with a high potency for iminium and amines, but not primary amines. 4-Aminopyrimidine-5-carboxamide is orally bioavailable and has shown to be effective in animal models. The compound has been optimized for oral administration and has shown to produce good yields. 4-Aminopyrimidine-5-carboxamide also possesses transcription factor inhibitory activity against interleukin, which may provide therapeutic benefit for inflammatory disorders.

4-Methylphthalazin-1-amine is a heteroaromatic compound that can be synthesized by cyclization of phenacyl bromides and bromoacetates. It has been found in Australian plants and may have a role in the development of schizophrenia. 4-Methylphthalazin-1-amine is not soluble in water, but it can be dissolved in solvents such as acetone or ethanol. It is also insoluble in most organic solvents.

1-Chloro-1-phenylpropan-2-one is an exploratory compound that has been deployed as a mechanistic probe to probe the radical mechanism of aldehydes. It has been shown that 1-chloro-1-phenylpropan-2-one can be used to generate fluorescent compounds and study the fluorescence, UV radiation, and radical mechanism of aldehydes. This molecule also has the ability to react with electron rich compounds such as aziridines to form chiral products. The substituent on this molecule will affect its biological activity.

Versatile small molecule scaffold

2-Chloro-2-phenylethylbenzene is an organic compound that is used in the synthesis of other compounds. It is produced by reacting a chlorinated benzene with an alkali, such as sodium hydroxide, potassium hydroxide, or lithium hydroxide. The reaction produces a mixture of 2-chloro-2-phenylethylbenzene and phenylhydroxyethane. This compound can be converted to 2-chloro-2-(piperidin-1-yl)ethanol by refluxing it with morpholine in methanol and then adding amides such as piperidine or pyrrolidine. The resulting product can be alkylated with carbon tetrachloride to produce 2-chloro-2-(4'-methylphenoxy)ethanol. This compound can also be reduced to give 2-(4'-methylphenoxy)ethanol by heating it with sodium bor

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Iso-butylcyclopentanone is a ketone that has triplet and singlet states with rate constants of 8.9x10 M/s and 0.003 M/s, respectively. It has been shown to undergo photoelimination reactions in the presence of acyclic or cyclic triplet sensitizers. 2-Iso-butylcyclopentanone also undergoes a rate-limiting step in the formation of an excited state, which is called the S1 state or triplet. This reaction can be followed by measuring the fluorescence spectrum of the compound using a spectrofluorimeter, which shows that it emits light at wavelengths of 333 nm and 395 nm.

Versatile small molecule scaffold

1,3-Dimethyl-4-piperidone is a colorless liquid at room temperature that is soluble in water and polar organic solvents. It is a protonated nucleophile that reacts with electrophiles to form alkylations. 1,3-Dimethyl-4-piperidone also reacts with chloride to form an imine, which can be hydrolyzed to yield piperidine. A Grignard reagent can be formed from 1,3-dimethyl-4-piperidone and potassium phosphate. The nature of the product obtained depends on the order of addition of reactants. 1,3-Dimethyl-4-piperidone has been shown to have a number of isomers.

Methyl 2-acetyl-3-oxobutanoate (M2OB) is an acceptor molecule in the Michael reaction. The temperature of the reaction is usually between -20°C and 0°C. A primary amine, a trifluoroacetic acid, and vinylene are required for the reaction to occur. Methyl 2-acetyl-3-oxobutanoate can be converted to an amide or pyrazole derivatives by hydrogenolysis. M2OB has a carboxylate group that is hydrolyzed by acidic conditions. M2OB reacts with pentamethoxybenzene in a pyrimidine compound synthesis.

2-Prop-2-ynoxyisoindoline-1,3-dione is a multifunctional pyridine derivative with potential anticancer activity. It has been shown to inhibit HDAC and panobinostat, an inhibitor of histone deacetylase. 2-Prop-2-ynoxyisoindoline-1,3-dione has a solubility of less than 20 mg/mL in most solvents and is insoluble in water. This compound has been shown to have a low yield when synthesized from 2,6-dichloropyridine. These properties are advantageous for cell culture studies because they allow for the detection of changes in cellular morphology and the frequency of cell division. 2-Prop-2-ynoxyisoindoline-1,3-dione also has an activated aromatic ring that can be used as a prodrug to activate other compounds that need activation at this site (e.g., transition metals).

Versatile small molecule scaffold

Versatile small molecule scaffold