Building Blocks

Versatile small molecule scaffold

7-Benzyl-2,6-dichloro-7H-purine is a reagent that is used in the synthesis of adenine and other purines. It can be synthesized by coupling 3-methylxanthine with aminoacids and organometallic reagents. This chemical can also be used to selectively synthesize 6-benzyladenine, which is an important precursor to pharmaceuticals. The 7-benzyl group on this chemical has been shown to act as a positional group in the catalytic hydrogenation of amines. This selective hydrogenation process has been found to be regioselective for cycloalkyl amines.

Versatile small molecule scaffold

Rhosin hydrochloride is a cardiac glycoside derived from the plant Rhosinus peregrinus. It has been shown to have a regulatory effect on cardiac hypertrophy, and has been used in animal experiments to treat cancer. Rhosin hydrochloride is also known to inhibit cell factor and regulatory adhesions, which are proteins that aid in the binding of cells to other cells or tissue. It has been shown to be effective at inhibiting the uptake of calcium ions by rat cardiomyocytes. These properties make rhosin hydrochloride an attractive target for future research into cardiovascular disease treatment.

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Methyl-2-picolylmethylamine is a dimeric compound that contains two picolyl methyl groups per molecule. It can be prepared by the reaction of picolinic acid with an appropriate amine, such as methylamine. 6-Methyl-2-picolylmethylamine reacts with dioxane to form a yellow solid, which is a potentiometric indicator. The potentiometric titration of 6-methyl-2-picolylmethylamine has shown that it has a pK value of 7.3 and a color change at pH 7.8.

1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one is a potent inhibitor of the enzyme c-glycosylase. This compound has been used in pharmaceutical preparations and as a feedstock in organic syntheses. It is used to produce the anti-inflammatory drug piroxicam, which inhibits the action of cyclooxygenase and blocks the synthesis of prostaglandins. 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one also has been shown to inhibit crystallization of the bovine liver enzyme phosphatidylcholine:cholesterol acyltransferase (PCAT). The inhibition was found to be competitive with respect to PCAT substrate and was not due to inhibition of PCAT by 1,2,4-triazolo[4,3-a]pyridin-3(

Versatile small molecule scaffold

Versatile small molecule scaffold

2,3-Dibromo-propylamine, hydrobromide is an organolithium compound that is postulated to exist. It has been synthesized in the laboratory but its structure and properties have not yet been fully characterized. In addition to allylamine and azetidine, it has also been shown to react with benzoyl peroxide to form a peroxide. The magnesium ion coordinates the bromine atom of 2,3-dibromo-propylamine, hydrobromide. This mechanism is similar to that of other organolithium compounds.

2-(4-Bromo-2-methylphenoxy)acetic acid is a sulfonated phenolic compound that is synthesized by the sulfurylation of 2-methylphenoxyacetic acid with sulfuryl chloride. It has been used as a chemical intermediate in the synthesis of various drugs, such as triethanolamine. 2-(4-Bromo-2-methylphenoxy)acetic acid can also be used to produce fluorinated compounds, such as pentafluoropropionic and hexafluoroacetic acids. The chlorination reaction is an efficient method for the production of this compound.

Versatile small molecule scaffold

Versatile small molecule scaffold

3-[(Pyridin-2-ylmethyl)amino]propan-1-ol is an industrial chemical that is used in the production of peroxy compounds. It is a byproduct of hydrogenation and aluminium production processes, and can be produced using transition metal ions such as copper or nickel. 3-[(Pyridin-2-ylmethyl)amino]propan-1-ol has a low molecular weight, which allows it to be used in a variety of applications. This compound has been shown to interact with adsorption equilibrium and kinetic techniques, as well as being suitable for sustainable development.

Versatile small molecule scaffold

3-Acetamido-4-methylbenzoic acid is a product of organic synthesis. It is an amide compound and is synthesized by the condensation reaction of cyanamide and aniline. 3-Acetamido-4-methylbenzoic acid has been used in the synthesis of medicines such as nilotinib, which is a tyrosine kinase inhibitor that blocks cancer cell growth.