Building Blocks

Trans-2-nitrocinnamic acid is an organic compound that belongs to the ester compounds group. It is a precursor to cinnamic acid derivatives, which are used in analytical chemistry and as reagents in synthetic chemistry. Trans-2-nitrocinnamic Acid can be obtained from the reaction of nitrobenzene with acetic anhydride and hydrochloric acid. The spectra of trans-2-nitrocinnamic acid are characterized by a single peak at δ 3.4 ppm for the protonated molecule, and two peaks at δ 4.0 and δ 5.3 ppm for the deprotonated molecule. Trans-2-Nitrocinnamic Acid has been shown to have genotoxic activity in human lymphocytes in vitro, although this activity was not observed in mice or hamster cells.

4-Bromonaphthalene-2-carboxylic acid (4-BNCA) is a naphthalene derivative that is used as a starting material for the synthesis of binaphthyls and benzyne. 4-BNCA is a methyl ester that can be obtained from the reaction of 4-bromoaniline with formaldehyde and sodium hydroxide in ethanol. It has been shown to react with benzene, forming an adduct which is destabilized by acid methylation. This product has been used in the chemistry of cycloaddition reactions and aromaticity.

Versatile small molecule scaffold

1-(2,3-Dimethylphenyl)piperazine is a piperidine derivative that has been shown to have antidepressant activity in both in vitro and in vivo studies. It acts as an antagonist at the 5-HT1A receptor and as an agonist at the 5-HT2A receptor. 1-(2,3-Dimethylphenyl)piperazine has been shown to inhibit the production of dopamine, serotonin, and citric acid by inhibiting the enzyme citrate synthase. This drug also increases the concentration of chloride ions in cells. 1-(2,3-Dimethylphenyl)piperazine is used to treat depression, anxiety disorders, and other conditions that may be related to chemical imbalances of serotonin.

4-Chloro-1-naphthalenecarboxylic acid (4CNA) is a naphthalene derivative that can be used as a chlorinating agent. The optical rotation of 4CNA is -8 degrees in water and +10 degrees in acetonitrile. This compound has been shown to react with alkali metals to form metal salts, which are useful for the bioluminescent detection of DNA. 4CNA yields are increased by substituent effects, such as the introduction of an electron-withdrawing group on the ring, and decreased by electron donating groups on the ring. It also has been shown to have antirheumatic properties like salicylic acid, which is known to inhibit prostaglandin synthesis.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold