Building Blocks

<p>2,6-Dimethylphenylacetic acid is a hydrogen phosphate that is soluble in solvents such as acetonitrile. It has been used in the synthesis of lidocaine with high sensitivity and specificity. It can be used to detect phosphoric compounds, which are often present in pharmaceuticals and food supplements. This compound has also been shown to have a solvent effect on the conditions of the reaction, making it a useful additive for optimizing processes. The main impurities of this compound are 2-methylbenzoic acid and benzoic acid.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methylthiazole-4-carboxaldehyde is an aldehyde that is the product of the condensation of 2,4-dibenzoylacetone and acetone in the presence of diazomethane. It has been used as a precursor to other compounds such as benzoyl chloride, glyoxal, and aldehydes. 2-Methylthiazole-4-carboxaldehyde can be synthesized using acetylation or nitration of thiols or with glyoxal or aldehyde. The reactivity of this compound is high and can be carried out in high yield.</p>

<p>Versatile small molecule scaffold</p>

<p>3,6-Dichloropicolinonitrile is a peroxide that is used in the synthesis of organic compounds. It is produced by the reaction of sodium carbonate and hydrochloric acid with nitric acid as a catalyst. 3,6-Dichloropicolinonitrile has been shown to be more selective than other oxidizing agents such as hydrogen peroxide and potassium permanganate. The product can then be purified by adding diacetate, which selectively reacts with the chlorine to form acetyl chloride and glycolic acid. The resulting mixture can then be distilled to produce 3,6-dichloropicolinonitrile in high purity. 3,6-Dichloropicolinonitrile can also be used in electrochemical methods for the synthesis of cyanides or biochemically for virulent products such as pesticides and organic solvents.</p>

<p>Versatile small molecule scaffold</p>

<p>Nerol oxide is a natural compound and fragrance ingredient that has been shown to have anti-aging effects. Nerol oxide is an ester of citronellal, nerolic acid and ethyl decanoate. It is found naturally in orange blossoms and other citrus plants, as well as in lavender oil. Nerol oxide can be extracted from the plant material using solid phase microextraction. The chemical analyses of this extract reveal the presence of various fatty acids, including ethyl esters, fatty acids and their corresponding alcohols. These compounds are used to produce nerol oxide by polymerization with an initiator such as potassium hydroxide or sodium hydroxide at a neutral pH.</p>

<p>Versatile small molecule scaffold</p>

<p>Dimethyl pyridine-3,4-dicarboxylate is an organic compound that is used as a precursor to make other chemicals. It is a pyridinedicarboxylic acid and it can be synthesized from the reduction of pyridine with sodium borohydride in ethanol. Dimethyl pyridine-3,4-dicarboxylate is also used in the production of acetaldehyde by way of hydrosilylation with chloride and chloroform. This chemical has been found to be useful for the synthesis of various drugs such as antiepileptics, antihistamines, antipsychotics, and antidepressants.</p>

<p>4-Nitrophenylmethanethiol is a reactive molecule that reacts with dopamine D3, an important cytosolic protein, to form a stable covalent bond. This reaction was shown to be pH-dependent and the products were identified by x-ray diffraction data. The disulfide bond formed by this reaction is then reduced to the corresponding sulfhydryl group with sodium borohydride or hydroxide solution. 4-Nitrophenylmethanethiol also reacts with inorganic acid and sodium carbonate to form a molecule containing carbapenem, which is a model protein used in research on chemical reactions. 4-Nitrophenylmethanethiol reacts with chloride ions and phenyl groups to yield hydrochloric acid as the final product of the chemical reaction.</p>

<p>Bromo-PEG4-azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromo-PEG4-azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>(2S,6S)-2,6-Dimethylmorpholine is an optically pure compound that can be used to optimize the epoxidase reaction. It belongs to the class of morpholines and has two enantiomers. The (2R,6R)-enantiomer is more active than the (2S,6S)-enantiomer in catalyzing the epoxidase reaction. The temperature optima for both enantiomers are different with the (2R,6R)-enantiomer having a higher optimal temperature than the (2S,6S) enantiomer. This compound can be used as a chiral auxiliary to separate racemic mixtures by focusing on one enantiomer at a time. It can also be used as an analytical method for determining plate number and plate height.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(1H-Indazol-4-yl)acetic acid is a cation that has been shown to have pharmacological activity. It is hydrolyzable and is used as an anti-inflammatory agent. This compound also decarboxylates and hydrolyzes, which are processes that produce carboxyl and fluoro groups. (1H-Indazol-4-yl)acetic acid has been shown to be an anti-inflammatory agent, with effects against inflammation in the central nervous system. This drug also inhibits the production of inflammatory cytokines, including tumor necrosis factor alpha (TNFα), interleukin 1β (IL1β), and IL6.</p>

<p>4-Acetylimidazole is a histidine analogue that has been shown to have anticancer activity in breast cancer cells. It can react with amines and form imidazoles. The hydroxyl group on the 4-position of the imidazole ring is able to undergo dehydration, which leads to the formation of a chloride ion. This reaction mechanism is reversible and can be used in organic synthesis. 4-Acetylimidazole can also act as an h2 receptor antagonist, although it does not bind to the zwitterionic site of the h2 receptor. NMR spectra show that 4-acetylimidazole exists as a zwitterion in water solution, but becomes a monovalent ion when dissolved in an organic solvent such as methanol or acetone. 4-Acetylimidazole is chemically stable and does not react with poloxamer.</p>