Reagentes Sintéticos

<p>Stability Unstable in solution. Small amounts of precipitate should have no effect on use.<br>Applications 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction.<br>References Mun, B., et al.: Bioorg. Chem., 69, 64 (2016); Huang, J., et al.: Org. Lett., 18, 4702 (2016); Nakamura, H., et al.: Angew. Chem., Int. Ed., 54, 3136 (2015)<br></p>

<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>

<p>Applications (R)-Trolox is used in synthesis of vitamin E analogs.<br>References Dong, L., et al.: J. Biol. Chem., 286, 3717 (2011);<br></p>

<p>Applications (R)-α-Phenethyl Alcohol, is a chiral building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of biologically active cyclitols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Redgrave, A. J., et al.: No pp., Dissertation (1991);<br></p>

<p>Applications 2-Aminomethyl-1,4-benzodioxane is used in the synthesis of N-substituted (dihydrobenzodioxinyl)methylamine derivatives as D2 antagonists/5-HT1A partial agonists with potential as atypical antipsychotic agents in relation to affinity for α1 adrenoceptors.<br>References Birch, A. M., et al.: J. Med. Chem., 42, 3342 (1999);<br></p>

<p>Applications 4-(Trifluoromethyl)benzonitrile is used in the synthesis of quinazolines for amidines. Also used in the synthesis of s-transferase p1-1 and cancer cell proliferation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lv, Y. et al.: Chem. Comm., 49, 6349 (2013); Yang, X. et al.: J. Med. Chem., 53, 1015 (2010);<br></p>

<p>Applications Ruthenium(IV) Oxide Anhydrous is a research reagent and applied for exfoliation of layered metal oxide nanosheets.<br>References Lee, J.M., et al.: App. Mat. Interfaces, 11, 12121 (2019)<br></p>

<p>Applications 3'-Bromoacetophenone is a chemical reagent used in the synthesis of chalcone derivatives as anti-cancer agents. Also used in the preparation of biphenyl pyridazinone deriatives as PDE4 inhibitors in anti-inflammatory treatments.<br>References Madhavi, S. et al.: Lett. Org. 13, 682 (2016); Gracia, J. et al.: J. Med. Chem., 59, 10479 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Niperoditine is a H2 antagonists used in the treatment intestinal disorders.<br>References Mannino, S. et al.: Pharmacoepidemiol. Drug Safety, 7, 233 (1998); Miyaji, Y. et al.: Bioanalysis., 4, 263 (2012);<br></p>

<p>Applications 2-Cl-IB-MECA acts as an A3 adenosine receptor-selective nucleoside.<br>References Tosh, D. et al.: J. Med. Chem., 55, 4847 (2012);<br></p>

<p>Applications 1-Phenyl-1-cyclohexene is metabolite of Phencyclidine (P295500), an anesthetic.<br>References Wong, L.K., et al.L Biomed. Sci. Spec., 2, 204 (1975); Chen, G., et al.: J. Pharmacol. Exp. Ther., 127, 241 (1959); Bailey, K., et al.: J. Pharm. Pharmacol., 28, 713 (1976); Balster, R.L., J. Psychedelic Drugs., 10115 (1978); Johnson, K.M., et al.: Annu. Rev. Pharmacol. Toxicol., 30, 707 (1990)<br></p>

<p>Applications 4-(Aminomethyl)-Cyclohexanecarboxylic Acid (cas# 701-54-2) is a useful research chemical.<br></p>

<p>Applications 1-Carboxy-1-methylethoxyammonium Hydrochloride is used as a reactant in the synthesis of carbon-11 labeled celecoxib derivatives as new candidate PET radioligands for imaging of inflammation.<br>References Gao, M., et al.: Appl. Radiat. Isot., 67, 2019 (2009);<br></p>

<p>Applications Tetramethylammonium Tetrafluoroborate (cas# 661-36-9) is a useful research chemical.<br></p>

<p>Impurity Abacavir - In House Impurity<br>Applications (1R)-(-)-2-Azabicyclo[2.2.1]hept-5-en-3-one (Abacavir - In House Impurity) is an Abacavir (A105000) intermediate (1). It is also an intermediate in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (2).<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Slama, J.T., et al.: Biochemistry, 27, 183 (1988)<br></p>

<p>Applications Trimethylboroxin (50% Solution in THF) is used in a diverse array of areas, including as a polymerization additive. Trimethylboroxin is also used in the preparation of CBS catalysts for asymmetric reductions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gilmore, N., et al.: Tetrahedron Asy., 14, 2115 (2003); Najera, C., et al.: Adv. Synth. Catal., 346, 1798 (2004);<br></p>

<p>Applications N-DesBoc Docetaxel is an impurity in the synthesis of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications 1-Chloro-3-methyl-2-butene is a reactive allylic chloride that is used as an alkylating agent in synthetic chemistry. 1-Chloro-3-methyl-2-butene is also used as a reagent to synthesize Hyperforin, an antibiotic originating from St. John’s wort that has the ability to inhibit growth of tumour cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hatch, L. &amp; Gerhardt, L.: J. Am. Chem. Soc., 71, 1679 (1949); Lee, M., et al.: Org. Lett., 6, 1241 (2004); Reitsema, R. &amp; Hunter, J.: J. Am. Chem. Soc., 71, 1680 (1949); Schempp, C., et al.: Oncogene, 21, 1242 (2002); Sparling, B., et al.: J. Am. Chem. Soc., 135, 644 (2013)<br></p>

<p>Applications An intermediate in the preparation of pentafluoropentane-1-thiol: an important chain of anti-breast cancer agents.<br>References By Li, X. et al.: Tetrahedron Lett., 35, 9141 (1994);<br></p>

<p>Applications 5-Bromopentyltrimethylammonium Bromide (cas# 15008-33-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Hypotaurine is a metabolite of taurine and affects the regulation of the inflammatory aspects of the immune response. It is also converted into taurine in the body.<br>References Grove, R. et al.: Free Radical. Biol. med., 108, 575 (2017);<br></p>

<p>Applications N-Methyl-1,3-propanediamine is used as a reagent in the lipase-catalyzed synthesis of novel linear polyamidoamine oligomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Monsalve, L.N., et al.: Polymer, 51, 2998 (2010)<br></p>

<p>Applications WAY-100135 is a selective and potent 5-HT1A receptor antagonist.<br></p>

<p>Applications A Wittig reagent.<br></p>

<p>Applications (S,S)-(-)-Hydrobenzoin is a chral auxiliary with versatile applications. It is also used as a building block.<br>References Marshall, J., et al.: J. Org. Chem. 60, 7230 (1995); Stolle, A., et al. Tetrahedron Lett. 35, 3521 (1994); Burk, M., et al.: J. Am. Chem. Soc. 115, 10125 (1993); Burk, M., et al.: Tetrahedron Asymmetry 2, 569 (1991); Pichon, M., et al: Tetrahedron Asymmetry 7, 927 (1996)<br></p>

<p>Applications Lithium Chloride is primarily used in the synthesis of lithium metal by electrolysis. Also acts as a prescribed drug for bipolar mood disorder, it may also exhibit anti-inflammatory properties. Anti-cancer agent.<br>References Tsao, N. et al.: Antimicrob. Agents Chemother., 59, 1525 (2015); Cockle, J. et al.: 112, 693 (2015);<br></p>

<p>Applications Brincidofovir is an antiviral inhibitor, working against BK polymavirus replication in primary human urothelial cells. Cytostatic, cytotoxic agent.<br>References Tylden, G. et al.: Antimicrob. Agent. Chemother., 59, 3306 (2015); Cardile, A. et al.: Recent Patents Anti-Infect. Drug DIscov., 9, 97 (2014)<br></p>

<p>Applications 2-Fluoroiodobenzene is used as a reagent in various organic reactions. It is used in the synthesis of spirocyclic [1,2,3]-triazolooxazine nucleosides which have antiviral properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dell'Isola, A., et al.: Chem-Eur. J., 20, 11685 (2014)<br></p>

<p>Applications Di-O-glycinoylcurcumin Dihydrochloride is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disea<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications Lodoxamide is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>

<p>Applications Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.<br>References Stehlin, J.S., et al.: Int. J. Oncol., 14, 821 (1999), Verschraegen, C.F., et al.: Curr. Opin. Oncol. Endocr. Metab. Invest. Drugs, 1, 184 (1999),<br></p>

<p>Stability Store in Freezer<br>Applications Benzyl 3-Amino-3-deoxy-α-D-mannopyranoside Hydrochloride can be used for preparation of swainsonine analogs as immunostimulants.<br>References Dime, D., et al.: PCT Int. Appl., 74 pp. (1993),<br></p>

<p>Applications PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.<br>References Bryant, D.D. et al.: Psychopharmacology, 203, 703 (2009); Badura, L. et al.: J. Pharmacol. Exp. Therap., 322, 730 (2007); Sprouse, J. et al.: Psychopharmacology, 210, 569 (2010):<br></p>

<p>Applications Copper (I) bromide is used as a reagent to brominate electron-rich aromatic compounds (e.g. Phenol: P318000). Copper (I) bromide is also used to brominate aliphatic ketones (e.g. Acetone: A163800).<br>References Bhatt, S. &amp; Nayak, S.: Synth. Comm., 37, 1381 (2007); Kojima, Y. &amp; Kawaguchi, S.: Bull. Chem. Soc. Jpn., 45, 1293 (1972)<br></p>

<p>Applications Benzyltributylammonium Chloride (cas# 23616-79-7) is a useful research chemical.<br></p>

<p>Applications 3-Chloro-2-hydroxypropyltrimethyl ammonium chloride is used in the preparation of multifunctional cationized cotton fabric based on TiO2 nanomaterials.<br>References Farouk, A., et la.: Int. J. Biol. Macromolecules, 61, 230 (2013);<br></p>

<p>Applications 3,3-Dimethylacryloyl Chloride is a reactant in the synthesis of novel 4-substituted coumarin derivative, which exhibits significant antiproliferative activity toward tumor cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cao, Dong., et al.: J. Med. Chem., 59, 5721-5739 (2016)<br></p>

<p>Applications N-Phenylglycinonitrile is a useful building block used in the preparation of purine derivatives with ability to inhibit protein kinases by competitive displacement of ATP.<br>References Laufer, S., et al.: J. Med. Chem.: 48, 710 (2005);<br></p>

<p>Applications Bis(pinacolato)diboron is used as a condensation agent in the preparation poly(arylene)s. Bis(pinacolato)diboron is an organoboranate with potential use as matrix metallo-proteinase (MMP-2) inhibitor.<br>References Ali, H.A. et al.: Arch. Pharm., 337, 183 (2004); Izumi, A. et al.: Chem. Lett., 7, 728 (2000);<br></p>

<p>Applications Ethyl (2R,4S)-4-Methylpipecolate is an intermediate in the preparation of Argatroban (A769000).<br>References Hilpert, K. et al.: J. Med. Chem., 37, 3889 (1994), Kim, K. et al.: Med. Chem. Res., 6, 377 (1996),<br></p>

<p>Applications ABT 925 Fumerate is a dopamine D3 receptor antagonist that is used in the treatment of acute schizophrenia (1).<br>References (1) Redden, L., et al.: J. Clin. Psychopharmacol, 31, 221 (2011)<br></p>

<p>Applications A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic. Potent Hedgehog inhibitor.<br>References Berman, D., et al.: Science, 297, 1559 (2002), Varjosalo, M., et al.: Cell, 133, 537 (2008), Theunissen, J., et al.: Cancer Res., 69, 6007 (2009),<br></p>

<p>Applications Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis, used in the preparation of chiral 2-amino-1-phenylethanols as pharmaceutical intermediates.<br>References Bagnoli, L., et al.: Chem. Eur. J., 17, 993 (2011)<br></p>

<p>Applications Used in the synthesis of D-erythroascorbic acid from D-glucose.<br>References Gan, L.X., et al.: Carbohydrate Res., 220, 117 (1991),<br></p>

<p>Applications 4-Fluoro-1,2-phenylenediamine has shown anticancer activity in human prostate adenocarcinoma cell.<br>References Ahmed, H.A.: Bull. Faculty Pharmacy, 49, 25 (2011)<br></p>

<p>Applications 7-Amino-alpha-tetralone<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (2R,5R)-(+)-5-Benzyl-3-methyl-2-(5-methyl-2-furyl)-4-imidazolidinone is a reactant used in the preparation of allyl heterocycles using palladium-catalyzed allylic amination of allylic alcohols with heterocycles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Banerjee, D., et al.: Angew. Chem. Int. Ed., 51, 11556 (2012);<br></p>

<p>Applications 3-Aminobutyric Acid is one of the three positional isomer of the chemical compound butryric acid. 3-Aminobutyric Acid is a nonprotein amino acid. 3-Aminobutyric Acid has been shown to be a plant defense primer that suppresses growth of some insect herbivores when applied as a root drench.<br>References Hodge, S. et al.: Biocontrol, 56, 699 (2011); He, Y.-Y. et al.: 38, 641 (2010); Cohen, Y. et al.: Plant Dis., 86, 448 (2002);<br></p>

<p>Applications Manganese(II) chloride monohydrate (cas# 64333-01-3) is a useful research chemical.<br></p>

<p>Applications Intermediate used in the synthesis of a series of anaplastic lymphoma kinase (ALK) inhibitors, a new target for therapy of non-small-cell lung cancer (NSCLC).<br>References Okamoto, M., et al.: Bioorg. Med. Chem. Lett., 19, 3086 (2011),<br></p>

<p>Applications 15-Crown-5 is a catalyst used in the synthesis of organic molecules and lanthanide complexes. It can induce cytotoxicity and oxidative stress markers in WI38 cells. Studies show that 15-Crown-5 is also an effective chelating agent used for removing cesium in cesium-exposed mice.<br>References Li, L. et al.: J. Organometal. Chem., 794, 231 (2015); Gonzalez-Bello, C. et al.: J. Am Chem. Soc., 137, 9333 (2015); Llobet, J.M., et al.: Metal Ions Biol. Med., 4, 487 (1996)<br></p>

<p>Stability Hygroscopic<br>Applications A potent and discriminating antagonist for AMPA binding sites.<br>References HonorÈ, T., et al.: Science, 241, 701 (1988), Gill, et al.: Brain Res., 580, 35 (1992), Pook, et al.: Br. J. Pharmacol., 108, 179 (1993)<br></p>

<p>Applications 5-Chloro-2-methylaminopyridine is used in the preparation of aminosulfuranes with N-heterocyclic groups.<br>References Pashinnik, V.E. et al.: Ukr. Khim. Zhur., 73, 45 (2007);<br></p>

<p>Stability Hygroscopic<br>Applications Omeprazole Sodium Salt is the salt analogue of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Applications 2-Methoxybenzoyl Chloride is an aromatic acyl chloride derived from anisic acid. 2-Methoxybenzoyl Chloride is used in the preparation of a wide range of compounds such as anti-virals, anti-bacterials and antitumor agents.<br>References Li, Z. et al.: Chem. Biol. Drug Des., 79, 1018 (2012); Liu, W. et al.: Huax. Tong., 74, 665 (2011); Sousa, E. et al.: Eur. J. Med. Chem., 44, 3830 (2009);<br></p>

<p>Applications 1-Bromo-3,5-difluorobenzene is used in the synthesis of selective antagonists of GluN2C/GluN2D is used in the synthesis of COX-2 inhibitors as anti-inflammatory agents and anti-cancer agents.<br>References Khanna, I. et al.: J. Med. Chem., 40, 1634 (1997); Pommery, N. et al.: J. Med. Chem., 47, 6195 (2004);<br></p>

<p>Applications 4-Bromophenylhydrazine Hydrochloride is a reactant in the synthesis of fluoro substituted novel pyrazolylpyrazolines scaffold with antibacterial activity, antituberculosis activity against Mycobacterium tuberculosis H37Rv and antimalarial activity against Plasmodium falciparum.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Karad, S.C., et. al.: Eur. J. Med. Chem., 84, 51 (2014)<br></p>

<p>Applications Silver Carbonate is used in organic synthesis in the Koenigs-knorr glycosylation reaction. It is also known as Fetizon's reagent acting as an oxidising agent on celite forming lactones form diols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fetizon, M., et al.: J. Chem. Soc. Chem. Comm., 19, 1118 (1969);<br></p>

<p>Applications Zinc Acetate is used in biological studies and pharmacological activity of motexafin gadolinium disruptions of zinc metabolism in human cancer cell lines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Magda, D., et al.: Cancer Res., 65, 3837 (2005);<br></p>

<p>Applications Hydrazine Sulfate Salt is a reagent used in the heterocyclization of primary amines and may be cyclized itself. It is also used in the synthesis of novel triazole corrosion inhibitors for mild steel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bentiss, F. et al.: J. App. Electrochem., 29, 1073 (1999); Ju, Y. et al.: J. Org. Chem., 71, 135 (2006);<br></p>