Reagentes Sintéticos

<p>Applications A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.<br>References Rosen, L.S. et al.: J. Clin. Oncol., 26, 14585 (2008);<br></p>

<p>Applications 3-Cyanobenzoic Acid, is a building block used for the synthesis of a variety of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids, that can be used for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.<br>References Ramu, T., et al.: Chem. Lett., 42, 722 (2013);<br></p>

<p>Applications Galeterone is an androgen receptor antagonist and CYP17A1 enzyme inhibitor.<br>References Soifer, H.S., et al.: J. Biol. Chem., 287, 3777 (2012); Vasaitis, T., et al.: Molec. Cancer. Therap., 7, 2348 (2008);<br></p>

<p>Applications Phenidone is a dual LO (lipoxygenase) and Cox (cyclooxygenase) inhibitor.<br>References Pilar, G. et al.: J. Phycol., 52, 1085 (2016);<br></p>

<p>Applications Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase.<br>References Umezawa, H., et al.: J. Antib., 29, 97 (1976); Poloz, Y., et al.: Eukaryotic Cell, 11, 545 (2012);<br></p>

<p>Applications Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade. Bretylium tosylate is a class III antiarrhythmic agent and a competitive inhibitor of acetylcholinesterase.<br>References Kuntzman, R., et al.: Clin. Pharmacol. Ther., 11, 829 (1970), Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Carter, J.E., et al.: Anal. Profiles Drug Subs., 9, 71 (1980),<br></p>

<p>Applications 2-Bromophenylacetic Acid is used as the starting material in the synthesis of 2,3,3a,12b-Tetradehydro Asenapine (T291630); a degredation product of Asenapine (A788000) which is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist structurally related to Mianserin (M341500, HCl). Also used as an antipsychotic.<br>References Meltzer, H., et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A., et al.: Brain Res., 631, 191 (1993); Andree, B., et al.: Psychopharmacology, 131, 339 (1997); Richelson, E., et al.: Life Sci., 68, 29 (2000)<br></p>

<p>Stability Unstable in Solution<br>Applications 2-Pyrimidineacetic acid is a reagent that is used in the preparation of pyrimidine derivatives for treating and or preventing sexual dysfunction.<br>References Huang, Z., Faming Zhuanli Shenqing, 2012:400114<br></p>

<p>Applications CEP-28122 is used as an orally efficacious inhibitor of (ALK), analplastic lymphoma kinase, in the treatment of cancer.<br>References Gingrich, D. et al.: J. Med. Chem., 55, 4580 (2012);<br></p>

<p>Applications Acetylhistamine, is a histamine metabolite, and can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.<br>References Xu Y, et al. Asian Pac J Allergy Immunol. 2017 Dec;35(4):224-232.;<br></p>

<p>Applications (R)-Ethyl 4-chloro-3-hydroxybutanoate is used in biological studies for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate with two co-existing, recombinant Escherichia coli strains.<br>References Liu, Y., et al.: Biotech. Lett., 27, 119 (2005);<br></p>

<p>Applications (-)-DIBENZOYL-L-TARTARIC ACID MONOHYDRATE (cas# 62708-56-9) is a useful research chemical.<br></p>

<p>Applications Intermediate for the synthesis of enantiopure substituted 1,4-Dioxanes. Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis.<br>References Bagnoli, L., et al.: Chem. Eur. J., 17, 993 (2011)<br></p>

<p>Applications 2,2,2-Triphenylacetophenone is an endocrine disrupter that is medicated through estrogen receptors.<br>References Roncaglioni, A., et al.: SAR. QSAR. Environ. Res., 19, 697 (2008); Kuzmanich, G., et al.: Photochem. Photobiol., 10, 1731 (2011);<br></p>

<p>Applications BAY 11-7085 is a NF-κB (nuclear factor-κB) inhibitor and can be used as a therapeutic agent for the treatment of endometriosis. BAY 11-7085 inhibits the cell proliferation and DNA synthesis of endometriotic cyst stromal cells (ECSCs) and induces apoptosis by surpressing antiapoptotic proteins.<br>References Berger, N., et al.: Exp. Hematol., 35, 1495 (2007); Nasu, K., et al.: Am. J. Physiol., 293, E16 (2007)<br></p>

<p>Applications N-(2,4-Dinitro-5-fluorophenyl)-L-valinamide is used in the synthesis of chiral variants of Marfey’s reagent. It is also used in the preparation of phaeofungin from Phaeosphaeria.<br>References Bhushan, R. et al.: Acta. Chrom., 20, 329 (2008); Singh, S. et al.: J. Nat. Prod., 76, 334 (2013);<br></p>

<p>Applications 1,5-Difluoro-2,4-dinitrobenzene acts as an oleanolic acid NO-releasing derivative used towards the treatment of colon cancer. Also used in the synthesis of beta blockers used as bronchodialators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, J. et al.: RSC. Adv., 5,19445 (2015); Bhushan, R. et al.: Anal. Lett., 47, 202 (2014);<br></p>

<p>Applications MNI-caged-L-glutamate, is a new caged neuroactive amino acid, that use 4-methoxy-7-nitroindolinyl- (MNI) group to make caged ligands specific for glutamate receptor sub-types. MNI-caged-L-glutamate, rapidly release glutamate when photolysed.<br>References Palma-Cerda, F., et al.: Neuropharmacology, 63, 624 (2012); Canepari, M. J. Neuroscience Methods, 112, 29 (2001);<br></p>

<p>Applications Mercury(II) acetate is a reagent that is used in the investigation of diastereoselective acyclic α-alkoxydithioacetal substitutions involving thiacarbenium intermediates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prevost, M., et al.: J. Org. Chem. 79, 10504 (2014);<br></p>

<p>Applications 2-(2-Boc-aminoethoxy)ethanol is a reactant that has been used in the synthesis of RGD-conjugated MEK1/2 kinase inhibitors for integrin-targeted cancer therapy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, X., et. al.: Molecules, 18, 13957 (2013)<br></p>

<p>Applications Methyl 8-Chloro-8-oxooctanoate is used as a reagent in the synthesis of β-cyclodextrin-6-deoxy-6-NHC(O)(CH2)6C(O)NHOH which is a β-cyclodextrin-capped histone deacetylase inhibitor that may have potential for use in treatment of cancers and inflammatory diseases. It is also used in one synthetic route for tubacin which is a known anticancer agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amin, J., et al.: Bioorg. Med. Chem. Lett., 23, 3346 (2013); Hong, J., et al.: Lett. Org. Chem., 7, 50 (2010);<br></p>

<p>Applications Nimustine Hydrochloride is a DNA alkylator and cross-linking agent. It is used in chemotherapy in a part of anti-cancer cocktail used to treat malignant melanoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matsumoto, T. et al.: J. Eur. Acad. Dermatol. Venereol., 27, 1514 (2013);<br></p>

<p>Applications 1-(Tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (cas# 903550-26-5) is a useful research chemical.<br></p>

<p>Applications (S)-4-(prop-1-En-2-yl)cyclohex-1-enecarbaldehyde (cas# 18031-40-8) is a useful research chemical. A possible biomarker of Parkinson’s disease.<br>References Drupad, K. T., et al.: ACS Central Science, (2019)<br></p>

<p>Stability Hygroscopic<br>Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic.<br>References Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),<br></p>

<p>Applications Dichlorobis(triphenylphosphine) Palladium (II) is used primarily in organometallic catalytic reactions due to the palladium content of the compound. It is also involved in crystalized structures of metallacyclic complexes which show antiinflammatory and antifungal properties.<br>References Paul, P. et al.: J. Organometal. Chem., 724, 281 (2013); Pandiarajan, D. et al.: J. Organometal. Chem., 708-709, 18, (2012); Shhaheen, F. et al.: J. Organometal. Chem., 693, 315 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one is involved in the pharmacological inactivation of Skp2 E3 ligase.<br>References Chan, C., et al.: Cell, 154, 556-568 (2013)<br></p>

<p>Applications R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.<br>References Semmler, J., et al.: Int. J. Immunopharmacol.: 15, 409 (1993); Sommer, N., et al.: Nat. Med.: 1, 244 (1995); Robichaud, A., et al.: J. Clin. Invest., 110, 1045 (2002); Card, G., et al.: Structure: 12, 2233 (2004);<br></p>

<p>Applications AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma<br>References Burger, J.A., et al.: Leuke. Lympho.,53. 3 (2012); Lam, A.R., et al.: J. Chem. Info. Model., 51, 139 (2011); De Clercq. E., et al.: Pharmacol. Therap., 128. 509 (2010);<br></p>

<p>Applications Alpha-(trifluoromethyl)styrene<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Formyl-2-nitrophenol is an Intermediate used in synthesis of novel amodiaquine analogs as potential antimalarial and antifilarial compounds.<br>References Jiang, D.X., et al.: Int. J. Environ. Res., 5, 923 (2011); Al-Zereini, W., et al.: J. Antibiotic., 63, 297 (2010);<br></p>

<p>Applications 3,5-Dibromobenzaldehyde is a dibrominated benzaldehyde that is a very useful building block for the preparation of a wide range of biologically active compounds such as a antibacterials<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nielsen, S. et al.: Bioorg. Med, Chem., 12, 3017 (2004); Balderamos, M. et al.: Exp. Biol. Med., 233, 1395 (2008);<br></p>

<p>Applications Copper(II) Chloride Dihydrate is a substance used in the release of copper complexes from a nanostructured sol-gel titania for cancer treatment. Also in the solubilization of thymol in Tween 80 micelle to study solubilization mechanism of thymol and effect of solubilization on its antioxidant activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deng, L., et al.: Scientific Reports, 6, 38160 (2016); Lopez, T., et al.: J. Mater. Sci., 50, 2410 (2015)<br></p>

<p>Applications JNJ 17203212 is a high affinity TRPV1 receptor antagonist.<br></p>

<p>Applications 1-(azidomethyl)-3-methoxybenzene (cas# 123767-44-2) is a useful research chemical.<br></p>

<p>Applications Sildenafil (S435000) derivative.<br></p>

<p>Applications VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.<br>References Bridges, et al.: Bioorg. Med. Chem. Lett., 20, 1972 (2010); Lebois, et al.: ACS Chem. Neurosci., 1, 104 (2010),<br></p>

<p>Applications Benzyl Isocyanate is a general reagent used in the synthesis of complex bisindolylmethanes. Also used in the preparation of urea derivatives of thiazol-2-ethylamines for their anti-trypanosomal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patrick, D. et al.: Bioorg. Med. Chem., 24, 2451 (2016);<br></p>

<p>Applications (S,S)-2,3-Butanediol is the (S,S)-isomer of 2,3-Butanediol (B690020), a naturally occurring compound found in cocoa butter.<br>References Wang, Yu., et al.: J. Biological. Chem., 289, 6080 (2014); Cheng, C., et al.: J. Org. Chem., 78, 8562 (2013);<br></p>

<p>Applications Benzenesulfonyl Chloride is used in the synthesis of cecloprotoberberine derivatives as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, Y. et al.: Eur. J. Med. Chem., 68, 463 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications PHA-793887 is a potent CDK (cyclin-dependent kinase) inhibitor. Recent studies shows that PHA-793887 has promising therapeutic activity against acute leukemias in vitro and in vivo. PHA-793887 was used to successfully modulate E2F transcriptional factor-dependent cell cycle, DNA replication, mitosis and apoptosis related gene in both tumors and skin biopsy from patients with solid tumors.<br>References Alzani, R. et al.: Exp. Hematol., 38, 259 (2010); Locatelli, G. et al.: Mol. Cancer Ther., 9, 1265 (2010); Brasca, M. et al.: Bioorg. Med. Chem., 18, 1844 (2010);<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liau, B. et al.: J. Am. Chem. Soc., 134, 16765 (2012); Tatsuta, K. et al.: Tetrahedron Lett., 53, 422 (2012);<br></p>

<p>Applications Niobium Pentachloride is a reagent used in the synthesis of mixed chloro-aryloxide compounds and dyes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ilin, A. et al.: J. Alloy. Comp., 748, 543 (2018); Yuan, L. et al.: Inorg. Chem., 57, 4226 (2018);<br></p>

<p>Applications 18α-Glycyrrhetinic Acid rapidly and reversibly blocks gap junction intercellular communication (GJIC).<br>References Guo, Y., et. al.: Am. J. Phys.: 276, L1018 (1999)<br></p>

<p>Applications 6-Bromohexene is used as a reagent in the synthesis of carbendazim dithioate analogs which can exhibit antibacterial, antifungal, and soil dehydrogenase activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zahran, M.A H., et al.: Res. J. Pharm., Biol. Chem. Sci., 6, 1084 (2015)<br></p>

<p>Applications 5-Ethylpyridine-2-carboxylic Acid (cas# 770-08-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Tocainide Hydrochloride is used as an anti-arrythmic drug as myocardial depressants.<br>References Courtney, K. et al. J. Molec. Cell. Cardiol., 12, 1273 (1980); Kwok, D. et al.: Res. Comm. Chem. Path. Pharm., 67, 395 (1990);<br></p>

<p>Applications Phosphorothioic Acid Trisodium Salt Hydrate can be involved in reactions of alkali hexafluoroaluminates.<br>References Bukhalova, G. A., et al.: Issled. v Obl. Khim. i Technol. Mineral'n. Solei i Okislov, Akad. Nauk SSSR, Sb. Statei, 124 (1965)<br></p>

<p>Applications 4-​Methoxy-​6-​methyl-​2H-​pyran-​2-​one acts as a potential selective agonist for the ghrelin receptor (GHS-​R1a), a receptor which plays in a role in appetite.<br>References Pastor-Cavada, E., et al.: Sci. Rep., 6, 36456 (2016);<br></p>

<p>Applications 5-Methoxy-2-formylphenylboronic acid is a reagent used in the total synthesis of laetevirenol A via intramolecular Friedel-Crafts alkylation.<br>References Choi, Y. L., et al.: J. Org. Chem., 77, 8762 (2012)<br></p>

<p>Applications Aziridine carboxylic acid ester derivative used for the synthetic application of chiral aziridine via esterification.<br>References Minakata, S., et al.: Chem. Commun., 47, 6363 (2008); Li, Y.X., et al.: Tetrahedron. Lett., 49, 1480 (2008);<br></p>

<p>Applications D-Glyceraldehyde is the simplest of all aldoses and have been shown to be the one of the carbonyl metabolite of dietary fructose.<br>References Yang, K., et al.: Chem-Biol. Interact., 191, 315 (2011); Zheng, X.H., et al.: Chem. Med. Chem., 7, 1921 (2012);<br></p>

<p>Applications A phopshine ligand used in transition-metal mediated organic synthesis, in particular in wittig reactions to improved (Z) selectivity.<br>References Andersen N.G. et al.: Chem. Rev., 101, 997 (2001); Appel M. et al.: Eur. J. Org. Chem., 1143, (2002);<br></p>

<p>Applications 2,5-Dimethoxythiophenol is a thiophenol derivative used in the preparation of dihydrofolate reductase inhibitors and potential antitumor agents.<br>References Gangjee, A. et al.: J. Med. Chem., 52, 4892 (2009); Gangjee, A. et al.: Biiorg. Med. Chem., 18, 953 (2010);<br></p>

<p>Applications 3-Phenylpropyne is a useful synthetic intermediate. It is an intermediate used to synthesize carlina oxide. It can also be used to prepare triazole substituted pyrazolopyrimidinamide derivatives via click chemistry as potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klein, M., et al.: Org. Biomol. Chem., 7, 3421 (2009)<br></p>

<p>Applications tert-Butyl 2-(diethylphosphono)acetate is a chemical reagent used in the synthesis of pharmaceuticals such as Clopidogrel (C587250), s prodrug anticoagulant.<br>References Shaw, S. et al.: J. Org. Chem., 80, 7019 (2015);<br></p>

<p>Stability Air and Moisture Sensitive<br>Applications Diethyl Chlorophosphite is used in the synthesis of organophosphates and are considered anticholinesterase agents through observation in studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Segall, Y. et al.: Chem. Res. Toxicol., 16, 350 (2003);<br></p>

<p>Applications 2-Acrylamide-2-methylpropanesulfonic Acid is used in preparation of PAMPS/PHEMA/PEDOT Hydrogel Polyelectrolyte for activated carbon electrode.<br>References Zhang, X., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications SU11652 is a cell-permeable pyrrole-indolinone that acts as a tyrosine kinase receptor &amp; angiogenic inhibitor.<br></p>

<p>Applications Tin(II) trifluoromethanesulfonate (cas# 62086-04-8) is a useful research chemical.<br></p>

<p>Applications Procinolol is a beta adrenergic receptor antagonist. It is also an intermediate in synthesizing (±)-Procinolol Hydrochloride (P755815).<br>References Singh, K.: Indian J. Phsiol. Pharmacol., 27, 311 (1983)<br></p>

<p>Applications 3-Pyridinemethanol is a useful synthetic intermediate. It can be used in the synthesis of histone deacetylase inhibitors. It can also be used to prepare (phenyl)(cyanopyrazinyl)urea derivatives as possible kinase-1 (Chk1) inhibitors.<br>References Suzuki, T., et al.: J. Med. Chem., 42, 3001 (1999); Li, G., et al.: Bioorg. Med. Chem. Lett., 16, 2293 (2006)<br></p>

<p>Stability Hygroscopic<br>Applications XL413 is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koltun, E., et al.: Bioorg. Med. Chem. Lett., 22, 3727 (2012)<br></p>

<p>Applications Protected Glycidol, used as an intermediate in the preparation of neurochemicals.<br>References Qian, L., et al.: ChemMedChem., 1, 376 (2006), Shimizu, K., et al.: Bioorg. Med. Chem., 14, 1838 (2006), Pedersen, P., et al.: J. Med. Chem., 52, 3408 (2009),<br></p>

<p>Applications Diethyl (2-cyanoethyl)phosphonate, is a useful reactant used in various chemical synthesis such as in synthesis of lipophilic oxoamides with activity against phospholipase A2, Triose phosphate isomerase of muscle inhibitors, and also in base-catalyzed stereospecific anti-Markovnikov addition.<br></p>