Reagentes Sintéticos

<p>Applications 2-Fluoroiodobenzene is used as a reagent in various organic reactions. It is used in the synthesis of spirocyclic [1,2,3]-triazolooxazine nucleosides which have antiviral properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dell'Isola, A., et al.: Chem-Eur. J., 20, 11685 (2014)<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-Bromobenzenesulfonyl Chloride is an intermediate used to prepare sulfonamide-substituted cyclooctylpyranones as nonpeptidic HIV protease inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skulnick, H., et al.; J. Med. Chem., 40, 1149 (1997)<br></p>

<p>Applications ent-Ticagrelor is the enantiomer of Ticagrelor (T437700); the first reversible oral P2Y12 receptor antagonist that provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications methyl 5-(chloromethyl)-2-furoate (cas# 2144-37-8) is a useful research chemical.<br></p>

<p>Applications N-Boc-6-hydroxyhexylamine (cas# 75937-12-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Calcium Sulfate Dihydrate is obtained from gypsum, a naturally occurring compound. Also used in the preparation of calcium sulfate and calcium sulfoaluminate.<br>References Strydom, C. et al.: J. Therm. Anal., 49, 1501 (1997); Winnefeld, F. et al.: DGCh-Monograph., 44, 30 (2011);<br></p>

<p>Applications Mercury(II) acetate is a reagent that is used in the investigation of diastereoselective acyclic α-alkoxydithioacetal substitutions involving thiacarbenium intermediates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prevost, M., et al.: J. Org. Chem. 79, 10504 (2014);<br></p>

<p>Applications 1,5-Difluoro-2,4-dinitrobenzene acts as an oleanolic acid NO-releasing derivative used towards the treatment of colon cancer. Also used in the synthesis of beta blockers used as bronchodialators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, J. et al.: RSC. Adv., 5,19445 (2015); Bhushan, R. et al.: Anal. Lett., 47, 202 (2014);<br></p>

<p>Applications 4,4’,(5’)-Di-(tert-butylcyclohexano)-18-crown-6 is a crown ether-based sorbent used in the analysis and separation of minerals.<br>References Yankovskaya, V. et al: J. Radioanal. Nucl. Chem., 314, 119 (2017);<br></p>

<p>Applications Used in the preparation of sulfur aroma compounds.<br></p>

<p>Stability Hygroscopic<br>Applications 9-Mesityl-10-methylacridinium Tetrafluoroborate can be used for the synthesis of γ-butyrolactones, γ-lactams and pyrrolidines. 9-Mesityl-10-methylacridinium Tetrafluoroborate has been reported by Nicewicz et al. to mediate myriad transformations through Photoredox Catalysis. The applications include the anti-Markovnikov hydroamination of alkenes and addition of carboxylic acids to alkenes and the hydrotrifluoromethylation of styrenes using the Langlois reagent S673690.<br>References Gesmundo, N. J. et al.: Org. Lett. 17, 1316 (2015); Zeller, M. A., et al.: Org. Lett. 16, 4810 (2014); Nicewicz et al., J. Am. Chem. Soc., 135 (26), 9588–9591(2013)<br></p>

<p>Stability Hygroscopic<br>Applications Magnesium acetate tetrahydrate (cas# 16674-78-5) is a useful research chemical.<br></p>

<p>Applications 1-Acetyl-1H-pyrazole-4-boronic acid, pinacol ester<br></p>

<p>Applications ethyl 3-aminobutanoate (cas# 5303-65-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Batyl Alcohol is used to synthesize amphiphilic alkylglycerolipids with antitumor activities. It is also used in cosmetic compounds for prevention or treatment of erythema or dermatitis or promotion of wound healing.<br>References Ukawa, K., et al.: Chem. Pharma. Bull., 37, 3277 (1989); Schoenrock, U., et al.: Ger. (1995), DE 4420625 C1 19951102.<br></p>

<p>Applications Piperonylamine is a metabolite of dopamine analogs.<br>References Goodwin, B.L., et al.: Xenobiotica, 24, 129 (1994),<br></p>

<p>Applications NE-100 is a potent and selective σ1 receptor antagonist.<br>References Sabino, V., et al.: Psychopharmacology, 205, 327 (2009); Kunitachi, S., et al.: Brain Res., 1279, 189 (2009)<br></p>

<p>Applications Tetramethylammonium Bromide (cas# 64-20-0) is a useful research chemical.<br></p>

<p>Applications Tideglusib is used in the treatment of brain atrophy, and movement disorder issues.<br>References Hoeglinger, G. et al.: Movement DIs., 29, 579 (2014); Tolosa, E. et al.: Movement Dis., 29, 570 (2014);<br></p>

<p>Applications 2,3-Dichloropyrazine is a substrate used for an efficient synthesis of aloisine (A575450), a potent cyclin-dependent kinase.<br>References Chekmarev, D.S., et al.: Tetrahedron., 62, 9919 (2006);<br></p>

<p>Applications 1-Methyl-2-indolone is a reactant for preparation of fluorescent analogues of strigolactones as affectors of parasitic weed germination and fungal branching, irreversible Nek2 Kinase Inhibitors and anticancer agents.<br>References Prandi, C., et al.: Eur. J. Org. Chem., 3781, Henise, J., et al.: J. Med. Chem., 54, 4133 (2011); Kamal, A., et al.: Eur. J. Med. Chem., 46, 2427 (2011)<br></p>

<p>Applications (R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors.<br>References Biswas, S., et al.: J. Med. Chem., 51, 101 (2008); Prasad, C., et al.: Bioorg. Med. Chem. Lett., 14, 1917 (2004)<br></p>

<p>Applications Sch 527123 is a potent CXCR2 antagonist. It can potentially inhibits human colon cancer liver metastasis.<br>References Varney, M. L., et al.: Cancer Lett 300, 180 (2011); Arshi, K., et al.: Front Immunol. 8, 464 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications R-(-)-3-Quinuclidinol Hydrochloride is shown to have weak in vitro acetylcholinesterase inhibitory activity.<br>References Bosak, A., et al.: Croat. Chem. Acta, 78, 121 (2005); Pyttel, R., et al.: J. Pharm. Sci., 62, 684 (1973)<br></p>

<p>Applications K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.<br>References Sanvitale, C.E., et al.: PLoS One, 8, e62721 (2013)<br></p>

<p>Applications 3-Fluoro-4-methoxybenzaldehyde is a useful reagent in the synthesis of resveratrol derivatives as potent inhibitors of lysine specific demethylase 1 (LSD1), a therapeutic target for cancer treatment and other related diseases. Also a reagent for the synthesis of substituted pyrazolyl piperidine derivatives as antiplatelet agents with antiplatelet aggregation activity in the human body.<br>References Duan, Y., et al.: Eur. J. Med. Chem., 126, 246 (2017); Soni, J. Y., et al.: J. Heterocyclic Chem., 54, 1279 (2017)<br></p>

<p>Applications Trimethylboroxin (50% Solution in THF) is used in a diverse array of areas, including as a polymerization additive. Trimethylboroxin is also used in the preparation of CBS catalysts for asymmetric reductions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gilmore, N., et al.: Tetrahedron Asy., 14, 2115 (2003); Najera, C., et al.: Adv. Synth. Catal., 346, 1798 (2004);<br></p>

<p>Applications N-DesBoc Docetaxel is an impurity in the synthesis of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications tert-Butyl N-Tosyloxycarbamate is a sulfhydroxylamine that, when used in combination with Lithium, functions as an efficient electrophile in the amination of chiral amide cuprate compounds. tert-Butyl N-Tosyloxycarbamate is also used as a reagent to synthesize N-Boc protected primary amines (e.g. N-Boc-ethylenediamine [B655000]).<br>References Chiba, S. &amp; Narasaka, K.: Amin. Grou. Chem: Synth. Life Sci., No vol. given (2008); Gallou, I. &amp; Senanayake, C.: Chem. Rev.: 106, 2843 (2006); Genet, J., et al.: Tetrahedron Lett., 32, 2359 (1991); Zheng, N., et al.: ChemInform, 28, No pp. given (1997)<br></p>

<p>Applications An intermediate in the preparation of pentafluoropentane-1-thiol: an important chain of anti-breast cancer agents.<br>References By Li, X. et al.: Tetrahedron Lett., 35, 9141 (1994);<br></p>

<p>Stability Air Sensitive<br>Applications Can be used as a building block for chiral ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 5-Bromopentyltrimethylammonium Bromide (cas# 15008-33-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Potassium Iodide is used primarily used in the treatment of radiation poisoning due to environmental contamination by iodine-131.<br>References Wolff, J. et al.: Pharmacol. Rec., 50, 89 (1998);<br></p>

<p>Applications Copper (I) bromide is used as a reagent to brominate electron-rich aromatic compounds (e.g. Phenol: P318000). Copper (I) bromide is also used to brominate aliphatic ketones (e.g. Acetone: A163800).<br>References Bhatt, S. &amp; Nayak, S.: Synth. Comm., 37, 1381 (2007); Kojima, Y. &amp; Kawaguchi, S.: Bull. Chem. Soc. Jpn., 45, 1293 (1972)<br></p>

<p>Applications Benzyltributylammonium Chloride (cas# 23616-79-7) is a useful research chemical.<br></p>

<p>Applications 3-Chloro-2-hydroxypropyltrimethyl ammonium chloride is used in the preparation of multifunctional cationized cotton fabric based on TiO2 nanomaterials.<br>References Farouk, A., et la.: Int. J. Biol. Macromolecules, 61, 230 (2013);<br></p>

<p>Applications (S,S)-(-)-Hydrobenzoin is a chral auxiliary with versatile applications. It is also used as a building block.<br>References Marshall, J., et al.: J. Org. Chem. 60, 7230 (1995); Stolle, A., et al. Tetrahedron Lett. 35, 3521 (1994); Burk, M., et al.: J. Am. Chem. Soc. 115, 10125 (1993); Burk, M., et al.: Tetrahedron Asymmetry 2, 569 (1991); Pichon, M., et al: Tetrahedron Asymmetry 7, 927 (1996)<br></p>

<p>Applications A useful synthetic intermediate. Used for asymmetric hydroxylation.<br>References Davis, F.A., et al.: J. Am. Chem. Soc., 112, 6679 (1990)<br></p>

<p>Applications Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.<br>References Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995), Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (2001), Basso, A.D., et al.: Oncogene, 21, 1159 (2002),<br></p>

<p>Stability Volatile<br>Applications Allyltrimethylsilane is used in the allylation of aldehydes, imines, allylic and benzylic alcohols, and chiral α-keto-amides that are derived from (S)-proline esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yadav, J.S., et al.: Tetrahedron Lett., 43, 3783 (2002); Aggarwal, V.K., et al.: Tetrahedron Lett., 37, 3745 (1996); Wang, D.K., et al.: J. Org. Chem., 64, 4233 (1999); Kaur, G., et al.: Tetrahedron Lett., 38, 2521 (1997); Soai, K., et al.: J. Chem. Soc., Chem. Commun., 15, 1016 (1984)<br></p>

<p>Applications 4-Hydroxy-3,5-dimethylbenzoic Acid is used in the synthesis of Mexiletine (M340800) derivatives as orally bioavailable inhibitors. Also, used as a chemical reagent in the preparation of potent transthyretin (TTR) amyloidogenesis inhibitors affecting thyroid hormone.<br>References Frederickson, M. et al.: J. Med. Chem., 51, 183 (2008); Johnson, S. et al.: J. Med. Chem., 51, 260 (2008);<br></p>

<p>Applications Nimustine Hydrochloride is a DNA alkylator and cross-linking agent. It is used in chemotherapy in a part of anti-cancer cocktail used to treat malignant melanoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matsumoto, T. et al.: J. Eur. Acad. Dermatol. Venereol., 27, 1514 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic.<br>References Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),<br></p>

<p>Applications R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.<br>References Semmler, J., et al.: Int. J. Immunopharmacol.: 15, 409 (1993); Sommer, N., et al.: Nat. Med.: 1, 244 (1995); Robichaud, A., et al.: J. Clin. Invest., 110, 1045 (2002); Card, G., et al.: Structure: 12, 2233 (2004);<br></p>

<p>Applications 5-Methoxy-2-formylphenylboronic acid is a reagent used in the total synthesis of laetevirenol A via intramolecular Friedel-Crafts alkylation.<br>References Choi, Y. L., et al.: J. Org. Chem., 77, 8762 (2012)<br></p>

<p>Applications BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.<br>References Guagnano, V., et al.: J. Med. Chem., 54, 7066 (2011); Konecny, G., et al.: Mol. Cancer Ther., 12, 632 (2013)<br></p>

<p>Applications Ciproxifan is a potent histamine H3 receptor antagonist which affects histamine levels in the brain. It may be used in treatments for sleep and neurological disorders.<br>References Stark, H. et al.: J. Med. Chem., 43, 3987 (2000); Mahmood, D. et al.: Pharmacolol. Rep., 64, 191 (2012); Passani, M. et al.: Trends Pharmacol. Sci., 25, 618 (2004);<br></p>

<p>Applications Mirin is an MRN-ATM pathway inhibitor blocking 3’ and 5’ exonuclease activity associated with Mre11, inducing G2 cell cycle arrest.<br>References Shibata, A. et al.: Mol Cell., 53, 7 (2014);<br></p>

<p>Applications β-Naphthylcarbinol is an intermediate in the synthesis of 2-Naphthylcarbapenem derivatives with broad spectrum antibiotics with enhanced potency against MRSA.<br>References Martikainen, L.E., et al.: Euro. J. Pharma. Sci., 47, 996 (2012);<br></p>

<p>Applications 4-Tolylhydrazine Monohydrochloride has shown tumorigenic potential through studies. In addition, due to its hydrazine moiety, it has anti-cancer potential and is a compound from which derivatives are made in the search of novel anticancer drugs.<br>References Gohil, V. et al.: Ind. J. Exp. Biol., 48, 265 (2010); Toth, B. et al.: J. Toxicol. Environ. Health, 8, 1 (1981);<br></p>

<p>Applications 4,6-Di-tert-butyl-1,2-benzoquinone is a Ortho-Quinone derivative is know to possess a number of biological properties such as antitumoral, antimicrobacterial and anti-cardiovascular disease.<br>References Singh, R., et al.: Res. J. Med. Plant., 6, 123 (2012); Sygmund. C., et al.: Microbiol., 157, 3203 (2011); Vidal, J.C., et al.: Electroanal., 20, 865 (2008); Kaizer, J., et al.: Food. Chem., 93, 425 (2005);<br></p>

<p>Applications 2,6-Di-tert-butyl-4-nitrophenol is a potentially powerful uncoupler of ATP-generating oxidative phosphorylation that has been reported to be a contaminant in submarines and indoor spaces, causing a number of objects to turn yellow (even human skin).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ball, J., et al.: Science, 272, 101 (1996); Rivera-Nevares, J., et al.: Env. Toxicol. Chem., 14, 251 (1995); Rothweiler, H., et al.: Atm. Env. B: Urb. Atm., 25, 231 (1991)<br></p>

<p>Applications L-(-)-Lactide is a cyclic lactic acid derivative used in the ring-opening polymerization of Poly-L-lactic acid (PLLA), which is commonly found in biodegradable plastics. Polymers derived from L-(-)-Lactide also provide a therapeutic use in the field of prosthetics as they do not have any adverse effects on proliferation and differentiation of bone cells.<br>References Nakamura, T. et al.: J. Biomed. Mat. Res., 23, 1115 (1999); Otto, T.E. et al.: J. Biomed. Mat. Res., 32, 513 (1996); Kale, G. et al.: Pach. Technol. Sci., 20, 49 (2007);<br></p>

<p>Applications (+/-)-Nutlin-3 is a small molecule MDM2 antagonist.<br>References Vassilev, L.T., et. al.: Sci., 303, 844 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>

<p>Applications Methyl 3-Mercaptopropionate is used in the synthesis of thioisoindolinones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sakulsombat, M. et al.: Isr. J. Chem., 53, 127 (2013);<br></p>

<p>Applications (S)-(−)-α,4-Dimethylbenzylamine was used in the study of heterogeneous Raney nickel and cobalt catalysts for racemization and dynamic kinetic resolution of amines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parvulescu, A., et al.: Adv. Synth. Catal., 350, 113 (2008);<br></p>