Reagentes Sintéticos

<p>Applications Used in the preparation of α-aryl/pyridinyl ethanolamines as selective β3 adrenergic receptor agonists.<br></p>

<p>Applications Montmorillonite K 10 is used in the catalytic chemical process, including chemical cracking.<br>References Kaur, J. et al.: J. Chem. Pharm. Res., 4, 991 (2012);<br></p>

<p>Stability Light Sensitive<br>Applications Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kajikawa, N., et al.: Arzneim.-Forsch., 39, 495 (1989), Demolis, J.-L., et al.: J. Cardiovasc. Pharmacol., 22, 711 (1993), Okuda, Y., et al.: Prostaglandins, 52, 375 (1996),<br></p>

<p>Applications R-(+)-1,1'-Bi-2-Naphthol is used in biosynthetic preparation for enantioselective oxidation of naphthols to binaphthyldiols with horseradish peroxidase catalyst.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sridhar, M., et al.: Tetrahedron Lett., 38, 5695 (1997)<br></p>

<p>Applications 6-Quinolinol is used in the preparation of potential antifungal agents containing a quinoline structure. Also used in the preparation of novel pyridocoumarins.<br>References Galariniotou, E. et al.: Tetrahedron 63, 8298 (2007); Vandekerckhove, S. et al.: Bioorg. Med. Chem. Lett., 23, 4641 (2013);<br></p>

<p>Applications A specific serotonin-S2 antagonist. A selective drug for the control of behavioral disorders in epileptic and alcoholic patients.<br>References Gelders, Y.G., et al.: Acta Psychiatrica Belgica, 84, 151 (1984), Kennis, L.E.J., et al.: Drug Develop. Res., 8, 133 (1986),<br></p>

<p>Applications Disodium Tetrachloropalladate is an inorganic compound used in organometallic chemistry for the preparation of phosphine complexes of palladium.<br>References Ramirez-Rave, S., et al.: J. Orgometallic. Chem., 749, 287 (2014);<br></p>

<p>Applications A useful synthetic intermediate for carbohydrate synthesis.<br></p>

<p>Applications Cesium Acetate (cas# 3396-11-0) is a useful research chemical.<br></p>

<p>Applications Used in the preparation of 5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors.<br>References Dave, C., et al.: Indian J. Pharma. Sci., 48, 75 (1986),<br></p>

<p>Stability Moisture Sensitive<br>Applications An inhibitor with antitumor activity.<br>References Plumb, J., et al.: Mol. Cancer Ther., 2, 721 (2003), de Ruijter, A., et al.: Biochem. J., 370, 737 (2003), Dey, P., et al.: Curr. Med. Chem., 13, 2909 (2006), Maiso, P., et al.: Cancer Res., 66, 5781 (2006), Paris, M., et al.: J. Med. Chem., 51, 1505 (2008),<br></p>

<p>Applications Used for the preparation of N-sulfonylamino acid derivatives as metalloproteinase inhibitors.<br>References Reed, R., et al.: Biochem. J., 191, 867 (1980), Fehske, K., et al.: Biochem. Pharm., 30, 687 (1981),<br></p>

<p>Applications α-L-Idopyranose pentaacetate is used in the synthesis of mucopolysaccharides as antagonists agents.<br>References Hopwood., et al.: Clinica Chem. Acta, 123, 241 (1982), Ogamo., et al.: Carbohydr. Res., 105 (1982),<br></p>

<p>Applications 4-(Methylthio)benzaldehyde, is a building block for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the synthesis of sulfur-containing terpyridine ligands. It is the intermediate for the synthesis of a class of pyrrole derivatives showing analgesic/anti-inflammatory activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Romashkina, R. B., et al.: Russian Chemical Bulletin, 61, 2265 (2012); Battilocchio, C., et al.: Bioorg. Med. Chem., 21, 3695 (2013);<br></p>

<p>Applications Reducing reagent.<br></p>

<p>Applications 4-(2,3-Dimethoxyphenyl)butanoic acid is a butyrate analogue with effects on apoptosis, proliferation and histone deacetylase (HDAC) activity in HT-29 colorectal cancer cells.<br>References Scheppach, W., et al.: Eur. J. Cancer, 31A, 1077 (1995), Wu, J., et al.: J. Lipid Res., 46, 1944 (2005), Kiefer, J., et al.: Br. J. Nutr., 96, 803 (2006),<br></p>

<p>Applications 2',4',6'-Trihydroxyacetophenone monohydrate (cas# 249278-28-2) is a useful research chemical.<br></p>

<p>Applications 1,5-Dichloroanthraquinone is a reagent in the preparation of anthraquinones, which has antitumor activities.<br>References Barasch, D., et al.: Eur. J. Med. Chem., 34, 597 (1999)<br></p>

<p>Applications Troxipide is a drug used in the treatment of gastroesophageal reflux disease. It is capable of inhibiting the chemotactic migration and superoxide generation in the gastric mucosa.<br>References Yu, S., et al.: Eur. J. Clin. Pharmacol., 76, 547-555 (2020)<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Acetamido-5-nitrophenylboronic acid, pinacol ester<br></p>

<p>Applications AMG 337 is a potent and selective inhibitor of mesencymal epethelial transition factor (MET factor) which has been implicated in several cancers.<br>References Boezio, A. et al.: J. Med. Chem., 59, 2326 (2016);<br></p>

<p>Applications SP 2509 reduces the effect of the LSD1 binding to CoREST, resulting in increased methylation of H3K4 and driving increased expression of p21, p27 and CCAAT/enhancer binding protein α in acute myeloid leukemia cells. Anti-leukemia agent.<br>References Sorna, V. et al.: J. Med. Chem., 56, 9496 (2013); Fiskus, W. et al.: Leukemia, 11, 2155 (2014);<br></p>

<p>Applications Diphenyl Phosphite is a reactant used in the synthesis of α-hydroxyphosphonates and α-hydroxyphosphinates for their antioxidant and antimicrobial activity.<br>References Sampath, C. et al.: Phosphor. Sulfur Silicon. Rel. Elem., 191, 95 (2016);<br></p>

<p>Applications TETRAMETHYLAMMONIUM BOROHYDRIDE (cas# 16883-45-7) is a useful research chemical.<br></p>

<p>Applications 1-(2-Chloroethyl)pyrrolidine is a haloalkyl substituted pyrrolidine used in the preparation of various pharmaceutical compound such as the estrogen receptor antagonist Nafoxidine (N212800) and its analogues.<br>References Neyyarapally, A.T. et al.: Ind. J. Chem., 11, 325 (1973); Jones, C.D. et al.: J. Med. Chem., 27, 1057 (1984); Nakata, K. et al.: Molecules, 15, 6773 (2010);<br></p>

<p>Applications N-Acetyl-DL-Valine is an amino acid.<br>References Hirschmann R., et al.: Science, 265, 234 (1994); Gu Z. T., et al.: J. Magn. Reson., 140, 340 (1999); Bodalo, A., et al.: Enzyme Microb. Technol., 24, 381 (1999)<br></p>

<p>Applications (4R,5R)-2,2-Dimethyl-α,α,α',α'-tetra-2-naphthalenyl-1,3-dioxolane-4,5-dimethanol, is a privileged ligand analogue of TADDOLs. It can be broadly used in asymmetric synthesis. It is also shown that the titanium TADDOLate catalysts have broad application towards carbonyl addition and cycloaddition.<br>References Seebach, D., et al.: Ange. Chem. Inter. Ed., 40, 92, (20010;<br></p>

<p>Applications Hydrazine Sulfate Salt is a reagent used in the heterocyclization of primary amines and may be cyclized itself. It is also used in the synthesis of novel triazole corrosion inhibitors for mild steel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bentiss, F. et al.: J. App. Electrochem., 29, 1073 (1999); Ju, Y. et al.: J. Org. Chem., 71, 135 (2006);<br></p>

<p>Applications Used in the preparation of benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia.<br>References Chang, A., et al.: Diabetes, 32, 830 (1983), Goldstein, B. et al.: Cell Biochem., 48, 33 (1992), Sredy, J., et al.: Metabolism, 44, 1074 (1995),<br></p>

<p>Applications Tetramethoxymethane has application within an electrolyte solution for the use of rechargeable lithium batteries. It has also been used as a reactant in the synthesis of novel anti-HIV-1 compounds.<br>References Cadger, T.G. et al.: Proc. Electrochem. Soc., 88, 699 (1988); Kazmierski, W.M. et al.: J. Med. Chem., 54, 3756 (2011);<br></p>

<p>Applications 2-Amino-5-methylphenyboronic acid, pinacol ester<br></p>

<p>Applications 1,2,4,5-BENZENETETRACARBOXYLIC ACID (cas# 89-05-4) is a useful research chemical.<br></p>

<p>Applications 4-Nitro-benzeneethanol is a useful synthetic intermediate. It can be used to synthesize N-phenylethylindole carboxamides as SAR study of allosteric modulators of CB1 receptor. It can also be used to prepare 2-aza-2'-deoxyinosine-containing oligodeoxyribonucleotide duplexes.<br>References Piscitelli, F., et al.: J. Med. Chem., 55, 5627 (2012); Acedo, M., et al.: J. Org. Chem., 60, 6262 (1995)<br></p>

<p>Applications A useful synthetic intermediate. Used for asymmetric hydroxylation.<br>References Davis, F.A., et al.: J. Am. Chem. Soc., 112, 6679 (1990)<br></p>

<p>Stability Hygroscopic<br>Applications Omeprazole Sodium Salt is the salt analogue of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Applications 5-Chloro-2-methylaminopyridine is used in the preparation of aminosulfuranes with N-heterocyclic groups.<br>References Pashinnik, V.E. et al.: Ukr. Khim. Zhur., 73, 45 (2007);<br></p>

<p>Applications An Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia. It is a COVID19-related research product.<br>References Fancelli, D., et al.: J. Med. Chem., 49, 7247 (2006), Carpinelli, P., et al.: Mol. Canc. Ther., 6, 3158 (2007), Coumar, M., et al.: J. Med. Chem., 52, 1050 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications A potent and discriminating antagonist for AMPA binding sites.<br>References HonorÈ, T., et al.: Science, 241, 701 (1988), Gill, et al.: Brain Res., 580, 35 (1992), Pook, et al.: Br. J. Pharmacol., 108, 179 (1993)<br></p>

<p>Stability Moisture Sensitive<br>Applications Zinc Di[bis(trifluoromethylsulfonyl)imide] is a reactant used in the assembly of pyrene-based Schiff base MII4L6 architectures.<br>References Ronson, T. et al.: J. Am. Chem. Soc., 137, 14502 (2015); Riddell, I. et al.: Chem. Sci., 6, 3533 (2015);<br></p>

<p>Applications 15-Crown-5 is a catalyst used in the synthesis of organic molecules and lanthanide complexes. It can induce cytotoxicity and oxidative stress markers in WI38 cells. Studies show that 15-Crown-5 is also an effective chelating agent used for removing cesium in cesium-exposed mice.<br>References Li, L. et al.: J. Organometal. Chem., 794, 231 (2015); Gonzalez-Bello, C. et al.: J. Am Chem. Soc., 137, 9333 (2015); Llobet, J.M., et al.: Metal Ions Biol. Med., 4, 487 (1996)<br></p>

<p>Applications Dirhodium tetracaprolactamate is an organometallic complex used as a catalyst in the regioselective azidation of arenes.<br>References Wang, Y.; et al.: Org. Lett., 20, 5732 (2018).<br></p>

<p>Applications tert-Butyl 4-Hydroxybutanoate is used as a reagent in the synthesis of theranostic vitamin-linker-taxoid conjugates. tert-Butyl 4-Hydroxybutanoate is also used as a reagent in the synthesis of teroxazoles as α-helix mimetics.<br>References Vineberg, J.G., et al.: J. Med. Chem., 58, 2406 (2015); Pinto Gomes, C., et al.: Eur. J. Org. Chem., 2012, 3270 (2012)<br></p>

<p>Stability Toxic<br>Applications Sodium Tetraphenylboroate is a salt that is commonly used in inorganic and organometallic chemistry as a precipitating agent. Sodium Tetraphenylboroate is also utilized for the preparation of N-acylammonium salts and in coordination chemistry due to their favourable solubility in nonpolar sovlents and their crystallinity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jesson, J.P., et al.: Inorg. Syn., 20, 76 (2007); Kharitononv., S.V., et al.: J. Anal. Chem., 61, 9 (2006);<br></p>

<p>Applications α-Phenyllongifolol is an impurity in the synthesis of Longifolene (L469455) which is a constituent of black cumin seed and may exhibit anticancer and antibacterial activities.<br>References Hajhashemi, V., et al.: Phytother. Res 18, 195 (2004); Bourgou, S., et al.: S Afr J Bot 76, 210 (2010)<br></p>

<p>Applications 2-Acetamido-4-fluorophenylboronic acid, pinacol ester<br></p>

<p>Applications 2-Phenylpropionaldehyde is a precursor in the synthesis of N,N,β-Trimethyl-phenethylamine Hydrochloride (T796625).<br></p>

<p>Applications An oral, selective dual inhibitor of Src and ABL kinase. It is a COVID19-related research product.<br>References Schweppe, R., et al.: J. Clin. Endocrinol., Metab., 94, 2199 (2009), Chen, Y., et al.: Clin. Canc. Res., 15, 3396 (2009), McDermott, U., et al.: Cancer Res., 70, 1625 (2010),<br></p>

<p>Applications Manganese(II) chloride monohydrate (cas# 64333-01-3) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications GFT-505 is a dual PPARα/δ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders.<br>References Carious, B., et al.: Diabetes Care 36, 2923 (2013); Carious, B., et al.: Diabetes Care 34, 2008 (2011)<br></p>

<p>Applications Isaxonine is a neurotropic agent. Isaxonine prevents synaptic remodeling by suppression of the redundant nerve endings from additional axons. Isaxonine is transformed by cytochrome P 450 into reactive metabolites that lead to immunoallergic hepatitis in man.<br>References Becker, C.M., et. al.: Eur. Surg. Res., 18, 383 (1986); De Reuck, J., et. al.: Acta Neuropath., 72, 406 (1987); Loeper, J., et. al.: Hepatology, 9, 675 (1989)<br></p>

<p>Applications 3-Aminobutyric Acid is one of the three positional isomer of the chemical compound butryric acid. 3-Aminobutyric Acid is a nonprotein amino acid. 3-Aminobutyric Acid has been shown to be a plant defense primer that suppresses growth of some insect herbivores when applied as a root drench.<br>References Hodge, S. et al.: Biocontrol, 56, 699 (2011); He, Y.-Y. et al.: 38, 641 (2010); Cohen, Y. et al.: Plant Dis., 86, 448 (2002);<br></p>

<p>Applications (2R,5R)-(+)-5-Benzyl-3-methyl-2-(5-methyl-2-furyl)-4-imidazolidinone is a reactant used in the preparation of allyl heterocycles using palladium-catalyzed allylic amination of allylic alcohols with heterocycles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Banerjee, D., et al.: Angew. Chem. Int. Ed., 51, 11556 (2012);<br></p>

<p>Stability Very Hygroscopic<br>Applications Magnesium Bromide is an inorganic salt used in the synthesis of superconductors and nanowires. Also present in polymer nanocomposites to improve conductivity.<br>References Alam, M. et al.: Polym. Int., 63, 1465 (2014); McDonald, T. et al.: J. Am. Chem. Soc., 135, 7056 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications SIPr is used as a reagent in the synthesis of mononuclear [(η6-arene)Ni(N-heterocyclic carbene)] complexes which are useful precursors of the Ni0-NHC unit.<br>References Hoshimoto, Y., et al.: Organometallics, 33, 1276 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications N10-Trifluoroacetylpteroic acid is a derivative of Pteroic acid (P840110), both of which are used as reagents to synthesize target ligands, like Folic acid (F680300), that have the ability to deliver chemotherapeutic agents specifically to cancer cells.<br>References Leamon, C., et al.: Bioconjugate Chem., 14, 738 (2003); Leamon, C., et al.: J. Drug Target., 7, 157 (1999); Yonghua, Z., et al.: Anal. Biochem., 332, 168 (2004)<br></p>

<p>Applications An Aurora kinase inhibitor, used to treat patients with advanced solid tumors.<br></p>

<p>Applications (1S,2S)-1,2-Diphenyl-1,2-ethanediamine (cas# 29841-69-8) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications N,N′-Disuccinimidyl Carbonateis a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of ligands to proteins. The coupling reagent property of N,N’-Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.<br>References Rebane, R., et al.: J. Chromatography., 904, 99 (2012);<br></p>

<p>Applications is an (2S)-2-(Methoxydiphenylmethyl)pyrrolidine intermediate in the synthesis of α-Zingiberene which is a sesquiterpine found in leaf glandular trichomes that is currently being evaluated for its cytotoxicity towards human tumour cell lines.<br>References Bou, D., et al.: Molecules, 18, 9477 (2013); Freitas, J., et al.: Euphytica, 127, 275 (2002)<br></p>

<p>Stability Volatile<br>Applications N-Ethylbutylamine is used as a reagent in the synthesis of substituted pyrimidines as corticotropin releasing factor (CRF) receptor ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kuppast, B., et al.: Eur. J. Med. Chem., 78, 1 (2014)<br></p>

<p>Applications (3-Aminopropyl)trimethoxysilane is used in the synthesis of aspirin imprinted polymer on silica gel surface and appreciation on drug sustained release. Fluorine-doped; lectin functionalized ZnO nanoarrays as 3D nano-biointerface for bacterial detection.<br>References Lu, P., et al.: Gaofenzi Cailiao Kexue Yu Gongcheng, 33, 130 (2017); Zheng, L., Talanta, 167, 600 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications 2,4-Dinitrophenylsulfonyl Chloride, can be used to protect primary amines. It is also used as starting material in the synthesis of tert-butyl 2-[(2,4-dinitrophenyl) sulfonyl]aminoacetate.<br>References Rachel J Ball et. al.: Artificial DNA, PNA &amp; XNA, 1(1), undefined (2011-6-21);<br></p>

<p>Applications 3-Phenylpropionyl Chloride is a derivative of phenylpropionic acid used in the preparation of a wide range of pharmaceutical compounds such as antivirals and antitumor agents.<br>References Ermolova, G.I. et al.: Khim.-Farm. Zh., 24, 35 (1990); Bernier, J.L. et al.: J. Med. Chem., 28, 497 (1985); Jung, J.-C. et al.: Bioorg. Med. Chem. Lett., 14, 5527 (2004);<br></p>

<p>Applications 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride is a potent and selective Smad3 inhibitor that attenuates transforming growth factor (TGF)-β1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4 (1). It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and TGF-β2-induced endothelial cell differentiation in iPSCs (1,2).<br>References (1) Jinnin, M., et al. Mol.Pharmacol. 69 597 (2006). (2) Di Bernardini, M., et al.: J.Biol.Chem. 289 3383 (2014).<br></p>

<p>Applications 1,1,3,3-Tetramethyldisiloxane is an organosilane reducing agent and can be used in several reduction reactions including reductive formation of sulfides and reductive etherification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pesti, J., et al.: Org. Process Res. Dev., pages ahead of print (2016);<br></p>

<p>Applications 1-Chloro-3-methyl-2-butene is a reactive allylic chloride that is used as an alkylating agent in synthetic chemistry. 1-Chloro-3-methyl-2-butene is also used as a reagent to synthesize Hyperforin, an antibiotic originating from St. John’s wort that has the ability to inhibit growth of tumour cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hatch, L. &amp; Gerhardt, L.: J. Am. Chem. Soc., 71, 1679 (1949); Lee, M., et al.: Org. Lett., 6, 1241 (2004); Reitsema, R. &amp; Hunter, J.: J. Am. Chem. Soc., 71, 1680 (1949); Schempp, C., et al.: Oncogene, 21, 1242 (2002); Sparling, B., et al.: J. Am. Chem. Soc., 135, 644 (2013)<br></p>

<p>Applications Silver benzoate is an aromatic salt that is used as a catalyst to prepare β-amino acids (such as N-Acetyl-β-alanine [A168070]) from α-amino acids (such as D-Alanine [A480995]). Silver benzoate is also used as a catalyst in Wolff rearrangement reactions.<br>References Barnes, R. &amp; Prochaska, R.: J. Am. Chem. Soc., 72, 3188 (1950); Ogilvie, W., et al.: Bioorg. Med. Chem., 7, 1521 (1999); Podlech, J. &amp; Seebach, D.: Lieb. Ann., 1995, 1217 (1995)<br></p>

<p>Applications 4-(Chlorocarbonyl)benzoic Acid Methyl Ester, is a building block, that can be used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of benzophenone residues. and also for the synthesis of novel novel bulky hydrophobic retinoids, having therapeutic potential.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amano, Y., et al.: Bioorg. Med. Chem., 21 (14), 4342 (2013);<br></p>

<p>Applications Ifenprodil is a NMDA receptor antagonist.<br>References Berger, et al.: J. Pharmacol. Exp. Ther., 289, 1584 (1999);<br></p>

<p>Applications GSK126 is a potent and highly selective S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase enzyme activity. The inhibition activity of GSK126 on EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma.<br>References McCabe, M.T., et al.: Nature., 492, 108 (2012);<br></p>