Reagentes Sintéticos

<p>Stability Hygroscopic<br>Applications N10-Trifluoroacetylpteroic acid is a derivative of Pteroic acid (P840110), both of which are used as reagents to synthesize target ligands, like Folic acid (F680300), that have the ability to deliver chemotherapeutic agents specifically to cancer cells.<br>References Leamon, C., et al.: Bioconjugate Chem., 14, 738 (2003); Leamon, C., et al.: J. Drug Target., 7, 157 (1999); Yonghua, Z., et al.: Anal. Biochem., 332, 168 (2004)<br></p>

<p>Stability Moisture Sensitive<br>Applications SIPr is used as a reagent in the synthesis of mononuclear [(η6-arene)Ni(N-heterocyclic carbene)] complexes which are useful precursors of the Ni0-NHC unit.<br>References Hoshimoto, Y., et al.: Organometallics, 33, 1276 (2014)<br></p>

<p>Applications (2R,5R)-(+)-5-Benzyl-3-methyl-2-(5-methyl-2-furyl)-4-imidazolidinone is a reactant used in the preparation of allyl heterocycles using palladium-catalyzed allylic amination of allylic alcohols with heterocycles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Banerjee, D., et al.: Angew. Chem. Int. Ed., 51, 11556 (2012);<br></p>

<p>Applications 3-Aminobutyric Acid is one of the three positional isomer of the chemical compound butryric acid. 3-Aminobutyric Acid is a nonprotein amino acid. 3-Aminobutyric Acid has been shown to be a plant defense primer that suppresses growth of some insect herbivores when applied as a root drench.<br>References Hodge, S. et al.: Biocontrol, 56, 699 (2011); He, Y.-Y. et al.: 38, 641 (2010); Cohen, Y. et al.: Plant Dis., 86, 448 (2002);<br></p>

<p>Applications Manganese(II) chloride monohydrate (cas# 64333-01-3) is a useful research chemical.<br></p>

<p>Applications N-Methylcyclohexanamine is a chemical reagent used in the synthesis of Mps1 kinase inhibitors used in cancer research. Also used in the synthesis of antituberculosis agents as indole-2-carboxamides.<br>References Bursavich, M. et al.: Bioorg. Med. Chem. Lett., 23, 6829 (2013); Kondreddi, R. et al.: J. Med. CHem., 56, 8849 (2013);<br></p>

<p>Applications 2-Acetamido-4-fluorophenylboronic acid, pinacol ester<br></p>

<p>Stability Toxic<br>Applications Sodium Tetraphenylboroate is a salt that is commonly used in inorganic and organometallic chemistry as a precipitating agent. Sodium Tetraphenylboroate is also utilized for the preparation of N-acylammonium salts and in coordination chemistry due to their favourable solubility in nonpolar sovlents and their crystallinity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jesson, J.P., et al.: Inorg. Syn., 20, 76 (2007); Kharitononv., S.V., et al.: J. Anal. Chem., 61, 9 (2006);<br></p>

<p>Applications 15-Crown-5 is a catalyst used in the synthesis of organic molecules and lanthanide complexes. It can induce cytotoxicity and oxidative stress markers in WI38 cells. Studies show that 15-Crown-5 is also an effective chelating agent used for removing cesium in cesium-exposed mice.<br>References Li, L. et al.: J. Organometal. Chem., 794, 231 (2015); Gonzalez-Bello, C. et al.: J. Am Chem. Soc., 137, 9333 (2015); Llobet, J.M., et al.: Metal Ions Biol. Med., 4, 487 (1996)<br></p>

<p>Stability Moisture Sensitive<br>Applications Zinc Di[bis(trifluoromethylsulfonyl)imide] is a reactant used in the assembly of pyrene-based Schiff base MII4L6 architectures.<br>References Ronson, T. et al.: J. Am. Chem. Soc., 137, 14502 (2015); Riddell, I. et al.: Chem. Sci., 6, 3533 (2015);<br></p>

<p>Applications 5-Chloro-2-methylaminopyridine is used in the preparation of aminosulfuranes with N-heterocyclic groups.<br>References Pashinnik, V.E. et al.: Ukr. Khim. Zhur., 73, 45 (2007);<br></p>

<p>Applications Magnesium Bromide Hexahydrate is an inorganic salt used in the synthesis of superconductors and nanowires. Also present in polymer nanocomposites to improve conductivity.<br>References Alam, M. et al.: Polym. Int., 63, 1465 (2014); McDonald, T. et al.: J. Am. Chem. Soc., 135, 7056 (2012);<br></p>

<p>Applications Zinc Acetate is used in biological studies and pharmacological activity of motexafin gadolinium disruptions of zinc metabolism in human cancer cell lines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Magda, D., et al.: Cancer Res., 65, 3837 (2005);<br></p>

<p>Applications Hydrazine Sulfate Salt is a reagent used in the heterocyclization of primary amines and may be cyclized itself. It is also used in the synthesis of novel triazole corrosion inhibitors for mild steel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bentiss, F. et al.: J. App. Electrochem., 29, 1073 (1999); Ju, Y. et al.: J. Org. Chem., 71, 135 (2006);<br></p>

<p>Applications (4R,5R)-2,2-Dimethyl-α,α,α',α'-tetra-2-naphthalenyl-1,3-dioxolane-4,5-dimethanol, is a privileged ligand analogue of TADDOLs. It can be broadly used in asymmetric synthesis. It is also shown that the titanium TADDOLate catalysts have broad application towards carbonyl addition and cycloaddition.<br>References Seebach, D., et al.: Ange. Chem. Inter. Ed., 40, 92, (20010;<br></p>

<p>Applications 4-Fluoro-α-methylstyrene is used in the synthesis of Paroxetine (P205750), which is a selective serotonin reuptake inhibitor. Used as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978), Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982),<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Acetamido-5-nitrophenylboronic acid, pinacol ester<br></p>

<p>Applications 4-(2,3-Dimethoxyphenyl)butanoic acid is a butyrate analogue with effects on apoptosis, proliferation and histone deacetylase (HDAC) activity in HT-29 colorectal cancer cells.<br>References Scheppach, W., et al.: Eur. J. Cancer, 31A, 1077 (1995), Wu, J., et al.: J. Lipid Res., 46, 1944 (2005), Kiefer, J., et al.: Br. J. Nutr., 96, 803 (2006),<br></p>

<p>Applications Bevirimat is a HIV-1 maturation inhibitor, targetting the Gag CA-SP1 cleavage site. HIV Inhibitor.<br>References Coric, P. et al.: Eur. J. Med. Chem., 62, 453 (2013); Waki, K. et al.: PLoS Path., 8, e1002997 (2012);<br></p>

<p>Applications Dihydrokainic acid is an EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake.<br>References Grunewald, M., et al.: J. Biol. Chem., 275, 9684 (2000); Shimamoto, K., et al.: Mol. Pharmacol., 53, 195 (1998);<br></p>

<p>Applications 1-Iodo-3-nitrobenzene is a reactant used int he synthesis of Vismodegib (V674700), an, antineoplastic drug that targets the Hedgehog (Hh) pathway. Inhibition of the Hh signaling may be effective in the treatment and prevention of many types of human cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cao, M., et. al.: Chem. Papers, 68, 1408 (2014); Gupta, S. et al.: Ther. Advances in Med. Oncology 2,237(2010)<br></p>

<p>Applications ID 8 is an indole derivative that sustains embryonic stem cell self-renewal in long-term culture.<br>References Miyabayashi, T., et. al.: Biosci. Biotech Bioch., 72, 1242 (2008)<br></p>

<p>Applications (Chloromethyl)cyclopropane is a used as a reagent to synthesize 6-alkylamino-9-alkylpurines, compounds that have potential to be antipsychotic agents. (Chloromethyl)cyclopropane is also used as a reagent to prepare acylmorphinans, a class of compounds that have analgesic effects in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kelley, J., et al.: J. Med. Chem., 40, 3207 (1997); Mohacsi, E., et al.: J. Med. Chem., 28, 1177 (1985)<br></p>

<p>Stability Light Sensitive<br>Applications Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kajikawa, N., et al.: Arzneim.-Forsch., 39, 495 (1989), Demolis, J.-L., et al.: J. Cardiovasc. Pharmacol., 22, 711 (1993), Okuda, Y., et al.: Prostaglandins, 52, 375 (1996),<br></p>

<p>Applications Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3ß ( IC50 =2nM). Binds to the active site of GSK-3ß. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 &gt;100nM).<br>References Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)<br></p>

<p>Stability Light Sensitive<br>Applications Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties against gastric mucosal damange.<br>References Andrade, R.J., et al.: Hepatol., 44, 1581 (2006); Wajima, T., et al.: J. Pharma. Sci., 92, 2427 (2003); Sentellas, S.. et al.: J. Chroma., 976, 221 (2002);<br></p>

<p>Applications MK-886 is a potent and selective inhibitor of FLAP and Cox-1.<br>References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);<br></p>

<p>Stability Light Sensitive<br>Applications Belinostat is a novel histone deacetylase 3 selective inhibitor, which protects the β cells from cytokine-induced apoptosis.<br>References Chou, D.H., et al.: Chem. Biol., 19, 669 (2012); Hwang, J.J., et al.: Inves. New. Drugs., 30, 1434 (2012); Dizon, D.S., et al.: Gynecol. Oncol., 125, 367 (2012);<br></p>

<p>Applications 4-Nitrobenzoyl Chloride is used inorganic syntheses such as Michael additions. Also used in the synthesis of polysubstituted furanonaphthoquinoines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhong, J. et al.: Catal. Comm., 32, 18 (2013); Wu, Z. et al.: Org. Biomol. Chem., 11, 828 (2013);<br></p>

<p>Applications Di-tert-Butyl Disulfide is a general reagent used in the synthesis of a novel neuropeptide Y (NPY) Y5 receptor antagonist Velneperit) used in the treatment of obesity.<br>References Oda, S. et al.: Org. Proc. Res. Dev., 19, 531 (2015);<br></p>

<p>Applications Bis(1,5-cyclooctadiene)nickel(0) is a reagent in the synthesis of self-assembled organometallic nickel complexes as catalysts for selective dimerization of ethylene into butene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boulens, P., et al.: Organometallics, 34, 1139 (2015)<br></p>

<p>Applications (S)-(+)-3,3-Dimethyl-2-butylamine is a reagent used in organic synthesis. Used in the synthesis of allosteric modulators in the treatment of schizophrenia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, P. et al.: Org. Lett., 17, 3698 (2015); Turlington, M. et al.: J. Med. Chem., 56, 7976 (2013);<br></p>

<p>Applications Derivatives of 6-Amino-2-thiouracil as novel, potent, and selective A3 adenosine receptor antagonists.<br>References Ji, X., et al.: Drug Dev. Res., 33, 51 (1994), Poulsen, S., et al.: Bioorg. Med. Chem., 6, 619 (1998), Fredholm, B., et al.: Pharmacol. Rev., 53, 527 (2001), Gessi, S., et al.: Clin. Cancer Res., 10, 5895 (2004), Moro, S., et al.: Med. Chem. Res., 26, 131 (2006), Tafi, A., et al.: J. Med. Chem., 49, 4085 (2006),<br></p>

<p>Applications Acetylhistamine, is a histamine metabolite, and can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.<br>References Xu Y, et al. Asian Pac J Allergy Immunol. 2017 Dec;35(4):224-232.;<br></p>

<p>Applications (1S)-[1,1'-Binaphthalene]-2,2'-diol is used in the stereoselective synthesis of Peloruside A. Also used in the synthesis of BINAP-based aminophosphines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Raghavan, S. et al.: Tetrahedron, 69, 4835 (2013); Anstiss, C. et al.: Mol., 18, 2788 (2013);<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-Bromobenzenesulfonyl Chloride is an intermediate used to prepare sulfonamide-substituted cyclooctylpyranones as nonpeptidic HIV protease inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skulnick, H., et al.; J. Med. Chem., 40, 1149 (1997)<br></p>

<p>Applications methyl 5-(chloromethyl)-2-furoate (cas# 2144-37-8) is a useful research chemical.<br></p>

<p>Applications o-Chloramine T (cas# 110076-44-3) is a useful research chemical.<br></p>

<p>Applications Entinostat is an emerging HDACi (histone deacetylase inhibitor). Entinostat is used for treatment of solid tumors and hematologic malignancies. Potent Histone deacetylase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hu, E., et al.: J. Pharmacol. Exp. Ther., 307, 720 (2003), Maggio, S., et al.: Cancer Res., 64, 2590 (2004), Gojo, I., et al.: Blood, 109, 2781 (2007), Xu, W; Oncogene, 26, 5541 (2007),<br></p>

<p>Applications Nimustine Hydrochloride is a DNA alkylator and cross-linking agent. It is used in chemotherapy in a part of anti-cancer cocktail used to treat malignant melanoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matsumoto, T. et al.: J. Eur. Acad. Dermatol. Venereol., 27, 1514 (2013);<br></p>

<p>Applications AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.<br>References Yeh, T., et al.: Clin. Cancer Res., 13, 1576 (2007), Meng, J., et al.: Cancer Biol. Ther., 8, 2073 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic.<br>References Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),<br></p>

<p>Applications Ixabepilone is an anti-tumor agent used in the treatment of patients suffering from solid tumors, such as metastatic breast cancer.<br>References Duska, L. et al.: Gynecol. Oncol., 135, 44 (2014); Deeken, J. et al.: Cancer Chemother. Pharmacol., 73, 1071 (2014);<br></p>

<p>Applications R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.<br>References Semmler, J., et al.: Int. J. Immunopharmacol.: 15, 409 (1993); Sommer, N., et al.: Nat. Med.: 1, 244 (1995); Robichaud, A., et al.: J. Clin. Invest., 110, 1045 (2002); Card, G., et al.: Structure: 12, 2233 (2004);<br></p>

<p>Applications VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.<br>References Bridges, et al.: Bioorg. Med. Chem. Lett., 20, 1972 (2010); Lebois, et al.: ACS Chem. Neurosci., 1, 104 (2010),<br></p>

<p>Applications Benzyl Isocyanate is a general reagent used in the synthesis of complex bisindolylmethanes. Also used in the preparation of urea derivatives of thiazol-2-ethylamines for their anti-trypanosomal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patrick, D. et al.: Bioorg. Med. Chem., 24, 2451 (2016);<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liau, B. et al.: J. Am. Chem. Soc., 134, 16765 (2012); Tatsuta, K. et al.: Tetrahedron Lett., 53, 422 (2012);<br></p>

<p>Applications Niobium Pentachloride is a reagent used in the synthesis of mixed chloro-aryloxide compounds and dyes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ilin, A. et al.: J. Alloy. Comp., 748, 543 (2018); Yuan, L. et al.: Inorg. Chem., 57, 4226 (2018);<br></p>

<p>Applications 5-Methoxy-2-formylphenylboronic acid is a reagent used in the total synthesis of laetevirenol A via intramolecular Friedel-Crafts alkylation.<br>References Choi, Y. L., et al.: J. Org. Chem., 77, 8762 (2012)<br></p>

<p>Applications Ammonium Bicarbonate is a useful reagent in the synthesis of double-shelled CoMn2O5 hollow microcubes used as anode material for lithium-ion batteries.<br>References Zhou, L., et al.: Adv. Mater., 24, 745 (2012);<br></p>

<p>Applications LY2157299 is a TGF-β type I receptor kinase inhibitor. LY2157299 has been used to inhance chemotherapy action against triple negative breast cancer (TNBC).<br>References Bhola, N.E., et. al.: J. Clin. Invest., 123, 1348 (2013)<br></p>

<p>Applications AC 220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).<br>References Zarrinkar, P., et al.: Blood, 114, 2984 (2009); Sato, T., et al.: Blood, 117, 3286 (2011)<br></p>

<p>Applications ML324 is a JMJD2 demethylase inhibitor. It blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice.<br>References Liang, Y., et al.: Sci. Translational Med., 5, 167ra5 (2013)<br></p>

<p>Applications N-(3-Bromopropyl)phthalimide is used in synthesis of several organic compounds including that of flavonoid derivatives which act as selective ABCC1 modulators with potential use as pharmacological tools for investigation of the role of ABCC1. It is also used in the synthesis of Hederagenin which is a triterpene template for the development of new antitumor compounds.<br>References Obreque, B., et al.: Eur. J. Med. Chem., 109, 124 (2016); Rodriguez-Hernandez, D., et al.: Eur. J. Med. Chem., 105, 57 (2015);<br></p>

<p>Applications Bromomethyl Methyl Ether acts as a reagent in the synthesis and evaluation of hydroxymethyl-aminocyclitols as glycosidase inhibitors, preparation of pyridine derivatives for minimizing CYP2C9 inhibition for cancer therapy. Also a reagent in the discovery of GBT 440, an orally bioavailable R state stabilizer of sickle cell Hb.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trapero, A., et al.: J. Org. Chem., 80, 3512 (2015); Zak, M., et al.: J. Med. Chem., 59, 8345 (2016); Metcalf, B.; et al.: ACS Med. Chem. Lett., 8, 321 (2017)<br></p>

<p>Applications 1,2-Diformylhydrazine as a bidentate ligand forms 1:1 metal to ligand complexes with transition metals Mn, Zn and Ni. It combines with iron (II) and iron(III) in alkaline conditions to a complex of an intense red-purple color making it a useful reagent in spectrophotometric analysis of iron(II) and iron(III). It was observed that mice were more likely to develop lung tumor when administered 1,2-Diformylhydrazine as a 2% solution.<br>References Nagabhushana, B., et al.: Anal. Bioanal. Chem., 373, 299 (2002); Bhargavi, G., et al.: P. Indian As-chem. Sci., 115, 23 (2003); Toth, B., Z. Krebsforsch. Klin. O., 92, 11 (1978);<br></p>

<p>Applications (-)-O,O’-Di-p-toluoyl-L-tartaric Acid (cas# 32634-66-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Bromo-3-methylthiophene is used to prepare pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of human enterovirus, coxsackievirus, echovirus, influenza virus, herpes simplex virus and rhinovirus. It is also used in the synthesis of oral α7 nicotinic receptor agonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chern, J., et al.: Bioorg. Med. Chem. Lett., 14, 2519 (2004); Tatsumi, R., et al.: J. Med. Chem., 48, 2678 (2005)<br></p>

<p>Applications 4-Methoxybenzoyl Chloride is used in the synthesis of stilbene and dihydrostilbene derivatives as potential anti-cancer agents. It is also used in the synthesis of coumarin dimers with potential HIV-1 activity.<br>References Cushman, M., et al.: J. Med. Chem., 34, 2579 (1991); Mao, P., et al.: Chem. Pharm. Bull. 50, 1634 (2002);<br></p>

<p>Applications 4-Pyridineacetic Acid Hydrochloride is used in the preparation of a highly tumor-selective organometallic ruthenium(II)-Arene complex.<br>References Clavel, C.M., et. al.: J. Med. Chem., 57, 3546 (2014)<br></p>

<p>Applications 6-Methoxy-4-pyrimidinamine is used in the synthesis of carbamothiolacrylamides as selective EP2 antagonists in the treatment of neurodegenerative peripheral diseases. Also used in the preparation of PARP-1 inhibitors.<br>References Ganesh, T. et al.: ACS Med. Chem. Lett., 4, 616 (2013); Rhee, H. et al.: Bioorg, Med. Chem., 17, 7537 (2009);<br></p>

<p>Applications Manganese is a transition metal which is used as a component in alloys such as stainless steels. Manganese is also a component of many pigments and is used to make catalysts for reduction reactions.<br>References Tambat, S., et al.: World J. Pharm. Res., 6, 1570-1585 (2017); Leonard, D., et al.: ACS Catal., 9, 11125-112129 (2019)<br></p>

<p>Applications 1-Bromo-2-cyclohexylethane is a reagent used in the cross-coupling and Grignard reactions. It is used in the synthesis of immunosuppressive agents consisting of 5-phenylalkoxypsoralens as well as agonists for human vitamin-D resistant Rickets.<br>References Swann, S. et al.: J. Am. Chem. Soc., 124, 13795 (2002); Vennekamp, J. et al.: Mol. Pharm., 65, 1364 (2004); Bedford, R. et al.: Chem. Comm., 24, 2822 (2004); Lee, J. et al.: J. Am. Chem. Soc., 125, 5616 (2003);<br></p>

<p>Applications (+/-)-Nutlin-3 is a small molecule MDM2 antagonist.<br>References Vassilev, L.T., et. al.: Sci., 303, 844 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>

<p>Applications Methyl 3-Mercaptopropionate is used in the synthesis of thioisoindolinones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sakulsombat, M. et al.: Isr. J. Chem., 53, 127 (2013);<br></p>

<p>Applications Used in the preparation of sulfur aroma compounds.<br></p>

<p>Applications Erdafitinib is a fibroblast growth factor receptor inhibitor.<br>References Perera, T. P. S., et al.: Mol. Cancer Ther. 6, 1010 (2017);<br></p>

<p>Applications Ethyl (2R,4S)-4-Methylpipecolate is an intermediate in the preparation of Argatroban (A769000).<br>References Hilpert, K. et al.: J. Med. Chem., 37, 3889 (1994), Kim, K. et al.: Med. Chem. Res., 6, 377 (1996),<br></p>

<p>Applications N-Carbobenzyloxy-D-serine-beta-lactone (cas# 98632-91-8) is a useful research chemical.<br></p>