Anéis de 6 membros

<p>Applications 6-Bromo-8-fluoro-2,4-dihydro-1,4-benzoxazin-3-one is a reactant in preparation of benzoxazinone derivatives as potent and selective nonsteroidal mineralcorticoid receptor antagonists.<br>References Hasui, T., et al.: J. Med. Chem., 54, 8616 (2011);<br></p>

<p>Applications 5-Ethyl-2-fluorophenylboronic acid<br></p>

<p>Applications 1,6-Anhydro-β-L-gulopyranose is an intermediate used in the synthesis of Troxacitabine (T805580), which is a nucleoside analogue with potential anticancer activity. Troxacitabine have been studied in patients with refractory lymphoproliferative diseases.<br>References Robak, T., et al.: Curr. Med. Chem., 18, 638 (2011); Kornblau, S.M., et al.: Clin. Cancer. Res., 16, 3721 (2010);<br></p>

<p>Applications tert-Butyl (5-Chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate is used as a reactant in the synthesis of BRAF-kinase inhibitors.<br>References Repik, Alexey E., et al.: PCT Int. Appl., WO 2017146604 A1 20170831 (2017)<br></p>

<p>Applications (2S,2aR,2aS,8aR)-2a-(2-((Cyclopropylmethyl)(methyl)amino)ethyl)-2,4,8a-trihydroxy-2,2a,8a-tetrahydro-1H-indeno[1,7,6-bcd]benzo-2-carboxylic Acid is an intermediate used in the synthesis of (4R,4aS,6S,6aR,11bS)-6-Carboxy-3-(cyclopropylmethyl)-1,2,3,4,4a,5,6,6a-octahydro-4a,6,8-trihydroxy-3-methyl-4,11-methanobenzofuro[3',2':2,3]cyclopenta[1,2-c]pyridinium, Inner Salt (C176953), which is an impurity/degradation of N-methyl Naltrexone (M320350), a metabolite of Naltrexone (N285750).<br>References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)<br></p>

<p>Applications 5-[(4-Fluorobenzylidene]-2,4-thiazolidinedione (cas# 262601-87-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(Methylamino)-3-nitrobenzoic Acid (cas# 41263-74-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,5-Dibenzyloxybenzyl alcohol (cas# 24131-31-5) is a useful research chemical.<br></p>

<p>Applications O-Benzylmetaraminol is an impurity of M225565.<br></p>

<p>Applications 2,3-Dimethylbenzothiazolium Methyl Sulfate (cas# 2038-15-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 9-(2-(Benzyloxy)ethyl)-2-((2-(benzyloxy)ethyl)amino)-1H-purin-6-(9H)-one is an intermediate used in the synthesis of 9-(2-Hydroxyethyl)guanine (H942035), which is an impurity of the antiviral agent Acyclovir (A192400). 9-(2-Hydroxyethyl)guanine is a nucleoside phosphotransferase acceptor.<br>References Kamimura, A. et al.: Agric. Biol. Chem., 37, 2037 (1973);<br></p>

<p>Applications Used in the preparation of pyrimidine derivatives.<br></p>

<p>Applications 2-(3-Butynyloxy)tetrahydro-2H-pyran is used as a reagent in the synthesis of Phomoidride D, a bridged, polycyclic, natural compound that has the ability to inhibit squalene synthase and can be used as an antihypercholesterolemic agent. 2-(3-Butynyloxy)tetrahydro-2H-pyran is also used as a reagent to prepare Rugulactone, a natural compound that is isolated from Cryptocarya rugulosa.<br>References Allais, F., et al.: Synthesis, 2010, 2787 (2010); Biller, S., et al.: Curr. Pharm. Des., 2, 1 (1996); Chen, C., et al.: J. Am. Chem. Soc., 122, 7424 (2000); Murphy, G., et al.: J. Org. Chem., 78, 477 (2013)<br></p>

<p>Applications Methyl 4-Ethyloxybenzoate acts as a reagent used in the synthesis of novel inhibitors targeting HDAC8 from schistosoma mansoni for treatment of Scistosomiasis.<br>References Heimburg, T., et al.: J. Med. Chem., 59, 2423 (2016)<br></p>

<p>Applications Heptylbenzene is a useful synthetic intermediate. It is used in zirconia and titania based stationary phase capillary HTLC, to separate alkyl benzene derivatives using an acetonitrile-water eluent. It can also be used to prepare 3-chloropyridine-stabilized palladium imidazolylidene complexes as catalysts for Suzuki and Negishi cross-coupling reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kephart, T., et al.: Anal. Chim. Acta., 414, 71 (2000); O’Brien, C., et al.: Chem. Eur. J., 12, 4743 (2006)<br></p>

<p>Applications ethyl 3,5-dimethylbenzoate (cas# 21239-29-2) is a useful research chemical.<br></p>

<p>Applications N-Octyl 4-Hydroxybenzoate is a useful plasticizer.<br>References Shen, J., et al.: Faming Zhuanli Shenqing (2020), CN 111073279 A<br></p>

<p>Applications 1-[2-Hydroxy-5-(2-hydroxyethyl)phenyl]-ethanone (cas# 58282-51-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Nitro-5-phenylthioaniline is a useful synthetic intermediate. It was used to synthesize methyl 5(6)-phenylsulfinyl-2-benzimidazolecarbamate as a potent anthelmintic.<br>References Averkin, E., et al.: J. Med. Chem., 18, 1164 (1975);<br></p>

<p>Applications 1,1,2,2-tetraphenylethane-1,2-diol (cas# 464-72-2) is a useful research chemical.<br></p>

<p>Applications Nitrosobenzene (cas# 586-96-9) is a useful research chemical.<br></p>

<p>Applications 2-(methylamino)benzene-1-sulfonamide (cas# 21639-28-1) is a useful research chemical.<br></p>

<p>Applications 3-[(3-aminophenyl)amino]benzonitrile (cas# 1147094-81-2) is a useful research chemical.<br></p>

<p>Applications 4-Biphenylcarboxylic acid (cas# 92-92-2) is a useful research chemical.<br></p>

<p>Applications 4-Mercaptobenzonitrile is a building block used as a reactant in the synthesis and in vitro anti-hepatitis B virus activities of some ethyl 6-bromo-5-hydroxy-1H-indole-3-carboxylates.<br>References Chai, H., et al.: Bioorg. Med. Chem., 14, 911 (2006);<br></p>

<p>Applications tert-Butyl Phenyl Carbonate is used in the synthesis of carbamate protected polyamines as well as in the preparation of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 modulating long chain fatty acid biosynthesis.<br>References Pittelkow, M. et al.: Synth., 15, 2195 (2002); Bengtsson, C. et al.: Bioorg. Med. Chem., 19, 3039 (2011);<br></p>

<p>Applications 1-Nitro-2-[(1E)-2-nitroethenyl]-4-(phenylmethoxy)-benzene is an intermediate used in the synthesis of 5-Hydroxyindole-3-acetic acid (H953605), which is an impurity of chlorpheniramine (C424300), an antihistaminic agent.<br>References Josko, J., et al.: Annal. Acad. Med. Siles., 66, 13, (2012); Carson, R.P., et al.: Human. Molec. Genetics., 22, 140 (2013);<br></p>

<p>Applications 5-Bromo-2-ethoxy-benzenesulfonyl chloride<br></p>

<p>Applications 4-Biphenylacetonitrile is a useful synthetic intermediate. It was used to study the adsorption orientation of the biphenyl derivatives on the Au colloidal surfaces with α-cyclodextrins. 4-Biphenylacetonitrile on condensation reaction with ethyl phenyl propiolate yields biphenyl derivatives of acetylenic β-ketocyanide.<br>References Lee, J., et al.: Bull. Korean. Chem. Soc., 30, 1637 (2009); Al-Jallo, H., et al.: J. Chem. Eng. Data, 17, 513, (1972)<br></p>

<p>Applications 4-{[(p-Fluorophenyl)imino]methyl}phenol is used in the preparation of benzylacetones which promote anti-fungal activity.<br>References Sandhar, R. et al.: J. Ind. Council Chem., 22, 32 (2005);<br></p>