Naftalenos

Applications Labelled analogue trans-1,2-Dihydroxy-1,2-dihydronaphthalene, a metabolite of Naphthalene.
References Sun, Y. et al.: Arch. Toxicol., 80, 280 (2006); Cho, T. et al.: Drug Metab. Drug Interact., 22, 235 (2007); Iwamoto, N. et al.: J. Biol. Chem., 282, 33396 (2007);

1-(3-Carboxypropionyl)naphthalene is a drug that belongs to the class of reactive drugs. It is a prodrug that is metabolized by cytochrome P450 enzymes to 1-(3-carboxypropionyl)naphthoquinone (1CPRNQ). Its main mechanism of action is through binding to magnesium, which induces cell membrane permeability and results in apoptosis. 1-(3-Carboxypropionyl)naphthalene has shown an antibody response to eye disorders and cardiovascular diseases, as well as anti-angiogenic properties. It also has been shown to inhibit the proliferation of tumor cells and induce leukocyte antigen expression.

2-Naphthalenemethanol is a chemical compound that belongs to the group of organic compounds. It is one of the simplest aromatic alcohols and has been used as a model for the study of other more complex molecules. 2-Naphthalenemethanol is synthesized by reacting sodium salts with borane-tetrahydrofuran complex in dry diethyl ether. The reaction mechanism involves the formation of an ester linkage between the two naphthalenes, which can then undergo hydrolysis to form an alcohol. 2-Naphthalenemethanol can be converted into its structural analog, naphthalene, via condensation reactions with formaldehyde or ethylene glycol. The chemical properties of 2-naphthalenemethanol have been studied using nuclear magnetic resonance spectroscopy (NMR) and x-ray crystallography, which revealed that it exists as a zwitterion consisting of two covalently

1-Naphthalenesulfonic acid (1NS) is a sulfonated organic compound. It is an inhibitor of human serum albumin, with a high affinity for the hydroxyl group on the protein's surface. 1NS has been shown to have anti-cancer activity against malignant brain tumors in mice, and also inhibits HIV replication by inhibiting the function of the enzyme reverse transcriptase. 1NS has been shown to inhibit toll-like receptor 4 (TLR4), which may be related to its immunomodulatory effects.

5,6,7,8-Tetrahydro-1-naphthol is a natural compound that belongs to the group of diazonium compounds. It reacts with an alkanoic acid and a hydrochloric acid in the presence of a diazo compound to form an alkylating product. This product can be used as a precursor for the synthesis of other organic compounds. The reaction mechanism has been studied using rat liver microsomes. 5,6,7,8-Tetrahydro-1-naphthol can react with dopamine in human liver samples to form 1-hydroxyindole and phenylhydroxyl radicals (a reactive oxygen species). 5,6,7,8-Tetrahydro-1-naphthol also reacts with soybean lipoxygenase to produce an alkyl radical intermediate that can react with molecular oxygen to form peroxides.