Padrões Farmacêuticas

Stability Hygroscopic
Applications Genistein-7-sulfate 4’-β-D-glucuronide is a metabolite of Genistein (G350000), a compound that exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase.
References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987); O'Dell, T.J., et al.: Nature, 353, 588 (1991); Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992)

Applications A labelled form of (Z)-Tetrachlorvinphos (T292305), which is used in sensitive immunoassay for detection of organophosphorus pesticides. Also, used in exposure characterization of varied major insecticides including neonicotinoids, organophosphates and pyrethroids in urine of young children. Useful in cannabis testing kits as a component of pesticide mixes (P698240).
References Zhao, F., et al.: Anal. Bioanal. Chem., 408, 6423 (2016); Osaka, A., et al.: Environ. Res., 147, 89 (2016)

Applications 1-Naphthylhydrazine (cas# 2243-55-2) is a useful research chemical.

Applications Labelled insecticidal, acaricidal, and fungicidal combinations of carboxamides and other pesticides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dugo, G., et al.: Food Chem., 16, 435 (2005), Caldas, E., et al.: Toxicology, 222, 132 (2006), Cabras, P., et al.: J. Agric. Food Chem., 45, 2244 (1997), Wilkinson, C., et al.: Regul. Toxicol. Pharmacol., 31, 30 (2000),

Applications (1R,2S,5R)-(-)-Menthol β-D-Glucuronide is a metabolite of L-(-)-Menthol (M218875), the natural form of Methanol.
References Eccles, R., et al.: J. Pharm. Pharmacol., 46, 618 (1994), Feng, S., et al.: Toxicol. Lett., 173, 101 (2007), Dempsey, D., et al.: Clin. Pharmacol. Ther., 76, 64 (2004),

Stability Light Sensitive
Applications (S)-β-Pinene is a monoterpene that naturally occur in various plants. Due to its pine-like smell, its been used as a major constituent of hop aroma and flavor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, Jingyi., et la.: J. Neurochem., 121, 881 (2012); Wu, J., et al.: J. Med. Plants. Res., 6, 2832 (2012);

Applications An intermediate in the synthesis of the drug metabolite for Sertraline.

Applications A metabolic intermediate in nucleic acid metabolism.
References Yoon, K., et al.: Nat. Prod. Sci., 14, 254 (2008), Ramazzina, I., et al.: J. Biol. Chem., 283, 23295 (2008), Kim, K., et al.: J. Mol. Biol., 387, 1067 (2009),

Applications 4-Chloro-3-pyridinesulfonamide is a building block that has been used as a reactant for the preparation of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives as inhibitors of four isoforms of zinc enzyme carbonic anhydrase.
References Slawinski, J., et. al.: Eur. J. Med. Chem., 69, 701 (2013)

Applications Pinic Acid (Diastereomeric Mixture) can be used to prepare pinic acid diamides as herbicides.
References Zou,R., et al.: Guangxi Daxue Xuebao, Ziran Kexueban, 36, 463 (2011);

Applications Cabotegravir O-β-D-Glucuronide is a metabolite of Cabotegravir (C050100), a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.
References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015)

Applications (S)-2-Benzyl-N,N-dimethylaziridine-1-sulfonamide is a reagent for the synthesis of N-alkylsulfamic acid derivatives. It also has utility for preparing pharmaceutical peptide analog agents.
References Sherman, E. S., et al. Science of Synthesis 40b, 1285 (2008); Polniaszek, R., et al.: PCT Int. Appl. WO 2010115000 A2 20101007 (2010)

Applications Main Quinfamide (Q670600) metabolite.
References Bailey, D., et al.: J. Med. Chem., 22, 599 (1979),

Applications A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant.
References Kelsey, J., et al.: J. Clin. Psychopharmacol., 16, 21 (1996), Long, C., et al.: J. Anal. Toxicol., 21, 166 (1997), Deecher, D., et al.: J. Pharmacol. Exp. Ther., 318, 657 (2006)

Applications Labelled 4-Nitrophenol (N496945). Used in the manufacturing of pharmaceuticals, fungicides, dyes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Hygroscopic
Applications A metabolite of Valproic acid.
References Rudy, A., et al.: J. Pharmacol. Exp. Ther., 259, 1133 (1991), Nagai, K., et al.: J. Antimicrob. Chemother., 39, 295 (1997), Yamamura, N., et al.: Drug Metab. Dispos., 27, 724 (1999)

Applications 11-Hydroxytestosterone-[9,11,12,12-2H4] is a metabolite of Testosterone (T155000), a principal hormone of the testes, produced by the interstitial cells.
References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499

Applications Triclabendazole Sulfoxide-D3 is a stable isotopically labelled metabolite of Triclabendazole (T774175), an anthelmintic.
References Wolff, K., et al.: Vet. Parasitol., 13, 145 (1983)

Applications 1,3-Dimethyl 2-[4-(methoxycarbonyl)-2-nitrophenyl]propanedioate

Applications Bifenthrin intermediate.
References Hamed, M., et al.: J. Econ. Entomol., 81, 1295 (1988), Ruzo, Luis O., et al.: J. Agric. Food Chem., 36, 1040 (1988),

Applications Insecticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Devine, G., et al.: Pestic. Sci., 55, 405 (1999), Ahmad, M., et al.: Pest Manag. Sci., 58, 203 (2002), El Kady, H., et al.: Pest Manag. Sci., 59, 865 (2003).

Applications Cinnamic Acid is rac-form of trans-Cinnamic Acid (P336185) which is used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines and N-methylation of amides and O-methylation of carboxylic acids.
References Kunishima, M. et al.: Tetrahedron, 55, 13159 (1999); Xia, Q. et al.: Org. Lett., 15, 3326 (2013);

Applications Cyflumetofen is a novel acaricide that only affects spider mites.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hayashi, N., et al.: Pest Manag. Sci., 69, 1080 (2013); Van Leeuwen, T., et al.: Pestic. Biochem. Physiol., 121, 12 (2015);

Applications Labelled Isoprothiolane, a dithiolane pesticide. Isoprothiolane is commonly used in agriculture as a fungicide to control planthoppers and blast disease in rice plants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chin, K.M.: Malay. Agric. J., 50, 221 (1975); Ikeda, Y. et al.: Biosci. Biotech. Biochem., 57, 288 (1993); Nakamura, H.: Rev. Plant Prot. Res., 10, 1 (1977); Reddy, A.P.K. et al.: Pesticide, 22, 21 (1988);

Applications A major metabolite of Phenytoin, an anticonvulsant.
References Bowmer, C., et al.: Biochem. Pharmacol., 27, 937 (1978), Kober, A., et al.: Mol. Pharmacol., 18, 237 (1980), Dasgupta, A., et al.: Ther. Drug Monit., 21, 625 (1999),

Applications Barbadin is a selective β-arrestin/β2-adaptin inhibitor. It selectively inhibits the interaction between b-arrestin and the b2-adaptin subunit of the clathrin adaptor protein AP2 without affecting the formation of receptor/b-arrestin complexes.
References Beautrait, A., et al.: Nat Commun. 8, 15054 (2017)

Applications 2'-Deoxyadenosine-15N1 is an intermediate in the synthesis of 8-Oxo-2’-deoxyguanosine-13C,15N2 (O850252). A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.
References Ueda, T., et al.: Chem. Pharm. Bull., 26, 2122 (1978), Jiang, F., et al.: Nature, 183, 382 (1996),

Applications Methyl-(4-nitrophenylethyl)-(4-nitrophenoxyethyl)amine (cas# 115287-37-1) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications The main metabolite of Omeprazole.
References Renberg, L., et al.: Drug Metab. Dispos., 17, 69 (1989), Calabresi, L., et al.: Pharmacol. Res., 49, 493 (2004), Yin, O., et al.: J. Clin. Pharmacol., 44, 582 (2004),

Applications methyl 1,2,3,4-tetrahydronaphthalene-1-carboxylate (cas# 17502-86-2) is a useful research chemical.

Applications Amcinonide (A576150) analog as glucocorticoid receptor agonists for the treatment of inflammation and allergic conditions.
References Woodford, R., et al.: Curr. Ther. Res., 26, 301 (1979),

Applications Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive.
References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)

Applications D-(+)-Carvone, is used for the synthesis of (-)-terpestacin, a fungal metabolite with anticancer activity.It is also found in the essential oils of the in vitro M. longifolia plantlets and callus, that can be used as a potential source of a safe flavouring agent.
References Jin , Y., et al.: Org. Biomol. Chem., 10(28), 5452 (12012); Morcia, C., et al.: Acta. Biochimica. Polonica., 58(4), 581 (2011);

Applications Tetrahydrodehydrocorticosterone inhibits aldosteronogenesis by intact cells at concentrations that inhibited angiotensin binding.
References Campanile, C.P., Goodfriend, T.L.: Steroids, 37, 681(1981)

Applications Labelled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.
References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),

Applications Tirofiban intermediate.

(-)-beta-Elemene is a natural product with antifungal and anticancer properties. It has been shown to have strong in vitro activity against myeloma cell lines, HL-60 cells, and K562 cells, which are all human cancer cell lines. (-)-beta-Elemene has also been shown to be active against group P2 bacteria, including Streptococcus pneumoniae and Haemophilus influenzae. This compound has been found to inhibit the growth of solid tumours in vivo. (-)-beta-Elemene inhibits the energy metabolism of cells by altering the mitochondrial membrane potential and blocking ATP synthesis. It also induces apoptosis by regulating key cell signaling pathways, such as caspase activation and Akt/mTOR pathway inhibition.

Please enquire for more information about Pigment Yellow 127 including the price, delivery time and more detailed product information at the technical inquiry form on this page

3-Fluoro-DL-tyrosine is a model system for the study of tyrosine transfer reactions. It is used to study the reaction mechanism and kinetics of tyrosine transfer from a donor molecule to an acceptor molecule. 3-Fluoro-DL-tyrosine reacts with trifluoroacetic acid to form 3,4-dihydroxybenzoic acid, which is a chemical analog of tyrosine. The hydroxyl group on this molecule can react with the proton on the amino acid side chain, forming a covalent bond that does not break down under normal conditions. This reaction is reversible and has been shown to be catalyzed by polymerase chain reactions (PCR).

N4-Boc-cytosin-1-yl acetic acid is a fine chemical that is used as a reagent, and can be used as a building block in the synthesis of various compounds. It has been shown to be an effective intermediate in the synthesis of various compounds, and can be used as a scaffold for drug discovery. N4-Boc-cytosin-1-yl acetic acid is also useful in the production of other chemicals, such as pharmaceuticals and pesticides.

2,2'-Dihydroxy-6,6'-dinaphthyldisulphide (DIDS) is a potent surfactant that can be used to induce inflammation and tissue damage in an animal model. This compound is also reactive in the presence of histochemical stains. DIDS reacts with disulfides found in the cytoplasm of cells to produce sulfenic acid intermediates. These intermediates are then converted into sulphonic acid by oxidation, which results in histochemical staining of tissues. Abdominal tissue samples stained with DIDS show a decrease in the number of neutrophils and macrophages as well as an increase in mast cells. Histochemical staining has been shown to be useful for diagnosing autoimmune diseases such as Crohn's disease or ulcerative colitis.

Please enquire for more information about 3’-Azido-3’-deoxyguanosine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Naphth[4,5-A]isoxazole is a chemical compound that has been shown to react with other organic compounds and is used as a reagent in organic synthesis. Naphth[4,5-A]isoxazole can be used as a building block for the synthesis of complex compounds, such as heterocycles. This chemical is also useful for the production of fine chemicals and pharmaceuticals.

3,3'-Dimethoxybenzidine dihydrochloride is a fluorogenic probe that has been shown to have activity index in the range of 0.1-0.5, which makes it suitable for use as a fluorescent dye in biological samples such as human serum or cerebrospinal fluid. 3,3'-Dimethoxybenzidine dihydrochloride can be used in histological studies for the detection of cell lysis and cardiac disease activity. It has also been shown to cause liver lesions when administered orally to rats.