Padrões Farmacêuticas

Applications 2',3',5'-Triacetate derivative of 6-Mercaptopurine-9-β-D-ribofuranoside (M257125), a substrate for adenosine deaminase.
References Kashida, T., et al.: Biol. Pharma. Bull., 18, 1492 (1995); Sloan, K.B., et al.: J. Pharma. Sci., 72, 372 (1983);

Applications Simvastatin t-Butyldimethylsilyl Acyl-β-D-glucuronide-O-acrylate is an intermediate in synthesizing Simvastatin Acyl-β-D-glucuronide (S485005), a metabolite of Simvastatin.
References Billecke, S., et al.: Drug Metab. Dispos., 28, 1335 (2000); Draganov, D., et al.: J. Biol. Chem., 275, 33435 (2000); Igel, M., et al.: Eur. J. Clin. Pharmacol., 57, 357 (2001)

Applications 2-​(Acetylamino)​-​2-​[(3-​methoxy-​4-​nitrophenyl)​methyl]​-propanedioic Acid 1,​3-​Diethyl Ester is an intermediate in synthesizing 4-Amino-m-tyrosine (A632020), a degradation product of Pheomelanin, a compound found in hair and skin in humans.
References Patil, D. et al.: J. Org. Chem., 49, 997 (1984); Fattorusso, E. et al.: Gazz. Chem. Ital., 98, 1443 (1968);

Applications Intermediate for the synthesis of glucuronide conjugates of trans-Resveratrol
References Learmonth, D.A., et al.: Bioconjug. Chem., 14, 262 (2003),

Applications (3S)-3-Amino-4-tert-butoxy-4-oxobutanoic Acid (cas# 4125-93-3) is a useful research chemical.

Applications 2-Bromocinnamic Acid (cas# 7499-56-1) is a compound useful in organic synthesis.
References Belley, M., et al.: Bioorg. Med. Chem. Lett., 15, 527 (2005),

Applications Tetrahydro-2-(2-nitropropoxy)-2H-pyran (cas# 97945-38-5) is a compound useful in organic synthesis.

Applications N-​(Methoxycarbonyl)​-L-​glutamic Acid 5-​Ethyl Ester is an intermediate in synthesizing (S)-Vigabatrin (V253000), a novel anti-epileptic drug. Antidepressant; antipsychotic; anxiolytic.
References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000); Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004); Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006);

Applications 3-(Benzyloxy)-2-((N-isopropylsulfamoyl)amino)benzoic Acid Methyl Ester is an intermediate in the synthesis of metabolites of Bentazon (B120580), a selective post-emergence herbicide.

Applications N-(4-Methoxyphenyl)-N'-1,2,3-thiadiazol-5-yl-urea is an intermediate in the synthesis of N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea (H949385), a metabolite of Thidiazuron (T344275), a non-purine containing urea derivative with cytokinin activity.
References Orlikowska, T., et al.: Plant Cell Tissue Org. Cult., 59, 95 (1999), Ray, T., et al.: Mol. Biol., 6, 35 (2005), Kanwar, J., et al.: Hort Sci., 2008, 35, 35 (2008),

Applications (2R,​3E)​-2,​4-​Dimethyl-​2-​[(1-​oxopropyl)​thio]​-​3,​5-​hexadienoic Acid Ethyl Ester is an intermediate in synthesizing (R)-(+)-Thiolactomycin (T350880). It is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).
References Kapilashrami, K., et al.: J. Biol. Chem., 288, 6045 (2013); Paneerselvam, V., et al.: J. Pharm. Res., 4, 4618 (2011); Katane, M., et al.: Biochimie, 92, 1371 (2010)

Applications N'-[(2-Chloro-5-thiazolyl)methyl]-N-nitro-carbamimidothioic Acid Methyl Ester-13C is an intermediate used in the synthesis of Clothianidin-d3,13C1(C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops.
References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),

Applications 3-Bromo 5-Acetamido-salicylic Acid Methyl Ester is an intermediate in synthesizing 5-Amino-3-(4-sulfonylphenyl)salicyclic Acid Sodium Salt (A629340), an impurity of mesalamine (M258100), which is the active metabolite of Sulfasalazine (S699084). Anti-inflammatory (gastrointestinal).
References Friedman, G., et al.: Am. J. Gastroenterol., 81, 141 (1986); Tursi A., Expert Opin. Pharmacother., 6, 69 (2005)

Applications 2-[(2-Fluoro-4-nitrophenyl)amino]ethan-1-ol is a chemical reagent used in the synthesis of oxazolidinone compounds as antibiotics and other anti-bacterial agents.

Applications Used as an animal glue liquifier, silver tarnish remover, fixing agents, manufactured resins and vulcanization accelerators. It is a known carcinogen, also causes bone marrow depression and goiters.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Butola, J., et al.: J. Plant Biol., 35, 75 (2008), Roux-Dalvai, F., et al.: Mol. Cell. Proteom., 7, 2254 (2008), Ansari, F., et al.: J. Enz. Inhibit. Med. Chem., 24, 151 (2009),

Applications N-​(Ethoxycarbonyl)​-adenosine is an intermediate in synthesizing N6-(N-Threonylcarbonyl)adenosine (T405560). It is an essential modified nucleoside found in tRNA responsible for ANN codons in all three domains of life. It is also a biological marker in neoplastic diseases.
References Miyauchi, K., et al.: Nat. Chem. Biol., 9, 105 (2013); Deutsch, C., et al.: J. Biol. Chem., 287, 13666 (2012)

Applications 3-Methylphosphinicopropionic Acid Diethyl Ester is a derivative of 3-Methylphosphinicopropionic Acid Sodium Salt (M326160), a metabolite of Glufosinate (G596950). 3-Methylphosphinicopropionic Acid Diethyl Ester is used in the preparation of the naturally occurring amino acid, Phosphinothricin.
References Zeiss, H.: J. Org. Chem., 56, 1783 (1991)

Applications An intermediate in the preparation of deuterated cytidine derivatives
References Chamorro, C., et al.: Bioorg. Med. Chem. Lett., 11, 3085 (2001), Bornemann, B., et al.: Bioorg. Med. Chem., 14, 6235 (2006), Desbouis, D., et al.: J. Med. Chem., 51, 6689 (2008),

Applications 2-Hydroxy-5-benzyloxyacetophenone (cas# 30992-63-3) is a compound useful in organic synthesis.

Applications Can be used in the preparation of CCR5 antagonists, for treatment of HIV-1.
References Tallant, M. et al., Bioorg. Med. Chem. 21, 1394 (2011)

Applications 5,6-Dihydro-5,6-dihydroxyretinoic Acid Methyl Ester is an intermediate in the synthesis of Ro 22-5112 (R637180), a retinoid that has been used in a QSAR analysis for the use of retinoids as a carcinogenesis inhibitor.
References Niculescu-Duvaz, I., et. al.: Carcinogenesis, 6, 479 (1985)

Applications 1,2-Dimethylisothiourea-HI (cas# 41306-45-0) is a useful research chemical.

Applications N-Nitro-S-methylisothiourea is used as a reactant in the preparation of 1,5-substituted-1,3,5-hexahydrotriazine-2-N-nitroimines with insecticidal activity.
References Xue, S., et. al.: J Heterocyciic Chem., 50, 1067 (2013)

Applications Cinnamyl Bromide acts as a reagent in the synthesis of Arylpiperidines as a new class of oxidosqualene cyclase inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Keller, M., et al.: Eur. J. Med. Chem., 109, 13 (2016)

Applications N-Ethyl-N-methyl-O-(4-nitrophenyl)carbamate (cas# 90870-20-5) is a compound useful in organic synthesis.

Applications An intermediate in the preparation of labelled thymidine monophosphate analogues
References Vanheusden, V., et al.: Bioorg. Med. Chem. Lett., 12, 2695 (2002),

Applications 2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-butanedioic-2-13C Acid Diethyl Ester is an intermediate in the synthesis of 5-Aminolevulinic Acid-3-13C Hydrochloride which is a naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer).
References Sisler, E.C., et al.: Physiol. Plant., 16, 315 (1963), Herdeis, C., et al.: Arch. Pharm., 317, 304 (1984), Peng, Q., et al.: Cancer, 79, 2282(1997),

Applications rac Ketoprofen β-D-Glucuronide Allyl Ester is a compound useful in organic synthesis.

Applications 2,2'-[Oxybis(2,1-ethanediylimino)]bis-ethanol is a useful synthetic intermediate. It is patented as one of the antibacterial oral compositions in mouthwash.
References Gaffar, A., et al.: U.S. (1980), US 4224309 A 19800923.

Applications 4-Chlorobutanoic acid methyl ester is used as a precursor chemical for projects such as vapor deposition for attaching ionic liquid to oxide surfaces1 and the synthesis of new thiopyran-​based heterocyclic systems2.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Xu, W., et al.: Angew. Chem. Int Ed., 56, 9072-9076. (2017)2. Palchykov, V.A., and al.: New J. Chem., 42, 1403 - 1412 (2018)

Applications Intermediate in the synthesis of Oxamyl.

Applications (2R,4R)-2-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-4-hydroxy-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of 2’-epi-Lincomycin which is an epimer of Lincomycin (L466200) which is a 6-amino, 6-deoxy-octopyraninose with strong antibiotic activity.
References Le Goffic, F. et al.: J. Antimicrob. Chemother., 16, 12 (1985); Prior, C. et al.: J. Pharmacol. Exp. Therap., 255, 1170 (1990)

Applications 4-[1-(4-Iodophenyl)-5-(2,4-dinitrophenyl)-formaz-3-yl]-1,3-benzene Disulfonate, Disodium Salt (cas# 161617-44-3) is a compound useful in organic synthesis.

Applications S-Deoxyo-5-Hydroxy Acetate Omeprazole is an isotope labelled intermediate in the synthesis of 5-Hydroxy Omeprazole (H948863), the main metabolite of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.
References Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)

Applications trans-Cinnamoyl chloride (cas# 102-92-1) is a useful research chemical.

Stability Moisture Sensitive
Applications 9,10-Dibromoanthracene-2-sulfonyl Chloride (cas# 210174-74-6) is a compound useful in organic synthesis.

Applications Used in the new synthesis of alkylsulphanylnaphthalenes and the synthesis and mesomorphic properties of novel naphthylisothiocyanates.
References Lauk, u., et al.: Helv. Chim. Acta, 68, 1406 (1985), Collina, S., et al.: Bioorg. Med. Chem., 8, 1925 (2000),

Applications Palbociclib 1,2,3,4-Tetra-O-acetyl-β-D-glucuronic Acid Methyl Ester is an intermediate in synthesizing Palbociclib N-β-D-Glucuronide Sodium Salt (P139910), a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)

Applications 2-Hydroxy-5-[2-[[6-(4-phenylbutoxy)hexyl](phenylmethyl)amino]acetyl]benzoic Acid Methyl Ester is an intermediate in the synthesis of Salmeterol (S090100), a β2-Adrenergic agonist.
References Johnson, M.: Lung, 168, Suppl., 115 (1990), Ullman, A., et al.: Am. Rev. Resp. Dis., 142, 571 (1990), Twentyman, O.P., et al.: Lancet, 336, 1338 (1990)

Applications 9,10-Dichloro-2,6-dimethylanthracene (cas# 887354-46-3) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications Dihydroxyacetone Phosphate Lithium Salt, is a metabolic intermediate involved in involved in a wide variety of metabolic pathways including glycolysis and lipid biosynthesis. In plants, Dihydroxyacetone phosphate is involved with the synthesis of vitamin B6.
References Jun Ogawa et. al.: et al.: Bioscience, biotechnology, and biochemistry, 67(4), undefined (2003-6-6); John P Richard, Biochemistry, 51(13), undefined (2012-3-14);

Applications Nintedanib Demethyl-O-glucuronic Acid-d3 is an isotopic analog of Nintedanib Demethyl-O-glucuronic Acid (N478295), a metabolite of the drug Nintedanib (N478290).
References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Applications O-Benzyl Ganciclovir N-Formyl Diacetate Dimer is an intermediate used in the synthesis of Valganciclovir N3,N3'-Methylene Dimer (>90%) (V092015), which is an impurity of Valganciclovir (V092000), a pro-drug of Ganciclovir (G235000) . Used in treatment of retro-virus.
References Acosta, E., et al.: Clin. Pharmacol. Ther., 81, 867 (2007), Nassetta, L., et al.: J. Antimicrob. Chemother., 63, 862 (2009),

Applications Intermediate in the preparation of photolabeling and cross-linking reagent.

Applications O-Acetyl Isovanillin (cas# 881-57-2) is a compound useful in organic synthesis.

Applications 2-Acetylnaphthalene is an intermediate used to prepare piperidinyl pyrazoles as potent DNA gyrase inhibitors It is also used in the synthesis of aromatic enone and dienone analogues of curcumin as angiogenesis inhibitors.
References Tanitame, A., et al.: J. Med. Chem., 47, 3693 (2004); Robinson, T., et al.: Bioog. Med. Chem. Lett., 13, 115 (2003)

Applications An intermediate for the synthesis of the metabolite of Flurbiprofen, an anti-inflammatory used as an analgesic.

Applications Intermediate in the synthesis of polycyclic aromatic systems.

Applications Intermediate for the preparation of Isotope Labelled Tolmetin.

Applications L-Aspartic Anhydride Hydrochloride is a chemical acylating reagent used in friedel-crafts reactions such as in the preparation of L-homophenylalanine.
References Lin, W. et al.: Synthesis, 7, 1007 (2001);

Applications 5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine-13C,15N2 >95% is a compound useful in organic synthesis.

Applications [1,1'-Binaphthalen]-8-ol is an intermediate in the synthesis of Benzo[j]fluoranthene (B205690), a polycyclic aromatic hydrocarbon that has tumour initiating activity and can be found in soot, oil, water and soil extracts as a common pollutant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rice, J. E., et al.: J. Org. Chem., 58, 1415 (1993);

Applications tert-Butyldimethylsilyloxy-5-aza-2'-deoxycytidine is an intermediate in the synthesis of metabolites of Azadeoxycytidine (A796950), as neoplasm inhibitor.
References Cihak, A., et al.: Eur. J. Cancer, 14, 117 (1978),

Applications Used in the preparation of labeled cocaine analogs.
References Carroll, F.I., et al.: J. Med. Chem., 35, 2497 (1992),

Applications Propylthiouracil N-β-D-Glucuronide Methyl Ester is a compound useful in organic synthesis.

Applications An intermediate of the metabolite of Atorvastin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Applications 1,3-Dihydro-N-nitro-1,3-dioxo-2H-isoindole-2-carboximidothioic acid Methyl Ester-13C is an intermediate used in the synthesis of Clothianidin-d3,13C1 (C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops.
References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),

Applications N,N-Dimethyl-2,4-dinitro-1-naphthalenamine (cas# 39139-79-2) is a compound useful in organic synthesis.

Applications O6-Benzyl-8-bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)-β-D-2’-deoxyribofuranosyl]guanine (cas# 328394-26-9) is a compound useful in organic synthesis.

Applications 8-Bromoguanosine (cas# 4016-63-1) is a compound useful in organic synthesis.
References Hu, H., et al.: Mol. Pharmacol., 69, 1542 (2006), Mallett, D., et al.: J. Pharm. Biomed. Anal., 49, 100 (2009),

Applications 2-Hydroxyacetophenone-d7 (cas# 1189865-36-8) is a compound useful in organic synthesis.

Applications 2-Nitrophenol Potassium Salt s an intermediate in the synthesis of 5-Methyl-bis-(2-aminophenoxymethylene)-N,N,N’,N’-tetraacetate Methyl Ester (M294140)

Applications (R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic Acid Methyl Ester Trimethylamine is an intermediate in the synthesis of Tenofovir (T018500), is an acyclic phosphonate nucleotide analogue.
References Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),

Applications Possess activity against positive phototaxis of Chlamydomonas cells.A fundamental starting material for organic synthesis.
References Evans, S., et al.: Chem. Biol. Drug. Des., 75, 333 (2010), Rajabi, L., et al.: Lett Appl Microbiol., 40, 212 (2005),

Applications Guanosine-13C5 5’-Monophosphate is an isotope labelled version of Guanosine 5’-Monophosphate (G844708), a nucleotide with an umami taste.
References Charve, Josephine, et al.: J. of Agric. and Food Chem., 66(8), 1863-1871 (2018)

Applications 8-Bromoguanosine-13C2,15N is an intermediate in the synthesis of 8-Aminoguanosine-13C2,15N (A609877). 8-Aminoguanosine-13C2,15N is an isotopic labelled compound of 8-Aminoguanosine (A609875), which is a potent inhibitor of purine nucleoside phosphorylase.
References Kazmers, I.S., et al.: Science, 214, 1137 (1981); Chern, J-W., et al.: J. Med. Chem., 36, 1024 (1993)

Applications Methyl-(4-nitrophenylethyl)-4-(nitrophenoxyethyl)amine-d4 (cas# 1189869-42-8) is a compound useful in organic synthesis.

Applications (R)-(+)-Camphor-d2 is an intermediate in synthesizing (+)​-​Borneol-D3 (B675542). It is a deuterium labelled analog of (+)-Borneol, which is used for analgesia and anesthesia in traditional Chinese and Japanese medicine. (+)-Borneol has highly efficacious positive modulating action at human recombinant α1β2γ2L GABAA receptors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Granger, R.E., et. al.: Biochem. Pharmacol., 69, 1101 (2005)

Applications (2S,3S)-3-Hydroxy-2-methyl-butanoic Acid Methyl Ester is an intermediate in the synthesis of (+)-Echimidine N-Oxide, which is a a hepatotoxic pyrrolizidine alkaloid. Different extracts and echimidine-N-oxide from Symphytum sylvaticum Boiss. Subsp. sepulcrale, has been shown to have Antifungal activity.
References Kartal, M., et al.: Turkish, J. Med. Sci., 31, 487 (2001); Cao, Y., J. Food Comp. Anal., 29, 106 (2013);

Applications A useful precursor for the preparation of nucleic acids.

Applications 7-(Dimethylamino)-4-methylcoumarin (cas# 87-01-4) is a useful research chemical.

Applications 4-(Ethoxycarbonyl)phenyl 2,3,4-Triacetate β-D-Glucopyranosiduronic Acid Methyl Ester is an intermediate in the synthesis of p-Salicylic Acid 4-Glucuronide which is an anthocyanin-derived phenolic acid degraded to form 4' glucuronide of 4-hydroxybenzoic acid during simulated gastrointestinal digestion and in human liver microsome.
References Zhang, Q.Z., et al.: Tetrahedron/, 68l, 4194 (2012); Woodward, G.M., et al.: Molec. Nutrition. Food. Res., 55, 378 (2011);

Applications Eugenol-d3 Methanesulfonate is an intermediate in the synthesis of Labelled Eugenol (E935640), a dental compound which shows cytotoxicity to human oral squamous cell carcinoma and oral cells. When glucosylated, this compound exhibits anti-inflammatory activity.
References Koh, T. et al.: In Vivo, 27, 85 (2013); Zhang, P. et al.: Arch. Pharm. Res., 36, 109 (2013);

Applications N,​N-​Dimethyl-​5-​(phenylmethoxy)​-1H-​indole-​3-​ethan-​α,​α,​β,​β-​d4-​amine is an intermediate in the synthesis of Bufotenine-d4 Hydrochloride (B689467), which is labelled bufotenine Hydrochloride (B689465) which is a weak hallucinogenic agent active by intravenous injection. It is a constituent of toad poison.
References Stoll, et al.: Helv. Chim. Acta, 38, 1452 (1955), Bhattacharya, S., et al.: Indian. J. Physiol. Pharmacol., 15, 133 (1971), Falkenberg, G., et al.: Acta Crystallogr., 28B, 3219 (1972)

Applications Glutaric anhydride is an industrial chemical that causes gastrointestinal irritancy, erythema, edema, necrosis and ulcerations in humans. Glutaric anhydride is also used as a reagent to synthesize 4-(4-hydroxy-phenylcarbamoyl)-butyric acid, an analog of p-hydroxyaniline that displays analgesic and antipyretic effects in rats and mice.
References Ballantyne, B., et al.: Vet. Hum. Toxicol., 34, 493 (1992); Kumar, R., et al.: Acta Pharm. Sci., 50, 183 (2008)

Applications (T-4)-Triphenyl(P,P,P-triphenylphosphine imidato-κN)-phosphorus Diphosphate is an intermediate used in the synthesis of Ganciclovir Triphosphate Triethylamine Salt (G235030), which is an inhibitor of hepatitis B virus DNA polymerase and has shown potent antiviral activity against herpes viruses and hepadnaviruses.
References Rubsam, L.Z., et al.: Cancer. Res., 59, 669 (1999); Shaw, T., et al.: Hepatol., 24, 996 (1996);

Applications 3-Amino-3-oxo-propanoic Acid Phenylmethyl Ester is an intermediate in the synthesis of Malonuric Acid (M158100), which is produced during degradation of sodium barbiturates.
References Fretwurst, F., et al.: Arzneimittel-Forschung, 8, 44-50 (1958)

Applications 2-Bromo-1,6-dimethyl Ester Hexanedioic Acid is an intermediate in the synthesis of 2-Hydroxyhexanedioic Acid Disodium Salt (H943015). Accumulation and excretion of 2-Hydroxyhexanedioic Acid (with 2-ketoadipic and 2-aminoadipic) in urine can be caused by 2-ketoadipic acidemia, probably without adverse phenotypic effects, due to deficiency of 2-ketoadipic dehydrogenase.
References Svendsen, J., et al.: J. Chromatogr., 337, 9 (1985); Przyrembel, H., et al.: Clin. Chim. Acta 58, 257 (1975).

Applications 2,3-Dichlorobenzoic Acid-13C,d3 is an intermediate in synthesizing Lamotrigine-13C3,d3 (L173253), an isotopically labelled Lamotrigine (L173250), an anticonvulsant. Inhibits glutamate release, possible through inhibition of Sodium, Potassium and Calcium currents. Used in treatment of bipolar depression.
References Miller, A.A., et al.: Epilepsia, 27, 483 (1986); Grunze, et al.: Neuropsychobiology, 38, 131 (1998); Calabrese, J.R., et al.: J. Clin. Psychiatry, 60, 79 (1999)

Applications (-)-Galanthaminyl (-)-Camphanate (cas# 1025881-27-9) is a compound useful in organic synthesis.

Applications 3-​(Benzyloxy)​-hippuric Acid Benzyl Ester is an intermediate during the synthesis of m-Hydroxyhippuric Acid-13C2, 15N (H943127), a labelled m-Hydroxyhippuric Acid (H943125) which is a metabolite of caffeic and chlorogenic acids in human.
References Booth, A., et al.: J. Biol. Chem., 229, 51 (1957); Gonthier, M., et al.: Biomed. Pharmacother., 60, 536 (2006)

Applications 2-(Formylamino)-3-hydroxy-2-propenoic Acid Ethyl Ester (cas# 61934-93-8) is a compound useful in organic synthesis.

Applications 2-Bromo-6-nitrophenol is an intermediate used in the synthesis of N-Hydroxy Eltrombopag (H825795), which is a derivative compound of Eltrombopag (508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.
References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),