Padrões Farmacêuticas

<p>Applications Labelled Vanillin. Occurs naturally in a wide variety of foods and plants such as orchids; major commercial source of natural vanillin is from vanilla bean extract. Synthetically produced in-bulk from lignin-based byproduct of paper processes or from guaicol.<br>References Jenner, P.M., et al.: Food Cosmet. Toxicol., 2, 327 (1964), Clark, G.S., et al.: Perfum. Flavor., 15, 45 (1990),<br></p>

<p>Applications DL-Methionine methylsulfonium chloride (cas# 3493-12-07) is a useful research chemical.<br></p>

<p>Applications Dihydro Artemisinin (D448360) dimer with anticancer and antiprotozoal activity.<br>References Galal, A. et al.: Bioorg. Med. Chem., 17, 741 (2009); Beekman, A. et al.: Phytother. Res., 10, 140 (1996)<br></p>

<p>Applications Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.<br>References Hombhanje, F., et al.: Pharma., 3, 3581 (2010), Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011),<br></p>

<p>Impurity Artemether USP Related Compound B<br>Applications Derivative of Artemisinin (A777500). Shows antimalarial and antifungal activity.<br>References Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011), Galal, A. et al.: J. Nat. Prod. 68, 1274 (2005)<br></p>

<p>1-(3,4-Methylenedioxyphenyl) 2-nitropropene (1-MPNP) is a phosphatase inhibitor that is active against gram-negative bacteria by inhibiting enterotoxins and chlamydia. 1-MPNP inhibits the activity of tyrosine phosphatases, which are enzymes that play a major role in bacterial virulence. 1-MPNP competitively inhibits the activity of tyrosine phosphatases and prevents them from catalyzing the hydrolysis of polyphosphate substrates. This inhibition leads to an accumulation of polyphosphates in the bacterial cell membrane, which disrupts its permeability and leads to cell death.</p>

<p>L-Methionine is a non-essential amino acid that belongs to the group of essential amino acids. It is a major constituent of proteins and is used in the metabolism of lipids, carbohydrates, and nucleic acids. Methionine is also involved in the synthesis of cysteine, which is an important antioxidant. L-Methionine can be found in many foods such as eggs, dairy products, fish, poultry, soybean products, peanuts, beans and seeds. Studies have shown that L-methionine has effects on liver function and may be useful for prevention or treatment of liver disorders such as primary sclerosing cholangitis (PSC). This compound also plays a role in the formation of body tissues and cells. L-Methionine has been shown to increase glutathione levels which are important for detoxification reactions and protection against oxidative stress. It also helps regulate calcium metabolism by reducing calcium absorption from food and increasing excretion via</p>

<p>3,3',4',5,5',8-Hexahydroxyflavone is a naturally occurring flavonoid, which is a type of polyphenolic compound. It is derived from various plant sources, including fruits, vegetables, and certain medicinal herbs. The compound is characterized by its chemical structure, which includes multiple hydroxyl groups, contributing to its biological activity.<br><br>The mode of action of 3,3',4',5,5',8-Hexahydroxyflavone involves its interaction with various cellular pathways and enzymes. Primarily, it is known for its antioxidant properties, where it scavenges free radicals and reactive oxygen species, thereby reducing oxidative stress. Additionally, it may exhibit anti-inflammatory effects by modulating signaling pathways involved in inflammation.<br><br>In terms of uses and applications, 3,3',4',5,5',8-Hexahydroxyflavone is primarily explored in scientific research focusing on its potential health benefits. Studies investigate its role in disease prevention, particularly conditions associated with oxidative stress and inflammation, such as cardiovascular diseases and neurodegenerative disorders. While it holds promise in these areas, further research is necessary to fully understand its mechanisms and therapeutic potential.</p>

<p>Applications Guanosine-5'-triphosphate disodium salt (CAS# 56001-37-7) is a nucleotide used in the preparation of photoreactive GTP affinity probes, and in inhibitors of eukaryotic initiation factor eIF-4E.<br>References George Cisar, E. A.; J. Am. Chem. Soc., 135, 4676 (2013); Ghosh, P.; et al.: Bioorg. Med. Chem. Lett., 16, 750 (2006).<br></p>

<p>Applications Triethylborane reacted with 8-hydroxyquinoline to synthesize three 8--​hydroxyquinolato (q) boron compounds B(C2H5)​2q (1)​, BPh2q (2)​, and B(2-​naph)​2q (3).<br>References Wu, Q., et al.: Chem. Mater., 12, 79 (2000).<br></p>

<p>Applications N-Acetylethylene Urea-d4 (cas# 1189701-94-7) is a compound useful in organic synthesis.<br></p>

<p>Applications The formation of p-Cresol-(methyl-13C) via phenol methylation at higher temperature from the deactivation of basic catalyst.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Borodina, I. B., et al.: Russ. J. Phys. Chem., 80, 892-898 (2006)<br></p>