Padrões Farmacêuticas

Applications 6-Methyl-2,3'-bipyridine (cas# 78210-78-3) is a useful research chemical.

Applications (R,E)-2-Acetamido-3-((phenyldiazenyl)thio)propanoic-13C6 Acid is labelled N-Acetyl-S-phenyl-L-cysteine (P335600), which is an important metabolite of Benzene.
References Muller, G., et al.: Anal. Hazard. Subst. Biol. Mater., 5, 143 (1997)

Applications N2'-Deacetyl-N2'-[3-[(1-ethyl-2,5-dioxo-3-pyrrolidinyl)thio]-1-oxopropyl]-maytansine-d5 is labelled N2'-​Deacetyl-​N2'-​[3-​[(1-​ethyl-​2,​5-​dioxo-​3-​pyrrolidinyl)​thio]​-​1-​oxopropyl]​-maytansine (D199030), a derivative of Mertansine (M257800) which is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.
References Erickson, H., et al.: Cancer Res., 66, 4426 (2006); Kellogg, B., et al.: Bioconjugate Chem., 22, 717 (2011)

Applications Methyl 3'-Amino-1,1'-biphenyl-3-carboxylate is a useful reagent for organic synthesis and other chemical processes.
References Uehling, D. E., et al.: J. Med. Chem., 49, 2758 (2006); Kuppusamy, R., et al.: Eur. J. Med. Chem., 143, 1702 (2018)

Applications 2'-Hydroxypropiophenone (cas# 610-99-1) is a useful research chemical.

Applications Zymosterol is an sterol intermediate in the biosynthesis of cholesterol (C432501). Cholesterol is a major component of all biological membranes; ~25% of total brain lipid is Cholesterol. Zymosterol was also found to be located in the plasma membrane of cultured human fibroblasts via labeling studies.
References Roland, E.D., et al.: J. Am. Chem. Soc., 111, 278 (1989); Echevarria, F., et al.: J. Biol. Chem., 265, 8484 (1990); Baranovskii, A.V., et al.: Russian. J. Bioorg. Chem., 28, 250 (2002); Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934);

Applications 2-Chloro-3-nitropyridine (cas# 5470-18-8) is a useful research chemical.

Applications 1,​3-​Bis(benzyloxycarbony​l)​-​2-​methyl-​2-​thiopseudourea is a useful reactant for the preparation of Leucetta alkaloids via tandem oxidative dearomatizing spirocyclizations.
References Singh, R.P., et al.: Org. Lett., 19, 4110-13 (2017);

Applications Dihydronaftazone-d4 O-β-D-Glucuronide is labelled Dihydronaftazone O-β-D-Glucuronide (D450330) which is a metabolite of Naftazone (N359270) which is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure.
References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011)

Applications 2-Anthracenecarboxylic Acid (cas# 613-08-1) is a useful research chemical.

Applications 4-Bromo-1,8-naphthalic Anhydride is used as a starting material in the synthesis of a fluorescent probe for the detection of copper ions in living human LO-2 cell lines.
References He, Guangjie, et al.: PLoS One, 12(10), e0186994/1-e0186994/11 (2017)

Stability Hygroscopic
Applications L-Aspartic acid 4-tert-butyl ester is a protected form of L-Aspartic acid (A790024). L-Aspartic acid is a nonessential amino acid that is used to biosynthesize other amino acids within the human body. L-Aspartic acid also increases membrane conductance of mammalian neurons by voltage-dependent means, causing depolarization and nerve impulses that travel to key areas of the central nervous system.
References Anderson, H., et al.: J. Nutr., 99, 82 (1969); Honey, C., et al.: Neurosci. Lett., 61, 135 (1985); MacDonald, J., et al.: Brain Res., 237, 248 (1982)

Applications A new anti-inflammatory drug. Effect of SAS 650 (Furofenac) on malondialdehyde production by platelets.
References Bertoli, D., et al.: Int. J. Tissue Reactions, 2, 217 (1980),

Impurity Atorvastatin 2-Hydroxy Lactone
Stability Hygroscopic
Applications A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Impurity Fulvestrant Impurity E;
Applications Fulvestrant (F862500) impurity E.

Applications Morphine 3-Acetate 6-β-D-Glucuronide 2,3,4-Triacetate Methyl Ester is an intermediate in the synthesis of Morphine 6-β-D-Glucuronide (M652310), a major metabolite of Morphine that is a potent opioid receptor agonist. Analgesic (narcotic).
References Frances, B., et al.: J. Pharmacol. Exp. Ther, 262, 25 (1992); Wu, D., et al.: Drug Metab. Dispos., 25, 768 (1997); Krzanowska, E.K., et al.: Brain Res., 799, 329 (1998)

Applications DL-Homocysteine Thiolactone-3,3,4,4-d4 HCl (CAS# 1219805-31-8) is a useful isotopically labeled research compound.

Applications Lodoxamide-15N2,d2 is the labelled form of Lodoxamide which is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.
References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)

Applications Dimethyl 2,7-Naphthalenedicarboxylate (cas# 2549-47-5) is a useful research chemical.

Applications A Labelled metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.
References Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 958 (1998).

Applications Protected Varenicline metabolite.

Applications m-Salicylic Acid is widely used in organic synthesis. It is also an important active metabolite of aspirin (A187780).
References Haynes, M., et al.: CRC H.b Chem. Phys., 92, 306 (2011)

Applications Lactams inhibit type Q arylesterase activity of human serum paraoxonase PON1.
References Aldridge, W., et al.: Biochem. J., 53, 110 (1953), Antikainen, M., et al.: J. Clin. Invest., 98, 883 (1996), Aviram, M., et al.: J. Clin. Invest., 101, 1581 (1998), Biggadike, K., et al.: J. Med. Chem., 43, 19 (2000),

Stability Hygroscopic
Applications Atorvastatin impurity in bulk drug and tablets.
References Posvar, E., et al.: J. Clin. Pharmacol., 36, 728 (1996), Lea, A., et al.: Drugs, 53, 828 (1997), Miao, X., et al.: J. Chromatogr., 998, 133 (2003),

Applications A useful building block for oligoribonucleotide synthesis.

Applications 9-Chloroanthracene is a chlorinated anthracene compound used for biochemical research

Applications 4,6-Dichloro-5-nitropyrimidine (cas# 4316-93-2) is a compound useful in organic synthesis.

Applications cis-Chrysanthemic Acid is an intermediate in synthesizing (+)-cis-Phenothrin (P318100), an isomer of Phenothrin (P318095), which is a pesticide used in the control of pests and insects.
References Wang, Y. et al.: Chemopshere, 90, 848 (2013); Hirahara, Y. et al.: Japan. J. Toxicol. Env. Health, 44, 451 (1998)

Applications 1-Acetyl-N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1h-imidazol-2-amine is a useful synthesis intermediate.

Applications A metabolite of Eplerenone. Used in combination therapy for treatment of cardiovascular disorders.
References Staessen, J., et al.: J. Endocrinol., 91, 457 (1981), de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), MacFadyen, R., et al.: Cardiovasc. Res., 35, 30 (1997),

Applications 3,5-Dibromosalicylic Acid

Impurity Atorvastatin lactam phenanthrene calcium salt impurity
Applications Atorvastatin (A791750) impurity. A stable Atorvastatin formulation.

Applications Calcium Chloride Dihydrate is used in the preparation of bisphosphonates used in attacking cancer cells.
References Liu, D. et al.: Chem. Comm., 48, 2668 (2012);

Stability No Data Availableg
Applications (1S,αS)-trans-Cypermethrin is an impurity in the synthesis of θ-Cypermethrin which a synthetic pyrethroid used as an insecticide in large-scale commercial agricultural applications as well as in consumer products for domestic purposes. It behaves as a fast-acting neurotoxin in insects. Cypermethrin can exhibit a toxic effect on the reproductive system.
References Hu, J., et al.: J. Appl. Toxicol., 33, 576 (2011); Singh, A., et al.: Neurobiol. Aging., 33, 404 (2012); Amer, S., et al.: J. Mut. Res., 155, 135 (1985)

Applications Texas Red 4’-Propargyl Sulfonamide 2’-Sulfate is an intermediate in the synthesis of Texas Red-5-dUTP (T320100), a fluorescence-labelled nucleotide analog. Texas Red-5-dUTP is used diagnostically for detection of rearranged SS18 in formalin-fixed, paraffin-embedded synovial sarcoma.

Applications 2'-O-Methyl-d3 Paclitaxel is a labeled analogue of 2'-O-Methyl Paclitaxel (M326135), a potential cytotoxic agent.
References Kant, J., et. al.: Bioorg. med. Chem. Lett., 3, 2471 (1993)

Applications 2-Nonyn-1-ol is a Propargyl alcohol (P762550) derivative that is used as a reagent to synthesize Microcarpalide, a microfilament disrupting agent that is weakly cytotoxic to mammalian cells. 2-Nonyn-1-ol is also thought to have potential antifungal properties.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gershon, H., et al.: J. Pharm. Sci., 73, 1840 (1984); Ratnayake, A., et al.: Org. Lett., 3, 3479 (2001); Tamao, K., et al.: Tetrahedron Lett., 29, 6955 (1988)

Stability Light Sensitive
Applications Efavirenz 1-Desamine is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.
References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)

Applications A glucuronide of monohydroxylated Warfarin metabolite, 7-Hydroxy Warfarin (H996130).
References Zielinska, A., et al.: J. Pharmacol. Exp. Ther., 324, 139 (2008);

Applications Riluzole N-β-D-Glucuronide is the glucuronide conjugate and metabolite of Riluzole (R510000), a neuroprotective agent.

Applications O-Methyl Oxazepam Acetate is an impurity of Oxazepam (O845700), which is an anxiolytic; muscle relaxant (skeletal); anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Controlled substance (depressant).
References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Sisenwine, et al.: Arzneim. Forsch., 22, 682 (1972), Shearer, C.M., et al.: Anal. Profiles Drug Subs., 3, 441 (1974), Greenblatt, D.J., et al.: Clin. Pharmacokinet., 6, 89 (1981),

Stability Temperature Sensitive
Applications It is used in efficient synthesis of 1β-O-acyl glucuronides via regioselective acylation of allyl or benzyl D-glucuronate.Αcyl glucuronides are known metabolites of important drugs.
References Kaspersen, F., et al.: Xenobiotica, 17, 1451 (1987), Ebner, T., et al.: Drug Metab. Dispos., 27, 1143 (1999), Shipkova, M., et al.: Ther. Drug Monit., 25, 1 (2003), Stachulski, A., et al.: J. Med. Chem., 49, 6931 (2006),

Applications 2,3,4-Tri-O-benzoyl Propofol-β-D-glucuronide Methyl Ester is a compound useful in organic synthesis.

Applications 2-(Bromomethyl)-5-(trifluoromethyl)furan is an intermediate used to prepare tertiary sulfonamides as liver X receptor antagonists. It is also used to synthesize hydantoin based inhibitors of MMP13 with potential use in osteoarthritis.
References Zuercher, W., et al.: J. Med. Chem., 53, 3412 (2010); De Savi, C., et al.: Bioorg. Med. Chem. Lett., 23, 4705 (2013)

Applications (S)-Metalaxyl is the S-enantiomer of Metalaxyl (M258740(P)), an agricultural fungicide. Metalaxyl is a contaminant of emerging concern (CECs). It is useful in cannabis testing kits as a component of pesticide mixes (P698235(M)).
References Boughalleb, N., et al.: Int. J. Agric. Res., 5, 1057 (2010), Lian, Y., et al.: J. Agric. Food Chem., 58, 9428 (2010)

Stability Moisture Sensitive, Temperature Sensitive
Applications A metabolite of Lumiracoxib.
References Fu, J., et al.: J. Biol. Chem., 265, 16737 (1990), Goldstein, J., et al.: Am. J. Gastroenterol., 96, 1019 (2001), Flower, R., et al.: Nat. Rev. Drug Discov., 2, 179 (2003), Grillo, M., et al.: Drug Metab. Dispos., 31, 1327 (2003),

Applications 21-Di[methylenebis(oxy)] 5α-Dihydrocortisol is an intermediate in the synthesis of Allo-3α-tetrahydro Cortisol 3-O-β-D-Glucuronide Sodium Salt-d7 (A548512), which is a metabolite of Cortisol (H714615) in human plasma.
References Ikegawa, S. et al.: Anal. Chem., 81, 10124 (2009); Kornel, L. et al.: J. Steroid. Biochem., 13, 751 (1980); Kornel, L. et al.: J. Steroid Biochem., 6, 1267 (1975);

Stability Hygroscopic
Applications 3,3',5-triiodo-β-hydroxy-D/L-thyronine is an impurity or analog of 3,3’,5-Triiodo-D-thyronine (T795375), which is a structural analogue of the thyroid hormone Thyroxine (T425600). 3,3’,5-Triiodo-D-thyronine has been shown to reduce cholesterol in blood serum.
References Mintz, D.O., et. al.: New Engl. J. Med., 266, 808 (1962)

Applications A dinitronaphthaloyl derivative as disinfectants and antiseptics.
References Brana, M., et al.: Anti-Cancer Drug Des., 8, 257 (1993), Griffin, B., et al.: Science, 281, 269 (1998), Huh, W., et al.: Nature, 425, 686 (2003),

Applications 2,4,5-Trichlorophenoxyacetic Acid Isobutyl Ester is a component in herbicide formulation used in the protection of crops.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Noble, A. et al.: Pest. Sci., 28, 203 (1990);

Applications N-Methyl(p-tosyl)carbamic Acid Methyl Ester is a methyl ester derivative of N-[(arylsulfonyl)methyl]carbamates that display intramolecular shielding.
References Van der Werf, S. et al.: Rec. Trav. Chim. Pays-Bas, 89, 423 (1970);

Applications Estradiol 6-N3-Adenine is a depurinating adduct that is created by the interaction of specific metabolites of estrogens in the body with DNA. Unfortunately, these adducts are endogeneous initiators of various human cancers, such as breast & prostate.
References Yang, L., et al.: Prostate, 69, 41 (2009); Zahid, M., et al.: Chem. Res. Toxicol., 19, 164 (2006); Zhang, Y., et al.: Metabol. Clin. Exp., 56, 887 (2007)

Applications ((2R,5S)-5-(4-Amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate is an impurity of Emtricitabine (E525000), a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).
References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)

Applications A reactant used in the preparation of Liraglutide, a GLP-1R agonist.

Applications N-Isopropyl-3,4-dimethyl-2,6-dinitroaniline is a dinitro herbicides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chen, Y., et al.: Green Chemistry, 15, 91 (2013)