Padrões Farmacêuticas

Stability Hygroscopic
Applications Tixocortol is an anti-inflammatory agent. Tixocortol is used in fluorescent chemoaffinity labeling.
References Torossian, D.R., et al.: Arzneim.-Forsch., 31, 453 (1981),

Applications A metabolite of 13-cis-Retinoic Acid (R250000).
References Samokyszyn, V., et al.: J. Biol. Chem., 262, 14119 (1987), Oldfield, N., et al.: Drug Metabol. Dispos., 18, 1105 (1990), Samokyszyn, V., et al.: Chem. Res. Toxicol., 10, 795 (1997),

Applications Isometheptene Maleate belongs to a group of sympathomimetic amine and shows very little antihypertensive activity. Isometheptene Maleate is used as an antispasmodic drug.
References Vidrio, H. et al.: J. Pharmacol. Exp. Therap., 187, 308 (1973); Taylor, W.G. et al.: Drug Metab. Disp., 5, 564 (1977);

Applications A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
References Agarwal, N. et al.: Fut. Oncol., 7, 15 (2011); Mita, A. et al.: Clin. Cancer Res., 15, 723 (2009); Figg, W.D. et al.: Cancer Biol. Ther., 10, 1233 (2010);

Applications Glutaric Acid (2,2,4,4-D4, 98%) (cas# 19136-99-3) is a useful research chemical.

Stability Air Sensitive
Applications 2-AMINOANTHRACENE (cas# 613-13-8) is a useful research chemical.

Applications S-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.
References Noel, P.R.B., et al.: Arzneim.-Forsch., 19, 1246 (1969), Cartwright, K., et al.: J. Pharm. Pharmacol., 23, Suppl., 247S (1971), Moreo, GC., et al.: Gazz. Med. Ital., 140, 409 (1981),

Applications 3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine is a building block used in various chemical synthesis.

Stability Moisture Sensitive
Applications A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2.
References Inoue, T., et al.: J. Biol. Chem., 284, 9566 (2009), Kang, J., et al.: Bioorg. Med. Chem., 17, 1498 (2009), Rath, G., et al.: Int. J. Biochem. Cell Biol., 41, 1165 (2009),

Stability Temperature Sensitive
Applications Indole-3-acetic acid is a plant growth regulator. It induces cell division and cell elongation that promotes plant growth.
References Fawcett, C., et al.: Nature, 178, 972 (1956); Fawcett, C., et al.: Annals Appl. Bio., 43, 342 (1955); Korshak, V., et al.:Vysokomolekulyarnye Soedineniya, Seriya B:  Kratkie Soobshcheniya, 22, 791 (1980)

Applications A metabolite of Mirtazapine (M365000). This compounds contains some of the alpha anomer.
References Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Dahl, M., et al.: Clin. Drug Invest., 13, 37 (1997),

Applications A metabolic intermediate in nucleic acid metabolism.
References Yoon, K., et al.: Nat. Prod. Sci., 14, 254 (2008), Ramazzina, I., et al.: J. Biol. Chem., 283, 23295 (2008), Kim, K., et al.: J. Mol. Biol., 387, 1067 (2009),

Applications Deschloro-2-phenylthio-thiamethoxam is an impurity of thiamethoxam (T344180), which is a neonicotinoid insecticide. Reports show that when exposed to neonicotinid pesticides honeybees have probelms returnign home after foraging and bumblebee colonies grow poorly and produce fewer queens.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Oliver, J., et al.: J. Environ. Horticult., 28, 135 (2010), Ghosh, A., et al.: J. Entomol. Res., 34, 35 (2010), Chem. and Eng. News 90: 10 (2012)

Applications (Benzy-d5)ldecyldimethylammonium Chloride is labelled Benzyldecyldimethylammonium Chloride (B234550) which is a biocide.
References Lee, M., et al.: Appl. Micro. Biotech., 87, 1109 (2010); Campanac, C., et al.: Antimicrob. Agents Ch., 46, 1469 (2002); Shen, J., et al.: Anal. Chem., 62, 116 (1990)

Applications A novel utilization of aminophenone derivative in toxicology, for treating intoxications with cyanogenic toxic substances.
References Donoghue, N., et al.: Eur. J. Biochem., 60, 1 (1975), Chen, Y., et al.: J. Bacteriol., 170, 781 (1988),

Applications N-Acetyl-L-tyrosine is an analogue of L-tyrosine which stimulate the transport of L-Tyr, mainly by the ASC system.
References Jara, J. et al.: Melanoma Res., 1, 15 (1991),

Applications 5-(4-Fluorophenyl)-2,3-dihydro-3-(1-methylethyl)-2-oxo-N,4-diphenyl-1-[2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide is a photodegradation product of Atorvastatin (A791750).
References Cermola, F., et al.: Tetrahedron., 62, 7390 (2006);

Applications 2,4-Bis(2-ethylhexyl) benzene-1,2,4-tricarboxylic Acid 1-Benzyl Ester-d34 is an isotope labelled intermediate in the synthesis of Trioctyl Trimellitate (T804400), a plasticizer that was evaluated for endocrine disrupting activities through estrogen receptor alpha binding assay.

Applications Cupriethylenediamine Hydroxide is used as a solvent for cellulose.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yang, L., et al.: J. Applied Polym. Sci., 126, E244 (2012); Shi, W., et al.: Ind. Eng. Chem. Res., 52, 586 (2013); Cyrot, J., et al.: Bulletin de l'Institut Textile de France, 18, 211 (1964)

Applications Antihypertensive; diuretic.
References Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961), Orzech, C.E., et al.: Anal. Profiles Drug Subs., 7, 297 (1978),

Applications It is listed as a known human carcinogen. Used in manufacturing of dyes, as antioxidant in rubber.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References IARC Monographs, 4, 97 (1974),

Stability Hygroscopic
Applications 2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid is a transformation product of Valsartan (V095750); a nonpeptide angiotensin II AT1-receptor antagonist and antihypertensive. 2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid is also referred to as Valsartan acid.
References Noedler, K., et al.: Water Res., 47, 6650 (2013); Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993); Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)

Impurity Calcium Folinate Hydrate EP Impurity E
Stability Unstable in Basic Solution
Applications 5-Formyltetrahydropteroic Acid is an impurity of Folic Acid (F680300); a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA. It also acts as a cofactor in biological reactions involving folate.
References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010); Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010); Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010); McKay, D., et al.: Nut. J., 9 (2010)

Applications Isocarbofos D7 (isopropyl D7) is the labelled analogue of Isocarbophos(I789303). Isocarbophos is an organophosphorus pesticide residue found in spicy foods and nuts.
References Gao, Y., et al.: Huaxue Shiji, 39, 1083 (2017); Dong, Y., et al.: Fenxi Huaxue, 45, 1397 (2017)

Applications 6-Hydroxy Bromantane is a metabolite of Bromantane (B678450).
References Bi, H., et al.: J. Steroid Biochem. Mol. Biol., 42, 229 (1992), Pozo, O., et al.: Anal. Bioanal. Chem., 389, 1209 (2007), Kiousi, P., et al.: Bioanalysis, 1, 1209 (2009),

Applications Methyl-(4-nitrophenylethyl)-(4-nitrophenoxyethyl)amine (cas# 115287-37-1) is a compound useful in organic synthesis.

Applications N-(Phenyl)-2-naphthylamine is a reagent in the preparation of unsymmetrical triaryldiamines as thermally stable hole transport layers for various organic LEDs.
References Koene, B. et al.: Chem. Mat., 10, 2235 (1998)

Applications Nonpeptide endothelin ETA receptor antagonist. Antihypertensive.
References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996), Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002), Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003),

Applications 2,5-Dinitrophenol (wetted with ca. 20% Water) (unit weight on dry weight basis) is a useful reagent for the preparation of yttrium nitrophenolate aminebis(benzotriazolylphenolate) complexes.
E0
References Su, Y. C., et al.: J. Polym. Sci. A Polym. Chem., 57, 2038 (2019)

Applications 1,2-Bis(3,5-di-tert-butyl-4-hydroxyhydrocinnamoyl)hydrazine is used as a stabilizer for Irganox MD 1024 on thermo-oxidative stability of PP/PP-g-MA/OMMT nanocomposites.
References Fitaroni, L, B.; et al.: Polym. Test., 53, 165 (2016).

Impurity Beclomethasone Dipropionate EP Impurity H
Applications Beclomethasone 17-Propionate (Beclomethasone Dipropionate EP Impurity H) is an active metabolite of Beclomethasone Dipropionate (BDP).
References Soria, I., et al.: Biopharm. Drug Dispos., 19, 297 (1998), Harrison, L., et al., J. Pharm. Pharmacol., 51, 1235 (1999), Daley-Yates, P., et al.: Br. J. Clin. Pharm., 51, 400 (2001).

Applications 1,3-Dimethyl 2-[4-(methoxycarbonyl)-2-nitrophenyl]propanedioate

Applications Sinensetin exhibits anti-fungal, anti-histamine activity; induce cell differentiation, inhibition of linoleic acid oxidation, inhibition of white blood cells in the human zona protein Interleukin -1-induced expression of tissue factor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Elliott, A., et al.: Biochem. Pharmacol., 44, 1603 (1992), Furuta, S., et al.: J. Food Sci., 62, 526 (1997),

Applications A reagent used to synthesize various dyes used in the textile industry. This is the labeled analog.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rosenkranz, H.S. et al.: Mutagen., 5, 137 (1990);

Applications 2-(Dimethylamino)guanosine (cas# 2140-67-2) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications Salbutamol Glyoxal Impurity that is synthesized from C369215 (3-Chloromethyl-4-hydroxyacetophenone).

Applications Acetyl-1,2-13C2 Coenzyme A Sodium Salt is a useful synthetic intermediate.

Stability Light Sensitive
Applications 8-((4-Amino-2-nitrophenyl)diazenyl)-7-hydroxy-N,N,N-trimethylnaphthalen-2-aminium Chloride is used in the preparation of hair dyes and color intensifiers in cosmetics.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Moeller, H., Oberkobusch, D.: Ger. Offen. (2003), DE 10148841 A1 20030410

Applications 3-[2-N-(Biotinyl)aminoethyldithio]propanoic Acid (cas# 104582-29-8) is a compound useful in organic synthesis.
References Kobayashi, N., et al.: Anal. Biochem., 357, 311 (2006),

Applications Labelled 4-Nitrophenol (N496945). Used in the manufacturing of pharmaceuticals, fungicides, dyes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package