Glicociência

(2S, 3S, 4S, 5S) -3, 4- Dihydroxy- 5- (hydroxymethyl) - N- methyl- 2- pyrrolidinecarboxami de is a custom synthesis of an oligosaccharide. It is a complex carbohydrate that can be modified to the customer's specifications. The product is available in high purity and with good monosaccharide and methylation yield. The chemical structure of this product contains a fluorinated saccharide.

Sodium salt of a polysaccharide obtained from the brown seaweeds (e.g. Laminaria hyperborea, Fucus vesiculosus, Ascophyllum nodosum). The chemical structure consists of blocks of (1,4) linked-β-D-polymannuronic acid (poly M), (1,4) linked-α-L-polyguluronic acid (poly G) and alternating blocks of the two uronic acids (poly MG). Alginates form strong gels with divalent metal cations and the egg box model has been used to describe this form of gelation. The main use for alginate is in textile printing as a thickener in the printing of cottons with reactive dyes. In the food industry it is used as a thickener and gelling agent.  Recently, it has been shown that ternary mixtures of Konjac glucomannan, Xanthan gum and Sodium alginate can form a non-covalently linked complex which exhibits enhanced rheological properties of value in, for example, functional foods. The image was kindly provided by Prof Mike Guiry from Cork who runs ‘The Seaweed Site’.High viscosity (500-500mPa.s).

This gamma-cyclodextrin (γ-CD) derivative is a modified cyclic oligosaccharide composed of eight glucose units, featuring a larger cavity size than α- and β-cyclodextrins. This structural characteristic allows γ-CDs to form inclusion complexes with a wider range of guest molecules, making it particularly versatile in various industries. In the food sector, it is used as a carrier and stabilizer for flavors, fat-soluble vitamins, and polyunsaturated fatty acids, protecting volatile compounds from evaporation. In pharmaceuticals, it enhances the solubility and bioavailability of poorly water-soluble drugs and, thanks to its larger ring size, allows for the encapsulation of larger molecules or even entire drug molecules. γ-CDs and derivatives are also used for environmental remediation and, in analytical chemistry, for the extraction and concentration of target substances.

This gamma-cyclodextrin (γ-CD) derivative is a modified cyclic oligosaccharide composed of eight glucose units, featuring a larger cavity size than α- and β-cyclodextrins. This structural characteristic allows γ-CDs to form inclusion complexes with a wider range of guest molecules, making it particularly versatile in various industries. In the food sector, it is used as a carrier and stabilizer for flavors, fat-soluble vitamins, and polyunsaturated fatty acids, protecting volatile compounds from evaporation. In pharmaceuticals, it enhances the solubility and bioavailability of poorly water-soluble drugs and, thanks to its larger ring size, allows for the encapsulation of larger molecules or even entire drug molecules. γ-CDs and derivatives are also used for environmental remediation and, in analytical chemistry, for the extraction and concentration of target substances.

The tetrasaccharide 1,2-ethanediol is a synthetic compound that is used in pharmaceuticals and as an intermediate for other compounds. This product is a high purity custom synthesis that can be used for methylation or glycosylation reactions. The CAS number for this product is 615-86-1.

Gum arabic is an exudate gum picked from Acacia trees growing in tropical arid regions (typically Acacia senegal and Acacia laetia). The polysaccharide is branched with a main chain of (1-3) linked β-D-galactopyranosyl units with side chains of (1-3) β-D-galactopyranosyl units joined to it by (1-6) links. The side chains are 2-5 units in length. Both the main chain and the side chains have attached units of α-L-arabinofuranosyl, α-L-rhamnopyranosyl, β-D-glucuronopyranosyl and 4-O-methyl-β-D-glucuronopyranosyl units.

D-Allono-1,5-lactone is a glycoside that has been custom synthesized. It is a high purity product with a variety of modification options. This compound can be used for the synthesis of sugars, Click modification, fluorination, and glycosylation. D-allono-1,5-lactone has CAS No. 894408-50-5 and is classified as an oligosaccharide or sugar. It can also be methylated or modified to create saccharides or complex carbohydrates.

1,2:3,4-Di-O-isopropylidene-a-D-galactopyranose, also known as diacetone-D-galactose and galactose diacetonide, is a partially protected monosaccharide building block with isopropylidene groups on the 1,2 and 3,4 hydroxyls. The 6-hydroxyl is unprotected and able to undergo a variety of chemical transformations, such as glycosylation acting as a glycosyl acceptor to form 1,6-linked disaccharides.

Raffinose is the most abundant of the family of oligosaccharides that are α-galactosyl derivatives of sucrose (Collins, 2006). The other main member of the group is the tetrasaccharide stachyose. Raffinose is found in sugar beet molasses and whole grains. Soybean oligosaccharides make up approximately 5% of dry matter in whole beans and up to 8% of dry matter in soybean meal. Together raffinose and stachyose rank second only to sucrose in abundance, as water-soluble carbohydrates (Kumar, 2010).

(2S, 3S, 4R) -2- [(1R) - 1, 2-Dihydroxyethyl] -3, 4- pyrrolidinediol is a benzyl-containing compound that is used as a glycoside hydrolase inhibitor. It has been shown to be an effective treatment for inflammatory bowel disease. This drug binds to the active site of glycosidases and blocks the hydrolysis of c-glycosides in the intestine. (2S, 3S, 4R) -2- [(1R) - 1, 2-Dihydroxyethyl] -3, 4- pyrrolidinediol also inhibits chloride channels and has been shown to have antiinflammatory properties.

Methyl 2,3,4-tri-O-pivaloyl-6-O-trityl-a-D-galactopyranoside is a sugar with a molecular weight of 576.6 g/mol. The chemical formula for this compound is C36H50O24 and the structural formula is CH2(COOCH2)5(CHO)3(CHOH)4(COOCH2)5. This product can be custom synthesized to order. Methyl 2,3,4-tri-O-pivaloyl-6-O-trityl-a-D galactopyranoside is used in glycosylation reactions as a protecting group for the hydroxyl groups on the carbohydrate chain. It can also be used as a fluorination agent or in Click modification reactions to modify sugars and oligosaccharides. Methyl 2,3,4 tri - O - p

This compound is a glycosylation product of the monosaccharide fucose and the disaccharide 2-O-benzyl-a-L-thiofucopyranoside. It is a custom synthesis that has been modified by fluorination, methylation and click chemistry. This product is available in high purity and with a CAS No. 183051-73-2.

1,5-Anhydro-D-glucitol 6-dihydrogenphosphate is a biochemical analog. It has been shown to have anti-inflammatory effects in rat models of inflammatory bowel disease and metabolic disorders. 1,5-Anhydro-D-glucitol 6-dihydrogenphosphate inhibits the activity of bacterial enzymes that catalyze protein glycosylation. It also blocks the production of inflammatory cytokines and colony stimulating factors. The enzyme inhibition may be due to its ability to inhibit the synthesis of D-glucose from D-galactose by blocking the enzyme DALR (deleted in liver cancer).

Tri-b-GalNAc-6-aminohexanoate TFA is the peracetylated TFA salt from MT184237. It is a synthetic ligand designed to target the asialoglycoprotein receptor (ASGPR) on hepatocytes. The three terminal beta-N-acetylgalactosamine (GalNAc) sugars provide an efficient ASGPR binding. It serves as a platform for lysosomal targeting chimera (LYTAC) development, allowing for the creation of chimeras that specifically target unwanted proteins for degradation within hepatocytes. In addition, tri-b-GalNAc-6-aminohexanoate facilitates the delivery of therapeutic cargo, such as RNA or Cas9 complexes, directly to hepatocytes via ASGPR-mediated endocytosis. This approach is promising for gene therapy and RNAi applications in the liver due to the specificity of ASGPR targeting and the versatility of the conjugation moiety.

Phenyl 2,3,4,6-tetra-O-acetyl-a-D-thiomannopyranoside is an analog of a sugar molecule. This compound can be synthesized by the metathesis reaction between phenyl 2,3,4,6-tetra-O-acetyl-α-(2′→3′)-D-thiomannopyranoside and bis(trimethylsilyl) sulfate in the presence of polyphosphoric acid and potassium sulfate. The yield of this synthesis is high and can be increased with the addition of potassium sulfonate as a cofactor.

Methyl 2-acetamido-3-O-(2,3,4,6-tetra-O-acetyl-a-D-galactopyranosyl)-2-deoxy-a-D-galactopyranoside is a custom synthesis product that can be fluorinated, methylated and glycosylated. This compound has a CAS number and is polysaccharide in nature. It's complex carbohydrate with oligosaccharides and saccharides.

N- [(3R, 4R, 5R) - 4- Hydroxy- 5- (hydroxymethyl) - 3- pyrrolidinyl] -acetamide is a synthetic compound that is composed of two molecules of acetamide linked to each other by an ester linkage. The acetamide group is attached to the nitrogen atom of the heterocycle. The N-COOH carbonyl group is attached to the oxygen atom of the heterocycle. N-[(3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(pyrrolidin-1-yl)pyrrolidinium]acetamide has not been studied in humans or animals.

Fluorescent substrate used to monitor glucose uptake