Glicociência

<p>Methyl α-L-daunosamide hydrochloride is a drug that inhibits the production of DNA. It is used to treat infectious diseases such as malaria, in which it can inhibit the growth of the parasite by preventing DNA replication and transcription. The methyl α-L-daunosamide hydrochloride molecule is a polymerase chain inhibitor that binds to the enzyme adriamycin synthetase, which catalyzes the conversion of daunosamine into adriamycin. This binding prevents the formation of stable complexes with the target enzymes and blocks their activity, leading to inhibition of DNA synthesis and transcription. Methyl α-L-daunosamide hydrochloride has been shown to inhibit glycan biosynthesis in rat liver microsomes and does not have significant interactions with other drugs or with glycan in human serum.</p>

<p>4-O-(b-D-Mannopyranosyl)-D-glucose is a metabolite of D-mannose. It is a bacterial metabolite produced by Streptococcus pneumoniae that has been shown to inhibit the growth of bacteria by binding to the 50S ribosomal subunit. 4-O-(b-D-Mannopyranosyl)-D-glucose inhibits bacterial growth by binding to DNA dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifapentine also specifically binds to markers expressed at high levels in Mycobacter</p>

<p>Sodium carboxymethyl dextran is a white, odourless and tasteless powder, which is freely soluble in water or electrolyte solutions. Applications that have been described for carboxymethyl dextran include carriers of paramagnetic contrast agents, preparation of conjugates of pharmacologically active compounds and carboxymethyl dextrans in biosensors.  A number of other uses in cosmetics, agriculture, foods, paints and textiles have been the subject of patent applications.</p>

<p>Leucrose (5-O-a-d-glucopyranosyl-D-fructose) is formed by enzymatic synthesis using Leuconostoc mesenteroides in the presence of sucrose.</p>

1,2:3,5-Di-O-isopropylidene-a-D-xylofuranose is a synthetic glycoside that is used in the synthesis of complex carbohydrates. It has been used for the modification of polysaccharides and oligosaccharides. This compound has also been modified with fluorine to form 1,2:3,5-Di-O-isopropylidene-a-D-(1'-fluoro)-xylofuranose. The chemical name of this product is CAS No. 20881-04-3.

<p>Sialyl Lewis X ceramide is a monosaccharide that belongs to the pentasaccharide group. It is expressed in the cells of leukemia and erythrocytes, as well as other tissues. Sialyl Lewis X ceramide is a hybrid molecule that has a backbone consisting of four sugar molecules and an amino acid sequence, with hydroxyl groups on one end and an acetyl glucosamine on the other end. The molecule has a carbohydrate skeleton consisting of galactose, glucose, mannose, and sialic acid. Sialyl Lewis X ceramide also interacts with selectins to mediate leukocyte-endothelial interactions in inflammation.</p>

<p>3,5-Dideoxy-3,5-imino-1,2-O-isopropylidene-N-methyl-L-idofuranose is a custom synthesis that can be modified to the customer's specifications. This product has CAS No. and is a polysaccharide with modification. It is a carbohydrate that is a saccharide with methylation, glycosylation and click modification. This product is high purity, fluorinated and synthetic.</p>

<p>6-Deoxy-L-tallose is a heterocyclic compound that is an enol ether with a vicinal, β-unsaturated aldehyde and the correct stereochemistry. It can be synthesized from D-glucose by enolization of the hydroxyl group at C2, followed by oxidation to form an aldehyde. This reaction can also be accomplished using hydrogen peroxide in acetic acid. 6-Deoxy-L-tallose can also be synthesized from D-mannitol or D-sorbitol by reduction of the carbonyl group at C1, followed by oxidation to form an aldehyde. The synthesis of 6-deoxy L -tallose has been shown to be useful as a chiral synthon for the synthesis of other molecules.END&gt;</p>

<p>(2R,3S,4R)-4-O-Benzyl-N-benzyloxycarbonyl-2-hydroxymethyl-3,4-pyrrolidinediol is a carbohydrate that is used in the synthesis of oligosaccharides. This molecule can also be modified with fluorine to produce a complex carbohydrate. The carbons at positions 1 and 2 are hydroxymethylated to create a glycosylated and methylated molecule.</p>

1-O-Galloyl-b-D-glucose is a molecule that is found in plants and has been used as an inhibitor of p-hydroxybenzoic acid (PHBA) enzyme activities. 1OGG inhibits the growth of viruses by inhibiting the enzymatic activity of their RNA polymerases. It also inhibits mitochondrial membrane potential, which is vital for cellular respiration. 1OGG has shown to be active against urinary infections and opportunistic fungal infections such as Candida glabrata. In vitro assays have shown that it may have anti-inflammatory properties.

<p>Substrate for N-acetylglucosaminyltransferases</p>

Myo-Inositol trispyrophosphate (ITPP) hexasodium salt is a drug with anti-cancer properties. It is an allosteric effector that interact with hemoglobin, releasing oxygen into the target tissues to avoid hypoxia. Several studies has shown an increase on the affinity of hemoglobin to oxygen when using ITPP, fact that demonstrated it can be a good strategy for the treatment of several cardiovascular diseases.

<p>Vitamin added to plant cell culture medium to promote growth. Used to differentiate microorganisms based on their metabolic properties.</p>

<p>Starch is a two component polysaccharide mixture of amylose and amylopectin. Amylose is a linear polysaccharide of α (1,4)-linked glucose residues and averages 20 to 30% of the total in most native starches. Amylopectin is a highly branced glucan containing both a (1,4) and a (1,6) linkages. The number of glucose residues in a single starch molecule can vary from five hundred to several hundred thousand, depending on the type of starch. Starch is the major storage form of energy in plants, just as glycogen is the storage form of energy for animals. The plant directs the starch molecules to the amyloplasts, where they are deposited to form granules. Thus, both in plants and in the extracted concentrate, starch exists as granules varying in diameter from 2 to 130 μm.</p>

<p>6-Azido-6-deoxy-D-glycero-L-gulo-heptitol is a methylated, saccharide, polysaccharide, click modification, and modification of oligosaccharides. The chemical name for the compound is 6-[(1S)-1-(2-aminoethyl)propyl]-2,4 -dioxopentanedioic acid. It has CAS No. 1458063-96-1 and has a molecular weight of 374.5 g/mol. This product can be custom synthesized with high purity and it is a carbohydrate sugar that is synthetic.</p>

<p>(1R) -1- [(2R, 3S) -3-Hydroxy- N-nonyl-1- azetidinyl] -1, 2- ethanediol is a methylated saccharide that can be used in the synthesis of oligosaccharides. It has been shown to be an effective inhibitor of glycosylation and can be used for the modification of carbohydrates. The compound has a CAS number and is available for custom synthesis. It also has high purity and stability, as well as being a synthetic product.</p>

<p>Synthetic building block</p>

1-Chloro-2-deoxy-3,5-di-O-p-nitrobenzoyl-D-ribofuranose is a fluorinated sugar that can be used as a probe for the study of glycosylation and methylation reactions. It is also a complex carbohydrate with an Oligosaccharide modification. It is available for custom synthesis and has high purity. This product can be methylated, glycosylated, or modified using Click chemistry. 1-Chloro-2-deoxy-3,5-di-O-p nitrobenzoyl D ribofuranose is also an oligosaccharide sugar that contains one Monosaccharide unit.

(2R, 3S, 4R) -4- Azido- 3 benzhydryloxybis(trimethylsilyloxy)silyloxy - 2- [(benzhydryloxybis(trimethylsilyloxy)silyloxy) methyl] - 1- benzyl- pyrrolidine is a highly pure and custom synthesized oligosaccharide. It is a methylated saccharide with a high purity. The CAS number for this compound is 102780-43-1. This compound has been modified by Click chemistry to allow for the modification of saccharides, polysaccharides and other complex carbohydrates.

Fluorination is the introduction of a fluorine atom into a molecule. In this article, we will discuss the synthesis of a fluorinated sugar (4-azido-5,6,8-tri-O-benzyl-1,2,4-trideoxy-1C-(trimethylsilyl)-D-gluco-oct-1yn3ulopyranose) using an oxidative route. The desired product was obtained in high yield by reacting the corresponding monosaccharide with ethylenediamine and potassium perchlorate in acetic acid at room temperature. br>br> The Monosaccharides are a class of simple sugars that are used as building blocks for larger carbohydrates and polysaccharides. They contain one or more single carbohydrate units joined together by glycosidic bonds. These single units can be classified as alpha or beta based on their stereochemistry and reactivity with

<p>(1S) -1- [(2S, 3R) - N-(Methoxyphenyl)methyl-3- hydroxy- 1- azetidinyl] -1, 2- ethanediol is a synthetic modification of the sugar glucose. It has been fluorinated at the hydroxyl group of the C2 position to produce (1S) -1-[(2S, 3R)-N-(methoxyphenyl)methyl]-3-hydroxy-1-azetidinol. This compound can be used as an intermediate for glycosylation and methylation reactions. It is also available with high purity and custom synthesis.</p>

Ethyl 2,3,4,6-tetra-O-benzyl-b-D-thioglucopyranoside is a sugar alcohol that is selective for the formation of disaccharides. It has a constant yield and can be synthesized from phenyl glycosides or acetonitrile.

<p>1,5-Anhydro-4,6-O-benzylidene-3-deoxy-D-glucitol (1,5BPG) is a form compound that is conformationally restricted to the chair conformation. It has inhibitory activity against human macrophages and low activity against thp-1 cells. The 1,5BPG inhibits the activation of Nlrp3 and induces apoptosis in macrophages. These effects are mediated through binding to the hydroxyl group of C2 on the glucose moiety of 1,5BPG. The 1,5BPG also has high activity against marrow derived macrophages. This is due to its ability to inhibit the synthesis of phosphatidic acid and other lipids in these cells.</p>

<p>2N-Boc-amino-2-deoxy-b-D-galactopyranosylamine is a synthetic sugar that can be used in the synthesis of oligosaccharides and glycosylations. It is a modification of galactose, which is an important saccharide in the synthesis of polysaccharides. 2N-Boc-amino-2-deoxy-b-D-galactopyranosylamine is also an excellent fluorinating agent that can be used for complex carbohydrate syntheses.</p>

Similar to Raffinose but with the galactose residue attached 1,4 to the glucose

Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside is a carbohydrate compound that is a modification of the saccharide and oligosaccharide. It is fluorinated at the 3' position. The monosaccharide is synthesized from D-ribose and methylated at the 2' and 5' positions. Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside is a synthetic sugar that has been modified with glycosylation and Click chemistry.

<p>Sodium Trigalacturonate (α-1,4 sodium galacturonotriose) is derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s), and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, and tetra-galacturonate oligosaccharides, restore development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).</p>

<p>2,4-Di-O-methyl-D-glucose is a partially O-methylated glucose sugar.</p>

<p>This product is a high purity, custom synthesis, sugar. It is Click modification, fluorination, glycosylation and synthetic. This product has CAS No. and Oligosaccharide, Monosaccharide, saccharide and Carbohydrate. This product also has complex carbohydrate.</p>

Torachrysone 8-O-glucoside is a natural product found in the rhizome of Chinese medicinal plant Rhubarb. It is an antiinflammatory that has been shown to be effective in vitro against inflammation induced by spleen, blood, and the stomach. Torachrysone 8-O-glucoside has also been shown to have protective effects on the kidney and bladder.

2,6-Dideoxy-D-glucose is a glycosyl acceptor that has been shown to induce apoptosis in cancer cells. It is an anticancer agent that inhibits the production of ATP by inhibiting glycolysis. 2,6-Dideoxy-D-glucose can also inhibit the translocation of proteins from the cytoplasm to the nucleus and thereby prevent nuclear accumulation of these proteins. This drug may also have anticancer effects through its ability to inhibit DNA synthesis and potentiate anticancer effects of other chemotherapeutic agents. 2,6-Dideoxy-D-glucose has been shown to be effective against cardiac cancer cells and leukemia cells.

<p>D-Fructose (Fru) is the most common reducing keto-hexose and is often known as levulose, arabino-hexulose, fruit sugar (Collins, 2006). In an aqueous solution, fructose exhibits mutarotation (approx., 70-75% β-pyranose, 20-23% β-furanose, 5% α-furanose, 2% α-pyranose, 0.7% open chain) (Angyal, 1984). Sucrose from sugar cane and sugar beet is made up of 50% fructose and is found in many fruits and vegetables; it is the predominant sugar in apples, grapes, oranges and watermelon, as well as comprising of up to half of the total sugars in honey. High fructose corn syrup (HFCS) containing around 50% fructose is an important food ingredient produced from glucose syrup by the action of the enzyme glucose isomerase (Hanover, 1993). However, dietary sugars including fructose, have long been implicated in the epidemic of obesity. Evidence to link the relation of foods and beverages containing fructose with overweight or obesity has recently been obtained (Zurbau, 2020).</p>

<p>Man-6 Glycan, 2-AB labelled is a custom synthesis of mannose-6-phosphate, a monosaccharide. The molecule contains six carbons and one phosphate group. It can be modified with fluorination, methylation, or click modification. This glycan is synthesized by the addition of an oligosaccharide to a polysaccharide. Mannose-6-phosphate is an Oligosaccharide that carries out glycosylation reactions in the body. It is used as a precursor for other glycans such as N-Acetylglucosamine and N-Acetylgalactosamine.</p>

<p>2-Azido-2-deoxy-3,5-O-benzylidene-L-xylono-1,4-lactone is a sugar compound that can be custom synthesized. It has been shown to be a methylation product of 2,3,4,6-tetraacetylgalactose and is an oligosaccharide with a saccharide chain that includes glucose and xylose. The chemical formula for this compound is C11H13NO7. This compound has a CAS Number of 73028-81-2 and can be purchased from various vendors at high purity levels. 2Azido2deoxy3,5ObenzylideneLxylono1,4lactone is used as a reagent in the synthesis of complex carbohydrates. It can also be used to modify monosaccharides and sugar compounds with fluorination or modification reactions.</p>

<p>1,4-D-Xylobiose, also called 4-O-(b-D-Xylopyranosyl)-D-xylopyranose, is a beta 1-4 linked disaccharide made of 2 xylose monomers. 1,4-D-Xylobiose is a low-calories sweetener that can be used as an alternative or additive to sucrose. Supplementing a high fat diet with 1,4-D-xylobiose has been shown to prevent and treat obesity in mice.</p>

<p>Dextran 2000 is a high molecular weight biocompatible polymer with transport properties. It is used in a variety of medical applications, such as red blood cell transfusions and the prevention of post-surgical adhesions. Dextran 2000 has been shown to be a safe and effective means of preventing hemolysis during red blood cell transfusion. This agent binds to amine groups on the surface of erythrocytes, which prevents complement activation and subsequent lysis. Additionally, dextran 2000 has been shown to exhibit low cytotoxicity against neuronal cells in vitro.</p>

<p>Glucose metabolite</p>

<p>2-Acetamido-6-O-(a-2-N-acetylneuraminyl)-2-deoxy-a-D-galactopyranosyl N-acetylserine is a synthetic glycosyl amino acid.</p>

<p>Chromogenic substrate targeting beta-glucuronidase</p>

<p>3-O-Benzyl-1,2,4-tri-O-acetyl-D-xylopyranoside is a methylated saccharide that has been modified with the click chemistry. This product can be used for the synthesis of complex carbohydrates and glycosylations. This product is available in high purity and custom synthesis. It is soluble in water or aqueous solutions, making it ideal for use in biological applications. 3-O-Benzyl-1,2,4-tri-O-acetyl-D-xylopyranoside can be used as an intermediate for the synthesis of oligosaccharides and glycoconjugates. It has CAS number 69936–76–5.</p>

<p>Water-soluble, nontoxic, enzyme-resistant polymer for biological applications</p>

<p>6-Deoxy-L-allitol is a white crystalline solid that melts at 122°C. It has an amorphous character and may be present as a mixture of rotations, form, and crystalline polymorphs. 6-Deoxy-L-allitol can be oxidized to its diol derivative by hydrogen peroxide or sodium periodate. This compound is soluble in water, methanol, and acetone. The molecular weight of this compound is 179.06 g/mol.</p>

<p>Benzyl 4,6-O-benzylidene-2-deoxy-2-phthalimido-b-D-glucopyranoside is a modified glycosylated deoxyhexose. It is synthesized from benzaldehyde and 2,4,6-O benzyldiphenol by means of a glycosylation reaction with hexose. This product has been fluorinated to give it the desired properties. Methylation of the benzyl group converts the product into an intermediate that can be used in click chemistry reactions. Monosaccharides are then added to produce oligosaccharides. The sugar chain is then complete with a saccharide being added at the end.</p>

<p>Arabinoxylans consist of α-L-arabinofuranose residues attached as branch-points to β-(1,4)-linked D-xylopyranose main chains. These may be 2- or 3-substituted or 2- and 3- di-substituted. The arabinose residues may also be linked to other groups attached such as glucuronic acid residues, ferulic acid cross links and acetyl groups. Arabinoxylans generally consist of between 1500 - 5000 residues.</p>

Ethyl 2,3-di-O-benzoyl-4,6-O-benzylidene-b-D-thioglucopyranoside is a modified sugar that is used as an intermediate in the synthesis of saccharides and oligosaccharides. It is synthesized by a modification of the Knorr reaction. This product has been shown to be high purity and can be custom synthesized with a variety of functional groups, such as fluorination. Ethyl 2,3-di-O-benzoyl-4,6-O-benzylidene-b-D-thioglucopyranoside is also available in CAS No. 11764719.

<p>1,2,3,4-Tetra-O-benzoyl-6-O-triisopropylsilyl-b-D-galactopyranose is an oligosaccharide. The carbohydrate is a complex carbohydrate that has been custom synthesized and high purity. The CAS number for this compound is 10981-97-5. This compound is a monosaccharide that has been methylated and glycosylated. It is also a polysaccharide composed of sugar molecules with the molecular formula C8H18O6. This compound has been fluorinated and saccharided.</p>

<p>Ethyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-thioglucopyranoside is a modified carbohydrate that has been synthesized by the click modification of an acetylated triose. This chemical was synthesized by reacting ethyl 2-(2'-deoxy-(1-&gt;4)-beta--D--glucopyranoside) with trimethylsilylacetamide and copper(I) chloride in dry tetrahydrofuran. This product has high purity and is used as a research tool for glycobiology.</p>

<p>2, 5-Anhydro-3-azido-3-deoxy-D-altronic acid methyl ester is a Carbohydrate that belongs to the saccharide class. It is an Oligosaccharide containing 2 Monosaccharides and 1 Disaccharide. This product is custom synthesized, high purity, and has been Fluorinated and Methylated. The modification of this product includes Click chemistry.</p>

3-C-Methyl-allonolactone is an oligosaccharide that is modified by methylation, glycosylation, and polysaccharide. It is a custom synthesis and has a high purity. 3-C-Methyl-allonolactone may be used as a precursor to 3-carbon sugars.

<p>2,5:3,4-Dianhydro-6-O-2-propenyl-dimethyl acetal-L-talose is a fluorinated sugar that is synthesized by the reaction of an acetal with glycosylation. It has been modified to contain a methyl group and a click modification. 2,5:3,4-Dianhydro-6-O-2-propenyl-dimethyl acetal-L-talose is used as a fluorescent probe for the detection of nucleic acids in living cells. It has high purity and can be custom synthesized to meet customer specifications.</p>