Antifúngicos
Os antifúngicos são compostos especificamente projetados para interromper, prevenir e eliminar o crescimento de fungos. Nesta categoria, você encontrará uma ampla variedade de agentes antifúngicos essenciais para pesquisa e aplicações terapêuticas. Esses compostos são cruciais no tratamento de infecções fúngicas e na prevenção de sua recorrência, tornando-os ferramentas vitais tanto em ambientes médicos quanto agrícolas. Pesquisadores e profissionais de saúde podem explorar inúmeros antifúngicos para entender seus mecanismos, otimizar sua eficácia e desenvolver novos tratamentos para combater cepas fúngicas resistentes. A extensa seleção de antifúngicos apoia os avanços contínuos na pesquisa sobre fungos e no desenvolvimento de terapias antifúngicas eficazes.
Foram encontrados 835 produtos de "Antifúngicos"
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(R)-(-)-2-Oxothiazolidine-4-carboxylic Acid
CAS:Produto ControladoFórmula:C4H5NO3SCor e Forma:NeatPeso molecular:147.15Gibberellin A7 Methyl Ester
CAS:Produto ControladoFórmula:C20H24O5Cor e Forma:NeatPeso molecular:344.42-(1-(Allyloxy)-2-(1H-imidazol-1-yl)ethyl)-3,5-dichlorophenol
Produto ControladoFórmula:C14H14Cl2N2O2Cor e Forma:NeatPeso molecular:313.1795-Fluoro-2-mercaptobenzothiazole
CAS:Produto Controlado<p>Applications 5-Fluoro-2-mercaptobenzothiazole is used as a reagent in the synthesis of [[(benzothiazolyl)thio]methyl]phenyl]furanone derivatives with agrochemical fungicidal activities.<br>References Zhao, P., et al.: Youji Huaxue, 30, 1567 (2010);<br></p>Fórmula:C7H4FNS2Cor e Forma:NeatPeso molecular:185.24TH-302
CAS:Produto Controlado<p>Applications TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard. Studies have shown that TH-302 treatment exhibited hypoxia-selective cytotoxicity and DNA damage in human cancer cell<br>References Meng, F. et al.: Mol. Cancer Ther., 11, 740 (2012); Liu, Q. et al.: Cancer Chemother. Pharmacol., 69, 1487 (2012); Sun, J.D. et al.: Clin. Cancer Res., 18, 758 (2012);<br></p>Fórmula:C9H16Br2N5O4PCor e Forma:NeatPeso molecular:449.04α-Butylpiperonyl Alcohol
CAS:Produto Controlado<p>Applications Intermediate in the preparation of insecticides, fungicides, and other pesticides.<br>References Wilkinson, C., et al.: J. Agric. Food Chem., 14, 73 (1966), Zhong, W., et al.: J. Chem. Res., 6, 370 (2009),<br></p>Fórmula:C12H16O3Cor e Forma:NeatPeso molecular:208.25cis-2-(2,4-Dichlorophenyl)-2-(4H-1,2,4-triazol-4-ylmethyl)-1,3-dioxolane-4-methanol
CAS:Produto Controlado<p>Applications cis-2-(2,4-Dichlorophenyl)-2-(4H-1,2,4-triazol-4-ylmethyl)-1,3-dioxolane-4-methanol is an impurity in the synthesis of Itraconazole (I937500); an orally active antimycotic structurally related to Ketoconazol.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984); Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989); Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993)<br></p>Fórmula:C13H13Cl2N3O3Cor e Forma:NeatPeso molecular:330.171-(4-Chlorophenyl)-3-[(2-nitrophenyl)methoxy]pyrazole
CAS:Produto Controlado<p>Applications 1-(4-Chlorophenyl)-3-[(2-nitrophenyl)methoxy]pyrazole is an intermediate for the synthesis of Pyraclostrobin-d6 (P840402). Isotope labelled Pyraclostrobin is a fungicide for use in seed grass and food crops.<br>References Gyldenkaerne, S., et al.: Pestic Sci., 55, 1210 (1999), Pennington, D., et al.: Environ. Sci. Technol., 39, 1119 (2005), Wang, S., et al.: Food Control., 18, 731 (2007),<br></p>Fórmula:C16H12ClN3O3Cor e Forma:NeatPeso molecular:329.74Nitrefazole
CAS:Produto Controlado<p>Applications Nitrefazole is a nitroimidazole derivative with the ability to inhibit aldehyde dehydrogenase, and enzyme crucial to the metabolism of alcohol. This compound is suitable for aldehyde dehydrogenase (ALDH) related research.<br>References Klink, R. et al.: Arzneimittelforschung., 35, 1220 (1985); Koda L. et al.: Life Sci., 35, 1659 (1984);<br></p>Fórmula:C10H8N4O4Cor e Forma:Light Yellow To YellowPeso molecular:248.195-Mercapto-1H-1,2,3-triazole Sodium Salt
CAS:Produto Controlado<p>Applications 5-Mercapto-1H-1,2,3-triazole Sodium Salt is used as a reactant in the preparation of cephem derivatives as anti-Helicobacter pylori agents in relation to lability towards β-lactamase and potential for causing diarrhea.<br>References Yoshida, Y., et al.: Bioorg. Med. Chem., 8, 2317 (2000);<br></p>Fórmula:C2H2N3NaSCor e Forma:NeatPeso molecular:123.111-Methyl-4-nitroimidazole
CAS:Produto Controlado<p>Applications 1-Methyl-4-nitroimidazole is a moiety of Azathioprine (A803350) and is predicted to have mutagenic potential.<br>References Rosenkranz, H. S., et al.: Mutat. Res-Fund. Mol. M., 251, 157 (1991); Kelly, G. E., et al.: Photochem. Photobiol., 49, 59 (1989)<br></p>Fórmula:C4H5N3O2Cor e Forma:White To Light YellowPeso molecular:127.12-Methylbenzothiazole-6-carboxylic Acid (~90%)
CAS:Produto Controlado<p>Applications 2-Methylbenzothiazole-6-carboxylic Acid (~90%) is a useful research chemical, a reagent for the synthetic studies on fungicidal agents.<br>References Saikachi, H., et al.: Yakugaku Zasshi, 78, 376 (1958); Bosco, M., et al.: Annali di Chimica, 58, 1148 (1968)<br></p>Fórmula:C9H7NO2SPureza:~90%Cor e Forma:NeatPeso molecular:193.22(AlphaE)-2-[(6-Chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)benzeneacetic Acid Methyl Ester
CAS:Produto Controlado<p>Applications (αE)-2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)benzeneacetic Acid Methyl Ester is an intermediate in the synthesis of Azoxystrobin (A965150), an strobilurin fungicide.<br></p>Fórmula:C15H13ClN2O4Cor e Forma:NeatPeso molecular:320.73[1,1'-Biphenyl]-4-yl(phenyl)(1-trityl-1H-imidazol-5-yl)methanol
Produto Controlado<p>Applications [1,1'-Biphenyl]-4-yl(phenyl)(1-trityl-1H-imidazol-5-yl)methanol is an intermediate in synthesizing 2-Biphenylyl Sulfate-d5 Potassium Salt (B397897), which is the isotope labelled analog of 2-Biphenylyl Sulfate Potassium Salt. 2-Biphenylyl Sulfate Potassium Salt is a derivative of 2-Phenylphenol (P335870). 2-Phenylphenol is a agriculture fungicide and is no longer used as a food additive.<br>References Scheuhly, W., et al.: Chem. Biol., 18, 1053 (2011); Singh, H.P., et al.: Food. Chem. Toxicol., 48, 1040 (2010); Gouin, T., et al.: Envro. Pollu., 165, 208 (2012);<br></p>Fórmula:C41H32N2OCor e Forma:NeatPeso molecular:568.706Levofloxacin
CAS:<p>Levofloxacin is a fluoroquinolone antibiotic with a mode of action that inhibits bacterial DNA gyrase and topoisomerase IV. It is used for treating bacterial infections like pneumonia and urinary tract infections.</p>Fórmula:C18H20FN3O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:361.37 g/molBeauvericin
CAS:<p>Beauvericin is a cyclic peptide that is isolated from the fungus Fusarium. It has been shown to have antimicrobial activity against bacteria, as well as a variety of other biological properties. Beauvericin has been shown to inhibit mitochondrial membrane potential and induce toxicity in some animal models. Beauvericin also inhibits protein synthesis and causes cell death by inhibiting DNA polymerase activity. This compound is active against cancer cells, including HL-60 cells, which are derived from human lymphocytes and are used as a model for leukemia. Beauvericin can be extracted from an ETOA extract of the fungus Fusarium oxysporum; this extract has shown anti-cancer effects in vitro assays.</p>Fórmula:C45H57N3O9Pureza:Min. 95%Peso molecular:783.95 g/mol2-Methyl-4-isothiazolin-3-one
CAS:Produto Controlado<p>2-Methyl-4-isothiazolin-3-one or MIT is a powerful antimicrobial and antifungal agent which is widely used in personal care products. It is also used in industrial applications as a preservative and antifouling agent.</p>Fórmula:C4H5NOSPureza:Min. 96%Cor e Forma:Yellow PowderPeso molecular:115.15 g/molAureothin
CAS:<p>Aureothin is a bioactive compound, classified as a polyketide antibiotic, which is derived from the culture of the bacterium Streptomyces thioluteus. This compound operates primarily through the inhibition of protein synthesis by interfering with the aminoacylation of tRNA with specific amino acids. Its mode of action disrupts cellular protein synthesis, which is essential for cell growth and function, leading to its potent antibacterial and antifungal activities.</p>Fórmula:C22H23NO6Pureza:Min. 95%Cor e Forma:PowderPeso molecular:397.42 g/molCaerulomycin A
CAS:<p>Caerulomycin A is a bioactive compound classified as a natural broad-spectrum antibiotic, which is derived from various Streptomyces species found in soil. Its mode of action involves inhibiting fungal and bacterial growth by interfering with essential cellular processes, effectively curbing the proliferation of pathogenic microorganisms. This potent molecule achieves its effects by binding to specific cellular targets, thereby disrupting cell wall synthesis and other critical metabolic pathways.</p>Fórmula:C12H11N3O2Pureza:Min. 95%Peso molecular:229.23 g/molSordarin sodium salt
CAS:<p>Sordarin sodium salt is an antifungal agent, characterized as a semisynthetic derivative produced from the fermentation products of filamentous fungi, specifically belonging to the phylum Ascomycota. This compound exerts its effects by selectively inhibiting fungal protein synthesis. It achieves this by obstructing the function of elongation factor 2 (EF-2), an essential component of fungal ribosomal activity, thereby disrupting the translational elongation step of protein synthesis.</p>Fórmula:C27H39NaO8Pureza:Min. 95%Peso molecular:514.58 g/molFilipin III
CAS:<p>Filipin III is a polyene macrolide antibiotic, which is extracted from Streptomyces filipinensis. Known for its unique mode of action, Filipin III interferes with cholesterol-rich membranes by binding to ergosterol and cholesterol. This interaction disrupts the membrane structure, altering membrane permeability and ultimately affecting cell viability.</p>Pureza:Min. 95%Naftifine N-Oxide
CAS:<p>Naftifine N-Oxide is an antifungal agent, which is derived from synthetic chemical processes. Its structure is based on the modification of the known antifungal, naftifine, by introducing an N-oxide functional group, which may enhance certain pharmacokinetic properties. As a synthetic derivative, Naftifine N-Oxide is specifically designed to interfere with the biosynthesis of ergosterol, an essential component of fungal cell membranes. By inhibiting squalene epoxidase, an enzyme crucial to the ergosterol pathway, Naftifine N-Oxide effectively disrupts the development and maintenance of the fungal cell membrane, compromising cell integrity and leading to antifungal activity.</p>Fórmula:C21H21NOPureza:Min. 95%Peso molecular:303.4 g/molNeoaureothin
CAS:<p>Neoaureothin is a natural antibiotic product, which is derived from marine actinomycetes with a complex polyketide structure. Its mode of action involves the inhibition of bacterial protein synthesis by binding selectively to the ribosomal subunits, thereby obstructing the translation process in susceptible microbial strains. The specificity of its action allows it to target a broad spectrum of Gram-positive bacteria while presenting a lower risk of resistance development compared to traditional antibiotics.</p>Fórmula:C28H31NO6Pureza:Min. 95%Peso molecular:477.5 g/mol21-Norrapamycin
CAS:<p>21-Norrapamycin is a macrocyclic lactone antibiotic, which is derived from the bacterium Streptomyces hygroscopicus. Its chemical structure is closely related to that of rapamycin, a well-known immunosuppressant. The mode of action of 21-Norrapamycin involves the inhibition of the mechanistic target of rapamycin (mTOR) signaling pathway. By binding to the FK506-binding protein 12 (FKBP12), it forms a complex that then inhibits mTOR, a crucial regulator of cell growth, proliferation, and survival.</p>Fórmula:C50H77NO13Pureza:Min. 95%Peso molecular:900.1 g/molZelkovamycin
CAS:<p>Zelkovamycin is a novel antibacterial compound isolated from endophytic microorganisms, specifically Streptomyces sp. Endophytes are bacteria or fungi that reside within plant tissues, forming symbiotic relationships and often producing bioactive metabolites. The mode of action of Zelkovamycin involves the inhibition of bacterial cell wall synthesis, interfering with the biosynthesis pathways essential for maintaining the structural integrity and function of bacterial cell walls, particularly in Gram-positive strains.</p>Fórmula:C36H45N9O9SPureza:Min. 95%Cor e Forma:PowderPeso molecular:779.86 g/molPropiconazole
CAS:<p>Propiconazole is a triazole fungicide with action on fungal cell membranes by inhibiting ergosterol biosynthesis and is used for controlling fungal diseases in crops and turf.</p>Fórmula:C15H17Cl2N3O2Pureza:Min. 95%Cor e Forma:Clear LiquidPeso molecular:342.22 g/molMalformin C
CAS:<p>Malformin C is a cyclic pentapeptide, which is a secondary metabolite derived from certain strains of the fungus Aspergillus. Its mode of action involves disrupting cellular processes by interfering with cell division. Specifically, it is thought to affect mitotic spindle formation, leading to abnormal cell cycle progression.</p>Fórmula:C23H39N5O5S2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:529.72 g/molMiconazole
CAS:<p>Anti-fungal; sterol 14α-demethylase inhibitor</p>Fórmula:C18H14Cl4N2OPureza:Min. 95 Area-%Cor e Forma:White Off-White PowderPeso molecular:416.13 g/mol41-Oxo-rapamycin
CAS:<p>41-Oxo-rapamycin is a synthetic derivative of rapamycin, which is a macrocyclic lactone. It is derived from Streptomyces hygroscopicus, a gram-positive bacterium known for producing various bioactive compounds. The mode of action of 41-Oxo-rapamycin involves binding to the FK506-binding protein (FKBP12), forming a complex that subsequently inhibits the mammalian target of rapamycin (mTOR) pathway. This inhibition results in the suppression of T-cell proliferation and modulation of immune responses.</p>Fórmula:C51H77NO13Pureza:Min. 95%Peso molecular:912.2 g/molHexamide
CAS:<p>Hexamide is a protein inhibitor.</p>Fórmula:C13H17NOCor e Forma:SolidPeso molecular:203.28SSF-109
CAS:<p>SSF-109 is a broad-spectrum fungicide, has protective activity against plant disease.</p>Fórmula:C15H18ClN3OPureza:98%Cor e Forma:SolidPeso molecular:291.78Kayahope
CAS:<p>Kayahope is a novel antifungals.</p>Fórmula:C15H14ClNO3SPureza:98%Cor e Forma:SolidPeso molecular:323.79Fenhexamid
CAS:<p>Fenhexamid (Elevate), a sterol biosynthesis inhibitor, shows antifungal activity against the plant pathogenic fungus.</p>Fórmula:C14H17Cl2NO2Pureza:99.56%Cor e Forma:SolidPeso molecular:302.20Fosravuconazole
CAS:<p>Fosravuconazole is a ravuconazole prodrug. It has antifungal activity.</p>Fórmula:C23H20F2N5O5PSPureza:98%Cor e Forma:SolidPeso molecular:547.47Prochloraz
CAS:<p>Prochloraz: broad-spectrum imidazole fungicide; blocks placental aromatase (IC50=40nM), estrogen/androgen receptors; activates aryl hydrocarbon receptors.</p>Fórmula:C15H16Cl3N3O2Pureza:99.75% - 99.79%Cor e Forma:Colorless SolidPeso molecular:376.67Antifungal agent 67
CAS:<p>Compound 9 (Antifungal agent 67), an imidazole class antifungal, exhibits efficacy against Candida and possesses a CC50 value of 33.6 μM in neonatal rat</p>Fórmula:C23H25ClN2O3Cor e Forma:SolidPeso molecular:412.91Fuberidazole
CAS:<p>Fuberidazole is an antifungal agent.</p>Fórmula:C11H8N2OPureza:98.95%Peso molecular:184.19Silthiofam
CAS:<p>Silthiofam effectively combats Ggt, a wheat take-all fungus, now widely used for control in China.</p>Fórmula:C13H21NOSSiPureza:98%Cor e Forma:SolidPeso molecular:267.46Fungicide4
CAS:<p>Fungicide4 exhibits the high activity against the P. infestans strain.</p>Fórmula:C14H11N3OCor e Forma:SolidPeso molecular:237.26Chitin synthase inhibitor 10
CAS:<p>Chitin Synthase Inhibitor 10: potent antifungal with 0.11 mM IC50, effective against resistant C. albicans and C. neoformans. Used in IFI research.</p>Fórmula:C24H23Br2N3O6Cor e Forma:SolidPeso molecular:609.26Isobellidifolin
CAS:<p>Isobellidifolin, a xanthone compound, serves as a free radical scavenger and antioxidant. It exhibits a potent antifungal effect.</p>Fórmula:C14H10O6Cor e Forma:SolidPeso molecular:274.23Cercosporamide
CAS:<p>Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor.</p>Fórmula:C16H13NO7Pureza:98%Cor e Forma:SolidPeso molecular:331.289-OxoOTrE
CAS:<p>9-OxoOTrE, made by oxidizing 9-HpOTrE, has antimicrobial effects on plant pathogens like bacteria and fungi.</p>Fórmula:C18H28O3Cor e Forma:SolidPeso molecular:292.41BHBM
CAS:<p>BHBM, an acylhydrazone antifungal, halts C. neoformans growth (MIC80 = 1 μg/ml) by blocking glucosylceramide synthesis.</p>Fórmula:C15H13BrN2O2Cor e Forma:SolidPeso molecular:333.18Ametoctradin
CAS:<p>Ametoctradin is a Qo-site inhibitor of mitochondrial respiratory complex III and is used in the study of oomycete diseases.</p>Fórmula:C15H25N5Pureza:99.65%Cor e Forma:SolidPeso molecular:275.39NB-598 hydrochloride
CAS:<p>NB-598 hydrochloride is a competitive squalene epoxidase (SE) inhibitor.</p>Fórmula:C27H32ClNOS2Pureza:98%Cor e Forma:SolidPeso molecular:486.13Antifungal agent 33
CAS:<p>Antifungal 33 (4e) strongly inhibits Candida albicans. MIC: 16 μg/ml; IC50: 0.19 μg/ml.</p>Fórmula:C21H14ClN5O3Cor e Forma:SolidPeso molecular:419.82Antifungal agent 22
CAS:<p>Orally active antifungal D16 (IC50: 0.5 μg/mL) passes blood-brain barrier, stable, low toxicity, targets C. neoformansH99 cells.</p>Fórmula:C21H26Cl3NOSCor e Forma:SolidPeso molecular:446.86P163-0892
CAS:<p>P163-0892: potent, specific antifungal for Cryptococcus; moderate blood-brain barrier penetration.</p>Fórmula:C19H20N2O3SCor e Forma:SolidPeso molecular:356.44
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