Antifúngicos
Os antifúngicos são compostos especificamente projetados para interromper, prevenir e eliminar o crescimento de fungos. Nesta categoria, você encontrará uma ampla variedade de agentes antifúngicos essenciais para pesquisa e aplicações terapêuticas. Esses compostos são cruciais no tratamento de infecções fúngicas e na prevenção de sua recorrência, tornando-os ferramentas vitais tanto em ambientes médicos quanto agrícolas. Pesquisadores e profissionais de saúde podem explorar inúmeros antifúngicos para entender seus mecanismos, otimizar sua eficácia e desenvolver novos tratamentos para combater cepas fúngicas resistentes. A extensa seleção de antifúngicos apoia os avanços contínuos na pesquisa sobre fungos e no desenvolvimento de terapias antifúngicas eficazes.
Foram encontrados 908 produtos de "Antifúngicos"
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CDA-IN-3
CAS:CDA-IN-3 (NCDI) is a chitin deacetylase (CDA) inhibitor with antiparasitic properties. It disrupts chitin metabolism in nematodes, increasing ROS levels within these organisms and causing cellular damage. CDA-IN-3 significantly inhibits all developmental stages of Caenorhabditis elegans and can be utilized in research focused on anti-infective applications.Fórmula:C16H27N3O3S2Cor e Forma:SolidPeso molecular:373.534GW461484A
CAS:GW461484A is a small molecule inhibitor targeting Candida albicans Yck2, exhibiting an IC50 of 0.11 µM. It has a MIC80 of 12.5 µM against C. albicans. GW461484A shows potential for research into fungal diseases, including drug-resistant Candida infections.Fórmula:C19H14FN3Cor e Forma:SolidPeso molecular:303.333Antifungal agent 17
Antifungal agent 17 showed good antifungal activity against B. cinerea (EC50: 2.86 μg/mL).Fórmula:C18H16Br2O2Cor e Forma:SolidPeso molecular:424.13SDH-IN-25
CAS:SDH-IN-25 is an SDH inhibitor with an IC50 of 4.82 mg/L, demonstrating broad-spectrum and potent antifungal activity. By binding to SDH amino acid residues (TRP173, TYR58, and ARG43), it mimics the action mode of the commercial fungicide flutolanil. SDH-IN-25 induces changes in hyphal morphology, disrupts respiratory metabolism by binding to complex II, generates reactive oxygen species (ROS), and affects mitochondrial membrane potential (MMP) in hyphae. This compound is utilized in agricultural disease control research.Fórmula:C19H15BrCl2N2O4Cor e Forma:SolidPeso molecular:486.143Pyriofenone
CAS:Pyriofenone (IKF-309) is an aryl phenyl ketone fungicide predominantly used to control powdery mildew on crops such as cereals, rice, fruit trees, and vegetables. It exhibits moderate efficacy against rice blast disease. Pyriofenone functions through prevention, residue activity, treatment, rainfastness, translaminar action, and fumigation.Fórmula:C18H20ClNO5Cor e Forma:SolidPeso molecular:365.81Chitin synthase inhibitor 12
Chitin synthase inhibitor 12: potent CHS blocker (IC50: 0.16 mM), broad-spectrum antifungal, effective against resistant strains. Useful in IFI research.Fórmula:C23H21ClFN3O5Cor e Forma:SolidPeso molecular:473.88ATPase-IN-5
CAS:ATPase-IN-5 (Compound 11) is an antifungal Pma1p (H+ -ATPase) inhibitor (IC50 = 12.7 μM) that inhibits the growth of Candida albicans and Saccharomyces cerevisiae.Fórmula:C10H10N4O3SPureza:99.19%Cor e Forma:SolidPeso molecular:266.28Chitin synthase inhibitor 7
Compound 9c, a chitin synthase inhibitor, has an IC50 of 0.37 nM and is useful for studying fungal infections.Fórmula:C24H25N3O5Cor e Forma:SolidPeso molecular:435.47EGFR-IN-133
CAS:EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.Fórmula:C27H29F2N7O3Cor e Forma:SolidPeso molecular:537.56CYP51-IN-7
CAS:CYP51-IN-7 (compound 1g) is an analogue of Fluconazole and serves as an effective antifungal agent. It exhibits inhibitory activity against Microsporum gypseum and Candida albicans, with MIC80 values of 62.5 ng/mL and 250 ng/mL, respectively.Fórmula:C21H21ClF2N4OPeso molecular:418.87HSP90-IN-9
HSP90-IN-9: potent HSP90 inhibitor, dose-dependent fungicide, impedes biofilm/morphology with FLC, reverses FLC resistance.Cor e Forma:SolidEthaboxam
CAS:Ethaboxam is a β-tubulin inhibitor and antifungal agent used against oomycete pathogens.Fórmula:C14H16N4OS2Pureza:99.37%Cor e Forma:SolidPeso molecular:320.43Chitin synthase inhibitor 8
Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal effects that can be used in studies related to fungal infectionsFórmula:C23H23N3O5Cor e Forma:SolidPeso molecular:421.45Antifungal agent 127
CAS:Antifungalagent 127 (Compound 6c) is an antifungal agent with potent inhibitory activity against Botrytis cinerea and Rhizoctonia solani.Fórmula:C13H12ClN3OCor e Forma:SolidPeso molecular:261.707CDA-IN-1
CAS:CDA-IN-1 (Compound vs#2-1) is an inhibitor of chitin deacetylase (CDA) that exhibits antifungal activity. By inhibiting fungal CDA activity, it activates plant immune responses and leads to the accumulation of reactive oxygen species (ROS), hindering fungal growth. At a concentration of 100 μM, CDA-IN-1 achieves inhibition rates of 86.9% on P. xanthii's PxCDA1 and 74.5% on PxCDA2. CDA-IN-1 is applicable in research on fungal plant diseases, such as cucumber powdery mildew and tomato gray mold.Fórmula:C15H14N2O6Cor e Forma:SolidPeso molecular:318.281(3R,6S)-Bassiatin
CAS:(3R,6S)-Bassiatin represents the enantiomeric form of the fungal metabolite known as bassiatin.Fórmula:C15H19NO3Cor e Forma:SolidPeso molecular:261.32HDAC-IN-87
CAS:HDAC-IN-87 (Compound XII6) is a non-selective HDAC inhibitor with pIC50 values of 6.9 for HDAC4 and 5.8 for HDAC6. It exhibits fungicidal activity against P. sorghi and P. pachyrhizi. The acute oral LD50 in both male and female rats is greater than 500 mg/kg.Fórmula:C13H7F5N4O2SCor e Forma:SolidPeso molecular:378.277Isopyrazam
CAS:Isopyrazam, a plant protection product, exhibits potent antifungal activity. When applied to crops, it effectively inhibits the growth of various plant pathogenic fungi, significantly enhancing both the yield and quality of the crops. This compound demonstrates exceptional disease resistance capabilities in agricultural applications.Fórmula:C20H23F2N3OCor e Forma:SolidPeso molecular:359.41FDU-PB-22
CAS:FDU-PB-22, a novel synthetic cannabinoid, undergoes rapid metabolism in human liver microsomes (HLM) with a half-life of 12.4 minutes.Fórmula:C26H18FNO2Cor e Forma:SolidPeso molecular:395.43Antifungal agent 12
Antifungal agent 12 is a new fluconazole-like compound that exhibits good antifungal effects.Fórmula:C20H16F3N7O2S2Cor e Forma:SolidPeso molecular:507.51VNI
CAS:VNI is an effective inhibitor of CYP51. It suppresses sterol synthesis in Trypanosoma cruzi, exhibiting anti-Trypanosoma cruzi activity.Fórmula:C26H19Cl2N5O2Cor e Forma:SolidPeso molecular:504.37(Z)-Lanoconazole
(Z)-Lanoconazole, an imidazole antifungal for dermatophytosis and onychomycosis, inhibits fungal ergosterol production.Fórmula:C14H10ClN3S2Cor e Forma:SolidPeso molecular:319.83CYP51-IN-14
CAS:CYP51-IN-14 (compound 1n), a derivative of Fluconazole, functions as an effective antifungal agent. This compound inhibits Microsporum gypseum and Candida albicans with a minimum inhibitory concentration (MIC80) of 1 μg/mL.Fórmula:C21H20Cl2F2N4OPeso molecular:453.31bc1 Complex-IN-1
CAS:Bc1 Complex-IN-1 (compound 12g) is a potent inhibitor of the bc1 complex, demonstrating fungicidal properties against cucumber downy mildew (CDM).Fórmula:C16H22N6O5S2Cor e Forma:SolidPeso molecular:442.513Chitin synthase inhibitor 6
Compound 9b inhibits CHS with an IC50 of 0.21 mM; it's a broad-spectrum antifungal, effective against resistant strains.Fórmula:C24H25N3O6Cor e Forma:SolidPeso molecular:451.47Antifungal agent 25
Antifungal agent 25: broad-spectrum, stable in vivo, effective against Candida albicans, including fluconazole-resistant strains.Cor e Forma:SolidBenzohydroxamic acid
CAS:Benzohydroxamic acid (BHA) is a chitin deacetylase (CDA) inhibitor with notable antifungal properties. It displays Ki values of 8.31 μM against Verticillium dahliae CDA and 9.83 μM against Puccinia striiformis f. sp. tritici CDA. BHA can restore the defense responses in infected host plants by upregulating the expression of defense-related genes, thereby reducing fungal growth and proliferation within the plants. It is applicable in the research of agricultural fungal diseases, such as cotton wilt and wheat stripe rust, caused by pathogens like Verticillium dahliae and Puccinia striiformis.Fórmula:C7H7NO2Cor e Forma:SolidPeso molecular:137.136Antifungal agent 42
Antifungal 42 blocks biofilm formation and inhibits C.albicans' CYP51.Fórmula:C22H20Cl2N4Se2Cor e Forma:SolidPeso molecular:569.25Antifungal agent 13
CAS:Antifungal agent 13 demonstrates significant antifungal activity against Sclerotinia sclerotiorum, achieving an EC50 of 1.25 mg/L.Fórmula:C21H16ClF3N4OCor e Forma:SolidPeso molecular:432.83Complex III-IN-1
Complex III-IN-1 inhibits complex III, has antifungal properties, and an EC50 of 18.53 mg/L against S. sclerotiorum.Fórmula:C14H20ClNO2S2Cor e Forma:SolidPeso molecular:333.9AnCDA-IN-1
CAS:AnCDA-IN-1 (Compound J075-4187) is an inhibitor of chitin deacetylase (CDA) exhibiting antifungal properties. It possesses an IC50 of 4.24 μM against A. nidulans AnCDA. The compound demonstrates a minimum inhibitory concentration (MIC) of 260 μg/mL and a minimum fungicidal concentration (MFC) of 520 μg/mL for food spoilage fungi and plant pathogenic fungi. AnCDA-IN-1 is applicable for research in the antifungal domain.Fórmula:C16H13ClN4O2Cor e Forma:SolidPeso molecular:328.753Griseofulvic Acid
CAS:Griseofulvic Acid ((±)-Griseofulvic acid) is a metabolite of the antifungal agent Griseofulvin. It induces protein aggregation and tubulin polymerization in cell-free assays.Fórmula:C16H15ClO6Peso molecular:338.74Complex III-IN-2
Complex III-IN-2 inhibits complex III, with antifungal EC50: 29.31 mg/L vs R. solani, 29.98 mg/L vs S. sclerotiorum.Fórmula:C15H21ClN2O2SCor e Forma:SolidPeso molecular:328.86Chitin synthase inhibitor 5
Calpain Inhibitor-2, lipophilic, inhibits calpain; shows anti-proliferative effects on melanoma, PC-3 cells; blocks 80% DU-145 cell invasion.Fórmula:C23H22BrN3O5Cor e Forma:SolidPeso molecular:500.34Antifungal agent 134
CAS:Antifungalagent 134 (Compound B13) is an antifungal agent effective against Botrytis cinerea, Alternaria solani, Fusarium graminearum, Rhizoctonia solani, Colletotrichum orbiculare, and Alternaria alternata with EC50 values of 3.24, 1.89, 1.70, 0.36, 4.27, and 1.50 μg/mL, respectively. It disrupts the fungal cell membranes and mitochondria, leading to substantial accumulation of reactive oxygen species (ROS). Additionally, Antifungalagent 134 exhibits significant herbicidal activity on field weeds such as Amaranthus retroflexus L and Abutilon theophrasti Medicus, and is applicable in crop disease and field weed research.Fórmula:C18H12F4N2O4Cor e Forma:SolidPeso molecular:396.29RMG8-8
RMG8-8 shows the excellent efficacy against C. neoformans (1.56 μg/mL).Fórmula:C41H78N8O5Cor e Forma:SolidPeso molecular:763.11Antifungal agent 39
CAS:Antifungal agent 39 (Compound 9h) is a broad-spectrum antifungal agent.Fórmula:C23H22ClN3O5Cor e Forma:SolidPeso molecular:455.89Wikstrol A
CAS:Wikstrol A: antifungal, anti-mitotic, anti-HIV agent with various IC50/MDC values (67.8-131 µM) and deforms P. oryzae mycelia.Fórmula:C30H22O10Cor e Forma:SolidPeso molecular:542.49Chitin synthase inhibitor 9
CHS inhibitor 9: a broad-spectrum antifungal for studying fungal infections.Fórmula:C24H25N3O6Cor e Forma:SolidPeso molecular:451.47D75-4590
CAS:D75-4590, a β-1,6-Glucan synthetase inhibitor, combats fungal infections by targeting cell walls.Fórmula:C21H27N5Pureza:98.56% - 98.85%Cor e Forma:SolidPeso molecular:349.47Ref: TM-T61194
5mg39,00€1mL*10mM (DMSO)46,00€10mg62,00€25mg122,00€50mg187,00€100mg269,00€200mg358,00€4-Hydroxyvoriconazole
CAS:Metabolite of voriconazole; sterol 14?-demethylase inhibitorPureza:Min. 95%Tetraconazole
CAS:Tetraconazole is an agent of pesticides.Fórmula:C13H11Cl2F4N3OCor e Forma:Liquid ViscousPeso molecular:372.14Pam2CSK4 TFA
Pam2CSK4 TFA (PUL-042 TFA) is a potent dual agonist of TLR2 and TLR6, a peptide that mimics bacterial lipoproteins.Pam2CSK4 TFA promotes platelet aggregation, and can be used to study the effects of lipoproteins on the periodontium.Fórmula:C67H127F3N10O14SPureza:99.90%Cor e Forma:SoildPeso molecular:1385.842,7-Dihydroxynaphthalene
CAS:2,7-Dihydroxynaphthalene is a useful organic compound for research related to life sciences. The catalog number is T67338 and the CAS number is 582-17-2.Fórmula:C10H8O2Cor e Forma:SolidPeso molecular:160.17Rhizocticin A
CAS:Rhizocticin A is a potential inhibitor of threonine synthase.Fórmula:C11H22N5O6PPureza:98%Cor e Forma:SolidPeso molecular:351.3Terconazole
CAS:Terconazole is an azole antifungal agent with action on fungal cell membranes by inhibiting ergosterol biosynthesis and is used for treating vaginal yeast infections.
Fórmula:C26H31Cl2N5O3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:532.46 g/molAmphotericin A
CAS:Amphotericin A is a polyene macrolide antibiotic, which is derived primarily from the soil bacterium *Streptomyces nodosus*. This compound functions by binding to ergosterol, an essential component of fungal cell membranes. This binding creates pores in the membrane, increasing its permeability and ultimately leading to cell death. Unlike its more widely used counterpart Amphotericin B, Amphotericin A is less frequently utilized but is critical in the study and understanding of antifungal activity.
Fórmula:C47H75NO17Pureza:Min. 95%Peso molecular:926.09 g/molCiclopirox olamine - Bio-X ™
CAS:Ciclopirox is a broad-spectrum antifungal agent that is used to treat onychomycosis of fingernails and toenails in immunocomprised patients. Ciclopirox has been shown to work by binding to polyvalent metal cations such Al3+ and Fe3+. These cations interfere with cellular processes including mitochondrial electron transport and energy synthesis by inhibiting numerous enzymes, including cytochromes. Additionally, the plasma membrane of fungi appears to be altered by ciclopirox as well, leading to the disorder of internal structures.
Fórmula:C12H17NO2•C2H7NOPureza:Min. 95%Cor e Forma:PowderPeso molecular:268.35 g/molVoriconazole - Bio-X ™
CAS:Voriconazole is a synthetic, lipophilic molecule that is used in the treatment of fungal infections. Voriconazole binds to ergosterol which is the major sterol in the cell wall of fungi and inhibits its synthesis, leading to cell death. This drug binds to the enzyme 14α-demethylase allowing the conversion of lanosterol into ergosterol. As a result, this binding leads to the inhibition of ergosterol synthesis, as well as other sterols that are necessary for fungal growth (e.g., squalene).
Fórmula:C16H14F3N5OPureza:Min. 95%Cor e Forma:PowderPeso molecular:349.31 g/molDelafloxacin
CAS:Delafloxacin is a fluoroquinolone antibiotic with action on bacterial DNA gyrase and topoisomerase IV and is used for treating acute bacterial skin and skin structure infections.
Fórmula:C18H12ClF3N4O4Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:440.76 g/mol
