Antifúngicos

Y12196, a newly developed succinate dehydrogenase inhibitor (SDHI), demonstrates potent fungicidal effects specifically targeting F. graminearum.

Antifungal agent 82 (compound G34) demonstrates outstanding in vitro antifungal efficacy against Valsa mali, exhibiting an EC50 value of 0.57 μg/mL, and has

Akrobomycin is an anthracycline antibiotic.

Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 µg/ml and Ki of 0.8 µM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 µg/ml. It also suppresses antigen-induced β-hexosaminidase release in IgE-sensitized RBL-2H3 mast cells (IC50= 25.1 µM) and shows cytotoxicity against A549 non-small cell lung cancer cells with an LC50 of 35.27 µg/ml. Furthermore, thujopsene causes mortality in mites D. farinae and T. putrescentiae, with LC50s of 9.82 and 10.92 µg/cm2, respectively.

Antifungal agent 78 (compound 25am) exhibits potent activity, with an EC50 of 13.46 μM against Fusarium graminearum [1].

Restricticin is used as a naturally-occurring antifungal agent which contains triene, pyran and glycine ester functionalities.

WAY-324208 shows antifungal properties against S. dermatitidis (skin-infecting fungi), with activity against other fungi to be explored.

Gamma-Glutamyl Transferase-IN-2 (compound 4dq), a β-carboline 1-hydrazide inhibitor, exhibits both antifungal and antibacterial properties by targeting

Furmecyclox is a biochemical.

Rabdoserrin A is a diterpenoid. Rabdoserrin A has antifungal activity [1] [2] .

Triclopyricarb (SYP-7017), a strobilurin fungicide, controls crop diseases, halting mycelial growth (EC50: 0.006-0.047 μg/mL).

6-O-Methylreticulol, an isocoumarin derivative and fungal metabolite identified in S. mobaraensis, exhibits the characteristic structural features of its class.

Antifungal agent 15 exhibits remarkable potency, with EC50 values of 0.52 and 0.50 μg/mL against S. sclerotiorum and B. cinerea, respectively.

(E)-Ajoene, found in A. sativum, fights bacteria (MICs: 10-500 μg/ml), fungi (MICs: 15-50 μg/ml), cancer cells, and protects neurons in ischemia.

Sodium formate has antiviral and antifungal properties, can inhibit carbonic anhydrase, and can also be used as a biochemical buffer.

N-563 promotes resistance to Candida albicans infection in mice

Metalaxyl (CGA 48988) is a fungicide that inhibits protein synthesis in fungi and interferes with skeletal development in zebrafish embryos.