Antimicrobianos

<p>Herbicidin E is a potent herbicidal compound, derived from blue-green algae, with a biochemical mode of action focused on inhibiting photosynthetic electron transport. It effectively disrupts the photosynthetic process by binding to specific sites within the chloroplasts of target plants, impairing their ability to convert light energy into chemical energy. This leads to a depletion of essential energy reserves, resulting in the controlled demise of the plant.</p>

<p>Orbifloxacin is a fluoroquinolone antibiotic with action on bacterial DNA gyrase and topoisomerase IV and is used for treating bacterial infections in veterinary medicine.</p>

<p>Azithromycin N-oxide is a macrolide antibiotic derivative and is used for research purposes. Its mode of action is similar to azithromycin.</p>

<p>Meropenem trihydrate has broad spectrum activity against Gram-positive and Gram-negative bacteria, as well as, some mycoplasma species. It inhibits cell wall synthesis by binding to bacterial penicillin-binding proteins (PBP), which impairs cell wall integrity, induces the formation of reactive oxygen species, and inhibits macromolecular synthesis in bacteria. It can be used to prevent bacterial growth after being exposed to meropenem through fluorescence imaging of human blood plasma. Meropenem trihydrate research studies showed a reduction of the allergen levels in patients with respiratory allergies or asthma, specifically dust mites, cockroaches, animal dander, pollen grains, etc. by inhibit allergen-induced sensitization of mast cells.</p>

<p>Polymyxin B is a sulfonamide antibiotic with broad spectrum of activity against Gram-negative bacteria. It binds to the bacterial membrane, causing an increase in the cell’s permeability and thus leading to cell death. A study on human neutrophils showed that polymyxin B reduces the expression of neomycin sulfate through inhibition of protein synthesis, which leads to cell death by lysosomal enzyme release. This antibiotic has been shown to be effective on clostridium perfringens, where it inhibits bacterial growth and leads to hypersensitivity reactions in some patients.</p>

<p>Paromomycin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating intestinal infections and leishmaniasis.</p>

<p>Cephalothin sodium is a first-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating bacterial infections such as respiratory tract infections and skin infections.</p>

Versalide is a synthetic musk compound with action as a fragrance ingredient and is used for adding scent to perfumes and personal care products.

<p>Griselimycin is an antibiotic, which is derived from the bacterial genus *Streptomyces*. This compound exhibits its mode of action by targeting bacterial protein synthesis, specifically binding to the DNA polymerase sliding clamp, thereby inhibiting replication and cell division in a range of bacterial pathogens. Griselimycin has been the focus of renewed scientific interest due to its potent activity against Mycobacterium tuberculosis, including multi-drug-resistant strains. The compound’s unique mode of action makes it a promising candidate for further development in the treatment of tuberculosis and potentially other bacterial infections that have developed resistance to more commonly used antibiotics. Advances in understanding its biosynthesis have facilitated semi-synthetic modifications, potentially enhancing its pharmacokinetic properties and antimicrobial spectrum. The applications of Griselimycin extend to research contexts where understanding resistance mechanisms and novel antibiotic development are critical. Continued exploration of this compound may contribute significantly to addressing the global challenge of antibiotic resistance.</p>

<p>Omadacycline tosylate is a aminomethylcycline antibiotic with action on bacterial protein synthesis inhibition and is used for treating community-acquired bacterial pneumonia and skin infections.</p>

<p>Gatifloxacin is an antibiotic, which is a synthetic fluoroquinolone with broad-spectrum antibacterial activity. Its source lies in its chemical synthesis, designed to inhibit bacterial enzymes necessary for DNA replication. The mode of action involves the inhibition of bacterial DNA gyrase and topoisomerase IV, which are critical enzymes for bacterial DNA replication, transcription, and repair. This dual inhibitory mechanism disrupts bacterial cell division and growth, leading to the eventual eradication of susceptible bacterial strains.</p>

<p>Gentamycin sulphate is the salt form of the broad-spectrum antibiotic gentamycin (a.k.a. gentamicin). Gentamycin is active against clinically relevant bacteria, such as: Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Serratia marcescens, and is used to fight infections from Staphylococcus, Citrobacter and Enterobacteriaceae species. Gentamycin is a natural mixture of four congeners, one of which is gentamicin C2a. Gentamycin has been included in biomedical implantable materials, such as, bone grafts, to reduce the risk of infection.</p>

<p>Meayamycin B is a synthetic macrolide, a complex organic compound, which is derived from the natural product FR901464. This compound functions as an antagonist of the spliceosome, the cellular machinery responsible for pre-mRNA splicing. By binding to specific components of the spliceosome, Meayamycin B disrupts the splicing process, leading to the accumulation of unspliced precursor mRNA. This action effectively induces apoptosis in cancer cells, making it a notable candidate for cancer therapy research.</p>

<p>Ethambutol is an antimicrobial compound, specifically an antitubercular agent, which is a synthetic derivative of ethylenediamine. It is classified as a bacteriostatic agent that primarily targets Mycobacterium tuberculosis. The mode of action of Ethambutol involves the inhibition of arabinosyl transferases, enzymes essential for the polymerization of arabinogalactan, a critical component of the mycobacterial cell wall. By disrupting cell wall biosynthesis, Ethambutol effectively hampers the growth and proliferation of the bacteria.</p>

<p>Antibiotic; anti-protozoal; anti-helmintic; protein synthesis inhibitor</p>

<p>Antibiotic; inhibits bacterial mRNA translation; inhibits monoamine oxidase</p>

<p>CCR-5 chemokine receptor antagonist; inhibits HIV entry via gp120 protein</p>

(S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine ia slo known as PA-824. An anti-tuberculosis drug that affects both replicating and non-replicating Mycobacterium tuberculosis via cell wall inhibition and respiratory poisoning..

<p>Validamycin A is an antibiotic and fungicide with action as a trehalase inhibitor, disrupting carbohydrate metabolism in fungi and is used for controlling fungal diseases like sheath blight in rice and damping-off in cucumbers.</p>

<p>Clotrimazole is an azole antifungal medication with action on fungal cell membrane disruption and is used for treating fungal infections like athlete's foot, ringworm, and vaginal yeast infections.</p>