Antimicrobianos

<p>Fementation intermediate of Oritavancin</p>

<p>Netropsin dihydrochloride is a pyrrole-amidine antibiotic with action on AT-rich sequences of DNA to inhibit replication and is used for research on DNA-binding properties and antiviral activity.</p>

<p>Cefacetrile is a first-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating bacterial infections in humans and animals.</p>

<p>Torezolid (Tedizolid) is an oxazolidinone antibiotic with action on bacterial protein synthesis by binding to the 50S ribosomal subunit and is used for treating acute bacterial skin and skin structure infections.</p>

<p>Cefpodoxime proxetil is a prodrug of cefpodoxime with action on bacterial cell wall synthesis and is used for treating bacterial infections such as pneumonia, bronchitis, and gonorrhea.</p>

<p>Griselimycin is an antibiotic, which is derived from the bacterial genus *Streptomyces*. This compound exhibits its mode of action by targeting bacterial protein synthesis, specifically binding to the DNA polymerase sliding clamp, thereby inhibiting replication and cell division in a range of bacterial pathogens. Griselimycin has been the focus of renewed scientific interest due to its potent activity against Mycobacterium tuberculosis, including multi-drug-resistant strains. The compound’s unique mode of action makes it a promising candidate for further development in the treatment of tuberculosis and potentially other bacterial infections that have developed resistance to more commonly used antibiotics. Advances in understanding its biosynthesis have facilitated semi-synthetic modifications, potentially enhancing its pharmacokinetic properties and antimicrobial spectrum. The applications of Griselimycin extend to research contexts where understanding resistance mechanisms and novel antibiotic development are critical. Continued exploration of this compound may contribute significantly to addressing the global challenge of antibiotic resistance.</p>

<p>Natural diterpene; anti-microbial</p>

<p>Gamithromycin is a macrolide antibiotic with action on bacterial protein synthesis and is used for treating respiratory infections in cattle, pigs, and sheep.</p>

<p>HIV-1 Integrase Inhibitor is an antiretroviral compound with a mode of action that blocks the viral enzyme integrase, preventing the integration of viral DNA into the host genome. It is used for the treatment of HIV infection.</p>

<p>Rifapentine is a rifamycin antibiotic with action on bacterial RNA polymerase to inhibit transcription and is used for treating active and latent tuberculosis.</p>

<p>Dihydrostreptomycin sesquisulfate, EP is an aminoglycoside antibiotic, structurally derived from Streptomyces griseus. This compound originates from microbial biosynthesis, a method which harnesses the natural antibiotic-producing capabilities of microbial cultures. The mode of action of dihydrostreptomycin sesquisulfate involves binding to the 30S subunit of bacterial ribosomes, which interrupts the process of protein synthesis, ultimately leading to bacterial cell death.</p>

<p>A fluoroquinolone antibiotic which inhibits nucleic acid synthesis by targeting the DNA gyrase and topoisomerase IV. This second-generation fluoroquinolone has a broad spectrum of action and is more effective against Gram-negative bacteria.</p>

<p>Orbifloxacin is a fluoroquinolone antibiotic with action on bacterial DNA gyrase and topoisomerase IV and is used for treating bacterial infections in veterinary medicine.</p>

Versalide is a synthetic musk compound with action as a fragrance ingredient and is used for adding scent to perfumes and personal care products.

<p>Pimodivir is a non-nucleoside-derived inhibitor of the polymerase basic protein 2 (PB2) subunit found in the polymerase complex of the influenza A virus. In general, pimodivir is indicated for the treatment of patients with severe influenza although knowledge about possible rise of resistance is not available.</p>

<p>Temocillin disodium is a beta-lactamase-resistant penicillin antibiotic with action on bacterial cell wall synthesis and is used for treating infections caused by multidrug-resistant gram-negative bacteria.</p>

<p>Inhibitor of protein synthesis; aminocyclitol class</p>

<p>Benethamine penicillin is a beta-lactam antibiotic, which is a semi-synthetic derivative of penicillin. It is sourced from the modification of naturally occurring penicillin compounds, typically produced through the fermentation of Penicillium mold cultures. Benethamine penicillin operates by inhibiting bacterial cell wall synthesis. It targets the penicillin-binding proteins within bacterial cell membranes, disrupting peptidoglycan cross-linking, which is essential for cell wall structural integrity. This leads to cell lysis and death in susceptible bacteria.</p>

<p>Herbicidin K is a naturally derived herbicide, known for its biological origin from microbial fermentation processes. It is primarily sourced from certain strains of Streptomyces, a genus of Gram-positive bacteria notable for their diverse secondary metabolites. The mode of action of Herbicidin K involves the inhibition of key enzymatic pathways within target plants, leading to the disruption of cellular functions and ultimately plant death. This selectivity is particularly effective against broadleaf weeds, providing a targeted approach to weed management.</p>

<p>Doxorubicin (DOX) is an antineoplastic chemotherapy drug used to treat breast, ovarian and pancreatic cancers. It is an antitumor antibiotic that inhibits DNA topoisomerase II. DOX interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. It also leads to the generation of reactive oxygen species (ROS), which further damage DNA as well as proteins and membranes. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance. Pegylated liposomal doxorubicin has also been developed to treat breast and ovarian cancers, myeloma, and HIV-related Kaposi’s sarcoma.</p>