Vitaminas

<p>Applications 1-O-Hexadecyl-sn-glycerol restores plasmalogen levels in Chinese hamster ovary (CHO) cells and human pulmonary arterial endothelial cells (PAEC). Plasmalogen may play a role in protecting animal cells against photosensitized killing.<br>References Zoeller, R., et al.: J. Biol. Chem., 263, 11590 (1988); Zoeller, R., et al.: Am. J. Physiol., 283, H671 (2002)<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications Used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.<br>References Lerche, C., et al.: Exp. Dermatol., 17, 972 (2008), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Gan, J., et al.: Chem. Res. Toxicol., 22, 690 (2009), Macejova, D., et al.: Toxicol. Lett., 184, 114 (2009), Chen, P., et al.: Toxicol. App. Pharmacol., 234, 143 (2009),<br></p>

<p>Applications 2-Phospho-L-ascorbic Acid Trisodium Salt is a long-lasting vitamin C derivative used in studies of gene repression. Maximizes the benefical properties of vitamins C for personal care and a main active ingredient in medicated cosmetics for whitening. Also, it is substrate in the chromoamperometric method to detect tungsten in water.<br>References Fuchihata, M.: Frag. J., 43, 64-68 (2015); Alvarado-Gamez, A. L., et al.: Sens., 15, 2232-2243 (2015);<br></p>

<p>Stability Temperature and Light Sensitive<br>Applications 3-Aminopropyl-24,25-dihydroxy Vitamin D3 is a derivative of Vitamin D3 (V676045), an important factor in maintaining bone health, and has also been associated with cardiovascular health in humans.<br>References Dawson-Hughes, B., et al.: 16, 713 (2005); Lee, J., et al: J. Am. Coll. Cardio., 52, 1949 (2008)<br></p>

<p>Applications HX 531 is a novel RXR antagonist used to enhance transactivation of PPARγ and ST 13 preadipocyte differentiation. Helps in the reduction of triglyceride content in white adipose tissue, skeletal muscle and liver.<br>References Yamauchi, T. et al.: J. Clin. Invest., 108, 1001 (2001);<br></p>

<p>Applications GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.<br>References Fowler, A.J., et. al.: J. Invest. Dermatol., 120, 246 (2003)<br></p>

<p>Applications A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb<br>References Huang, J.T., et al.: Nature, 400, 378 (1999), Wilson, T.M., et al.: J. Med. Chem., 43, 527 (2000), Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)<br></p>

<p>Applications Α hydroxylated metabolite of Vitamin D2 (V676040); a synthetic analog of Vitamin D.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matsuoka, M. et al.: J. Nutrit. Sci. Vitaminol., 35, 253 (1989); Jones, G. et al.: Arch. Biochem. Biophys., 202, 450 (1980); Goff, J. et al.: J. Nutrit., 112, 1387 (1982);<br></p>

<p>Applications SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays.<br>References Wang, Y., et al.: ACS Chem. Biol., 5, 1029 (2010); Wang, Y., et al.: PLoS One, 7, 1 (2012)<br></p>

<p>Applications SC-58236 is a highly selective and potent cyclooxygenase-2 inhibitor which has been shown to induce apoptosis in gastric cells via down-regulation of Akt and then release of cytochrome c. Its anti-inflammatory effects allows for potential use in therapy for inflammatory allergic diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fan, X.M. et al.: Digestion, 2, 75 (2006); Kim, S. et al.: Life Sci., 81, 863 (2007); Kim, S. et al.: J. Pharmacol. Exp. Therap., 313, 27 (2005);<br></p>

<p>Applications Isotope labelled d3; 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene-d3; (Vitamin K3), precursor to various types of Vitamin K. Used as a micronutrient for livestock and pet foods.<br>References Sakamoto, S., et al.: Anal. Bioanal. Chem., 396, 2955 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Hu, W., et al.: Anal. Biochem., 398, 245 (2010),<br></p>