Nucleosídeos
Foram encontrados 3569 produtos de "Nucleosídeos"
6-Amino-9-(1-deoxy-b-D-psicofuranosyl)purine
CAS:6-Amino-9-(1-deoxy-β-D-psicofuranosyl)purine (6APdP) is a nucleoside with potential chemotherapeutic activity. It has been shown to suppress the expression of genes that encode proteins involved in cell proliferation and differentiation, including suppressor genes. 6APdP is activated by methyladenosine monophosphate kinase and binds to the ribose hydroxyl group on RNA molecules. This molecule has been shown to inhibit hepatitis B virus replication and cancer cell growth in animal models. The hydrogen bonding interactions between 6APdP and the ribose hydroxyl group are stronger than those associated with ethylene diamine tetraacetic acid (EDTA). 6APdP is also an inhibitor of protein synthesis.Fórmula:C11H15N5O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:281.27 g/mol2-Amino-8-bromo-9-(b-D-ribofuranosyl)purine
CAS:2-Amino-8-bromo-9-(b-D-ribofuranosyl)purine is a modified nucleoside that inhibits viral DNA and RNA synthesis. It has antiviral properties against influenza, herpes simplex virus type 1, hepatitis B virus, and human immunodeficiency virus type 1. 2-Amino-8-bromo-9-(b-D-ribofuranosyl)purine has been shown to be effective in the treatment of cancers such as leukemia, lymphoma, and breast cancer. This drug is a novel nucleoside analogue that is used for cancer chemotherapy. 2-Amino 8 bromo 9 (b D ribofuranosyl) purine is not active against bacteria or fungi.Fórmula:C10H12BrN5O4Pureza:Min. 95%Peso molecular:346.14 g/mol3-Deazauridine-5'-triphosphate triethylamine salt
CAS:3-Deazauridine-5'-triphosphate triethylamine salt is a xanthosine analog that has been used as a biochemical reagent in animals and humans. It is postulated to be a potential cancer therapeutic agent because of its ability to inhibit DNA synthesis and cell division. 3-Deazauridine-5'-triphosphate triethylamine salt inhibits the biosynthesis of uridine in leukemic mice, hamster V79 cells, and mammalian cells. This drug inhibits the incorporation of uracil into RNA by competitive inhibition with respect to ATP. 3DATTP also inhibits the incorporation of thymidine into DNA by competitive inhibition with respect to dCTP.Fórmula:C10H16NO15P3Pureza:Min. 95%Peso molecular:483.15 g/mol8-Bromo-5'-o-(dimethyoxytrityl)-N2-(dimethyl-aminomethylidene)-2'-deoxyguanosine
CAS:8-Bromo-5'-O-(dimethyoxytrityl)-N2-(dimethyl-aminomethylidene)-2'-deoxyguanosine (8-Bromo-5'-O-(DMT)-dG) is a novel nucleoside that is synthesized by reacting 8-bromo-5'-O-(dimethyoxytrityl)-2'-deoxyguanosine with dimethylaminomethylidene. It has antiviral, anticancer, and ribonucleoside activities. 8-Bromo-5'-O-(DMT)-dG is used as a building block for the synthesis of oligonucleotides, phosphoramidites, and other modified nucleosides. 8-Bromo-5'-O-(DMT)-dG is currently being developed as an anticancer drug.Fórmula:C34H35BrN6O6Pureza:Min. 95%Peso molecular:703.6 g/mol2'-O-tert-Butyldimethylsilyl-5'-O-DMT-adenosine
CAS:2'-O-tert-Butyldimethylsilyl-5'-O-DMT-adenosine is a modified nucleoside that is used to synthesize oligonucleotides. It is a phosphoramidite, and can be used in the synthesis of DNA or RNA. 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-adenosine is an antiviral agent that has been shown to have anticancer activity in animal models. It has been shown to inhibit the production of tumor necrosis factor alpha (TNFα) and serum enzymes, such as dismutase activity, in mice with lung cancer. This drug also has a toxic effect on respiratory system cells, which may be due to its ability to induce apoptosis.
Pureza:Min. 95%1-(5-o-(Dimethoxytrityl)-β-D-2-deoxyribofuranosyl)-3-nitropyrrole
CAS:1-(5-O-(dimethoxytrityl)-β-D-2-deoxyribofuranosyl)-3-nitropyrrole is a novel nucleoside phosphoramidite that has been modified to include an oxazole moiety. It is an antiviral and anticancer drug that inhibits the replication of DNA by binding to the enzyme DNA polymerase. 1-(5-O-(dimethoxytrityl)-β-D-2-deoxyribofuranosyl)-3-nitropyrrole is also a substrate for monophosphate, diphosphate, and triphosphate nucleotide kinases, which are enzymes that catalyze the phosphorylation of 5'-monophosphates. This nucleoside phosphoramidite can be used in the synthesis of oligonucleotides and modified oligonucleotides.Fórmula:C30H30N2O7Pureza:Min. 95%Peso molecular:530.6 g/mol5'-Fluoro-5'-deoxy-adenosine
CAS:5'-Fluoro-5'-deoxy-adenosine (FDA) is a fluorinated adenosine derivative that has been shown to regulate glucose levels in plasma. It has been shown to increase the uptake of glucose in cells and improve insulin sensitivity, which may be due to its ability to increase the production of nitric oxide. FDA is also thought to act as an antioxidant and may be useful for treating autoimmune diseases such as insulin resistance and type II diabetes.Fórmula:C10H12FN5O3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:269.23 g/mol5'-Hydrazino-5'-deoxyguanosine
CAS:5'-Hydrazino-5'-deoxyguanosine is a novel diphosphate nucleoside analog that has been shown to be an efficient activator of the anti-cancer enzyme ribonucleotide reductase. It is synthesized by reacting 5'-hydrazinouridine with hydroxylamine and then coupling with 5'-deoxyguanosine. The resulting product has been shown to inhibit DNA synthesis in vitro and in vivo, as well as to produce cytotoxic effects in human cancer cells. This compound also inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or
Fórmula:C10H15N7O4Pureza:Min. 95%Peso molecular:297.27 g/mol2'-Deoxy-5'-DMT-5-ethynyluridine 3'-CE phosphoramidite
CAS:2'-Deoxy-5'-DMT-5-ethynyluridine 3'-CE phosphoramidite is a nucleoside that is used as an activator for DNA synthesis. It has been shown to be effective against viruses such as HIV and herpes simplex virus. This compound also has anticancer properties. 2'-Deoxy-5'-DMT-5-ethynyluridine 3'-CE phosphoramidite binds to the viral RNA or DNA, displacing the natural phosphate group on the 5' end of the viral chain and preventing viral replication.Fórmula:C41H47H40O8Pureza:Min. 95%Peso molecular:708.12 g/mol2',3',5'-Tri-O-(p-chlorobenzoyl)-5-azacytidine
CAS:2',3',5'-Tri-O-(p-chlorobenzoyl)-5-azacytidine is a novel nucleoside phosphoramidite for the synthesis of DNA and RNA. It has been modified to be resistant to antiviral and anticancer agents, as well as to be an activator of monophosphate. 2',3',5'-Tri-O-(p-chlorobenzoyl)-5-azacytidine has high purity and quality, as well as being novel and modified.Fórmula:C29H21Cl3N4O8Pureza:Min. 95%Peso molecular:659.86 g/mol5-Bromo-2'-deoxyuridine-5'-triphosphate sodium salt
CAS:5-Bromo-2'-deoxyuridine-5'-triphosphate sodium salt is a modified nucleoside with antiviral properties. This drug inhibits the polymerase activity of reverse transcriptase and thus prevents the synthesis of DNA from RNA. 5-Bromo-2'-deoxyuridine-5'-triphosphate sodium salt has been shown to be effective against herpes viruses, influenza virus, and cytomegalovirus. This drug also prevents the replication of HIV.Fórmula:C9H14N2O14P3BrPureza:Min. 95%Peso molecular:547.04 g/molThymidylyl-(3'-5')-2'-deoxyadenosine ammonium salt
CAS:Thymidylyl-(3'-5')-2'-deoxyadenosine ammonium salt is a nucleoside that is a synthetic analog of thymidine. It has antiviral activity and is used in the synthesis of DNA and RNA. This product has shown to be effective against HIV, influenza, polio, herpes, and human papillomavirus. Thymidylyl-(3'-5')-2'-deoxyadenosine ammonium salt can also be used for the synthesis of phosphoramidites for oligonucleotide synthesis.Fórmula:C20H26N7O10P·NH3Pureza:Min. 95%Peso molecular:572.47 g/mol(-)-Adenosine 3'-monophosphate hydrate
CAS:Adenosine 3'-monophosphate hydrate is a nucleoside that is an important intermediate in the biosynthesis of DNA and RNA. It is a phosphodiesterase inhibitor, which prevents the breakdown of adenosine 3'-monophosphate (cAMP). This compound also has a role in various other metabolic pathways, such as the synthesis of purines. Adenosine 3'-monophosphate hydrate is used for preparing adenosylcobalamin and for studies on phosphodiesterases. The nature of this compound is determined by its chemical structure, including functional groups and sequences. Its modification includes the addition of phosphate groups to its ribose sugar moiety. Adenosine 3'-monophosphate hydrate has a molecular weight of 372.4 g/mol and optimum pH of 7-8.
The hybridization behavior and ph optimum are characteristic properties of this compound.Fórmula:C10H16N5O8PPureza:Min. 95%Peso molecular:365.24 g/molN6-Methyl-2'-O-methyladenosine 5'-monophosphate
N6-Methyl-2'-O-methyladenosine 5'-monophosphate (N6-MMAMP) is a nucleoside analogue that is used as an anticancer and antiviral agent. N6-MMAMP is a modified nucleoside that has been shown to be effective in the treatment of some cancers, such as leukemia. It also has antiviral properties and can be used to inhibit the replication of viruses such as human immunodeficiency virus type 1 (HIV). N6-MMAMP has been shown to have high purity and quality, making it an excellent choice for research purposes.Pureza:Min. 95%Kinetin riboside-5'-diphosphate sodium salt
Kinetin riboside-5'-diphosphate sodium salt is a synthetically modified nucleoside that is used as an activator for DNA synthesis and in the treatment of cancer. Kinetin riboside-5'-diphosphate sodium salt has been shown to have antiviral and anticancer effects, as well as being able to modify the activity of natural substances such as kinetin. This compound has been shown to inhibit tumor growth and reduce the size of some types of tumors in mice. It also inhibits viral replication by blocking viral RNA polymerase activity and inhibiting viral protein synthesis.Pureza:Min. 95%2'-Deoxy-2'-fluoroadenosine 5'-a-thiotriphosphate sodium salt
2'-Deoxy-2'-fluoroadenosine 5'-a-thiotriphosphate sodium salt (2'F-ATP) is a nucleoside analog that inhibits viral DNA polymerase and induces apoptosis in cancer cells. It is a novel, modified nucleotide that can be phosphorylated to 2'F-dATP, 2'F-AMP, or 2'F-GMP. The phosphate group in 2'F-ATP is replaced by a thiophosphate group, which increases the stability of the molecule and prevents it from being hydrolyzed by phosphatases. This makes it an effective activator for DNA synthesis reactions.Pureza:Min. 95%5,6-Dihydrothymidine
CAS:5,6-Dihydrothymidine is a hydroxylated thymidine analogue. It binds to the leukocyte antigen, which is found on many different types of cells. 5,6-Dihydrothymidine inhibits the replication of herpes simplex virus and can be used for diagnostic purposes. 5,6-Dihydrothymidine has been shown to have conformational properties that are similar to those of thymine, which allows it to bind to the template strand in DNA. This binding prevents the synthesis of messenger RNA from DNA. 5,6-Dihydrothymidine is also able to inhibit cell growth in culture and can be used as a cell culture medium supplement.Fórmula:C10H16N2O5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:244.24 g/molN4-Benzoyl-1-(a-D-mannopyranosyl)cytosine
N4-Benzoyl-1-(a-D-mannopyranosyl)cytosine is a modified deoxyribonucleoside that has antiviral and anticancer activities. It is a phosphoramidite, which can be converted to nucleosides using standard methods. N4-Benzoyl-1-(a-D-mannopyranosyl)cytosine is also an activator of the DNA polymerase enzyme and a high quality, novel anti-cancer drug.Fórmula:C17H19N3O7Pureza:Min. 95%Cor e Forma:White to off-white powder.Peso molecular:377.35 g/mol5'- O- [Bis(4- methoxyphenyl) phenylmethyl] - thymidine 3'- (hydrogen phosphonate) ,compd. with N, N- diethylethanamine (1:1)
CAS:5'- O- [Bis(4- methoxyphenyl) phenylmethyl] - thymidine 3'- (hydrogen phosphonate) ,compd. with N, N- diethylethanamine (1:1) is a novel monophosphate nucleoside that has been synthesized and evaluated in vitro as an anticancer agent. It inhibits the proliferation of various human tumor cell lines, including breast cancer cells. This compound is also active against HIV-1 virus but not against other viruses tested. 5'- O- [Bis(4- methoxyphenyl) phenylmethyl] - thymidine 3'- (hydrogen phosphonate) ,compd. with N, N- diethylethanamine (1:1), like other nucleosides, can be modified to suit particular needs and then used for therapeutic purposes.
Fórmula:C31H33N2O9PPureza:Min. 95%Peso molecular:608.58 g/mol6-Thioguanosine-5'-O-monophosphate sodium salt
CAS:6-Thioguanosine-5'-O-monophosphate sodium salt is a nucleotide that is an endogenous purine nucleotide. It has been shown to inhibit the phosphorylation of adenosine monophosphate (AMP) by camp levels, which leads to increased cellular levels of cAMP and cyclic adenosine 3',5'-monophosphate (cAMP). 6TGMP has been shown to inhibit the growth of cancer cells in vitro, including hepatoma cells and ovcar-3 cells. This nucleotide also inhibits the activity of several growth factors, such as insulin-like growth factor 1 (IGF1), transforming growth factor beta (TGFβ), and fibroblast growth factor 2 (FGF2).Fórmula:C10H13N5O7PS·xNaPureza:Min. 95%Cor e Forma:PowderPeso molecular:378.28 g/mol
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