Nucleosídeos

<p>3'-O-Azidomethyl 2'-deoxythymidine 5'-O-triphosphate sodium salt is a nucleoside that inhibits the replication of DNA and RNA. It has antiviral activity against influenza A and herpes simplex virus, as well as anticancer activity.</p>

N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine-3'-lcaa-CPG is an antiviral agent that inhibits the RNA polymerase of the virus. It is a phosphoramidite, which is a nucleoside with a phosphate group at the 5' position. N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine has been shown to be cytotoxic against cancer cells, and have less side effects than other nucleosides. It has been shown to selectively bind to ribonucleosides and deoxyribonucleosides and inhibit their synthesis by binding to the enzyme DNA polymerase. This stops DNA replication and causes cell death.

<p>A cap analog that can incorporated into mRNA</p>

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<p>Ribonucleosides, deoxyribonucleosides, and their activated forms (e.g., 4-methyl-2-(methylsulfanyl)-5-pyrimidinecarboxylic acid) are all important intermediates for the synthesis of DNA and RNA. Ribonucleosides are the key building blocks for the synthesis of DNA. They can be converted to nucleosides by removal of the ribose moiety. Deoxyribonucleosides are synthesized from ribonucleosides by removal of the hydroxyl group from carbon 2' position of ribose. The activated forms (e.g., 4-methyl-2-(methylsulfanyl)-5-pyrimidinecarboxylic acid) are useful in phosphoramidite chemistry as they have a free amine group on one side and a free sulfonyl group on the other side that can be used to react with a growing oligo or polyphosph</p>

<p>5,6-Dihydro-2'-deoxy-5'-O-DMT-uridine 3'-CE phosphoramidite is a modified nucleoside that is used as an activator in DNA synthesis. It has been shown to have anticancer properties by inhibiting the growth of cancer cells. 5,6-Dihydro-2'-deoxy-5'-O-DMT-uridine 3'-CE phosphoramidite is synthesized from the monophosphate form and can be used for the synthesis of both DNA and RNA.</p>

<p>2',5'-Dideoxy-2'-fluoro-5'-iodouridine is a modified nucleoside that is used in the synthesis of oligonucleotides. It can be used as an antiviral and anticancer agent. The drug has been shown to inhibit the replication of DNA and RNA, which may lead to cell death. 2',5'-Dideoxy-2'-fluoro-5'-iodouridine is also known for its high purity, novel structure and stability.</p>

<p>8-Aza-2'-deoxyadenosine is an anion that is cytotoxic to cells and can be activated to form a phosphate ester. It has been shown to have a higher cytotoxicity than adenosine in cell cultures, but is less effective in animal studies. 8-Aza-2'-deoxyadenosine has been shown to have a significant toxicity in rats and mice when administered at doses greater than 500 mg/kg body weight. The activation of 8-aza-2'-deoxyadenosine into the phosphate ester can be stereoselective. This activation has also been shown to cause enhancement of tumor growth inhibition.</p>

Adenosine 5'-difluoromethylene-5'-triphosphate triethylammonium salt is a novel nucleotide activator that has antiviral, anticancer, and ribonucleoside activities. This activator is a phosphoramidite monomer with an adenine base. The pharmaceutical industry uses this activator as a starting material in the synthesis of anticancer drugs and antiviral drugs. It is also used as a reagent in the production of modified DNA and RNA molecules for use in gene therapy and drug discovery.

2'-Deoxy-2'-fluoroadenosine-5'-monophosphate is a nucleotide that is used as an anthelmintic drug. It inhibits the synthesis of fatty acids and ATP levels in tissue culture cells. This nucleotide has also been shown to have immunomodulatory effects, which may be due to its ability to bind to receptor activity. 2'-Deoxy-2'-fluoroadenosine-5'-monophosphate binds with high affinity to the response elements of transcription factors such as NF-κB and AP1, which are involved in the regulation of gene expression and inflammatory responses.

<p>2'-Deoxy-N7-methylguanosine is a hydrogenolysis product of guanosine. It can be synthesized in four steps from glycosyl chloride, glycosylamine, and methyl iodide. The catalytic hydrogenolysis of 2'-deoxy-N7-methylguanosine with Raney Ni gives the corresponding 6-amino derivative. Hydrolysis of this amino group converts it to a nucleoside. This nucleoside has been shown to hydrolyze with half-life of about 1 hour at pH 8.5 and 37°C. The hydrolysis of purines by 2'-deoxy-N7-methylguanosine is inhibited by adenosine analogues like 2',3'-dideoxyadenosine and 3',4'-dideoxyadenosine.</p>

2'-Deoxy-5'-DMT-5-[3-(trifluoroacetylamino)-1-E-propenyl]-uridine 3-CE phosphoramidite is a synthetic nucleoside analog that has been modified to contain a triphosphate group. It is used in the synthesis of DNA or RNA. The compound is synthesized from 2,4-dichloro-N-(2,6-dimethoxybenzyl)phenylamine, which was reacted with ethyl (3-[(trifluoroacetyl)amino]propanoate) and deoxythymidine 3'-monophosphate. The CAS number for this product is 851520-76-8.

<p>2’,5’-Dideoxy-5’-iodouridine is an antiviral drug that inhibits DNA synthesis. It is a modified nucleoside analog with a phosphoramidite derivative of the natural ribonucleosides and deoxyribonucleosides. This drug is synthesized through the reaction of 2’,5’-dideoxyadenosine with 5-iodo-2-deoxyuridine in the presence of a strong base such as sodium hydride. The resulting product has a high purity, high yield, and can be used for the synthesis of DNA. 2’,5’-Dideoxy-5’-iodouridine also has anticancer properties and has been shown to inhibit cell growth in vitro at concentrations ranging from 0.1 to 1 μM.</p>

Guanosine 5'-triphosphate trisodium hydrate is a novel antiviral agent that was discovered in the course of a research program to find new antiviral agents. It is an activator of guanylyl cyclase and it has been shown to have high quality and high purity. Guanosine 5'-triphosphate trisodium hydrate binds to ribonucleosides and deoxyribonucleosides, preventing their incorporation into viral DNA or RNA. This compound also has anticancer activity.

<p>3'-Deoxy-5'-O-trityluridine is a nucleoside that is structurally related to uridine. It belongs to the class of nucleosides and has a hydroxyl group at the 3' position. The 5' position is modified by an anion (most often trityl) sterically, which prevents hydrolysis by esterases or phosphatases. The efficiency of this modification can be increased by using diethyl phosphate as the protecting agent. This modification also provides protection against nucleophiles, such as hydroxyl groups in nucleosides or phosphite triester derivatives. 3'-Deoxy-5'-O-trityluridine is used in the synthesis of other nucleosides and as a substrate for diffraction experiments.</p>

N2-Benzoyl-2'-deoxy-5'-O-DMT-guanosine is a novel and potent anticancer nucleoside with antiviral activity. It is an analog of 2'-deoxy-5'-O-DMT guanosine, which was reported to be the first phosphoramidite nucleoside. N2-Benzoyl-2'-deoxy-5'-O-DMT-guanosine is an excellent candidate for DNA synthesis and has been shown to inhibit viral replication. This product is also of high purity and high quality, and can be used in research applications.

2-Methylthio-N6-methyladenosine is an adenosine nucleoside that is found in the DNA of eukaryotes. It is similar to 2-methylthio-n6-isopentenyladenosine, which is a modified form of n6-methyladenosine. The chemical structures of both molecules are related to the thermodynamic properties of the molecule and their ability to be postsynthetically modified. These modifications can lead to changes in their translation, which can have implications for the development and progression of disease. 2-Methylthio-N6-methyladenosine has a role in epigenetics, which is defined as changes in gene expression without any alterations in DNA sequence. In this case, it may modify the chloride ion concentration by changing its chemical structure, leading to epigenetic changes that can affect how genes are expressed or translated into proteins.

2',3'-Anhydroinosine is an analog of the purine nucleoside inosine, which has been synthesized by catalytic dehalogenation of 2-fluoro-adenosine. The synthesis of this compound is based on a chemical reaction between 2-fluoro-adenosine and sodium hydroxide. This reaction produces 2',3'-anhydroinosine as a byproduct. 2',3'-Anhydroinosine inhibits the enzyme purine nucleoside phosphorylase, which prevents the conversion of inosine to hypoxanthine. This prevents purines from being used for protein synthesis, leading to cell death.

5'-Deoxy-5'-(1,3-diphenyl-2-imidazolidinyl)thymidine is a modified nucleoside analog that inhibits the growth of viruses. It has been shown to be active against herpes simplex virus type 1 and 2, varicella zoster virus, cytomegalovirus, and Epstein-Barr virus. This drug is used as an antiviral medication in the treatment of viral infections.

<p>2'-Deoxy-5'-O-DMT-2'-fluorouridine 3'-O-succinate triethylammonium salt is a nucleoside that is modified with a 2,2,2-trifluoroethoxycarbonyl group on the 5' position of the sugar moiety. It is an activator for phosphoramidites in DNA synthesis and has been shown to have anticancer activity. It is also used as an antiviral agent and to treat HIV and herpes virus infections. This compound has a molecular weight of 439.5 g/mol and its CAS number is 62273-03-3.</p>