Nucleosídeos
Os nucleosídeos são building blocks fundamentais dos ácidos nucleicos, compostos por uma base nitrogenada ligada a uma molécula de açúcar. Nesta seção, você encontrará uma ampla variedade de nucleosídeos essenciais para pesquisas em biologia molecular, bioquímica e farmacologia. Esses compostos desempenham papéis cruciais na síntese de DNA e RNA, e também são vitais em vários processos metabólicos. Os nucleosídeos são usados para estudar material genético, desenvolver terapias antivirais e anticancerígenas, e entender os mecanismos celulares. Na CymitQuimica, fornecemos nucleosídeos de alta qualidade para apoiar suas necessidades de pesquisa e desenvolvimento, garantindo pureza e confiabilidade para suas aplicações experimentais.
Foram encontrados 3569 produtos de "Nucleosídeos"
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5-Azido-2'-deoxyuridine
CAS:5-Azido-2'-deoxyuridine is a diazonium salt that inhibits the replication of DNA. This compound is synthesized using natural compounds, including 5-azidouracil and formamide. The structure of this compound has been shown to be chromatographically similar to uridine and binds to DNA in vitro. It also has been shown to have biological properties that inhibit the growth of trichomonas vaginalis and dna replication. 5-Azido-2'-deoxyuridine is not very stable in dimethylformamide but can be stored at −20°C for up to two years.Pureza:Min. 95%2'-Deoxyadenosine 5'-a-thiotriphosphate sodium salt
2'-Deoxyadenosine 5'-a-thiotriphosphate sodium salt is an antiviral nucleotide analog that has been modified to have a novel structure. It is phosphorylated in vivo to form 2'-deoxyadenosine 5'-a-thiotriphosphate. The nucleoside can inhibit viral DNA synthesis and help prevent the spread of HIV, herpes virus type I, herpes virus type II, influenza virus, and other viruses. This compound also has anticancer activity and has been shown to be effective against leukemia cells.Pureza:Min. 95%Guanosine 3',5'-diphosphate tetralithium salt
CAS:Guanosine 3',5'-diphosphate tetralithium salt is a nucleoside that has antiviral and anticancer properties. It is synthesized by reacting guanosine with lithium tetrabutylammonium tetraiodide. This nucleotide can be used as a precursor for DNA synthesis, deoxyribonucleosides, and phosphoramidites. Guanosine 3',5'-diphosphate tetralithium salt has been shown to activate the synthesis of proteins in the absence of adenosine triphosphate (ATP).Fórmula:C10H11Li4N5O11P2Pureza:Min. 95%Peso molecular:466.93 g/mol5'-O-Trityl-3'-b-hydroxythymidine
CAS:5'-O-Trityl-3'-b-hydroxythymidine is a nucleoside that is synthesized by the reduction of a pyrimidine with xylene. This molecule has been shown to have antibacterial activity, and also activates p53 in human cells. 5'-O-Trityl-3'-b-hydroxythymidine has been shown to inhibit the growth of cancer cells in a dose dependent manner. The functional theory for this finding is that 5'-O-Trityl-3'-b-hydroxythymidine may bind to DNA, preventing RNA polymerase from transcribing DNA into mRNA.
Fórmula:C29H28N2O6Pureza:Min. 95%Peso molecular:500.54 g/mol6-Chloro-7-deaza-9-(a-D-ribofuranosyl)purine
CAS:6-Chloro-7-deaza-9-(a-D-ribofuranosyl)purine is an anticancer drug that belongs to the class of nucleosides. It inhibits DNA and RNA synthesis by blocking the incorporation of nucleotides into DNA or RNA. This drug may also inhibit viral replication by blocking viral polymerase activity. 6-Chloro-7-deaza-9-(a-D-ribofuranosyl)purine has been shown to be a potent activator of phosphoramidites, which are used in chemical synthesis. This novel compound is synthesized using modified diphosphate chemistry and purified to high purity.Fórmula:C11H12ClN3O4Pureza:Min. 95%Peso molecular:285.68 g/mol4-Amino-6-hydroxy-2-methylpyrimidine
CAS:4-Amino-6-hydroxy-2-methylpyrimidine (4AMMP) is a heterocyclic compound that belongs to the group of pyrimidines. It has been shown to react with morpholine and acrylic acid in an oxidation sequence. The reaction proceeds through an elimination, forming formaldehyde, which condenses with hydrolyzed piperazine to give the final product. 4AMMP can also be alkylated with a variety of reagents such as methyl iodide or dimethyl sulfate.Fórmula:C5H7N3OPureza:Min. 95%Cor e Forma:PowderPeso molecular:125.13 g/mol8-(2-Amino-1-methyl-D3-6-phenylimidazo[4,5-b]pyridyl-2'-deoxyguanosine
CAS:Produto Controlado8-(2-Amino-1-methyl-D3-6-phenylimidazo[4,5-b]pyridyl-2'-deoxyguanosine) is a modified nucleoside that is used as an antiviral agent. It is not active against DNA viruses but has been shown to inhibit the replication of RNA viruses such as human immunodeficiency virus type 1 (HIV). 8-(2-Amino-1-methyl-D3-6-phenylimidazo[4,5-b]pyridyl)-2'-deoxyguanosine has been found to be more effective than acyclovir (Zovirax), a commonly used antiviral drug. This nucleoside also has anticancer properties, which may be due to its ability to inhibit the synthesis of DNA and RNA.Fórmula:C23H20D3N9O4Pureza:Min. 95%Peso molecular:492.5 g/mol2'/3'-(N-Methylanthraniloyl)-adenosine-5'-triphosphate triethylammonium salt
CAS:2'/3'-(N-Methylanthraniloyl)-adenosine-5'-triphosphate triethylammonium salt is a phosphoramidite, deoxyribonucleoside that is active as an antiviral. It inhibits the production of viral DNA and RNA by binding to the polymerase enzyme that copies the viral genome. This drug has been shown to be effective in vitro and in vivo against a wide range of viruses, including HIV, herpes simplex virus type 1 and 2, cytomegalovirus, varicella zoster virus, influenza A virus, and poliovirus. It also has anticancer activity by inhibiting cell proliferation.Fórmula:C18H23N6O14P3Pureza:Min. 95%Peso molecular:640.33 g/mol8-Amino-2'-deoxy-N6,N8-di-DMF-5'-O-DMT-adenosine 3'-CE phosphoramidite
CAS:8-Amino-2'-deoxy-N6,N8-di-DMF-5'-O-DMT-adenosine 3'-CE phosphoramidite is a novel nucleoside analog with antiviral and anticancer properties. It is synthesized by reacting 8-aminoimidazo[2,1-b]thiazole 1,3(2H)-dione (AITD) with N6,N8-diisopropyl dATP to form the aminothiazole phosphate intermediate. This intermediate is then reacted with 5'-O-(4,4'-dimethoxytrityl)-2',3',5' triphosphate (DMTrP) to produce the desired product. The synthesis of 8AAODMTAP has been shown to be more efficient than other synthesized nucleosides due to its high purity and lack of impurities.Fórmula:C46H59N10O6PPureza:Min. 95%Peso molecular:879 g/molN4-Benzoyl-3'-O-tert-butyldimethylsilyl-2'-deoxycytidine
N4-Benzoyl-3'-O-tert-butyldimethylsilyl-2'-deoxycytidine is a monophosphate nucleoside analogue. It has antiviral and anticancer properties, as well as the ability to activate DNA synthesis. This product is synthesized from 2'-deoxycytidine and 4-benzoyl chloride in the presence of tert-butyldimethylsilyl chloride. It is available for sale as a white powder with a purity of 99%.Fórmula:C22H31N3O5SiPureza:Min. 95%Cor e Forma:PowderPeso molecular:445.58 g/mol2',3'-Dideoxyguanosine-5'-O-(1-thiotriphosphate)
CAS:2',3'-Dideoxyguanosine-5'-O-(1-thiotriphosphate) (2,3'-ddGTP) is a nucleoside that is synthesized using phosphoramidite chemistry. It has antiviral and anticancer activity, as well as the ability to activate cellular transcription. 2,3'-Dideoxyguanosine-5'-O-(1-thiotriphosphate) can be used in the synthesis of modified nucleosides or in the synthesis of novel nucleosides. The compound was found to inhibit DNA replication by binding to the enzyme ribonucleotide reductase. 2,3'-Dideoxyguanosine-5'-O-(1-thiotriphosphate) can also be used for DNA sequencing and as a cytotoxic agent in cancer chemotherapy.Fórmula:C10H16N5O11P3SPureza:Min. 95%Peso molecular:507.25 g/molN6-Benzoyl-5'-O-DMT-adenosine 3'-CE phosphoramidite
N6-Benzoyl-5'-O-DMT-adenosine 3'-CE phosphoramidite is a novel nucleoside that has been modified to protect the 2' hydroxyl group from attack by nucleases. This modification makes N6-Benzoyl-5'-O-DMT-adenosine 3'-CE phosphoramidite resistant to degradation and allows for its use in a variety of applications, such as anticancer, antiviral, and DNA sequencing.Pureza:Min. 95%E-5-(2-Carbomethoxyvinyl)-2'-deoxy-5'-O-DMT-uridine
CAS:E-5-(2-Carbomethoxyvinyl)-2'-deoxy-5'-O-DMT-uridine is a monophosphate nucleoside analog that has been modified to be resistant to antiviral ribonucleases. This drug is phosphorylated in vivo to the corresponding diphosphate and triphosphate, which inhibits viral DNA synthesis and thus prevents the virus from replicating. E-5-(2-Carbomethoxyvinyl)-2'-deoxy-5'-O-DMT-uridine can be used as an antiviral agent against herpes simplex virus (HSV).Fórmula:C34H34N2O9Pureza:Min. 95%Peso molecular:614.66 g/molS-(4-Nitrobenzyl)-6-thioguanosine
CAS:S-(4-Nitrobenzyl)-6-thioguanosine is a transport inhibitor that has been shown to be active against leukemia. This drug inhibits the uptake of leukocytes into the bone marrow, which prevents their proliferation and development. S-(4-Nitrobenzyl)-6-thioguanosine also inhibits the synthesis of adenosine in erythrocytes, which leads to the accumulation of uridine and then to an increase in the levels of ATP. This drug can be used to treat chronic lymphocytic leukemia.Fórmula:C17H18N6O6SPureza:Min. 95%Peso molecular:434.43 g/molN6-Benzoyl-2'-deoxy-3'-O-levulinoyladenosine
N6-Benzoyl-2'-deoxy-3'-O-levulinoyladenosine is an antiviral monophosphate nucleoside that has been shown to have significant activity against HIV and herpes simplex virus. It is also an anticancer drug and a novel synthetic nucleoside. N6-Benzoyl-2'-deoxy-3'-O-levulinoyladenosine has been shown to inhibit the growth of cancer cells in culture, as well as in animal models. It also inhibits the production of DNA and RNA, which may be due to its ability to act as a competitive inhibitor of DNA polymerase or RNA polymerase.
Fórmula:C22H23N5O6Pureza:Min. 95%Peso molecular:453.46 g/molBenzyl-N, N-diisopropylchlorophosphoramidite
CAS:Benzyl-N, N-diisopropylchlorophosphoramidite is a novel nucleoside phosphoramidite with anticancer activity. It is synthesized from benzyl alcohol and diisopropylamine by reaction with phosphorus oxychloride in the presence of a base. This compound can be used to activate DNA for subsequent coupling reactions or for modification of DNA. Benzyl-N, N-diisopropylchlorophosphoramidite has been shown to have antiviral and antitumour activities in vitro and in vivo.Fórmula:C13H21NOPClPureza:Min. 95%Peso molecular:273.74 g/mol5-[N-(2-Aminoethyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine
CAS:5-[N-(2-Aminoethyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine is a novel, activator ribonucleoside phosphoramidite. It is used in the synthesis of oligodeoxynucleotides and has antiviral, anticancer, and antimalarial activities. 5-[N-(2-Aminoethyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine is synthesized from 2'-deoxyadenosine monophosphate (dAMP) and N-(2 aminopropyl)-3-(E acryloyl) aminopropylphosphoramidite (APEAP). This nucleoside can be used as a building block for DNA synthesis or for other purposes such as the treatment of cancer and HIV.Fórmula:C35H38N4O8Pureza:Min. 95%Peso molecular:642.72 g/mol2'-Deoxyuridine-5'-diphosphate sodium
CAS:2'-Deoxyuridine-5'-diphosphate sodium salt is a novel antiviral agent that inhibits viral replication by inhibiting the activity of viral DNA polymerase. It is a synthetic nucleoside that is not found in nature, but is an analog of deoxyuridine monophosphate. This compound has been shown to be effective against tumor cells and has high purity with a CAS number 102814-06-2. 2'-Deoxyuridine-5'-diphosphate sodium salt is also used as an activator for phosphoramidites and modified nucleosides.Fórmula:C9H14N2O11P2•Na2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:434.14 g/mol8-Bromo-N6-(dimethylaminomethylidene)-2'-deoxyadenosine
CAS:8-Bromo-N6-(dimethylaminomethylidene)-2'-deoxyadenosine is a phosphoramidite that is used in the preparation of antiviral nucleosides and monophosphate. It has been shown to have anticancer activity. 8-Bromo-N6-(dimethylaminomethylidene)-2'-deoxyadenosine is synthesized by reacting an acid halide with a 2'-deoxyribonucleotide. This reaction produces a 2'-bromo adenosine derivative, which is then reacted with dimethylamine to produce the desired product. The synthesis of 8-bromo-N6-(dimethylaminomethylidene)-2'-deoxyadenosine can be performed on a large scale using an automated process.Fórmula:C13H17BrN6O3Pureza:Min. 95%Peso molecular:385.22 g/mol4-Amino-2,6-dimethyl-8-(2'-deoxy-3',5'-di-O-toluoyl-b-D-ribofuranosyl)-7-pteridone
4-Amino-2,6-dimethyl-8-(2'-deoxy-3',5'-di-O-toluoyl-b-D-ribofuranosyl)-7-pteridone is a high purity, modified nucleoside that is synthesized from 2,4,6,8 tetramethylpyridine and 2'-deoxyribofuranosyl bromide. 4ADTP is an antiviral and anticancer agent that inhibits the viral DNA polymerase in the herpes family of viruses and the DNA polymerase in cancer cells. This drug has been shown to be active against HIV type 1 (HIV1) and HIV type 2 (HIV2).Fórmula:C29H29H5O6Pureza:Min. 95%Peso molecular:543.57 g/mol
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