Nucleosídeos

N-(2'-Deoxy- 2', 2'- difluorocytidine 5'-P- phenyl phosphate) L- alanine benzyl ester, also known as Acelarin, is primarily used in cancer treatment, including leukemia and solid tumors.

3',5'-Bis-O-(t-butyldimethylsilyl)thymidine is a novel nucleoside phosphoramidite that can be used in the synthesis of oligonucleotides. This compound has antiviral and anticancer activities and is an excellent building block for the synthesis of modified nucleosides. 3',5'-Bis-O-(t-butyldimethylsilyl)thymidine is a high quality, high purity chemical with a CAS number of 40733-26-4.

3',5'-Di-O-p-chlorobenzoyl-2'-deoxy a-5-fluorouridine is a nucleoside that is used in the antiviral drug Aciclovir. It is an analog of 2'-deoxyadenosine and inhibits viral DNA synthesis by acting as a chain terminator. 3',5'-Di-O-p-chlorobenzoyl-2'-deoxy a-5-fluorouridine has shown some anticancer activity against human tumor cells in culture, but its mechanism of action is not well understood.

N6-Benzoyl-8-benzyloxy-2'-deoxyadenosine is a novel nucleoside with anticancer and antiviral properties. It is an antiviral that inhibits the synthesis of viral DNA by blocking the incorporation of ribonucleotide triphosphates into DNA, while leaving intact the synthesis of deoxyribonucleotides and phosphoramidites. In addition, it is a potent inhibitor of cellular DNA polymerases that catalyze synthesis of DNA from deoxyribonucleoside triphosphates. N6-Benzoyl-8-benzyloxy-2'-deoxyadenosine also has antitumor activity in animal models.

6-Amino-1-methyluracil is a synthetic drug that is used in the treatment of inflammatory diseases, including rheumatoid arthritis and psoriasis. It is also used to treat cancer, such as leukemia and in the treatment of bacterial infections. 6-Amino-1-methyluracil inhibits the synthesis of DNA by inhibiting the enzyme thymidylate synthetase. This inhibition prevents DNA replication and transcription, which leads to cell death. 6-Amino-1-methyluracil binds to cellular proteins through its amino group and hydroxyl group, which are not involved in its chemical reactions. 6-Amino-1-methyluracil has shown great promise as a template molecule for the synthesis of new drugs.

3-Benzoylpyridine is a natural product that has been isolated from the plant Plectranthus fruticosus. It is an aromatic compound, with a trifluoromethyl group and a hydroxy group. 3-Benzoylpyridine has been shown to react with amines in the presence of hydrogen gas to form 1H-1,2,3-triazole derivatives. This reaction is catalyzed by light or UV irradiation. The absorption maxima for 3-benzoylpyridine are at 270 nm and 330 nm in water and ethanol, respectively. In addition, 3-benzoylpyridine is able to combine with hydroxide ions to form the corresponding salt, which can be reduced to yield the nitrogen containing heterocyclic ring (3-benzo[b]pyridin).

2',3'-Dideoxy-2',2'-difluorocytidine is a monophosphate derivative of the antiviral and anticancer drug 2',3'-dideoxycytidine. It is an activator of DNA synthesis, nucleosides, and nucleotides. It is also a phosphoramidite for the synthesis of oligonucleotides and modified ribonucleosides. 2',3'-Dideoxy-2',2'-difluorocytidine has CAS number 124708-94-7. It is available in high purity and quality, which makes this product suitable for research purposes.

3',5'-Di-O-acetyl-2'-deoxyguanosine is a nucleoside that is activated by hypochlorous acid to form a reactive intermediate, which can then react with other molecules. 3',5'-Di-O-acetyl-2'-deoxyguanosine has been shown to be selectively cytotoxic to human tumor cells and may be used as a radiosensitizer for cancer treatment. The reaction products of this compound include hypochlorite and hydrogen peroxide, which are strong oxidizing agents that cause tissue injury. This compound is also an effective reagent for the detection of myeloperoxidase in plasma samples.

Cytidine 5'-monophosphate sodium salt is a nucleotide that is found in RNA and DNA. Cytidine 5'-monophosphate sodium salt is an intermediate in the biosynthesis of uridine, choline, and saccharose. It also plays an important role in the immune system as it can be a precursor for immunoglobulins. The reaction rate of cytidine 5'-monophosphate sodium salt with lipase has been shown to be constant at pH 7.5-8.0 and 37°C. This product has been shown to have emulsifying properties by forming micelles with water-immiscible solvents such as hexane or heptane, which may be due to its ability to form hydrogen bonds with other molecules such as saccharose or guanosine. Cytidine 5'-monophosphate sodium salt can also be used as a chromatographic material for separating saccharose from other sugars

N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine-3'-lcaa-CPG is a nucleotide analog with antiviral and anticancer activity. It is considered to be a novel nucleoside analogue. It is synthesized by attaching an acetyl group to the 2' position of the adenosine moiety, which prevents phosphorylation by kinase enzymes. This inhibits DNA synthesis and induces apoptosis in cancer cells.

5'-O-DMT-N2-phenylacetylguanosine is a novel synthetic nucleoside phosphoramidite which can be used for the synthesis of modified oligonucleotides. It has been shown to be an activator, anticancer, and antiviral agent in vitro. 5'-O-DMT-N2-phenylacetylguanosine is also a monophosphate, which can inhibit viral replication by interacting with the ribose sugar moiety of the nucleic acid strand. The antiviral activity has been demonstrated on human immunodeficiency virus type 1 (HIV-1), herpes simplex virus type 2 (HSV-2), and influenza A virus.

2’-Deoxy-2-methyladenosine is a nucleoside that is chemically synthesized by the phosphorylation of 2,6-diaminopurine. It has been shown to be an effective activator of RNA polymerase and it also has anticancer properties. 2’-Deoxy-2-methyladenosine can be used as a substitute for thymidine in DNA synthesis. This nucleoside has also been shown to inhibit bacterial growth in culture by inhibiting DNA synthesis and protein synthesis. It is a modified nucleoside that can be used for the synthesis of DNA, RNA, or ribonucleic acids. The CAS number for this compound is 110952-90-4.

Uridylyl-3'-5'-cytidine ammonium salt is a monophosphate of cytidine. It is an antiviral agent that inhibits the replication of human immunodeficiency virus type 1 (HIV-1). Uridylyl-3'-5'-cytidine ammonium salt is synthesized by the reaction of uridyl 3'-5' -adenosine monophosphate with cytidine. This compound has been shown to be effective in inhibiting the proliferation of cancer cells. Uridylyl-3'-5'-cytidine ammonium salt has shown activity against a variety of cancers, including breast, lung, and colon cancers.

Modulator of P2Y receptors

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3'-epi-5-chloro-2'-deoxyuridine is a nucleotide analog that has been shown to inhibit the growth of cells in tissue culture. It is not active against bacteria, but can be used as an antineoplastic agent for the treatment of cancer. 3'-epi-5-chloro-2'-deoxyuridine is metabolized by a number of enzymes, including mononucleotide reductase, thymidylate synthase, and cytosine deaminase. The reaction mechanism for this drug has been studied using nuclear dna polymerases and proteases. The metabolism of 3'-epi-5-chloro-2'-deoxyuridine results in its incorporation into DNA by means of an enzymatic reaction with DNA polymerase. The incorporation of the analog into DNA leads to cell death due to lysis or inhibition of protein synthesis.

5-Aminoallyl-2'-deoxyuridine is a bifunctional alkylating agent that has low affinity for DNA. It is used in the laboratory to measure the rate of synthesis of thymidylate, which is one of the four deoxythymidylate needed for DNA synthesis. 5-Aminoallyl-2'-deoxyuridine has been shown to be a stable complex with sulfoxide, which can be used as an alkylation agent in the laboratory. 5-Aminoallyl-2'-deoxyuridine has also been shown to have high affinity for cellular nucleic acids in l1210 cells and have a high uptake. The sequence of 5-aminoallyl-2'-deoxyuridine is: 5-(N-(2-(5-aminoallylamino)ethyl)-N-(carboxyethyl)glycine)-2',3',5'-triiod