Nucleosídeos

<p>5'-Azido-5'-deoxy-5-methyluridine is a nucleoside analog that can be used as an antiviral and anticancer agent. It is chemically modified to be phosphorylated by in vitro enzymes, which makes it more potent and selective than other nucleosides. The 5'-azido group on the sugar moiety of 5'-azido-5'-deoxy-5-methyluridine reacts with the hydroxyl group of the ribonucleoside triphosphate, forming a covalent bond. This reaction prevents the enzyme from releasing the sugar moiety, which blocks RNA synthesis. The lack of RNA synthesis prevents protein production, which leads to cell death.</p>

<p>5'-O-Levulinoylthymidine is a novel nucleoside analog that inhibits viral proliferation by inhibiting viral RNA polymerase. This drug is also an activator of ribonucleotide reductases, which are enzymes that synthesize deoxyribonucleotides from ribonucleotides. 5'-O-Levulinoylthymidine has been shown to inhibit the growth of cancer cells in vitro and in vivo. It has also been shown to be effective against HIV-1 infection in vitro.</p>

7-Deaza-2',3'-dideoxy-7-iodoguanosine is a nucleoside analog that inhibits the synthesis of DNA by inhibiting the activity of DNA polymerase. It is used to treat HIV and other viral infections. The compound is also active against cancer cells and has been shown to inhibit the growth of leukemia cells. 7-Deaza-2',3'-dideoxy-7-iodoguanosine is modified with an iodine atom at the 7 position and has a novel structure. This compound is used in biological research as a substrate for the preparation of phosphate esters such as phosphoramidites for use in oligonucleotide synthesis.

Guanosine 5'-monophosphate, also known as GMP, is a ribonucleoside monophosphate that becomes incorporated into RNAs when phosphorylated to GTP.

5-Iodo-2'-O-methyluridine is a novel antiviral drug that inhibits replication of DNA and RNA viruses. It is chemically synthesized from 2' deoxyuridine monophosphate, which is modified to create the 5-iodo derivative. The modification at the 5th position of the uracil ring prevents the incorporation of methylation into DNA and RNA, which can lead to cancerous growths. This compound has been shown to be an excellent activator for DNA synthesis in vitro. It has also been shown to have anticancer properties in vitro and in vivo.

<p>Cytidyl-3'-5'-uridine ammonium salt is a nucleoside analog that is used as an antiviral and anticancer agent. Cytidyl-3'-5'-uridine ammonium salt inhibits the synthesis of DNA by inhibiting the activity of enzymes such as DNA polymerase, RNA polymerase, or reverse transcriptase. It also has antitumor properties and can be used to treat leukemia and other types of cancer. Cytidyl-3'-5'-uridine ammonium salt has been shown to be more potent than cytidyl-2',4',6'-triaminopyrimidine (CTAP) in inhibiting the growth of lymphocytic leukemia cells.</p>

<p>3',5'-Bis-O-(triphenylmethyl)uridine is a partially protected uridine analogue</p>

5'-O-Trityl-2,3'-anhydrothymidine is a nucleoside analogue that inhibits HIV reverse transcriptase by binding to the enzyme and preventing RNA chain elongation. The compound is a potent inhibitor of HIV in cell cultures and has been shown to be active against a variety of HIV isolates. 5'-O-Trityl-2,3'-anhydrothymidine has also shown antiviral activity against other RNA viruses such as SARS coronavirus and influenza virus.

5-Fluorouridine-5'-O-b-D-galactopyranoside is a nucleoside that can be used as an activator to synthesize ribonucleosides and deoxyribonucleosides. This product is also an anticancer agent, as it inhibits cell proliferation by inactivating the enzyme DNA polymerase. It is highly purified, with a purity of 99%.

2'-Deoxy-2'-fluorocytidine is a nucleoside analog with the potential as an Crimean-Congo hemorrhagic fever virus antiviral

5-Aminoimidazole-4-carboxamide-1-b-D-ribofuranose 5'-monophosphate (AICAR) is an analogue of AMP that activates the AMPK pathway. It is a potent activator that increases the activity of this enzyme, which regulates cellular energy metabolism. AICAR has been shown to induce significant cytotoxicity in k562 cells and to increase the levels of ATP in these cells. This compound has also been shown to have potential use in metabolic disorders, such as type 2 diabetes, by increasing uptake and kinetic of glucose. AICAR has also been shown to activate the AMPK pathway in prostate cancer cells and increase cellular physiology.

5'-O-p-Anisoyl-N4-benzoyl-2'-O-tert-butyldimethylsilylcytidine 3'-CE phosphoramidite is a novel, modified compound that has been synthesized for the purpose of being used as an activator in the synthesis of DNA and RNA. This compound has been shown to have anticancer properties and antiviral effects. It is highly pure and can be used in the production of high quality ribonucleosides, deoxyribonucleosides, and phosphoramidites.

<p>Inosine 5'-monophosphate disodium salt hydrate is a nucleotide that is synthesized from adenosine triphosphate in the energy metabolism of cells. It is used as an activator of signal pathways and as a potent inducer of metabolic enzymes. Inosine 5'-monophosphate disodium salt hydrate has been shown to induce bowel disease in mice with experimental colitis, suggesting its utility for treating inflammatory bowel disease. Inosine 5'-monophosphate disodium salt hydrate binds to the ATP-binding site of GTPase, stimulating the hydrolysis of ATP to ADP and phosphate. This reaction causes a conformational change in the enzyme's active site that increases the affinity for GTP by about 10-fold. The binding site is composed of two alpha helices sandwiching a central beta sheet and the catalytic residues are located at both ends of this beta sheet. Structural analysis has revealed that this drug interacts with</p>

3-Methylpseudouridine is a uridine analog that inhibits the enzyme RNA polymerase. It has been shown to inhibit protein synthesis and can be used in the treatment of bacterial infections. 3-Methylpseudouridine is synthesized by solid-phase chemistry on a polymeric support and purified by high-performance liquid chromatography. It has been shown to inhibit the growth of bacteria in cell culture, but its effects on human cells are not known. 3-Methylpseudouridine also binds with high affinity to calf thymus DNA and it can be used as a substrate for aminoglycoside modification studies.

Metabolite of 8-Chloroadenosine

Uridine isomer; found in tRNA

<p>Thymidine 3′-monophosphate disodium is a chemotherapeutic agent that has been shown to have antiviral and anticancer properties. It is a nucleoside analogue, which mimics the structure of thymidine and inhibits DNA synthesis by interfering with the DNA replication process. Thymidine 3′-monophosphate disodium is also used as an activator in the synthesis of deoxyribonucleosides and ribonucleosides. This product is synthetic, high quality, and not chemically modified. It has CAS number 68698-19-1 and molecular weight of 242.06 g/mol.</p>

<p>IMP + GMP is a DNA synthesis activator that can be used to synthesize DNA, RNA, and oligonucleotides. It is modified to have antiviral and anticancer properties. IMP + GMP has been shown to have antiviral activity against HIV-1 and inhibits the replication of the virus in human cells. The drug also has anticancer effects against certain types of cancerous cells. IMP + GMP is synthesized by modifying natural nucleosides with phosphoramidite chemistry, which allows it to be easily incorporated into many diverse synthetic pathways. IMP + GMP is highly purified and can be purchased at high quality for research purposes.</p>

N2-Isobutyrylguanosine is a synthetic nucleoside analog. It is activated by the enzyme thymidine kinase and inhibits the synthesis of RNA and DNA, which leads to cell death. N2-Isobutyrylguanosine has been shown to be an effective inhibitor of epidermal growth factor receptor (EGFR) in mammalian cells. This drug has also been shown to inhibit insulin-like growth factor I and phosphorothioate monomers. N2-Isobutyrylguanosine inhibits the synthesis of fatty acids, leading to a decrease in lipid content in cells.

2'-Deoxy-5'-O-DMT-uridine is a bifunctional drug that has both antibacterial and anticancer activity. This drug is used to treat leishmania infections, which are caused by protozoan parasites. 2'-Deoxy-5'-O-DMT-uridine suppresses the growth of these organisms by inhibiting RNA synthesis and protein synthesis. It also inhibits proliferation of cancer cells in vivo by targeting cancer cells with high levels of primary amines. 2'-Deoxy-5'-O-DMT-uridine is an effective chemotherapeutic agent that can be used to treat pancreatic cancers with high rates of primary amines (e.g., insulinoma).