Nucleosídeos

<p>5-Ethynylpyrimidine is a supramolecular alkynyl group that has been shown to inhibit tyrosine kinase activity, cross-coupling, and the synthesis of proteins. It also exhibits luminescent properties and can be used in supramolecular chemistry. 5-Ethynylpyrimidine is a pyrimidine nucleoside, which is an organic compound that is a component of RNA. Pyrimidine nucleosides are important for protein synthesis and are used as luminophores or fluorescent resonance quenchers in biochemical assays for enzyme activity; they have also been shown to inhibit herpes simplex virus (HSV) replication. 5-Ethynylpyrimidine has been found to be able to bind terminal alkynes with high affinity.</p>

<p>AICAR 3',5'-cyclic phosphate is an antiviral and anticancer agent that inhibits the production of DNA and RNA, which may be due to its ability to activate AMP-activated protein kinase. AICAR 3',5'-cyclic phosphate has been shown to inhibit the proliferation of human breast cancer cells in vitro. This drug also has anticancer activity against various types of cancers, including prostate cancer and melanoma. AICAR 3',5'-cyclic phosphate is a novel compound that can be used as a phosphoramidite reagent for the synthesis of oligonucleotides.</p>

<p>2'-Methyl-guanosine-(iBu)-succinyl-CPG is a modified nucleoside with antiviral and anticancer properties. It is synthesized by the condensation of 2'-methyl-guanosine and succinic anhydride in the presence of tetrazole. The compound is a phosphoramidite, which is used as a building block for DNA synthesis.</p>

<p>4,5-Dimethoxy-2-nitrobenzyl adenosine 3',5'-cyclic monophosphate is a synthetic nucleotide that can be activated to form an antiviral and anticancer agent. This compound has been shown to inhibit the proliferation of leukemia cells in culture. It also inhibits the synthesis of DNA and RNA, leading to cell death by inhibiting the production of proteins vital for cell division. 4,5-Dimethoxy-2-nitrobenzyl adenosine 3',5'-cyclic monophosphate is a novel nucleoside with high purity and CAS number: 57314-27-1.</p>

<p>5'-O-Acetyl-2',3'-O-isopropylideneadenosine is an anti-leishmanial agent that is synthesized from 2,3-O-isopropylideneadenosine by acetylating the 5' hydroxyl group. It was found to be more potent than the parent compound and other related compounds in inhibiting Leishmania amazonensis promastigotes. The proposed mechanism of action of 5'-O-acetyl-2',3'-O-isopropylideneadenosine involves hydrogen bonding with the guanosine moiety of DNA and inhibition of RNA synthesis. This drug also has an effect on carbonyl oxygens and resonances, which are observed in the nmr spectra. The synthetic scheme for this drug starts with uridine, which is converted to cytidine by reacting it with sodium cyanide in aqueous solution at 0°C. Cytidine</p>

<p>2-Amino-benzoyl-9-(5'-O-DMT-b-D-ribofuranosyl)purine is an anticancer and antiviral agent. It has been shown to be active against many viruses, including herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, and human immunodeficiency virus type 1. This compound also exhibits antitumor activity in mice and rats.</p>

<p>5'-Deoxy-5'-iodo-2',3'-O-isopropylidene-5-chlorouridine is a novel antiviral agent that inhibits replication of viruses. It is synthesized from 5'-deoxy-5'-iodo-2',3'-O-isopropylideneuridine, which is then phosphorylated by the addition of a phosphate group. This compound has shown to be an activator in the synthesis of ribonucleosides and deoxyribonucleosides. The high purity and high quality of this compound make it suitable for use as a starting material for the synthesis of modified nucleosides for anticancer drugs.</p>

<p>N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine 3'-Q linker CPG 1000Å is a nucleoside analog that is used in the synthesis of DNA. It is a phosphoramidite that has been modified with an acetyl group at the 2' position and a Q linker at the 3' position. This product can be used as an antiviral or anticancer agent, as well as for other research purposes. The CAS number for this product is 62660-67-7, and it has been shown to be active against HIV and HCV.</p>

<p>2',3'-Dideoxycytidine-5'-triphosphate lithium salt is a novel nucleoside, which can be used in the synthesis of oligonucleotides and DNA. The phosphoramidite is highly reactive and stable, and has been shown to have antiviral activity against influenza A virus. This chemical has also been shown to inhibit the growth of cancer cells by inhibiting DNA synthesis.</p>

<p>N2-O-Acetyl-2'-deoxy-3',5'-di-O-acetyl-O6-DPC-a-b-guanosine is a modified nucleoside that has antiviral and anticancer activities. It is synthesized by the modification of deoxyribonucleosides with acetyl groups at the 2' position, which are then removed using hydrolysis. The resulting product is a phosphoramidite intermediate that can be used in the synthesis of oligodeoxynucleotides. This compound has shown to have high quality and purity, as well as being novel.</p>

<p>2',3'-Di-O-isopropylidene-isocytidine is a nucleoside that belongs to the group of antiviral and anticancer compounds. It is an analog of cytidine, and has been shown to be an activator of phosphoramidites, DNA, and RNA. 2',3'-Di-O-isopropylidene-isocytidine has been shown to have antineoplastic effects on tumor cells by inhibiting rna synthesis and protein synthesis. This compound also inhibits the growth of bacteria, including Mycobacterium tuberculosis and Mycobacterium avium complex. 2',3'-Di-O-isopropylidene-isocytidine has been shown to be a novel modified nucleoside with high purity and high quality.</p>

<p>2’,3’,5’-Tri-O-benzoyl-5-methoxyuridine is a modified nucleoside that is structurally similar to the natural nucleoside uridine. It has antiviral properties and can be used as a monophosphate, diphosphate, or nucleotide. 2’,3’,5’-Tri-O-benzoyl-5-methoxyuridine is synthesized by reacting 5′-(triacetyl)aminoimidazole with 5′-(triisopropyl)phosphoroamidite in acetonitrile. The product has been shown to have anticancer activity in vitro and in vivo.</p>

<p>O6-Benzyl-8-bromo-3',5'-O(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)2'-deoxyguanine is a modified nucleoside that is used as an antiviral and anticancer agent. It has been shown to be a potent activator of the immune system. The monophosphate form of O6-benzyl-8-bromo-3',5'-O(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)2'-deoxyguanine may be useful in the treatment of viral diseases such as HIV or herpes zoster.</p>

<p>2'-Deoxy-5'-O-DMT-5-fluorouridine (2'DFUR) is a synthetic nucleoside that inhibits the synthesis of DNA. 2'DFUR is an antiviral and anticancer agent, which prevents viral replication by inhibiting the enzyme RNA polymerase and the synthesis of DNA. 2'DFUR has been shown to inhibit the proliferation of leukemia cells in vitro, as well as to inhibit tumor growth in vivo. The molecular weight of 2'DFUR is 284.23 g/mol, with a CAS number of 52488-02-9.</p>

<p>5’-O-DMT-N4-Phenoxyacetyl-2’-O-methylcytidine is an Activator and Anticancer agent. The synthesis of this product is based on the modification of cytidine to 2’,4,6,-trimethoxybenzoylcytidine. This product has been shown to be more potent than other cytidine analogs in inhibiting the growth of cancer cells. 5'-O-DMT-N4-Phenoxyacetyl-2'-O-methylcytidine is a novel nucleoside that has been shown to have antiviral activity against human immunodeficiency virus (HIV).</p>

<p>Adenosine 3',5'-diphosphate barium salt is a nucleoside that is used in the synthesis of oligonucleotides. Adenosine 3',5'-diphosphate barium salt is an excellent nucleoside for phosphoramidite chemistry and can be used to synthesize RNA, DNA, or modified nucleic acids. It has antiviral and anticancer activity. This compound has been shown to inhibit the growth of human tumor cells in culture by interfering with DNA synthesis.</p>

<p>2’,3’-Dideoxy-3’-chloro-5-methyl-5’-O-trityluridine (ddCTP) is a novel nucleoside analog that is synthesized by the protection of the 5'-hydroxyl group with an acetyl group followed by a 2',3'-dideoxy substitution. This compound has been shown to have antiviral and anticancer activities. ddCTP is an activator of DNA polymerase and inhibits viral DNA synthesis in vitro. It also inhibits protein synthesis and cell division by binding to the RNA template strand, which prevents it from being used as a template for protein synthesis.</p>

<p>5-O-DMT-thymidine 3'-H phosphonate triethylammonium is a novel nucleoside analogue with anticancer activity. The monophosphate form of 5-O-DMT-thymidine 3'-H phosphonate triethylammonium is an activator of DNA, RNA, and protein synthesis in vitro. 5-O-DMT-thymidine 3'-H phosphonate triethylammonium has been shown to be active against herpes simplex virus type 1 and 2 and HIV type 1 in vitro.</p>

<p>6-(4-Fluorophenyl)pyrimidine-2,4-diamine is an organic compound that has been shown to inhibit the proliferation of cells in vitro and to induce apoptosis. It also inhibits the growth of cancer cells. 6-(4-Fluorophenyl)pyrimidine-2,4-diamine mediates the activation of arylation, which is a chemical reaction that produces a new carbon-carbon bond between two or more molecules. This reaction is involved in the process of angiogenesis. In addition, this compound has been shown to be reactive with other compounds that are known to cause mutations and cellular damage.</p>

<p>8-Azidoadenosine 5'-triphosphate tetralithium salt is a modified nucleoside phosphoramidite. It can be used as an activator for the synthesis of both DNA and RNA oligonucleotides. 8-Azidoadenosine 5'-triphosphate tetralithium salt has antiviral activity, which may be due to its ability to inhibit viral protein synthesis by blocking the function of the virus's ribonuclease. This compound also has anticancer properties, which are likely due to its ability to inhibit DNA synthesis in tumor cells.</p>

<p>BiotinTEG Phosphoramidite is a medicinal compound that acts as an inhibitor of cancer cell growth. It has been shown to induce apoptosis in human tumor cells, making it a promising anticancer agent. This compound is an analog of Chinese hamster ovary (CHO) kinase inhibitors and has been found to inhibit the activity of various kinases involved in cancer cell proliferation. BiotinTEG Phosphoramidite is also used as a protein labeling agent due to its ability to attach biotin molecules to proteins, allowing for their detection and purification. This compound can be detected in urine, making it useful for monitoring drug levels during treatment. Overall, BiotinTEG Phosphoramidite holds great potential as a therapeutic agent for cancer treatment and protein labeling in research applications.</p>

<p>(2R,3R,4S,5R)-2-[6-Amino-2-(propylsulfanyl)-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol is a novel nucleoside that has antiviral and anticancer properties. It is synthesized from deoxyribonucleosides and phosphoramidites by reacting with high purity acetic anhydride in the presence of triethylamine as catalyst. The compound is also known as (2R,3R,4S,5R)-2-[6-Amino-2-(propylsulfanyl)-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol or 2'-deoxy[(2R,3R,4S,5R)-2-[6-(aminopropyls</p>

<p>5'-O-DMT-2'-O-pentylaminoadenosine is a phosphoramidite nucleoside monophosphate. It is a novel anticancer and antiviral agent that has been shown to kill cancer cells, inhibit viral replication, and inhibit the synthesis of DNA in the cell. 5'-O-DMT-2'-O-pentylaminoadenosine has been shown to be an effective inhibitor of herpes simplex virus type 1 (HSV1) replication in vitro. This drug also inhibits the synthesis of DNA and RNA by inhibiting nucleoside diphosphate kinase, which is a key enzyme in the metabolism of nucleosides.</p>

<p>2'-Deoxycytidine phosphoramidite dimer is a Novel, high quality, and CAS No. Phosphoramidites that are synthesized from deoxyribonucleosides and have antiviral, anticancer, and ribonucleoside activities. These compounds are monophosphate, which means they can be used for the synthesis of DNA or RNA. The 2'-Deoxycytidine phosphoramidite dimer is modified with a 2'-deoxycytidine moiety. This modification increases the stability of the compound in cells and increases its ability to inhibit the replication of viruses such as HIV-1.</p>

<p>3'-Deoxyadenosine CPG is a nucleoside that is synthetically manufactured. It is a monophosphate, which can be activated to a diphosphate by the enzyme phosphoramidase. 3'-Deoxyadenosine CPG has antiviral activity and is used in the treatment of Hepatitis B and C. It also has been shown to inhibit replication of DNA and RNA viruses such as HIV-1. 3'-Deoxyadenosine CPG binds to viral DNA or RNA by base pairing with the phosphate group on its 5' carbon atom, which prevents viral replication by preventing the polymerization of nucleic acids during transcription. This product is purified with an average purity of 99% and CAS number 120775-80-0.br&gt;br&gt;<br>3'-Deoxyadenosine CPG (3'-DAD) is a modified nucleoside that was synthesized for use in antiviral therapy against hepatitis B virus</p>

<p>This is a nucleotide analog that is used as a building block in DNA synthesis. It can be obtained from various sources, such as Sigma-Aldrich, Inc.</p>

<p>6-Chloro-2-iodo-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine is a protected purine nucleoside</p>

<p>3'-Azido-3'-deoxythymidine-methyl-D3-b-D-glucuronide sodium salt is a novel antiviral nucleoside phosphoramidite that has been shown to be an effective activator in the synthesis of diphosphate and triphosphate analogs. The novel antiviral nucleoside phosphoramidite was synthesized from 3'-azido-3'-deoxythymidine, methyl bromoacetate and sodium hydroxide in methanol at room temperature. It is structurally similar to the natural nucleosides, deoxyribonucleosides and ribonucleosides with modifications on the sugar moiety and phosphate group. This compound is a high quality synthetic material for use in pharmaceutical research, as an anticancer agent and as a potential antiviral drug.</p>

<p>5-Bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid is a pyrimidine derivative that inhibits protein kinases. The compound has been shown to inhibit the activity of protein kinase C, which is involved in mediating inflammatory responses, and phosphorylation of the insulin receptor substrate 1. 5-Bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid is an efficient inhibitor of kinases and can be used as a lead compound for the development of new compounds with therapeutic potential.</p>

<p>5'-O-Acetyl-3'-azido-2',3'-dideoxy-N2-palmitoylguanosine is a novel antiviral and anticancer agent. It is an analogue of the natural nucleoside guanosine. It has been modified with an acetyl group at the 5' position of the pentose moiety and an azido group at the 2' and 3' positions of the ribose moiety. The acetyl group makes this compound more water soluble, which means it can be easily administered intravenously for treatment of cancer or infection.</p>

<p>1-(2-Deoxy-b-D-ribofuranosyl)-4-methylindole is a nucleoside that can be used as an activator for phosphoramidite synthesis. It is also known to have antiviral, anticancer, and antimalarial properties. 1-(2-Deoxy-b-D-ribofuranosyl)-4-methylindole has been shown to inhibit the proliferation of human leukemia cells in culture. It has also been shown to suppress HIV replication in vitro by inhibiting viral RNA synthesis.</p>

<p>2-Amino-4-(4-fluorophenyl)pyrimidine is a fluorinated derivative of imatinib, which is a chemical that inhibits the activity of tyrosine kinases. It has been shown to be a more potent inhibitor than imatinib, and it also offers high yields and regioselectivity. This compound can be used in organic chemistry to produce fluorinated derivatives.</p>

<p>2'-Amino-2'-deoxyguanosine-5'-triphosphate tetralithium salt is a novel nucleoside analog that has antiviral and anticancer activities. It is a high quality, modified nucleoside that can be used for the synthesis of deoxyribonucleosides or ribonucleosides. It is synthesized from 2'-amino-2'-deoxyguanosine triphosphate and a lithium salt of tetrabutylammonium. This product has a CAS number of 108269-13-2 and a purity level of ≥99%.</p>

<p>3'-Deoxy-2-fluoroadenosine is a byproduct of the metabolism of nucleoside phosphorylase. It can be used as a chromatographic agent for the separation of nucleic acids and proteins. 3'-Deoxy-2-fluoroadenosine can also be used in the preparation of immunofluorescence and immunohistochemical staining. 3'-Deoxy-2-fluoroadenosine is found in tissues that are rich in neurofilaments, such as brain tissue, and is often used to stain these tissues for histological examination. Cancer cells have been shown to produce 3'-deoxy-2-fluoroadenosine at a higher rate than normal cells, so it can also be used as an indicator of cancer. The thermophilic bacterium Thermus thermophilus produces high levels of this compound during DNA replication, which may be due to its role in the synthesis of d-arabinose from rib</p>

<p>2'-C-Ethynylcytidine is a synthetic surfactant that can be used in coatings and other surface treatments. It has been shown to inhibit the growth of bacteria and viruses, as well as being effective against a variety of bacterial species. 2'-C-Ethynylcytidine binds to sulfide, which is produced by bacteria, leading to cell death. The antimicrobial activity of 2'-C-Ethynylcytidine is due to its ability to form ester linkages with polyesters, which are able to penetrate the bacterial cell membrane and disrupt the integrity of the cytoplasmic membrane. This leads to leakage of intracellular contents, followed by cell death. 2'-C-Ethynylcytidine also has been shown to bind to metal ions such as silver, copper, zinc and cadmium and prevent their uptake into cells.</p>

<p>2-(2-Methylphenyl)pyrimidine-5-carbaldehyde is a crystalline solid that has been shown to have synergistic effects with polypropylene. It is synthesized from 2-methylphenylacetonitrile and 2,4-dichloro-6-(trifluoromethyl)pyrimidine in the presence of sodium metal. The product is soluble in alcohols and ethers, but insoluble in water.</p>

<p>5’-O-DMT-thymidine 3’-Me phosphoramidite is a novel and modified nucleotide analog that is used as an antiviral agent. It has been shown to be active against herpes simplex virus type 1 (HSV-1) and Epstein-Barr virus (EBV). 5'-O-DMT-thymidine 3’-Me phosphoramidite is not active against HIV, although it has been shown to inhibit the replication of Hepatitis B virus. This compound can also be used in cancer therapy.<br>5'-O-DMT-thymidine 3' -Me phosphoramidite inhibits cellular DNA synthesis by competing with natural thymidine monophosphate (TMP) for incorporation into DNA. The incorporation of 5'-O-DMT-thymidine 3' -Me into DNA leads to a high frequency of mutations, which causes the death of the cell.</p>

<p>2'-Deoxy-5'-O-DMT-5-fluoro-4-O-(2,4,6-trimethylphenyl)uridine 3'-CE-phosphoramidite is a novel phosphoramidite monophosphate. It is modified to include fluorine at the 5 position of the uridine moiety and has antiviral activity. This product is a nucleoside with antiviral properties that can be used in cancer treatments. 2'-Deoxy-5'-O-DMT-5-fluoro-4-O-(2,4,6-trimethylphenyl)uridine 3'-CE phosphoramidite is synthesized from deoxyribonucleosides and ribonucleosides by using a high purity process.</p>

<p>Building block for the introduction of uridine units into oligonucleotides</p>

<p>NPE-caged- GTP sodium salt is a novel nucleoside that can be used as a monophosphate or ribonucleotide, which is synthesized through the use of chemical phosphoramidites. NPE-caged- GTP sodium salt has been shown to have anticancer and antiviral properties in vitro. The synthesis of this compound is a novel modification of GTP, which makes it an activator for specific DNA sequences. It also has high purity and high quality.</p>

<p>Abacavir carboxylate is a prodrug of abacavir that is activated by the carboxylation of the terminal hydroxyl group in the liver. It has been shown to be quantified using a liquid chromatography-mass spectrometry (LC-MS) method. Abacavir carboxylate has an additional benefit of being less sensitive to degradation by nitrate, which can interfere with the analysis of acyclovir. The deuterium label on abacavir carboxylate ensures that it is not confused with acyclovir and facilitates identification in wastewater samples.</p>

<p>2'-Deoxy-2'-fluoroguanosine-5'-triphosphate lithium salt - 100mM aqueous solution is an antiviral agent of the deoxyribonucleoside family. It is a novel antiviral agent that inhibits viral replication by inhibiting viral DNA synthesis, and it also has anticancer activities. 2'-Deoxy-2'-fluoroguanosine-5'-triphosphate lithium salt - 100mM aqueous solution is modified from guanosine monophosphate (GMP), which is a nucleotide precursor in DNA synthesis, and can be used as an activator for phosphoramidites in the synthesis of DNA.</p>

<p>N6-Benzoyl-7'-OH-morpholino adenosine is a modified nucleoside with antiviral activity. It is being developed as an activator of ribonucleotide reductase and a potential anticancer agent. N6-Benzoyl-7'-OH-morpholino adenosine is synthesized by reacting benzoyl chloride with 7'-O-dimethoxytritylmorpholine. This reaction results in the formation of the desired product, which has been shown to be an activator of ribonucleotide reductase. The synthesis of this compound can be performed on a large scale, making it an attractive candidate for chemotherapeutic use.</p>

<p>2'-O-tert-Butyldimethylsilyluridine is a nucleoside that is used in DNA synthesis, antiviral research, and anticancer therapy. It is synthesized from 2'-deoxyuridine monophosphate (2'-dUMP) with the aid of a phosphoramidite coupling agent. It has shown to be an effective activator in the synthesis of oligonucleotides, which are short chains of nucleotide units that can be used for various purposes including the treatment of cancer cells. These chains are synthesized by linking together individual nucleosides with phosphate molecules at each end. The bonds between these phosphate groups and the sugar-phosphate backbone of the nucleotide units are called phosphodiester bonds. This synthetic process can be used to produce DNA or RNA strands as well as modified versions of these strands such as those that have been synthesized with other chemical groups on their sugar-phosphate backbones.</p>

<p>5'-O-DMT-2'-O-propynyluridine 3'-CE phosphoramidite is a novel nucleoside analogue that can be used to synthesize DNA and RNA. This compound has antiviral and anticancer properties, which may be due to its ability to inhibit the synthesis of RNA. This product is also high quality, high purity, and low cost. 5'-O-DMT-2'-O-propynyluridine 3'-CE phosphoramidite is an excellent chemical intermediate for the synthesis of nucleosides with modified sugar moieties. It can be used in pharmaceuticals and other chemical industries.</p>

<p>2'-Deoxy-2'-fluoro-2-hydroxy-b-D-arabinoadenosine is a novel nucleoside that was synthesized as a potential antiviral agent. It is an analog of adenosine and has been shown to inhibit the replication of HIV in vitro. This nucleoside is synthesized using a modified phosphoramidite approach and can be used in the synthesis of DNA or RNA. 2'-Deoxy-2'-fluoro-2-hydroxy-b-D-arabinoadenosine has also been shown to have anticancer activity.</p>

<p>2'-Deoxy-5'-O-DMT-N6-methyl-8-oxoadenosine 3'-CE phosphoramidite is a nucleotide analog that is used for the treatment of cancer. It inhibits sugar transport, which leads to tumor cell lysis. 2'-Deoxy-5'-O-DMT-N6-methyl-8-oxoadenosine 3'-CE phosphoramidite binds to glut1 and toll-like receptor 4 in the cell membrane, inhibiting the activation of these cells. This drug has been shown to have an antibody response in myeloma cells and basic fibroblast cell lines.</p>

<p>2'-Deoxy-5'-O-DMT-2'-fluoro-N2-isobutyrylguanosine 3'-O-succinate triethylammonium salt is a novel phosphoramidite that can be used as an activator for DNA synthesis. It is activated by the addition of an appropriate nucleophile and has been shown to be effective in antiviral and anticancer activities. This compound is synthesized through a modified diphosphate method and it is available in high purity with a CAS number.</p>

<p>2',3'-Dideoxy-3'-fluorocytidine is a synthetic nucleoside analog that inhibits DNA synthesis by blocking the incorporation of deoxycytidine into DNA. It is used to treat lymphocytic leukemia, hepatitis, and virus infections. 2',3'-Dideoxy-3'-fluorocytidine has been shown to inhibit cell growth in solid tumours. The drug has also been shown to inhibit the production of immunodeficiency viruses such as human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type I (HTLV-I), which causes acquired immune deficiency syndrome (AIDS). 2',3'-Dideoxy-3'-fluorocytidine inhibits viral replication by inhibiting the activity of the enzyme deaminase, which converts dATP to dTTP. This prevents DNA replication and transcription.</p>

<p>Valopicitabine is a prodrug that is converted to its active form, 3'-deoxy-3'-methylvalopicitabine, in the body. Valopicitabine inhibits viral replication by a mechanism that is not yet fully understood. It has been shown to inhibit NS3 protease and induce an interferon response. Valopicitabine has also been shown to inhibit Toll-like receptor 4 (TLR4) activity and elicit an antiviral response. Valopicitabine has low bioavailability, which may be due to its high lipophilicity.</p>